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Medicina (Kaunas, Lithuania) Aug 2023Recently, total talar prosthesis has been proposed to substitute the talus during the management of complex talar lesions such as talar extrusion, comminuted talar... (Review)
Review
Recently, total talar prosthesis has been proposed to substitute the talus during the management of complex talar lesions such as talar extrusion, comminuted talar fractures, or avascular necrosis. Herein, we report two cases of talar extrusion treated with total talar replacement after a high-intensity trauma. Both cases subsequently required revision surgery due to degenerative changes of the tibial plafond (arthrodesis in the first case, conversion to a total ankle prosthesis in the latter). We report and analyze the literature concerning total talar replacement to discuss strategies that could help improve prosthesis survival and reduce the incidence of osteoarthritis.
Topics: Humans; Prostheses and Implants; Prosthesis Implantation; Fractures, Bone; Osteoarthritis; Prosthesis Failure
PubMed: 37629788
DOI: 10.3390/medicina59081498 -
Aesthetic Surgery Journal Jul 2021
Topics: Humans; Prostheses and Implants; Titanium
PubMed: 33128363
DOI: 10.1093/asj/sjaa265 -
International Journal of Molecular... Sep 2021Biofilm-related implant infections (BRII) are a disastrous complication of both elective and trauma orthopaedic surgery and occur when an implant becomes colonised by... (Review)
Review
Biofilm-related implant infections (BRII) are a disastrous complication of both elective and trauma orthopaedic surgery and occur when an implant becomes colonised by bacteria. The definitive treatment to eradicate the infections once a biofilm has established is surgical excision of the implant and thorough local debridement, but this carries a significant socioeconomic cost, the outcomes for the patient are often poor, and there is a significant risk of recurrence. Due to the large volumes of surgical procedures performed annually involving medical device implantation, both in orthopaedic surgery and healthcare in general, and with the incidence of implant-related infection being as high as 5%, interventions to prevent and treat BRII are a major focus of research. As such, innovation is progressing at a very fast pace; the aim of this study is to review the latest interventions for the prevention and treatment of BRII, with a particular focus on implant-related approaches.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Biofilms; Humans; Orthopedic Procedures; Orthopedics; Postoperative Complications; Prostheses and Implants
PubMed: 34638591
DOI: 10.3390/ijms221910243 -
JACC. Cardiovascular Interventions Dec 2021
Topics: Aortic Valve; Aortic Valve Stenosis; Asian People; Humans; Prostheses and Implants; Transcatheter Aortic Valve Replacement; Treatment Outcome
PubMed: 34838465
DOI: 10.1016/j.jcin.2021.09.033 -
Journal of Orthopaedic Surgery (Hong... 2023The occurrence of prosthesis-related complications after total shoulder arthroplasty is devastating and costly. The purpose was to determine the incidence and risk of...
BACKGROUND
The occurrence of prosthesis-related complications after total shoulder arthroplasty is devastating and costly. The purpose was to determine the incidence and risk of in-hospital prosthesis-related complications after total shoulder arthroplasty utilizing a large-scale sample database.
METHODS
A retrospective database analysis was performed based on Nationwide Inpatient Sample from 2010 to 2014. Patients who underwent total shoulder arthroplasty were included. Patient demographics, hospital characteristics, length of stay, economic indicators, in-hospital mortality, comorbidities, and peri-operative complications were evaluated.
RESULTS
A total of 34,198 cases were capture from the Nationwide Inpatient Sample database. There were 343 cases of in-hospital prosthesis-related complications after total shoulder arthroplasty and the overall incidence was 1%, with a more than 2.5-fold decrease from 2010 to 2014. Dislocation was the most common category among prosthesis-related complications (0.1%). The occurrence of in-hospital prosthesis-related complications was associated with significantly more total charges and slightly longer length of stay while less usage of Medicare. Risk factors of prosthesis-related complications were identified including younger age (<64 years), female, the native American, hospital in the South, alcohol abuse, depression, uncomplicated diabetes, diabetes with chronic complications, fluid and electrolyte disorders, metastatic cancer, neurological disorders, and renal failure. Interestingly, advanced age (≥65 years) and proprietary hospital were found as protective factors. Furthermore, prosthesis-related complications were associated with aseptic necrosis, rheumatoid arthritis, rotator cuff tear arthropathy, Parkinson's disease, prior shoulder arthroscopy, and blood transfusion.
CONCLUSIONS
It is of benefit to study risk factors of prosthesis-related complications following total shoulder arthroplasty to ensure the appropriate management and optimize consequences although a relatively low incidence was identified.
Topics: Humans; Female; Aged; United States; Middle Aged; Arthroplasty, Replacement, Shoulder; Shoulder Joint; Incidence; Retrospective Studies; Medicare; Risk Factors; Prostheses and Implants; Diabetes Mellitus; Postoperative Complications; Treatment Outcome
PubMed: 37971330
DOI: 10.1177/10225536231214055 -
International Journal of Molecular... Oct 2019Implant‑associated infection (IAI), a common condition marked by progressive inflammation and bone destruction, is mentally and financially devastating to those it...
Implant‑associated infection (IAI), a common condition marked by progressive inflammation and bone destruction, is mentally and financially devastating to those it affects, causing severe morbidity, prolonged hospital admissions, significant hospital costs and, in certain cases, mortality. Aspirin, a popular synthetic compound with a history of >100 years, is antipyretic, anti‑inflammatory and analgesic. It is the most active component of non‑steroidal anti‑inflammatory drugs. However, the effects of aspirin on IAI remain unknown. In the present study, an IAI animal model was used, in which a stainless steel pin coated with Staphylococcus aureus was implanted through the left shaft of the tibia in mice. The animals were then randomized into five groups and subjected respectively to IAI, IAI + 15 mg aspirin treatment, IAI + 30 mg aspirin treatment, IAI + 60 mg aspirin treatment and IAI + 120 mg aspirin treatment groups. Aspirin was injected intraperitoneally twice daily for 11 days. Micro‑CT and histological assays were performed to assess the effects of aspirin on IAI. It was found that aspirin reduced osteolysis and periosteal reaction, inhibited the activation of osteoclasts, promoted the activation of osteoblasts and facilitated healing of the infected fracture.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Female; Humans; Immunohistochemistry; Mice; Osteolysis; Prostheses and Implants; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus; X-Ray Microtomography
PubMed: 31432131
DOI: 10.3892/ijmm.2019.4298 -
Trends in Biotechnology Oct 2019Biofabrication holds great potential to revolutionize important industries in the health, food, and textile sectors, but its translation to market is still challenging....
Biofabrication holds great potential to revolutionize important industries in the health, food, and textile sectors, but its translation to market is still challenging. I analyze the current state of innovation and commercialization in biofabrication and try to assess its limitations, strengths, and future progress.
Topics: Animals; Biocompatible Materials; Bioprinting; Commerce; Humans; Inventions; Precision Medicine; Printing, Three-Dimensional; Prostheses and Implants; Tissue Engineering
PubMed: 31153633
DOI: 10.1016/j.tibtech.2019.04.013 -
International Journal of Implant... Feb 2022To assess the biomechanical effects of different prosthetic/implant configurations and load directions on 3-unit fixed prostheses supported by short dental implants in...
OBJECTIVE
To assess the biomechanical effects of different prosthetic/implant configurations and load directions on 3-unit fixed prostheses supported by short dental implants in the posterior mandible using validated 3-D finite element (FE) models.
METHODS
Models represented an atrophic mandible, missing the 2nd premolar, 1st and 2nd molars, and rehabilitated with either two short implants (implant length-IL = 8 mm and 4 mm) supporting a 3-unit dental bridge or three short implants (IL = 8 mm, 6 mm and 4 mm) supporting zirconia prosthesis in splinted or single crowns design. Load simulations were performed in ABAQUS (Dassault Systèmes, France) under axial and oblique (30°) force of 100 N to assess the global stiffness and forces within the implant prosthesis. Local stresses within implant/prosthesis system and strain energy density (SED) within surrounding bone were determined and compared between configurations.
RESULTS
The global stiffness was around 1.5 times higher in splinted configurations vs. single crowns, whereby off-axis loading lead to a decrease of 39%. Splinted prostheses exhibited a better stress distribution than single crowns. Local stresses were larger and distributed over a larger area under oblique loads compared to axial load direction. The forces on each implant in the 2-implant-splinted configurations increased by 25% compared to splinted crowns on 3 implants. Loading of un-splinted configurations resulted in increased local SED magnitude.
CONCLUSION
Splinting of adjacent short implants in posterior mandible by the prosthetic restoration has a profound effect on the magnitude and distribution of the local stress peaks in peri-implant regions. Replacing each missing tooth with an implant is recommended, whenever bone supply and costs permit.
Topics: Artificial Limbs; Computer-Aided Design; Dental Implants; Finite Element Analysis; Mandible
PubMed: 35147791
DOI: 10.1186/s40729-022-00404-8 -
Schweizer Archiv Fur Tierheilkunde Mar 2021Based on a donation of more than 1000 Swiss dog license tags to the museum of veterinary medical history in Zurich, historic dog license taxes and tags are compared...
Based on a donation of more than 1000 Swiss dog license tags to the museum of veterinary medical history in Zurich, historic dog license taxes and tags are compared between Switzerland and other European countries. In 2006 the microchip was launched as mandatory identification for dogs in Switzerland and dog license tags became redundant.
Topics: Animal Identification Systems; Animals; Dogs; Prostheses and Implants; Switzerland; Taxes
PubMed: 33650522
DOI: 10.17236/sat00294 -
Current Opinion in Biotechnology Dec 2021Implantable brain machine interfaces (BMIs) are now on a trajectory to go mainstream, wherein what was once considered last resort will progressively become elective at... (Review)
Review
Implantable brain machine interfaces (BMIs) are now on a trajectory to go mainstream, wherein what was once considered last resort will progressively become elective at earlier stages in disease treatment. First-in-human successes have demonstrated the ability to decode highly dexterous motor skills such as handwriting, and speech from human cortical activity. These have been used for cursor and prosthesis control, direct-to-text communication and speech synthesis. Along with these breakthrough studies, technology advancements have enabled the observation of more channels of neural activity through new concepts for centralised/distributed implant architectures. This is complemented by research in flexible substrates, packaging, surgical workflows and data processing. New regulatory guidance and funding has galvanised the field. This culmination of resource, efforts and capability is now attracting significant investment for BMI commercialisation. This paper reviews recent developments and describes the paradigm shift in BMI development that is leading to new innovations, insights and BMI translation.
Topics: Brain-Computer Interfaces; Humans; Prostheses and Implants; Technology
PubMed: 34749248
DOI: 10.1016/j.copbio.2021.10.001