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Medicina (Kaunas, Lithuania) Dec 2019The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and... (Review)
Review
BACKGROUND AND OBJECTIVES
The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer. In addition, nonmalignant cells in the tumor microenvironment play critical roles in all the stages of carcinogenesis by stimulating and facilitating uncontrolled cell proliferation.
AIM
This study aims to explore the concept of the tumor microenvironment by conducting a critical review of previous studies on the topic. Methods: This review relies on evidence presented in previous studies related to the topic. The articles included in this review were obtained from different medical and health databases.
RESULTS AND DISCUSSION
The tumor microenvironment has received significant attention in the cancer literature, with a particular focus on its role in tumor development and progression. Previous studies have identified various components of the tumor microenvironment that influence malignant behavior and progression. In addition to malignant cells, adipocytes, fibroblasts, tumor vasculature, lymphocytes, dendritic cells, and cancer-associated fibroblasts are present in the tumor microenvironment. Each of these cell types has unique immunological capabilities that determine whether the tumor will survive and affect neighboring cells.
CONCLUSION
The tumor microenvironment harbors cancer stem cells and other molecules that contribute to tumor development and progression. Consequently, targeting and manipulating the cells and factors in the tumor microenvironment during cancer treatment can help control malignancies and achieve positive health outcomes.
Topics: Disease Progression; Humans; Neoplasms; Tumor Microenvironment
PubMed: 31906017
DOI: 10.3390/medicina56010015 -
Tuberkuloz Ve Toraks Dec 2022Progressive pulmonary fibrosis (PPF) is defined as the presence of at least two of the three criteria, which are worsening respiratory symptoms, functional decline, and... (Review)
Review
Progressive pulmonary fibrosis (PPF) is defined as the presence of at least two of the three criteria, which are worsening respiratory symptoms, functional decline, and radiological progression in patients with interstitial lung disease with radiological pulmonary fibrosis for known or unknown reasons other than IPF, within the previous year (1). A conditional recommendation has been made for nintedanib in the treatment of PPF, and further studies are needed for pirfenidone (1). In this review, the diagnostic and therapeutic approach to progressive pulmonary fibrosis with its new name, previously known as progressive fibrotic interstitial lung diseases, will be discussed, accompanied by updates.
Topics: Humans; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Disease Progression
PubMed: 36537095
DOI: 10.5578/tt.20229609 -
Acta Dermatovenerologica Alpina,... Dec 2020Parry-Romberg syndrome (PRS) is a rare disorder of uncertain etiology that is characterized by progressive atrophy of the soft and hard tissues of face, typically... (Review)
Review
Parry-Romberg syndrome (PRS) is a rare disorder of uncertain etiology that is characterized by progressive atrophy of the soft and hard tissues of face, typically occurring in the first 2 decades of life. It is more commonly seen in females. The disease progresses slowly with gradual atrophy, frequently associated with neurological, ophthalmological, and other system involvement, resulting in secondary complications. The severity of deformity varies depending on the age of onset of disease. Those in whom the disease starts at an earlier age will have more severe deformity. Due to the visible facial deformity, such patients usually suffer from social and psychological trauma. Management is mainly cosmetic, which is carried out after disease progression has stopped and stabilized. This brief review describes PRS in detail and compares it with linear morphea en coup de sabre (ECDS), its close differential, which is likely to be a milder variant sharing the same spectrum of disease.
Topics: Disease Progression; Facial Hemiatrophy; Humans; Scleroderma, Localized
PubMed: 33348939
DOI: No ID Found -
International Journal of Molecular... Feb 2023Appreciation of the importance of is growing, and it is becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut-liver-brain... (Review)
Review
Appreciation of the importance of is growing, and it is becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut-liver-brain axes for multiple diseases via . In recent years, and its components such as outer membrane proteins and extracellular vesicles have been known to ameliorate host metabolic health and intestinal homeostasis. However, the impacts of on host health and disease are complex, as both potentially beneficial and adverse effects are mediated by and its derivatives, and in some cases, these effects are dependent upon the host physiology microenvironment and the forms, genotypes, and strain sources of . Therefore, this review aims to summarize the current knowledge of how interacts with the host and influences host metabolic homeostasis and disease progression. Details of will be discussed including its biological and genetic characteristics; biological functions including anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, and anti-cancer therapy functions; and strategies to elevate its abundance. Key events will be referred to in some specific disease states, and this knowledge should facilitate the identification of -based probiotic therapy targeting multiple diseases via gut-liver-brain axes.
Topics: Humans; Verrucomicrobia; Probiotics; Homeostasis; Disease Progression; Liver; Brain
PubMed: 36835309
DOI: 10.3390/ijms24043900 -
International Journal of Molecular... Apr 2022The terminal stage of many chronic inflammatory diseases is organ fibrosis [...].
The terminal stage of many chronic inflammatory diseases is organ fibrosis [...].
Topics: Disease Progression; Fibrosis; Humans; Liver Cirrhosis; Neoplasms
PubMed: 35409286
DOI: 10.3390/ijms23073924 -
Frontiers in Immunology 2023
Topics: Humans; Tumor Microenvironment; Disease Progression
PubMed: 36761722
DOI: 10.3389/fimmu.2023.1141084 -
International Journal of Molecular... Sep 2023Kidney disease is a major global health concern, affecting millions of people. Nephrologists have shown interest in platelets because of coagulation disorders caused by... (Review)
Review
Kidney disease is a major global health concern, affecting millions of people. Nephrologists have shown interest in platelets because of coagulation disorders caused by renal diseases. With a better understanding of platelets, it has been found that these anucleate and abundant blood cells not only play a role in hemostasis, but also have important functions in inflammation and immunity. Platelets are not only affected by kidney disease, but may also contribute to kidney disease progression by mediating inflammation and immune effects. This review summarizes the current evidence regarding platelet abnormalities in renal disease, and the multiple effects of platelets on kidney disease progression. The relationship between platelets and kidney disease is still being explored, and further research can provide mechanistic insights into the relationship between thrombosis, bleeding, and inflammation related to kidney disease, and elucidate targeted therapies for patients with kidney disease.
Topics: Humans; Immunity, Innate; Blood Platelets; Hemostasis; Inflammation; Kidney Diseases; Disease Progression
PubMed: 37834171
DOI: 10.3390/ijms241914724 -
Journal of the American College of... Jan 2017
Topics: Calcium; Disease Progression; Heart Failure; Humans; Nod1 Signaling Adaptor Protein
PubMed: 28126161
DOI: 10.1016/j.jacc.2016.10.072 -
European Respiratory Review : An... Dec 2020The extracellular matrix (ECM) of the lung plays several important roles in lung function, as it offers a low resistant pathway that allows the exchange of gases,... (Review)
Review
The extracellular matrix (ECM) of the lung plays several important roles in lung function, as it offers a low resistant pathway that allows the exchange of gases, provides compressive strength and elasticity that supports the fragile alveolar-capillary intersection, controls the binding of cells with growth factors and cell surface receptors and acts as a buffer against retention of water.COPD is a chronic inflammatory respiratory condition, characterised by various conditions that result in progressive airflow limitation. At any stage in the course of the disease, acute exacerbations of COPD may occur and lead to accelerated deterioration of pulmonary function. A key factor of COPD is airway remodelling, which refers to the serious alterations of the ECM affecting airway wall thickness, resistance and elasticity. Various studies have shown that serum biomarkers of ECM turnover are significantly associated with disease severity in patients with COPD and may serve as potential targets to control airway inflammation and remodelling in COPD. Unravelling the complete molecular composition of the ECM in the diseased lungs will help to identify novel biomarkers for disease progression and therapy.
Topics: Airway Remodeling; Disease Progression; Extracellular Matrix; Humans; Lung; Pulmonary Disease, Chronic Obstructive
PubMed: 33208482
DOI: 10.1183/16000617.0124-2019 -
Trends in Molecular Medicine Sep 2022The environmental role in disease progression has been appreciated for decades; however, understanding how airborne toxicant exposure can affect organs beyond the lungs... (Review)
Review
The environmental role in disease progression has been appreciated for decades; however, understanding how airborne toxicant exposure can affect organs beyond the lungs is an underappreciated area of scientific inquiry. Particulate matter (PM) includes various gases, liquids, and particles in suspension and is produced by industrial activities such as fossil fuel combustion and natural events including wildfires and volcanic eruptions. Although agencies have attempted to reduce acceptable airborne particulate levels, with urbanization and population growth, these policies have been only moderately effective in mitigating disease progression. A growing area of research is focused on the role of PM exposure in the progression of Alzheimer's disease (AD). This review will summarize the knowns and unknowns of this expanding field.
Topics: Air Pollutants; Air Pollution; Alzheimer Disease; Disease Progression; Humans; Particulate Matter
PubMed: 35840480
DOI: 10.1016/j.molmed.2022.06.004