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European Journal of Translational... Oct 2022More than half of pregnant women are usually affected by odontogenic pain affects. Pain often accompanies periapical or pulp infections and increases the risks to... (Review)
Review
More than half of pregnant women are usually affected by odontogenic pain affects. Pain often accompanies periapical or pulp infections and increases the risks to pregnant patients and their fetuses. The American Dental Association, in partnership with the American College of Obstetricians and Gynecologists, has offered a strong declaration reaffirming the significance of suitable and timely oral health care as an indispensable constituent of a healthy pregnancy. However, there is lack of knowledge about the use of antibiotics in endodontic treatment. Therefore, the present study would review the researches done in this area and tries to provide comprehensive and complete information about the use of antibiotics in endodontic treatment during pregnancy. Based on the results, it can be said that using antibiotics during pregnancy are allowed, and they can be used normally and safely by pregnant women.
PubMed: 36268928
DOI: 10.4081/ejtm.2022.10813 -
Swiss Dental Journal Oct 2019These guidelines address the administration of systemic antibiotics in periodontics, especially in the treatment of periodontitis, necrotizing...
These guidelines address the administration of systemic antibiotics in periodontics, especially in the treatment of periodontitis, necrotizing gingivitis/periodontitis, periodontal abscess and periimplantitis. Microorganisms associated with these conditions aggregate as structured biofilms on tooth surfaces, and biofilms effectively protect microorganisms from antibiotics. It is therefore a central principle to use antibiotics only as adjunct to mechanical debridement. In fact, many cases can be resolved by mechanical therapy even without the prescription of antibiotics. Good oral hygiene is crucial for longterm success.
Topics: Anti-Bacterial Agents; Dental Implants; Gingivitis; Humans; Peri-Implantitis; Periodontics; Periodontitis
PubMed: 31607436
DOI: 10.61872/sdj-2019-10-03 -
Australian Journal of General Practice Sep 2020An orthopantomogram (OPG) is a common radiograph used to identify the hard tissues of the oral cavity and surrounding skeletal structures. It is an extra-oral...
BACKGROUND
An orthopantomogram (OPG) is a common radiograph used to identify the hard tissues of the oral cavity and surrounding skeletal structures. It is an extra-oral radiograph that approximates the focal trough of the mandible. Although resolution is not as detailed as intra-oral radiographs for examination of the teeth, gross changes in calcification of the dental structures, and changes in ossification of the underlying mandible and maxilla can aid in identification of dental disease such as caries (decay), periodontal bone loss, and abscess and cyst formation.
OBJECTIVE
This article outlines key anatomical features identifiable in an OPG and illustrates some common pathology that may be seen.
DISCUSSION
The large amount of data visible on an OPG may appear daunting to the viewer unless a systematic approach is used to examine structures present. Distortion due to flattening of the curve of the mandible and dentition will give an overall view of these structures and requires the viewer to reinterpret these in their mind for a three-dimensional appreciation of the image.
Topics: Humans; Mandible; Maxilla; Radiography, Panoramic
PubMed: 32864665
DOI: 10.31128/AJGP-07-20-5536 -
Dermatologic Clinics Oct 2020Oral health is a critical component of overall health and well-being. Dental caries and periodontitis are two of the most common oral diseases and, when not treated, can... (Review)
Review
Oral health is a critical component of overall health and well-being. Dental caries and periodontitis are two of the most common oral diseases and, when not treated, can have irreversible sequelae and overall psychosocial and physiologic impact on individuals, diminishing quality of life. The burden of advanced dental caries and periodontal disease leading to tooth loss is severe. Physicians and allied medical professionals can help in early detection of dental caries, abscess, and periodontal diseases and initiate management followed by prompt referral to dental colleagues.
Topics: Biofilms; Dental Caries; Dental Implants; Dental Plaque; Humans; Oral Health; Oral Hygiene; Periodontal Diseases; Stomatitis
PubMed: 32892850
DOI: 10.1016/j.det.2020.05.002 -
Antibiotics (Basel, Switzerland) Sep 2020Knowledge of microbial composition and antimicrobials' susceptibility to periodontal abscesses is vital for their successful treatment. The current study aims to provide...
Knowledge of microbial composition and antimicrobials' susceptibility to periodontal abscesses is vital for their successful treatment. The current study aims to provide a thorough overview of the clinical and microbial features of periodontal abscesses of the local community. The study was carried out at Rehman College of Dentistry, Peshawar, Pakistan between December 2019 to March 2020. Clinical measurements and microbial samples were collected from 45 subjects. Microbial samples were anaerobically cultured for the growth of selected bacterial species. E-test was used to assess the susceptibility of bacterial species grown from the patient samples to amoxicillin, azithromycin, metronidazole, and tetracycline. The majority of affected patients had preexisting chronic periodontitis. All abscesses clinically demonstrated bleeding on probing and suppuration. The periodontal abscess was most commonly associated with lower incisors and canines, followed by lower molars and then upper incisor and canine teeth. spp. (73%) was the most frequently detected species followed by (65%), (46%) and (24%). The detected clinical isolates of certain bacteria demonstrated resistance to all tested antibiotics except azithromycin. We conclude that spp., , and are closely associated with periodontal abscess. Bacterial species associated with periodontal abscess demonstrated some level of antimicrobial resistance to amoxicillin, metronidazole and tetracycline while antibiotic resistance to azithromycin could not be demonstrated.
PubMed: 33003527
DOI: 10.3390/antibiotics9100654 -
Evidence-based Dentistry Dec 2022Introduction A systematic review and meta-analysis of the effectiveness of Biodentine compared to formocresol for pulpotomies in the deciduous dentition.Data sources and... (Meta-Analysis)
Meta-Analysis Review
Introduction A systematic review and meta-analysis of the effectiveness of Biodentine compared to formocresol for pulpotomies in the deciduous dentition.Data sources and study selection Four electronic data bases were searched (Medline, Embase, Cochrane Central Register of Controlled Trials and Web of Science). Randomised controlled trials (RCTs) which compared the use of Biodentine with formocresol were included in the screening. Two reviewers screened the titles and abstracts of the RCTs independently for inclusion in the review and a third reviewer was consulted in the case of any disagreements. Thirteen articles were used for full-text reading and nine were included in the review. Two investigators assessed risk of bias (RoB) by allocating a score of either high, low or unclear, in line with the Cochrane handbook for systematic reviews of interventions. Failure to blind practitioners paired with a lack of standardised application protocol results in high RoB.Data extraction and synthesis Data was extracted from the included studies using customised forms, including: sample size, patient ages, treatment and clinical and radiographic follow-up and results. Meta-analysis of the results was completed using ReviewManager version 5.4.0.Results In total, 626 children were assessed in the RCTs. All teeth were restored with a preformed metal crown placed directly after the procedure, except for two studies, which placed them 24 and 48 hours later. The primary outcomes of clinical failure were defined as pain, tenderness to percussion, swelling, abscess, fistula and pathological tooth mobility at 12 months. These showed that Biodentine had significantly lower failure rates (RR 0.16; 95% CI 0.003-0.87; N = 394). Radiographic failure rates defined as either internal or pathological external root resorption, furcation radiolucencies or a widened periodontal ligament showed significantly lower failure rates (RR 0.19; 95% CI 0.08-0.49; N = 393). However, the results showed no significant difference for secondary outcomes which assessed the teeth both clinically and radiographically at intervals up to 48 months. Outcomes were assessed using GRADE; this showed all results to be of low certainty due to the high RoB.Conclusions Biodentine may be the superior material to formocresol for pulpotomy in the deciduous dentition. However, the results for both primary and secondary outcomes have a very low to low GRADE rating due to high RoB; therefore, robust future studies should be completed to further substantiate these findings.
Topics: Child; Humans; Pulpotomy; Formocresols; Tooth, Deciduous; Molar; Systematic Reviews as Topic
PubMed: 36526840
DOI: 10.1038/s41432-022-0840-z -
Journal of Oral and Maxillofacial... 2022Diabetes mellitus, a chronic hyperglycemic disorder has been associated with several manifestations in the body including the oral cavity. The oral manifestations are of...
BACKGROUND
Diabetes mellitus, a chronic hyperglycemic disorder has been associated with several manifestations in the body including the oral cavity. The oral manifestations are of importance and may significantly contribute to the detection of undiagnosed diabetes.
OBJECTIVE
To find out the prevalence of oral diseases in type 1 and type 2 diabetics, to evaluate and compare the periodontal status of diabetics and non-diabetics.
MATERIALS AND METHODS
This was a cross sectional study conducted on 110 diabetic subjects of >5 years duration at the M.V. Hospital for Diabetes, Diabetes Research Centre, Chennai. One hundred apparently healthy non-diabetic subjects in the age group of 40-60 years were studied as control. The oral cavity was examined by using a mouth mirror and periodontal status was assessed by utilizing oral hygiene index - simplified (Greene and Vermillion), Miller's mobility index and Ramjford's periodontal disease index.
RESULTS
Subjects with diabetes were found to have significant association with xerostomia ( < 0.003) and chronic periodontitis ( < 0.026). However, no significant association was found forleukoplakia, traumatic ulcer, frictional keratosis, smoker's melanosis, mucocele, aphthous ulcer, fissured tongue, lichen planus, parotid enlargement, parulis, chronic gingivitis, fibroma, and periodontal abscess.
CONCLUSION
The study reaffirmed higher prevalence of xerostomia and periodontal disease among diabetic subjects. However, contrary to previous studies, no significant differences were found in the prevalence of traumatic ulcer, fissured tongue, lichen planus, and parotid enlargement.
PubMed: 36588835
DOI: 10.4103/jomfp.jomfp_37_21 -
MBio Jun 2023Pathogenic microbial ecosystems are often polymicrobial, and interbacterial interactions drive emergent properties of these communities. In the oral cavity,...
Pathogenic microbial ecosystems are often polymicrobial, and interbacterial interactions drive emergent properties of these communities. In the oral cavity, Streptococcus gordonii is a foundational species in the development of plaque biofilms, which can contribute to periodontal disease and, after gaining access to the bloodstream, target remote sites such as heart valves. Here, we used a transposon sequencing (Tn-Seq) library of S. gordonii to identify genes that influence fitness in a murine abscess model, both as a monoinfection and as a coinfection with an oral partner species, Porphyromonas gingivalis. In the context of a monoinfection, conditionally essential genes were widely distributed among functional pathways. Coinfection with P. gingivalis almost completely changed the nature of gene essentiality. Community-dependent essential (CoDE) genes under the coinfection condition were primarily related to DNA replication, transcription, and translation, indicating that robust growth and replication are required to survive with P. gingivalis . Interestingly, a group of genes in an operon encoding streptococcal receptor polysaccharide (RPS) were associated with decreased fitness of S. gordonii in a coinfection with P. gingivalis. Individual deletion of two of these genes (SGO_2020 and SGO_2024) resulted in the loss of RPS production by S. gordonii and increased susceptibility to killing by neutrophils. P. gingivalis protected the RPS mutants by inhibiting neutrophil recruitment, degranulation, and neutrophil extracellular trap (NET) formation. These results provide insight into genes and functions that are important for S. gordonii survival and the nature of polymicrobial synergy with P. gingivalis. Furthermore, we show that RPS-mediated immune protection in S. gordonii is dispensable and detrimental in the presence of a synergistic partner species that can interfere with neutrophil killing mechanisms. Bacteria responsible for diseases originating at oral mucosal membranes assemble into polymicrobial communities. However, we know little regarding the fitness determinants of the organisms that initiate community formation. Here, we show that the extracellular polysaccharide of Streptococcus gordonii, while important for streptococcal survival as a monoinfection, is detrimental to survival in the context of a coinfection with Porphyromonas gingivalis. We found that the presence of P. gingivalis compensates for immune protective functions of extracellular polysaccharide, rendering production unnecessary. The results show that fitness determinants of bacteria in communities differ substantially from those of individual species in isolation. Furthermore, constituents of communities can undertake activities that relieve the burden of energetically costly biosynthetic reactions on partner species.
Topics: Animals; Mice; Streptococcus gordonii; Coinfection; Ecosystem; Biofilms; Mouth
PubMed: 37042761
DOI: 10.1128/mbio.00658-23