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Behavioral Sciences (Basel, Switzerland) Mar 2023This study aimed to identify the relationship between grateful disposition and the subjective happiness of young adults; it examined a sequential double mediating effect...
Relationship between Grateful Disposition and Subjective Happiness of Korean Young Adults: Focused on Double Mediating Effect of Social Support and Positive Interpretation.
This study aimed to identify the relationship between grateful disposition and the subjective happiness of young adults; it examined a sequential double mediating effect model of social support and positive interpretation on this relationship. The study participants included 389 male and female Korean young adults. The Korean version of Gratitude Questionnaire-6, a modified subscale of the SU Mental Health Test, Iverson et al.'s scale for social support, and the Subjective Happiness Scale were used. PROCESS Macro 3.5 Model 6 was used to analyze the double mediating effect. The correlation analysis showed that grateful disposition was positively correlated with social support, positive interpretation, and subjective happiness in young adults. Moreover, social support was positively correlated with positive interpretation and subjective happiness, whereas positive interpretation was positively correlated with subjective happiness. In addition, the sequential mediating effect of social support and positive interpretation on grateful disposition and the subjective happiness of young adults was significant. This study confirmed the determinant roles of social support and positive interpretation in grateful disposition and the subjective happiness of young adults, providing useful information for planning future studies and developing education materials and interventions for cultivating grateful disposition in childhood and promoting happiness in young adults.
PubMed: 37102801
DOI: 10.3390/bs13040287 -
Frontiers in Neuroscience 2021Initial romantic attraction (IRA) refers to a series of positive reactions to potential romantic partners at the initial encounter; it evolved to promote mate selection,...
Initial romantic attraction (IRA) refers to a series of positive reactions to potential romantic partners at the initial encounter; it evolved to promote mate selection, allowing individuals to focus their mating efforts on their preferred potential mates. After decades of effort, we now have a deeper understanding of the evolutionary value and dominant factors of IRA; however, little is known regarding the brain mechanisms related to its generation and evaluation. In this study, we combined classic event-related potential analysis with dipole-source analysis to examine electroencephalogram (EEG) signals generated while participants assessed their romantic interest in potential partners. The EEG signals were categorized into IRA-engendered and unengendered conditions based on behavioral indicators. We found that the faces elicited multiple late positivities, including P300 over the occipital-parietal regions and late positive potentials (LPPs) over the anterior regions. When compared to faces that did not engender IRA, faces that did engender IRA elicited (1) enhanced P300 over the parietal regions and heightened neural activity in the insula and cingulate cortex and (2) larger LPPs over the anterior regions and heightened neural activity in the orbitofrontal cortex, dorsolateral prefrontal cortex, cingulate cortex, frontal eye field, visual cortex, and insula. These results suggest IRA is generated and evaluated by an extensive brain network involved in emotion processing, attention control, and social evaluations. Furthermore, these findings indicate that P300 and LPP may represent different cognitive processes during IRA.
PubMed: 34720856
DOI: 10.3389/fnins.2021.718847 -
Frontiers in Psychology 2019Emotional valence is predominately conveyed in social interactions by words and facial expressions. The existence of broad biases which favor more efficient processing... (Review)
Review
Emotional valence is predominately conveyed in social interactions by words and facial expressions. The existence of broad biases which favor more efficient processing of positive or negative emotions is still a controversial matter. While so far this question has been investigated separately for each modality, in this narrative review of the literature we focus on valence effects in processing both words and facial expressions. In order to identify the factors underlying positivity and negativity effects, and to uncover whether these effects depend on modality and age, we present and analyze three representative overviews of the literature concerning valence effects in word processing, face processing, and combinations of word and face processing. Our analysis of word processing studies points to a positivity bias or a balanced processing of positive and negative words, whereas the analysis of face processing studies showed the existence of separate positivity and negativity biases depending on the experimental paradigm. The mixed results seem to be a product of the different methods and types of stimuli being used. Interestingly, we found that children exhibit a clear positivity advantage for both word and face processing, indicating similar processing biases in both modalities. Over the course of development, the initial positivity advantage gradually disappears, and in some face processing studies even reverses into a negativity bias. We therefore conclude that there is a need for future research that systematically analyses the impact of age and modality on the emergence of these valence effects. Finally, we discuss possible explanations for the presence of the early positivity advantage and its subsequent decrease.
PubMed: 31402884
DOI: 10.3389/fpsyg.2019.01654 -
PloS One 2022The individual difference predictors of positive work attitudes and behaviors have been widely investigated in the field of positive organizational scholarship. However,...
BACKGROUND AND AIMS
The individual difference predictors of positive work attitudes and behaviors have been widely investigated in the field of positive organizational scholarship. However, to date, integrating studies linking positive psychological resources, such as Psychological Capital and influence regulation, with positive organizational outcomes are still scarce. Thus, the main aim of the present study was to examine the relationships of Psychological Capital and influence regulation with job satisfaction and job performance both at the individual and team levels.
METHODS
Within the cross-sectional multi-source research involving both team leaders and team members from 34 different teams, we examined the relationships of Psychological Capital and influence regulation with job satisfaction and job performance. The relationships of the study variables were based on the positive organizational behavior and the broaden-and-build theory of positive emotions, which suggest the positive relationships of distinct positive psychological resources with positive work outcomes. Accordingly, in addition to the widely accepted concept of Psychological Capital (PsyCap), we employed and analyzed the complimentary construct of influence regulation (i.e., the ability to intentionally share social influence with others in the workplace) both at the individual and group levels.
RESULTS
The results of hierarchical linear modeling with 304 individuals from 34 teams from a diverse sample of Polish employees indicated that team members' PsyCap was positively linked to individual-level job satisfaction and two facets of job performance, i.e. creative performance and in-role performance. In contrast, no relationship was found between influence regulation and job satisfaction or job performance at both levels of analysis.
CONCLUSION
With regard to positive interpersonal resources, the findings highlight the role of PsyCap in predicting job satisfaction and job performance and broaden the understanding of positivity in the workplace by introducing the construct of influence regulation. Also, based on the study results, managerial implications are discussed.
Topics: Cross-Sectional Studies; Humans; Job Satisfaction; Surveys and Questionnaires; Work Performance; Workplace
PubMed: 35943992
DOI: 10.1371/journal.pone.0272412 -
American Journal of Blood Research 2021Procoagulant profile of 2019-nCoV/SARS-CoV-2 has been well documented over the last year. Perturbance in coagulating factors has also been reported in Covid-19 patients,...
BACKGROUND
Procoagulant profile of 2019-nCoV/SARS-CoV-2 has been well documented over the last year. Perturbance in coagulating factors has also been reported in Covid-19 patients, including increased d-dimers and reports of lupus anticoagulant (LA).
METHODS
The current study aimed to identify the incidence of positivity of lupus anticoagulant in Covid-19 patients and analyze the association between LA and D-dimer in predicting thrombosis and mortality in one-hundred and five hospitalized adult (age >14 years) patients and forty-three hospitalized pediatric (age <14 years) patients with a confirmed diagnosis of Covid-19 between June 2020 and September 2020.
RESULTS
Twenty-one (20%) adult patients were tested positive for PTT LA, of which nine (8.6%) turned out to be confirmed positive for LA through StaClot and DRVVT Ratio tests. Six (14%) pediatric patients were positive for PTT LA, and only one (2.3%) had positive StaClot. Median D-dimer at admission was positively correlated with age and CRP among adult patients and was significantly higher in expired cases (P=0.001). No association between any of the coagulation tests and thrombosis or mortality was observed in the pediatric cohort.
CONCLUSION
We report an increased incidence of LA in Covid-19 patients, yet we didn't find any association between thrombotic events or mortality, probably due to the small sample size.
PubMed: 34322296
DOI: No ID Found -
The European Journal of Neuroscience May 2020The neural mechanisms involved in the processing of vocalizations and music were compared, in order to observe possible similarities in the encoding of their emotional...
The neural mechanisms involved in the processing of vocalizations and music were compared, in order to observe possible similarities in the encoding of their emotional content. Positive and negative emotional vocalizations (e.g. laughing, crying) and violin musical stimuli digitally extracted from them were used as stimuli. They shared the melodic profile and main pitch/frequency characteristics. Participants listened to vocalizations or music while detecting rare auditory targets (bird tweeting, or piano's arpeggios). EEG was recorded from 128 sites. P2, N400 and Late positivity responses of ERPs were analysed. P2 peak was earlier in response to vocalizations, while P2 amplitude was larger to positive than negative stimuli. N400 was greater to negative than positive stimuli. LP was greater to vocalizations than music and to positive than negative stimuli. Source modelling using swLORETA suggested that, among N400 generators, the left middle temporal gyrus and the right uncus responded to both music and vocalizations, and more to negative than positive stimuli. The right parahippocampal region of the limbic lobe and the right cingulate cortex were active during music listening, while the left superior temporal cortex only responded to human vocalizations. Negative stimuli always activated the right middle temporal gyrus, whereas positively valenced stimuli always activated the inferior frontal cortex. The processing of emotional vocalizations and music seemed to involve common neural mechanisms. Notation obtained from acoustic signals showed how emotionally negative stimuli tended to be in Minor key, and positive stimuli in Major key, thus shedding some lights on the brain ability to understand music.
Topics: Acoustic Stimulation; Auditory Perception; Brain Mapping; Electroencephalography; Emotions; Evoked Potentials; Female; Humans; Male; Music
PubMed: 31837173
DOI: 10.1111/ejn.14650 -
Cancers Mar 2022(1) Background: EBV-positive and mismatch repair-deficient (MMRd) gastric cancers (GCs) show higher levels of tumor-infiltrating lymphocytes (TILs) and PD-L1 expression...
(1) Background: EBV-positive and mismatch repair-deficient (MMRd) gastric cancers (GCs) show higher levels of tumor-infiltrating lymphocytes (TILs) and PD-L1 expression and thus a more profound response to immunotherapy. However, the majority of GCs are EBV-negative (EBV−) and MMR proficient (MMRp). We analyzed PD-L1 expression and TILs in EBV-MMRpGCs in comparison to EBV-positive (EBV+) and MMRdGCs to identify an immunogenic phenotype susceptible to immunotherapy. (2) Methods: A next-generation tissue microarray of 409 primary resected GCs was analyzed by Epstein-Barr encoding region (EBER) in situ hybridization for MSH1, PMS2, MSH2, MSH6, PD-L1, and CD8 immunohistochemistry. PD-L1 positivity was defined as a combined positive score (CPS) of ≥1. CD8+ TILs and their proximity to cancer cells were digitally analyzed on the HALO™ image analysis platform. (3) Results: Eleven cases were EBV+, 49 cases MMRd, and 349 cases EBV-MMRpGCs. The highest rate of PD-L1 positivity was seen in EBV+GCs, followed by MMRdGCs and EBV-MMRpGCs (81.8%, 73.5%, and 27.8%, respectively). EBV+ and MMRdGCs also demonstrated increased numbers and proximity of CD8+ TILs to tumor cells compared to EBV-MMRpGCs (p < 0.001 each). PD-L1 status positively correlated with the total numbers of CD8+ TILs and their proximity to tumor cells in all subtypes, including EBV-MMRpGCs (p < 0.001 each). A total of 28.4% of EBV-MMRpGCs showed high CD8+ TILs independent of PD-L1. (4) Conclusions: PD-L1 and CD8 immunohistochemistry, supplemented by digital image analysis, may identify EBV-MMRpGCs with high immunoreactivity indices, indicating susceptibility to immunotherapy.
PubMed: 35406506
DOI: 10.3390/cancers14071736 -
Clinical Microbiology and Infection :... Oct 2019To evaluate the impact of false-positive IgM immunoblots on Lyme disease treatment and case reporting in a large healthcare system.
OBJECTIVES
To evaluate the impact of false-positive IgM immunoblots on Lyme disease treatment and case reporting in a large healthcare system.
METHODS
We obtained the results of all Lyme disease serological tests ordered at U.S. Air Force healthcare facilities in the USA between January 2013 and December 2017. We conducted chart reviews to adjudicate positive IgM immunoblots (from two-tier and independent testing) as true positives or false positives using established criteria, and we assessed whether these cases were reported to the U.S. Department of Defense surveillance system.
RESULTS
Of the 18 410 serum tests (17 058 immunoassays and 1352 immunoblots) performed on 15 928 unique individuals, 249/1352 (18.4%) IgM immunoblots were positive. After excluding repeat tests, insufficiently documented cases, and participants with a history of Lyme disease, 212 positive IgM immunoblot cases were assessed. A total of 113/212 (53.3%) were determined to be false positives. Antibiotics were prescribed for Lyme disease for 97/99 (98.0%) participants with a true-positive test and 91/113 (80.5%) participants with a false-positive test. The number of false-positive cases reported to the surveillance system was identical to the number of unreported true-positive cases (n = 44).
CONCLUSIONS
Lyme disease serological tests were overused in a large healthcare system, and positive results were frequently misinterpreted, leading to misdiagnosis and widespread antibiotic misuse. Underreporting of true-positive cases was offset by overreporting of false-positive cases, suggesting that the discrepancy between the reported incidence and true incidence of Lyme disease may not be as significant as previously assumed.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Bacterial; Child; Child, Preschool; False Positive Reactions; Female; Humans; Immunoblotting; Immunoglobulin M; Incidence; Infant; Lyme Disease; Male; Medical Overuse; Middle Aged; Military Personnel; Retrospective Studies; Serologic Tests; United States; Young Adult
PubMed: 30802651
DOI: 10.1016/j.cmi.2019.02.020 -
Laboratory Investigation; a Journal of... Sep 2019The external validity of the scientific literature has recently come into question, popularly referred to as the "reproducibility crisis." It is now generally...
The external validity of the scientific literature has recently come into question, popularly referred to as the "reproducibility crisis." It is now generally acknowledged that too many false positive or non-reproducible results are being published throughout the biomedical and social science literature due to misaligned incentives and poor methodology. Pathology is likely no exception to this problem, and may be especially prone to false positives due to common observational methodologies used in our research. Spurious findings in pathology contribute inefficiency to the scientific literature and detrimentally influence patient care. In particular, false positives in pathology affect patients through biomarker development, prognostic classification, and cancer overdiagnosis. We discuss possible sources of non-reproducible pathology studies and describe practical ways our field can improve research habits, especially among trainees.
Topics: False Positive Reactions; Humans; Medical Overuse; Pathologists; Pathology; Reproducibility of Results
PubMed: 31019290
DOI: 10.1038/s41374-019-0257-2 -
Sexuality & Culture Jan 2023Prior research suggests that parents, peers, and media are popular sources of sexual information and beliefs among emerging adults. Sex-positivity is an orientation...
Prior research suggests that parents, peers, and media are popular sources of sexual information and beliefs among emerging adults. Sex-positivity is an orientation toward sex that emphasizes open-minded beliefs and communication about varying sexual behaviors, preferences, and orientations. The current study investigated whether these sexual information sources were associated with emerging adults' endorsement of sex-positive and sexual orientation-related sexual scripts, and if these sources and scripts were associated with sexual communication among a sample of college students ages 18-22 (n = 341). Results indicate that learning from television was positively related to sex-positive sexual script endorsement, and that sex-positive scripts were associated with more positive sexual communication. An interaction also emerged between gender and learning from television on sex-positive script endorsement, and between gender and learning from social media on sexual orientation-related script endorsement. The implications of these findings are contextualized within emerging adults' sexual agency and behavior. Future directions of research are also discussed.
PubMed: 36643189
DOI: 10.1007/s12119-022-10061-z