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American Journal of Biological... Mar 2022To assess manifestations of metabolic bone disease (MBD) and their potential environmental and phenotypic factors in captive and non-captive baboon (Papio spp.)...
OBJECTIVES
To assess manifestations of metabolic bone disease (MBD) and their potential environmental and phenotypic factors in captive and non-captive baboon (Papio spp.) specimens.
MATERIALS AND METHODS
Our sample consisted of 160 baboon specimens at the Smithsonian's National Museum of Natural History accessioned from 1890 to 1971. Combining cranial indicators of MBD and the museum's historical data, we examined factors contributing to likely instances of MBD. We used binomial-family generalized linear models to assess differences in MBD frequency by environment (captive, non-captive), specimen accession year, and skin color (light, medium, dark).
RESULTS
Indicators of MBD were most frequently observed in captive baboons, with a decrease in MBD frequency over time. Fifteen non-captive individuals showed indicators of MBD, which are the first published cases of MBD in non-captive nonhuman primates (NHPs) to our knowledge. The most common MBD indicators were bone porosity (n = 35) and bone thickening/enlargement (n = 35). Fibrous osteodystrophy was observed frequently in our sample, likely relating to nutritional deficiencies. We found no association between exposed facial skin color variation and MBD.
CONCLUSIONS
Our findings are consistent with historical accounts of MBD prevalence in captive facilities, especially earlier in the 20th century. A decrease in MBD prevalence later in the 20th century likely reflects improvements in housing, diet, and veterinary care in captive settings. Causes of MBD development in non-captive baboons should be further explored, as understanding the potential health impacts that anthropogenic environments impose on NHPs is imperative as humans increasingly alter the natural world in the 21st century.
Topics: Animals; Humans; Papio; Museums; Bone Diseases, Metabolic
PubMed: 36787760
DOI: 10.1002/ajpa.24450 -
Scientific Reports Mar 2023Identification of potential therapeutic targets and biomarkers indicative of burden of early atherosclerosis that occur prior to advancement to life-threatening unstable...
Identification of potential therapeutic targets and biomarkers indicative of burden of early atherosclerosis that occur prior to advancement to life-threatening unstable plaques is the key to eradication of CAD prevalence and incidences. We challenged 16 baboons with a high cholesterol, high fat diet for 2 years and evaluated early-stage atherosclerotic lesions (fatty streaks, FS, and fibrous plaques, FP) in formalin-fixed common iliac arteries (CIA). We used small RNA sequencing to identify expressed miRNAs in CIA and in baseline blood samples of the same animals. We found 412 expressed miRNAs in CIA and 356 in blood samples. Eight miRNAs (miR-7975, -486-5p, -451a, -191-5p, -148a-3p, -17-5p, -378c, and -144-3p) were differentially expressed between paired fatty streak lesion and no-lesion sites of the tissue, and 27 miRNAs (e.g., miR-92a-3p, -5001, -342-3p, miR-28-3p, -21-5p, -221-3p, 146a-5p, and -16-5p) in fibrous plaques. The expression of 14 blood miRNAs significantly correlated with extent of lesions and the number of plaques. We identified coordinately regulated miRNA-gene networks in which miR-17-5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis. In summary, we have identified miRNAs expressed in lesions and in blood that correlate with lesion burden and are potential therapeutic targets and biomarkers. These findings are a first step in elucidating miRNA regulated molecular mechanisms that underlie early atherosclerosis in a baboon model, enabling translation of our findings to humans.
Topics: Animals; Humans; Atherosclerosis; Aorta, Abdominal; Biomarkers; Diet, High-Fat; MicroRNAs; Papio; Plaque, Amyloid
PubMed: 36859458
DOI: 10.1038/s41598-023-29074-1 -
ELife Nov 2020In the mouse, the osteoblast-derived hormone Lipocalin-2 (LCN2) suppresses food intake and acts as a satiety signal. We show here that meal challenges increase serum...
In the mouse, the osteoblast-derived hormone Lipocalin-2 (LCN2) suppresses food intake and acts as a satiety signal. We show here that meal challenges increase serum LCN2 levels in persons with normal or overweight, but not in individuals with obesity. Postprandial LCN2 serum levels correlate inversely with hunger sensation in challenged subjects. We further show through brain PET scans of monkeys injected with radiolabeled recombinant human LCN2 (rh-LCN2) and autoradiography in baboon, macaque, and human brain sections, that LCN2 crosses the blood-brain barrier and localizes to the hypothalamus in primates. In addition, daily treatment of lean monkeys with rh-LCN2 decreases food intake by 21%, without overt side effects. These studies demonstrate the biology of LCN2 as a satiety factor and indicator and anorexigenic signal in primates. Failure to stimulate postprandial LCN2 in individuals with obesity may contribute to metabolic dysregulation, suggesting that LCN2 may be a novel target for obesity treatment.
Topics: Animals; Brain; Eating; Humans; Lipocalin-2; Macaca; Obesity; Papio; Positron-Emission Tomography; Protein Transport
PubMed: 33231171
DOI: 10.7554/eLife.58949 -
Primates; Journal of Primatology Jul 2023In this "tale" I summarize the major landmarks of my 50-year career watching wild olive baboons (Papio anubis). I review some major discoveries, like baboon hunting and... (Review)
Review
In this "tale" I summarize the major landmarks of my 50-year career watching wild olive baboons (Papio anubis). I review some major discoveries, like baboon hunting and baboon social strategies of competition and defense, that only a creature with a "mind" could manage. My efforts expanded beyond science to include community-based conservation because quite early on these baboons experienced many of the threats of the Anthropocene. My research expanded to include studying crop-raiding by naïve groups of baboons, the first scientific translocation of a primate species, and a detour to study the invasion of a non-indigenous cactus, Opuntia stricta. Throughout I worked with local communities to find solutions to problems that the baboons created, and also to develop new options for their livelihoods. As the baboon research became a long-term project, it depended on a team of Kenyan research assistants who made possible the simultaneous monitoring of up to six baboon troops as well as extensive ecological monitoring. Knowing the ecology, including the impact of the sedentarization of pastoralists in the area, meant we could interpret the process of invasion by a non-indigenous cactus for the first time. Ecological periods allowed comparisons of the same troop over time and different baboon groups during the same ecological phase. Although I began my work before hypothesis testing was the preferred approach, once the paradigm changed, I continued to study and learn what matters to baboons from their perspective. As a result of observing them for 50 years, the baboons showed me that evolution often does not work the way that I had been taught, and it took all my detours and studies to convince me that anecdotes, when they are systematic and comparative, are not stories to be discounted, but evidence, much like Darwin's natural history. Natural history can reassemble the pieces that quantitative hypothesis testing has teased apart to provide its larger meaning. Today, the lone scientist, like me, is an anachronism because no one person has expertise in the many fields needed to understand and save the primates we care about.
Topics: Animals; Papio; Kenya; Papio anubis
PubMed: 37165179
DOI: 10.1007/s10329-023-01060-1 -
ELife Apr 2021In a population of wild baboons, a new way to assess biological age reveals a surprising effect of social hierarchy.
In a population of wild baboons, a new way to assess biological age reveals a surprising effect of social hierarchy.
Topics: Animals; Hierarchy, Social; Papio
PubMed: 33929318
DOI: 10.7554/eLife.68790 -
Scientific Reports Apr 2020Language processing involves the ability to master supra-regular grammars, that go beyond the level of complexity of regular grammars. This ability has been hypothesized...
Language processing involves the ability to master supra-regular grammars, that go beyond the level of complexity of regular grammars. This ability has been hypothesized to be a uniquely human capacity. Our study probed baboons' capacity to learn two supra-regular grammars of different levels of complexity: a context-free grammar generating sequences following a mirror structure (e.g., AB | BA, ABC | CBA) and a context-sensitive grammar generating sequences following a repeat structure (e.g., AB | AB, ABC | ABC), the latter requiring greater computational power to be processed. Fourteen baboons were tested in a prediction task, requiring them to track a moving target on a touchscreen. In distinct experiments, sequences of target locations followed one of the above two grammars, with rare violations. Baboons showed slower response times when violations occurred in mirror sequences, but did not react to violations in repeat sequences, suggesting that they learned the context-free (mirror) but not the context-sensitive (repeat) grammar. By contrast, humans tested with the same task learned both grammars. These data suggest a difference in sensitivity in baboons between a context-free and a context-sensitive grammar.
Topics: Animals; Humans; Learning; Papio papio; Pattern Recognition, Visual
PubMed: 32355252
DOI: 10.1038/s41598-020-64244-5 -
Animals : An Open Access Journal From... Oct 2023Besides living as a free-ranging primate in the horn of Africa and the Arabian Peninsula, the hamadryas baboon has an important place in zoos and can be found in...
Besides living as a free-ranging primate in the horn of Africa and the Arabian Peninsula, the hamadryas baboon has an important place in zoos and can be found in biomedical research centers worldwide. To be valuable as a non-human primate laboratory model for man, its anatomy should be portrayed in detail, allowing for the correct interpretation and translation of obtained research results. Reviewing the literature on the use of the baboon in biomedical research revealed that very limited anatomical works on this species are available. Anatomical atlases are incomplete, use archaic nomenclature and fail to provide high-definition color photographs. Therefore, the skeletons of two male hamadryas baboons were prepared by manually removing as much soft tissues as possible followed by maceration in warm water to which enzyme-containing washing powder was added. The bones were bleached with hydrogen peroxide and degreased by means of methylene chloride. Photographs of the various bones were taken, and the anatomical structures were identified using the latest version of the Nomina Anatomica Veterinaria. As such, the present article shows 31 annotated multipanel figures. The skeleton of the hamadryas baboon generally parallels the human skeleton, but some remarkable differences have been noticed. If these are taken into consideration when evaluating the results of experiments using the hamadryas baboon, justified conclusions can be drawn.
PubMed: 37835730
DOI: 10.3390/ani13193124 -
Philosophical Transactions of the Royal... Jan 2022Conventions form an essential part of human social and cultural behaviour and may also be important to other animal societies. Yet, despite the wealth of evidence that...
Conventions form an essential part of human social and cultural behaviour and may also be important to other animal societies. Yet, despite the wealth of evidence that has accumulated for culture in non-human animals, we know surprisingly little about non-human conventions beyond a few rare examples. We follow the literature in behavioural ecology and evolution and define conventions as systematic behaviours that solve a coordination problem in which two or more individuals need to display complementary behaviour to obtain a mutually beneficial outcome. We start by discussing the literature on conventions in non-human primates from this perspective and conclude that all the ingredients for conventions to emerge are present and therefore that they ought to be more frequently observed. We then probe the emergence of conventions by using a unique novel experimental system in which pairs of Guinea baboons () can voluntarily participate together in touchscreen-based cognitive testing and we show that conventions readily emerge in our experimental set-up and that they share three fundamental properties of human conventions (arbitrariness, stability and efficiency). These results question the idea that observational learning, and imitation in particular, is necessary to establish conventions; they suggest that positive reinforcement is enough. This article is part of a discussion meeting issue 'The emergence of collective knowledge and cumulative culture in animals, humans and machines'.
Topics: Animals; Language; Learning; Papio papio; Primates; Social Behavior
PubMed: 34894743
DOI: 10.1098/rstb.2020.0310 -
Mathematical modelling Treponema infection in free-ranging Olive baboons (Papio anubis) in Tanzania.Epidemics Dec 2022Yaws is a chronic infection caused by the bacterium Treponema pallidum susp. pertenue (TPE) that was thought to be an exclusive human pathogen but was recently found and...
Yaws is a chronic infection caused by the bacterium Treponema pallidum susp. pertenue (TPE) that was thought to be an exclusive human pathogen but was recently found and confirmed in nonhuman primates. In this paper, we develop the first compartmental ODE model for TPE infection with treatment of wild olive baboons. We solve for disease-free and endemic equilibria and give conditions on local and global stability of the disease-free equilibrium. We calibrate the model based on the data from Lake Manyara National Park in Tanzania. We use the model to help the park managers devise an effective strategy for treatment. We show that an increasing treatment rate yields a decrease in disease prevalence. This indicates that TPE can be eliminated through intense management in closed population. Specifically, we show that if the whole population is treated at least once every 5-6 years, a disease-free equilibrium can be reached. Furthermore, we demonstrate that to see a substantial decrease of TPE infection to near-elimination levels within 15 years, the whole population needs to be treated every 2-3 years.
Topics: Animals; Humans; Treponema pallidum; Papio anubis; Yaws; Treponema; Tanzania
PubMed: 36283270
DOI: 10.1016/j.epidem.2022.100638 -
Animal Microbiome Jul 2020The hamadryas baboon (Papio hamadryas) is a highly social primate that lives in complex multilevel societies exhibiting a wide range of group behaviors akin to humans....
BACKGROUND
The hamadryas baboon (Papio hamadryas) is a highly social primate that lives in complex multilevel societies exhibiting a wide range of group behaviors akin to humans. In contrast to the widely studied human microbiome, there is a paucity of information on the host-associated microbiomes of nonhuman primates (NHPs). Here, our goal was to understand the microbial composition throughout different body sites of cohabiting baboons.
RESULTS
We analyzed 170 oral, oropharyngeal, cervical, uterine, vaginal, nasal and rectal samples from 16 hamadryas baboons via 16S rRNA gene sequencing. Additionally, raw Miseq sequencing data from 1041 comparable publicly available samples from the human oral cavity, gut and vagina were reanalyzed using the same pipeline. We compared the baboon and human microbiome of the oral cavity, gut and vagina, showing that the baboon microbiome is distinct from the human. Baboon cohabitants share similar microbial profiles in their cervix, uterus, vagina, and gut. The oral cavity, gut and vagina shared more bacterial amplicon sequence variants (ASVs) in group living baboons than in humans. The shared ASVs had significantly positive correlations between most body sites, suggesting a potential bacterial exchange throughout the body. No significant differences in gut microbiome composition were detected within the maternity line and between maternity lines, suggesting that the offspring gut microbiota is shaped primarily through bacterial exchange among cohabitants. Finally, Lactobacillus was not so predominant in baboon vagina as in the human vagina but was the most abundant genus in the baboon gut.
CONCLUSIONS
This study is the first to provide comprehensive analyses of the baboon microbiota across different body sites. We contrast this to human body sites and find substantially different microbiomes. This group of cohabitating baboons generally showed higher microbial diversity and remarkable similarities between body sites than were observed in humans. These data and findings from one group of baboons can form the basis of future microbiome studies in baboons and be used as a reference in research where the microbiome is expected to impact human modeling with baboons.
PubMed: 33499948
DOI: 10.1186/s42523-020-00040-w