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American Journal of Transplantation :... Dec 2020
Topics: Animals; Mice; Models, Theoretical; Organ Transplantation; Urinary Bladder; Vascularized Composite Allotransplantation
PubMed: 32406153
DOI: 10.1111/ajt.16008 -
American Journal of Transplantation :... Aug 2019
Topics: Brain Death; Death; Decision Making; Humans; Organ Transplantation; Tissue Donors; Tissue and Organ Procurement
PubMed: 31343845
DOI: 10.1111/ajt.15510 -
American Journal of Transplantation :... Nov 2020The COVID pandemic has impacted solid organ transplantation in unanticipated ways, including organ donation and procurement. Ahmed et al's article is on page 3081.
The COVID pandemic has impacted solid organ transplantation in unanticipated ways, including organ donation and procurement. Ahmed et al's article is on page 3081.
Topics: COVID-19; Humans; Organ Transplantation; Pandemics; SARS-CoV-2; Tissue and Organ Procurement
PubMed: 32761990
DOI: 10.1111/ajt.16235 -
Frontiers in Immunology 2022The transcriptional regulation of B-cell response to antigen stimulation is complex and involves an intricate network of dynamic signals from cytokines and transcription... (Review)
Review
The transcriptional regulation of B-cell response to antigen stimulation is complex and involves an intricate network of dynamic signals from cytokines and transcription factors propagated from T-cell interaction. Long-term alloimmunity, in the setting of organ transplantation, is dependent on this B-cell response, which does not appear to be halted by current immunosuppressive regimens which are targeted at T cells. There is emerging evidence that shows that B cells have a diverse response to solid organ transplantation that extends beyond plasma cell antibody production. In this review, we discuss the mechanistic pathways of B-cell activation and differentiation as they relate to the transcriptional regulation of germinal center B cells, plasma cells, and memory B cells in the setting of solid organ transplantation.
Topics: B-Lymphocytes; Germinal Center; Graft Rejection; Histocompatibility; Organ Transplantation
PubMed: 36016958
DOI: 10.3389/fimmu.2022.895157 -
The Journal of Heart and Lung... Oct 2022
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-ninth adult lung transplantation report-2022; focus on lung transplant recipients with chronic obstructive pulmonary disease.
Topics: Adult; Heart Transplantation; Heart-Lung Transplantation; Humans; Lung; Lung Transplantation; Organ Transplantation; Pulmonary Disease, Chronic Obstructive; Registries; Transplant Recipients
PubMed: 36050206
DOI: 10.1016/j.healun.2022.08.007 -
Xenotransplantation Mar 2023Formal clinical trials of pig-to-human organ transplant-known asxenotransplantation-may begin this decade, with the first trials likely to consist of either adult renal... (Review)
Review
Formal clinical trials of pig-to-human organ transplant-known asxenotransplantation-may begin this decade, with the first trials likely to consist of either adult renal transplants or pediatric cardiac transplant patients. Xenotransplantation as a systematic scientific study only reaches back to the latter half of the 20th century, with episodic xenotransplantation events occurring prior to that. As the science of xenotransplantation has progressed in the 20th and 21st centuries, the public's knowledge of the potential therapy has also increased. With this, there have been shifting ethical stances toward xenotransplantation in key areas, such as religious and public viewpoints towards xenotransplantation, animal rights, and public health concerns. This review provides a historical-ethical account of xenotransplantation and details if or how viewpoints have shifted over time.
Topics: Adult; Humans; Animals; Child; Swine; Transplantation, Heterologous; Organ Transplantation; Heart Transplantation; Kidney Transplantation; Transplants
PubMed: 36943143
DOI: 10.1111/xen.12797 -
Journal of the American College of... Jun 2020
Topics: Air Pollution; Heart Transplantation; Organ Transplantation
PubMed: 32498817
DOI: 10.1016/j.jacc.2020.01.065 -
Acta Haematologica 2020Amyloidosis comprises a diverse group of diseases characterized by misfolding of precursor proteins which eventually form amyloid aggregates and preceding... (Review)
Review
Amyloidosis comprises a diverse group of diseases characterized by misfolding of precursor proteins which eventually form amyloid aggregates and preceding intermediaries, which are deposited in target tissues causing progressive organ damage. In all forms of amyloidosis, vital organs may fail; depending on the specific amyloidosis type, this may occur rapidly or progress slowly. Beyond therapies to reduce the precursor protein (chemotherapy for light chain [AL] amyloidosis, anti-inflammatory therapy in serum A amyloid-osis [AA], and antisense RNA therapy in transthyretin amyloidosis [ATTR]), organ transplantation may also be a means to reduce amyloidogenic protein, e.g., in types of amyloid-osis in which the variant precursor is produced by the liver. Heart transplantation is a life-saving approach to the treatment of patients with advanced cardiac amyloidosis; however, amyloidosis may still be considered a contraindication to the procedure despite data supporting improved outcomes, similar to patients with other indications. Kidney transplantation is associated with particularly favorable outcomes in patients with amyloidosis, especially if the precursor protein has been eliminated. Overall, outcomes of solid organ transplantation are improving, but more data are needed to refine the selection criteria and the timing for organ transplantation, which should be performed in highly experienced centers involving multidisciplinary teams with close patient follow-up to detect amyloid recurrence.
Topics: Amyloidosis; Disease Management; Humans; Immunoglobulin Light-chain Amyloidosis; Organ Transplantation; Treatment Outcome
PubMed: 32535598
DOI: 10.1159/000508262 -
Viruses Oct 2021Solid organ transplant recipients are at increased risk for infections due to chronic immunosuppression. Diarrhea is a commonly encountered problem post transplantation,... (Review)
Review
Solid organ transplant recipients are at increased risk for infections due to chronic immunosuppression. Diarrhea is a commonly encountered problem post transplantation, with infectious causes of diarrhea being a frequent complication. Viral infections/enteritides in solid organ transplant recipients often result from frequently encountered pathogens in this population such as cytomegalovirus, adenovirus, and norovirus. However, several emerging viral pathogens are increasingly being recognized as more sensitive diagnostic techniques become available. Treatment is often limited to supportive care and reduction in immunosuppression, though antiviral therapies mayplay a role in the treatment in certain diseases. Viral enteritis is an important entity that contributes to morbidity and mortality in transplant recipients.
Topics: Adenoviridae; Adenoviridae Infections; Antiviral Agents; Communicable Diseases; Cytomegalovirus; Diarrhea; Enteritis; Humans; Immunocompromised Host; Immunosuppression Therapy; Norovirus; Organ Transplantation; Transplant Recipients; Virus Diseases
PubMed: 34696449
DOI: 10.3390/v13102019 -
The Journal of Heart and Lung... Oct 2022
The International thoracic organ transplant registry of the international society for heart and lung transplantation: Thirty-ninth adult heart transplantation report-2022; focus on transplant for restrictive heart disease.
Topics: Adult; Heart Diseases; Heart Transplantation; Heart-Lung Transplantation; Humans; Lung Transplantation; Organ Transplantation; Registries; Societies, Medical; Survival Rate
PubMed: 36031520
DOI: 10.1016/j.healun.2022.07.018