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Tuberkuloz Ve Toraks Dec 2022Progressive pulmonary fibrosis (PPF) is defined as the presence of at least two of the three criteria, which are worsening respiratory symptoms, functional decline, and... (Review)
Review
Progressive pulmonary fibrosis (PPF) is defined as the presence of at least two of the three criteria, which are worsening respiratory symptoms, functional decline, and radiological progression in patients with interstitial lung disease with radiological pulmonary fibrosis for known or unknown reasons other than IPF, within the previous year (1). A conditional recommendation has been made for nintedanib in the treatment of PPF, and further studies are needed for pirfenidone (1). In this review, the diagnostic and therapeutic approach to progressive pulmonary fibrosis with its new name, previously known as progressive fibrotic interstitial lung diseases, will be discussed, accompanied by updates.
Topics: Humans; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Disease Progression
PubMed: 36537095
DOI: 10.5578/tt.20229609 -
Nature Reviews. Gastroenterology &... Mar 2023
Topics: Humans; Carcinoma, Hepatocellular; Liver Neoplasms; Disease Progression
PubMed: 36750619
DOI: 10.1038/s41575-023-00746-7 -
Nature Immunology Dec 2023Visualization of the cellular heterogeneity and spatial architecture of the tumor microenvironment (TME) is becoming increasingly important to understand mechanisms of... (Review)
Review
Visualization of the cellular heterogeneity and spatial architecture of the tumor microenvironment (TME) is becoming increasingly important to understand mechanisms of disease progression and therapeutic response. This is particularly relevant in the era of cancer immunotherapy, in which the contexture of immune cell positioning within the tumor landscape has been proven to affect efficacy. Although single-cell technologies have mostly replaced conventional approaches to analyze specific cellular subsets within tumors, those that integrate a spatial dimension are now on the rise. In this Review, we assess the strengths and limitations of emerging spatial technologies with a focus on their applications in tumor immunology, as well as forthcoming opportunities for artificial intelligence (AI) and the value of integrating multiomics datasets to achieve a holistic picture of the TME.
Topics: Humans; Tumor Microenvironment; Artificial Intelligence; Disease Progression; Immunotherapy; Neoplasms
PubMed: 38012408
DOI: 10.1038/s41590-023-01678-9 -
Frontiers in Immunology 2023
Topics: Humans; Tumor Microenvironment; Disease Progression
PubMed: 36761722
DOI: 10.3389/fimmu.2023.1141084 -
Continuum (Minneapolis, Minn.) Feb 2024Immune-mediated myelopathies are conditions in which the immune system attacks the spinal cord. This article describes the distinguishing characteristics of...
OBJECTIVE
Immune-mediated myelopathies are conditions in which the immune system attacks the spinal cord. This article describes the distinguishing characteristics of immune-mediated myelopathies and treatment strategies for patients affected by these disorders.
LATEST DEVELOPMENTS
New biomarkers, such as aquaporin 4 and myelin oligodendrocyte glycoprotein antibodies, in the blood and spinal fluid have led to the identification of antigen-specific immune-mediated myelopathies and approved therapies to prevent disease progression.
ESSENTIAL POINTS
The first step in the diagnosis of an immune-mediated myelopathy is confirming that the immune system is the cause of the attack by excluding non-immune-mediated causes. The second step is to narrow the differential diagnosis based on objective biomarkers such as serology and MRI patterns. The third step is to treat the specific immune-mediated myelopathy by using evidence-based medicine.
Topics: Humans; Spinal Cord Diseases; Aquaporin 4; Disease Progression; Biomarkers
PubMed: 38330478
DOI: 10.1212/CON.0000000000001382 -
The AAPS Journal Aug 2023Macrophages, as one of the most abundant tumor-infiltrating cells, play an important role in tumor development and metastasis. The frequency and polarization of... (Review)
Review
Macrophages, as one of the most abundant tumor-infiltrating cells, play an important role in tumor development and metastasis. The frequency and polarization of tumor-associated macrophages (TAMs) correlate with disease progression, tumor metastasis, and resistance to various treatments. Pro-inflammatory M1 macrophages hold the potential to engulf tumor cells. In contrast, anti-inflammatory M2 macrophages, which are predominantly present in tumors, potentiate tumor progression and immune escape. Targeting macrophages to modulate the tumor immune microenvironment can ameliorate the tumor-associated immunosuppression and elicit an anti-tumor immune response. Strategies to repolarize TAMs, deplete TAMs, and block inhibitory signaling hold great potential in tumor therapy. Besides, biomimetic carriers based on macrophages have been extensively explored to prolong circulation, enhance tumor-targeted delivery, and reduce the immunogenicity of therapeutics to augment therapeutic efficacy. Moreover, the genetic engineering of macrophages with chimeric antigen receptor (CAR) allows them to recognize tumor antigens and perform tumor cell-specific phagocytosis. These strategies will expand the toolkit for treating tumors, especially for solid tumors, drug-resistant tumors, and metastatic tumors. Herein, we introduce the role of macrophages in tumor progression, summarize the recent advances in macrophage-centered anticancer therapy, and discuss their challenges as well as future applications. Graphical abstract.
Topics: Humans; Macrophages; Biomimetics; Disease Progression; Genetic Engineering
PubMed: 37589825
DOI: 10.1208/s12248-023-00845-y -
Hepatology (Baltimore, Md.) Apr 2022
Topics: Disease Progression; Frailty; Humans; Liver Cirrhosis
PubMed: 35006612
DOI: 10.1002/hep.32325 -
International Journal of Molecular... Apr 2022The terminal stage of many chronic inflammatory diseases is organ fibrosis [...].
The terminal stage of many chronic inflammatory diseases is organ fibrosis [...].
Topics: Disease Progression; Fibrosis; Humans; Liver Cirrhosis; Neoplasms
PubMed: 35409286
DOI: 10.3390/ijms23073924 -
Muscle & Nerve Aug 2023
Topics: Humans; Amyotrophic Lateral Sclerosis; Motor Neurons; Electromyography; Disease Progression
PubMed: 37165712
DOI: 10.1002/mus.27843 -
Clinical Gastroenterology and... Feb 2020
Topics: Aspirin; Disease Progression; Fibrosis; Humans; Non-alcoholic Fatty Liver Disease
PubMed: 31352095
DOI: 10.1016/j.cgh.2019.07.041