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Data in Brief Oct 2021The Domain Name Service (DNS) is a central point in the functioning of the internet. Just as organizations use domain names to enable the access to their computational...
The Domain Name Service (DNS) is a central point in the functioning of the internet. Just as organizations use domain names to enable the access to their computational services, malicious actors make use of domain names to point to the services under their control. Distinguishing between non-malicious and malicious domain names is extremely important, as it allows to grant or block the access to external services, maximizing the security of the organization and users. Nowadays there are many DNS firewall solutions. Most of these are based on known malicious domain lists that are being constantly updated. However, in this way, it is only possible to block known malicious communications, leaving out many others that can be malicious but are not known. Adopting machine learning to classify domains contributes to the detection of domains that are not yet on the block list. The dataset described in this manuscript is meant for supervised machine learning-based analysis of malicious and non-malicious domain names. The dataset was created from scratch, using publicly DNS logs of both malicious and non-malicious domain names. Using the domain name as input, 34 features were obtained. Features like the domain name entropy, number of strange characters and domain name length were obtained directly from the domain name. Other features like, domain name creation date, Internet Protocol (IP), open ports, geolocation were obtained from data enrichment processes (e.g. Open Source Intelligence (OSINT)). The class was determined considering the data source (malicious DNS log files and non-malicious DNS log files). The dataset consists of data from approximately 90000 domain names and it is balanced between 50% non-malicious and 50% of malicious domain names.
PubMed: 34541265
DOI: 10.1016/j.dib.2021.107342 -
Nature Communications Oct 2022To navigate social interactions successfully, humans need to continuously learn about the personality traits of other people (e.g., how helpful or aggressive is the...
To navigate social interactions successfully, humans need to continuously learn about the personality traits of other people (e.g., how helpful or aggressive is the other person?). However, formal models that capture the complexities of social learning processes are currently lacking. In this study, we specify and test potential strategies that humans can employ for learning about others. Standard Rescorla-Wagner (RW) learning models only capture parts of the learning process because they neglect inherent knowledge structures and omit previously acquired knowledge. We therefore formalize two social knowledge structures and implement them in hybrid RW models to test their usefulness across multiple social learning tasks. We name these concepts granularity (knowledge structures about personality traits that can be utilized at different levels of detail during learning) and reference points (previous knowledge formalized into representations of average people within a social group). In five behavioural experiments, results from model comparisons and statistical analyses indicate that participants efficiently combine the concepts of granularity and reference points-with the specific combinations in models depending on the people and traits that participants learned about. Overall, our experiments demonstrate that variants of RW algorithms, which incorporate social knowledge structures, describe crucial aspects of the dynamics at play when people interact with each other.
Topics: Humans; Learning; Algorithms; Computer Simulation
PubMed: 36266284
DOI: 10.1038/s41467-022-33418-2 -
Diagnostic Pathology Oct 2022Thymofibrolipoma has been described as a variant of thymolipoma. To date, 3 cases have been reported, and the lesion have been described to consist of extensive areas of... (Review)
Review
BACKGROUND
Thymofibrolipoma has been described as a variant of thymolipoma. To date, 3 cases have been reported, and the lesion have been described to consist of extensive areas of collagenous tissue interspersed with islands of mature adipose tissue and strands of thymic tissue.
CASE PRESENTATION
A 43-year-old woman had an anterior mediastinal tumor. Macroscopically, the cut surface of the tumor was composed of a yellowish lipomatous component and a uniform whitish fibrous component with elastic stiffness. Microscopically, the tumor was composed of collagenous fibrous tissue with sparse spindle cells, mature adipocytes and strands or islands of thymic tissue. The spindle cells in the fibrous tissue had monoallelic deletion of the 13q14 region and corresponding loss of RB1 and FOXO1A protein expression.
CONCLUSIONS
This case report may strengthen the hypothesis that thymofibrolipoma is a neoplastic lesion and a variant of thymolipoma and that thymofibrolipoma and lipofibroadenoma are different names for the same lesion. The name "lipofibroadenoma" was given to the lesion because of its histological resemblance to fibroadenoma of the mammary gland. However, this name does not reflect the pathogenesis of this lesion, and the name "thymofibrolipoma" would be preferable. It will be necessary to discuss whether lipofibroadenoma should be listed as an independent entity in the WHO classification.
Topics: Adult; Female; Humans; Lipoma; Mediastinal Neoplasms; Mediastinum; Thymus Neoplasms
PubMed: 36224593
DOI: 10.1186/s13000-022-01260-1 -
PloS One 2022Data sharing is very important for accelerating scientific research, business innovations, and for informing individuals. Yet, concerns over data privacy, cost, and lack...
Data sharing is very important for accelerating scientific research, business innovations, and for informing individuals. Yet, concerns over data privacy, cost, and lack of secure data-sharing solutions have prevented data owners from sharing data. To overcome these issues, several research works have proposed blockchain-based data-sharing solutions for their ability to add transparency and control to the data-sharing process. Yet, while models for decentralized data sharing exist, how to incentivize these structures to enable data sharing at scale remains largely unexplored. In this paper, we study different incentive mechanisms for decentralized data-sharing platforms. Smart contracts are used to automate different payment options between data owners and data requesters. We evaluate multiple cost pricing scenarios for data monetization by simulating incentive mechanisms on a blockchain-based data-sharing platform. We show that a cost compensation model for the data owner rapidly cover the cost of data sharing and balance the overall incentives for all the actors in the platform.
Topics: Blockchain; Humans; Information Dissemination; Motivation; Names; Privacy
PubMed: 35421150
DOI: 10.1371/journal.pone.0266624 -
Indian Journal of Ophthalmology Feb 2021The current practice for low vision management in India exclusively focuses on clinical aspects without much of the rehabilitation components. While making all efforts... (Review)
Review
The current practice for low vision management in India exclusively focuses on clinical aspects without much of the rehabilitation components. While making all efforts to improve independent living skills, daily living activities, and quality of life as a whole for people living visual disabilities, vision rehabilitation is an indispensable component. There is no single appropriate low vision and rehabilitation model implementable at health care institutions in the country to cover these fundamental aspects of a visually impaired individual. We did a literature review to know the existing practices of low vision and various disability models. The purpose of the review is to discern any pitfalls and shortcomings in managing visually disabled in India and to underpin the credibility and feasibility as well as suitability of the developed model. The review was done using search key terms low vision, current practices, visual disability, disability models, vision rehabilitation, and service delivery. Therefore, the article discusses the development of an inclusive low vision management model name as "Clinico-Social Model", which we consider the most appropriate for the best management of people with vision loss. The primary aim of this model is to provide both clinical and vision rehabilitation components of management for people with visual disabilities. Such an approach is likely to have the potential to improve the quality of life of people with vision loss and can provide practical guide to eye care managers across India. Given the specific context in the current practices of low vision in India, it is desirable to design a similar model to care for the visually disabled.
Topics: Disabled Persons; Humans; India; Quality of Life; Vision, Low; Visually Impaired Persons
PubMed: 33463601
DOI: 10.4103/ijo.IJO_236_20 -
Nutrients Jun 2023Certain nutrients cause discomfort, sensitivity reaction, and an intolerance for certain foods or their ingredients when ingested by some consumers. Food reactions and... (Review)
Review
Certain nutrients cause discomfort, sensitivity reaction, and an intolerance for certain foods or their ingredients when ingested by some consumers. Food reactions and gut inflammation-related problems are increasing worldwide. The primary form of management would be the avoidance of such foods, followed by treatment of their symptoms. Adopting a nutritional-therapeutic approach and establishing practices for the inclusion of functional foods and nutraceuticals in the diet could improve the ecology of gut microbiota and alleviate inflammation in the GIT. For this purpose, specific species of microorganisms characterized as probiotic strains have been studied to produce functional food and fermented beverage products. Commercially sold, such items are labelled as probiotic products, displaying the name/s of strain/s and the viable numbers of them contained in the portion size of the products. The importance of the growth of probiotic functional foods is that they can be consumed as a source of nutrition and their intake helps in the subsistence and recuperation of friendly gut bacteria. Probiotics have been reported for their role in ameliorating the risk of food reactions. Probiotic administration has been implemented for its role as an auxiliary improvement and for the prevention of food sensitivities common among pediatric patients. Probiotic products based on non-dairy substrates have potential as nutraceuticals for lactose intolerant consumers who are allergic to dairy milk products. Therefore, the aim of this article is to review GRAS microbial species characterized as probiotics up to the level of their specific strain's name and/or number. These have been used to produce nutraceuticals that are sources of beneficial bacteria for easing discomfort and allergic reactions by maintaining an inflammation-free gut.
Topics: Humans; Child; Animals; Gastrointestinal Microbiome; Probiotics; Dietary Supplements; Milk; Hypersensitivity
PubMed: 37447306
DOI: 10.3390/nu15132979 -
Neurology Aug 2022To characterize trends in antiseizure medication (ASM) fills and total prescription costs in people with epilepsy.
BACKGROUND AND OBJECTIVE
To characterize trends in antiseizure medication (ASM) fills and total prescription costs in people with epilepsy.
METHODS
This was a retrospective cohort study of beneficiaries with epilepsy (ASM, plus codes) in a 20% random Medicare sample, with continuous Fee-For-Service coverage (Parts A, B, and D) in 2008-2018. We summed the number of pill days and costs (adjusted to 2018 dollars) per person-year for each ASM. ASMs were categorized into brand vs generic, first vs newer generation, and enzyme inducers vs noninducers.
RESULTS
There were 77,000-133,000 beneficiaries with epilepsy per year. The most common ASM was phenytoin in 2008, which shifted to levetiracetam in 2018 (2008: phenytoin 25%, levetiracetam 14%; 2018: phenytoin 9%, levetiracetam 27%). Brand name (2008: 56%; 2018: 14%), first-generation (2008: 55%; 2018: 32%), and enzyme-inducing ASMs (2008: 44%; 2018: 24%) each decreased over time as a proportion of pill days. The number of brand pill days per person-year initially decreased (e.g., 2008: 250; 2009: 121; 2010: 96) but then plateaued (2013-2018: between 66 and 69) given a notable increase in lacosamide pill days per person (2008: 0; 2018: 20). Total brand name costs per year initially decreased 2008-2010 (2008: $150 million; 2010: $72 million) but then increased after 2010 (2018: $256 million). In 2018, brand name ASMs represented 79% of costs despite representing only 14% of pill days, a 1-year pill supply became 277% more expensive for brand name medications but 42% less expensive for generic medications over time (2008: brand ∼$2,800 vs generic ∼$800; 2018: brand ∼$10,700 vs generic ∼$460), and many common brand name ASMs cost approximately 10-fold more per pill day than their generic equivalents.
DISCUSSION
First-generation and enzyme-inducing ASMs waned from 2008 to 2018. Although brand name ASMs initially waned translating into lower costs and potentially higher value care, after 2010, brand name costs markedly increased because of increasing use of lacosamide plus a 277% increase in per-pill cost of brand name ASMs. Brand name ASMs represented a minority of prescriptions, but the majority of costs.
Topics: Aged; Humans; United States; Medicare; Retrospective Studies; Phenytoin; Levetiracetam; Lacosamide; Epilepsy; Prescriptions; Drugs, Generic
PubMed: 35705496
DOI: 10.1212/WNL.0000000000200779 -
Ophthalmology and Therapy Dec 2020Cross-sectional survey of 92 board-certified practicing Midwestern ophthalmologists to determine why prescribing habits favor brand-name drugs over generics and to...
INTRODUCTION
Cross-sectional survey of 92 board-certified practicing Midwestern ophthalmologists to determine why prescribing habits favor brand-name drugs over generics and to identify approaches for increasing generic drug utilization.
METHODS
A survey was sent to members of state ophthalmology societies, private practice groups, and individual ophthalmologists to evaluate basic demographic/practice information, knowledge and opinions on generic drugs, frequency of drug representative visits, understanding of the Food and Drug Administration's process of evaluating generics, knowledge of patients' financial status and preferences, and action items that would increase generic utilization.
RESULTS
Three factors increase the likelihood of ophthalmologists switching patients to generic drugs: increased knowledge of (1) generic options, (2) price differences between brand-names and generics, and ((3) patient preference for generics. The following four factors decrease the likelihood of ophthalmologists switching patients to generic drugs: (1) increased disease severity, (2) feeling that patient outcomes may be affected by choice of brand-name versus generic, (3) personal preference for taking a brand-name drug over a generic for their own hypothetical eye disease even if both were free, and (4) increased personal preference for taking a brand-name drug for their hypothetical eye disease.
CONCLUSION
Ophthalmologists should continue to update themselves on generic medication options, become familiar with the price difference of generics versus brand-name drugs for commonly prescribed medications, and seek patients' opinions on generics and correct them when possible to increase generic utilization. In addition, studies evaluating the clinical equivalence of generic drugs relative to brand-name drugs should be performed and may help increase generic utilization.
PubMed: 32813159
DOI: 10.1007/s40123-020-00292-4 -
Journal of Eating Disorders Mar 2023Eating disorder recovery is a complex phenomenon. While historical understandings focused on weight and behaviours, the importance of psychological factors is now widely...
Eating disorder recovery is a complex phenomenon. While historical understandings focused on weight and behaviours, the importance of psychological factors is now widely recognized. It is also generally accepted that recovery is a non-linear process and is impacted by external factors. Recent research suggests a significant impact of systems of oppression, though these have not yet been named in models of recovery. BODY: In this paper, we propose a research-informed, person-centered, and ecological framework of recovery. We suggest that there are two foundational tenets of recovery which apply broadly across experiences: recovery is non-linear and ongoing and there is no one way to do recovery. In the context of these tenets, our framework considers individual changes in recovery as determined by and dependent on external/personal factors and broader systems of privilege. Recovery cannot be determined by looking solely at an individual's level of functioning; one must also consider the broader context of their life in which changes are being made. To conclude, we describe the applicability of the proposed framework and offer practical considerations for incorporating this framework in research, clinical, and advocacy settings.
PubMed: 36949489
DOI: 10.1186/s40337-023-00768-1 -
Open-Label Placebo Effects on Psychological and Physical Well-Being: A Conceptual Replication Study.Clinical Psychology in Europe Dec 2022Contrary to traditional placebos, open-label placebos (OLP) abstain from deception, i.e., participants are openly informed to receive an inert substance. Studies in...
BACKGROUND
Contrary to traditional placebos, open-label placebos (OLP) abstain from deception, i.e., participants are openly informed to receive an inert substance. Studies in clinical and healthy samples evidence the efficacy of OLPs. This study aims to conceptually replicate and expand findings of a recent OLP study in healthy participants while implementing a within-subject design and daily instead of retrospective assessments. Additionally, the effect of a brand name on the medicine container is tested and possible predictors of the OLP effects are explored.
METHOD
Healthy participants (N = 75) received OLP and no placebo for 5 days each (randomized sequence) and answered daily questionnaires on sleep quality, bodily symptoms, mental well-being, and psychological distress. The medicine container of half the participants had a brand name, the remaining did not. Different personality traits and situational factors were assessed.
RESULTS
Mental and physical well-being did not differ between OLP and control phase, i.e., overall, no OLP effect emerged. Contrast analysis indicated that an OLP effect emerged for sleep quality and psychological distress when no brand name was present. Further, an OLP effect emerged in persons with higher expectations for bodily symptoms (r = .23, p = .046) and psychological distress (r = .24, p = .037).
CONCLUSIONS
Methodological differences to the original study are discussed as an explanation for the failure to induce overall OLP effects. Future studies should continue to replicate previous findings and determine the exact conditions of successful implementation of OLP effects in healthy as well as clinical samples.
PubMed: 36762351
DOI: 10.32872/cpe.7679