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Revista Espanola de Enfermedades... Apr 2023A 17-year-old male with no previous medical history presented with a 1-year history of rectal bleeding, mucus discharge and occasional rectal prolapse. Colonoscopy...
A 17-year-old male with no previous medical history presented with a 1-year history of rectal bleeding, mucus discharge and occasional rectal prolapse. Colonoscopy revealed several polypoidal growth masses in the distal rectum, formed by multiple sessile polyps with a glistening mucus-covered surface and fleshy, friable appearance, that coalesced forming large conglomerates. Given their complexity and large size, piecemeal endoscopic mucosal resection of the rectal lesions was performed and histopathological examination revealed ulcerated polypoid mucosa with mixed inflammatory cell infiltrate in the lamina propria and dilated cystic mucus-filled glands. Remarkably, bony trabeculae surrounded by osteoblastic cells were also seen. These findings were consistent with juvenile polyps with foci of osseous metaplasia. Osseous metaplasia has been described in a wide variety of tissue types, such as prostate, uterus, breasts, lungs and urinary tract, with respect to both neoplastic and non-neoplastic conditions. However, it is exceedingly rare in colonic polyps and, to the best of our knowledge, only 9 cases have been described in juvenile polyps.
Topics: Male; Female; Humans; Adolescent; Endoscopic Mucosal Resection; Intestinal Polyps; Colonic Polyps; Rectum; Colonoscopy; Calcinosis; Choristoma; Hamartoma; Metaplasia; Polyps
PubMed: 36719331
DOI: 10.17235/reed.2023.9489/2023 -
Cureus May 2024Rectal mucosal prolapse is uncommon in children. While most patients present with rectal bleeding and constipation, the occurrence of osseous metaplasia within the...
Rectal mucosal prolapse is uncommon in children. While most patients present with rectal bleeding and constipation, the occurrence of osseous metaplasia within the prolapsed mucosa is extremely rare. Overlapping clinical, gross, and histological features between rectal mucosal prolapse polyps and malignancy pose a challenge for diagnoses. We describe a case of a 16-year-old male who had a rectal mucosal prolapsed polyp with osseous metaplasia. He initially presented due to periumbilical pain with a sore throat and fever. Incidentally, during the workup of his periumbilical pain, he was found to have a soft tissue mass in his rectum on a CT scan, with a biopsy confirming the diagnosis. The case was complicated by the development of sepsis. The patient was treated with empiric antibiotics and was discharged without further complications.
PubMed: 38826948
DOI: 10.7759/cureus.59480 -
Archivos Espanoles de Urologia Sep 2020Renal cell carcinoma is constantly associated with calcification, but ossification is extremely scarce. METHOD: We retrospectively analyzed two cases with clear cell... (Review)
Review
Renal cell carcinoma is constantly associated with calcification, but ossification is extremely scarce. METHOD: We retrospectively analyzed two cases with clear cell renal cell carcinoma with osseous metaplasia. RESULTS: We criticized the oldest case of woman whose a 32x31mm irregular renal mass with calcifications and we also mentioned about a diffusely calcified mass of 90 mm of a 68-year-old male patient. The histopathological examinations of both were reported as clear cell carcinoma with metaplastic bone formation. CONCLUSION: Although there are no definitive data on prognosis and follow-up due to the low number of cases; this entity usually occurs with early stage disease and a favorable prognosis as in our cases. While the prognostic importance of osseous metaplasia existence in renal cell carcinoma is controversial, such that can safely be managed with nephron sparing surgery in appropriate cases. As the number of cases and follow-up periods increased; more definitive information will be obtained.
Topics: Aged; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; Male; Metaplasia; Ossification, Heterotopic; Retrospective Studies
PubMed: 32886080
DOI: No ID Found -
Frontiers in Veterinary Science 2023A 13-year-old neutered male Korean short-hair cat presented with anorexia, lethargy, and a severely distended abdomen, suggestive of ascites. Abdominocentesis yielded...
A 13-year-old neutered male Korean short-hair cat presented with anorexia, lethargy, and a severely distended abdomen, suggestive of ascites. Abdominocentesis yielded serosanguineous fluid. A subsequent diagnostic workup, including blood tests, ascitic fluid analysis, imaging studies [radiography, ultrasound, and computed tomography (CT)], and histopathological examination, was performed to identify the underlying cause. Imaging studies revealed characteristics of encapsulating peritoneal sclerosis (EPS) such as peritoneal thickening, fat stranding, and calcification. During laparotomy, fibrous membranes encapsulating the abdominal organs and ascites were observed, and multiple calcified regions were detected on the abdominal wall. Histopathological analysis confirmed the diagnosis of poorly differentiated invasive malignant neoplasms, which were further classified as carcinomatosis based on positive cytokeratin and negative vimentin immunohistochemistry results. To our knowledge, this is the first report of sclerosing peritoneal carcinomatosis with osseous metaplasia in a cat.
PubMed: 38105775
DOI: 10.3389/fvets.2023.1298736 -
Journal of Oral and Maxillofacial... 2022Lipomata are soft-tissue mesenchymal neoplasms that are benign in nature and often asymptomatic. Lipomata commonly occur in the body, however, only 1%-5% are identified...
INTRODUCTION
Lipomata are soft-tissue mesenchymal neoplasms that are benign in nature and often asymptomatic. Lipomata commonly occur in the body, however, only 1%-5% are identified within the oral cavity, and lipomata with osseous metaplasia account for <1% of all lipomata.
MATERIALS AND METHODS
A PubMed literature review designating search terms including "oral" and "parosteal lipoma" or "lipoma with osseous metaplasia" or "ossifying lipoma" or "osseous lipoma" was conducted.
RESULTS
The literature review identified two previous reports of parosteal localization of lipomata in the mandible and 22 cases of lipomata with osseous metaplasia within the oral cavity.
CONCLUSIONS
With the initial suspicion of a more malevolent diagnosis, this rare entity, with only two other cases identified, is important to consider in the clinician's differential diagnoses.
PubMed: 35571300
DOI: 10.4103/jomfp.jomfp_179_21 -
Rechtsmedizin (Berlin, Germany) 2023This article reports the autopsy findings of a 1.5-year-old girl with no history of previous hospital admission who suddenly collapsed at home. After 45 minutes of...
This article reports the autopsy findings of a 1.5-year-old girl with no history of previous hospital admission who suddenly collapsed at home. After 45 minutes of resuscitation efforts, the cardiac activity was restored. During hospitalization, she had ventricular arrhythmia and extremely elevated cardiac troponin levels. Internal examination and immunohistochemistry revealed cardiac fibromas of the right and left ventricles and extensive hypoxic myocardial damage. The right ventricular fibroma demonstrated interdigitating and entrapped myocardium visible at the edges and within the central portion of the tumor. The left ventricular fibroma originated in the subepicardial region and propagated towards the endocardium.
PubMed: 36778761
DOI: 10.1007/s00194-023-00615-2 -
Turk Patoloji Dergisi 2020Bronchial carcinoid tumors are primary lung neoplasms thought to originate from neuroendocrine cells, i.e. Kulchitsky cells, in the bronchial mucosa, although the type... (Review)
Review
Bronchial carcinoid tumors are primary lung neoplasms thought to originate from neuroendocrine cells, i.e. Kulchitsky cells, in the bronchial mucosa, although the type of cellular origin has not been clearly understood. A 61-year-old male patient underwent surgery and microscopic examination of the specimen revealed an anastomosing trabecular bony structure among the nests of tumor cells with round nucleus, granular chromatin, and large eosinophilic cytoplasm. Our case has been deemed worthy of being presented as bronchial carcinoid tumor with exaggerated osseous metaplasia.
Topics: Bronchi; Carcinoid Tumor; Humans; Lung Neoplasms; Male; Metaplasia; Middle Aged; Ossification, Heterotopic
PubMed: 30977863
DOI: 10.5146/tjpath.2018.01457 -
International Journal For Parasitology.... Apr 2022A female Cuvier's Beaked Whale () specimen measuring 580 cm in length died after being stranded in Southeastern Brazil. Following a necropsy, organ samples were...
A female Cuvier's Beaked Whale () specimen measuring 580 cm in length died after being stranded in Southeastern Brazil. Following a necropsy, organ samples were obtained, fixed in 10% neutral buffered formalin and histopathologically analyzed. A severe and generalized hypodermis infection by (Phyllobothriidae) was observed, resulting in granulomatous panniculitis. Severe renal and arterial lesions were also noted, including a severe bone metaplasia in the aorta artery, associated with a massive infection by sp, (Tetrameridae). A significant thoracic hemorrhage due to thoracic aorta artery rupture was noted, also likely due to this infection, resulting in a fatal injury. This study contributes towards knowledge on histopathologic changes in the scarcely studied Cuvier's Beaked Whale, is the first to associate a sp. infection in this whale species in the Brazilian region and also the first to indicate a resulting osseous metaplasia due to this parasitism and granulomatous dermatitis associated with . Furthermore, this is also, to the best of our knowledge, the first report of cysts in a specimen to date.
PubMed: 34984168
DOI: 10.1016/j.ijppaw.2021.12.005 -
International Journal of Clinical and... 2021Heterotopic ossification (HO), a synonym for osseous metaplasia, is a pathological phenomenon, characterized by abnormal bone formation outside the skeletal system...
Heterotopic ossification (HO), a synonym for osseous metaplasia, is a pathological phenomenon, characterized by abnormal bone formation outside the skeletal system observed commonly in various neoplastic and non-neoplastic diseases. HO occurring in meningioma is exceptionally rare. We reportherein an unusual case of spinal meningioma containing numerous calcified psammoma bodies and extensive HO in a 75-year-old woman, who presented with progressive worsening bilateral lower limb weakness and numbness. The presence of remarkable bone formation within a meningioma is controversial among pathologists; while some regard them as psammomatous meningioma as the primary diagnosis, others prefer osteoblastic meningioma, a form of metaplastic meningioma. There is compelling molecular data to advocate that HO is an active disease process involving metaplastic (osseous) differentiation of meningioma stroma mesenchymal stem-like cells, but not the meningothelial-derived tumor cells. Henceforth, the term "metaplastic meningioma" may not be appropriate in this context. A plausible designation as "psammomatous meningioma with osseous metaplasia" defines this entity more accurately. This paper highlights the need for a unifying nomenclature to reduce diagnostic controversy caused by conflicting terms in the literature. The possible pathogenesis of this intriguing phenomenon is discussed.
PubMed: 34093948
DOI: No ID Found -
Scientific Reports Oct 2019Preclinical trials of cancer drugs in animal models are important for drug development. The Rip1Tag2 (RT2) transgenic mouse, a model of pancreatic neuroendocrine tumours...
Preclinical trials of cancer drugs in animal models are important for drug development. The Rip1Tag2 (RT2) transgenic mouse, a model of pancreatic neuroendocrine tumours (PNET), has provided immense knowledge about PNET biology, although tumour progression occurs in a location inaccessible for real-time monitoring. To overcome this hurdle we have developed a novel platform for intravital 3D imaging of RT2 tumours to facilitate real-time studies of cancer progression. Pre-oncogenic islets retrieved from RT2 mice were implanted into the anterior chamber of the eye (ACE) of host mice, where they engrafted on the iris, recruited blood vessels and showed continuous growth. Noninvasive confocal and two-photon laser-scanning microscopy through the transparent cornea facilitated high-resolution imaging of tumour growth and angiogenesis. RT2 tumours in the ACE expanded up to 8-fold in size and shared hallmarks with tumours developing in situ in the pancreas. Genetically encoded fluorescent reporters enabled high-resolution imaging of stromal cells and tumour cell migration. Sunitinib treatment impaired RT2 tumour angiogenesis and growth, while overexpression of the vascular endothelial growth factor (VEGF)-B increased tumour angiogenesis though tumour growth was impaired. In conclusion, we present a novel platform for intravital high-resolution and 3D imaging of PNET biology and cancer drug assessment.
Topics: Animals; Antineoplastic Agents; Bacterial Proteins; Disease Models, Animal; Disease Progression; Drug Screening Assays, Antitumor; Fluorescent Dyes; Genes, Reporter; Humans; Imaging, Three-Dimensional; Intravital Microscopy; Islets of Langerhans; Islets of Langerhans Transplantation; Luminescent Proteins; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Neovascularization, Pathologic; Neuroendocrine Tumors; Orbit; Pancreatic Neoplasms; Sunitinib
PubMed: 31601958
DOI: 10.1038/s41598-019-51093-0