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Diagnostics (Basel, Switzerland) May 2022To systematically review the clinicopathological features of oral warty keratoma based on published literature. (Review)
Review
OBJECTIVE
To systematically review the clinicopathological features of oral warty keratoma based on published literature.
MATERIALS AND METHODS
PubMed and Scopus databases were searched for reports of oral warty dyskeratoma. Of the 52 identified articles, only 25 articles (43 cases) satisfied the selection criteria (case report/series in the English language reporting clinicopathologically diagnosed oral warty dyskeratoma/oral focal acantholytic keratosis/oral isolated dyskeratosis follicularis in humans). Risk of bias was assessed using the Joanna Briggs institute critical appraisal checklist for case reports and case series.
RESULTS
Most cases had well-circumscribed, white, nodular verruco-papillary lesions with a central depressed/crater-like area. Alveolar ridges were the most frequent sites of occurrence and tobacco was the most commonly associated risk factor. Histopathologically, the most pathognomonic feature was the supra-basal clefting. The cleft had dyskeratotic acantholytic cells (corps ronds, and grains). Below the cleft were projections of the connective tissue villi lined by basal cells. The basal cells in a few cases exhibited hyperplasia in the form of budding into the stroma, but epithelial dysplasia was not reported. The surface epithelium had crypts filled with keratin debris.
CONCLUSION
Oral warty dyskeratoma is a rare solitary self-limiting benign entity, which due to its clinical and histopathological resemblance and associated habit history could be misdiagnosed as leukoplakia or carcinoma. None of the assessed articles provided molecular data, which in turn could be the reason for the lack of insight into the etiopathogenesis of this enigmatic lesion.
PubMed: 35626429
DOI: 10.3390/diagnostics12051273 -
Dermatology Reports Jun 2020Warty dyskeratoma is an uncommon benign skin lesion, which is mostly limited to the head or neck and is rarely seen in other areas of the skin or mucous membranes....
Warty dyskeratoma is an uncommon benign skin lesion, which is mostly limited to the head or neck and is rarely seen in other areas of the skin or mucous membranes. Although it is clinically similar to many skin lesions, its distinctive histopathologic features help distinguish it from other identical lesions. Herein, we report a case of warty dyskeratoma in a very unusual site (lateral border of the tongue) in a 56-year-old woman.
PubMed: 32670533
DOI: 10.4081/dr.2020.8236 -
Clinical Case Reports Jun 2023On dermoscopy, the central area was greenish-yellow with a coarse cobblestone-like structureless material-filled pattern, along with a bull's-horn-like tip and white...
KEY CLINICAL MESSAGE
On dermoscopy, the central area was greenish-yellow with a coarse cobblestone-like structureless material-filled pattern, along with a bull's-horn-like tip and white globules. The marginal area was skin-colored with a dark red background and a dome-shaped pattern. A collarette with white ring and radial streaks, and whitish globules was noted.
ABSTRACT
In recent years, the dermoscopic findings of Warty dyskeratoma have only been reported in a few cases. A 71-year-old man presented with a brownish papular lesion, with a central umbilical fossa, posterior to the right auricle. Histopathologically, a keratocystic tumor with a dome-like morphology and an epidermal invagination in its limbic part was noted. The central part surrounding the fissure was filled with horn-like cells with cornification tendency. Corps ronds were mostly distributed in the stratum corneum and granulosa, and grains were observed in the stratum corneum as acantholytic cells within the epidermal voids (lacunae). On dermoscopy, the central area was greenish-yellow with a coarse cobblestone-like structureless material-filled pattern, along with a bull's-horn-like tip and white globules. The marginal area was skin-colored with a dark red background and a dome-shaped pattern. A collarette with white ring and radial streaks, and whitish globules was noted. No prominent vascular pattern was observed.
PubMed: 37305894
DOI: 10.1002/ccr3.7495 -
Indian Journal of Pathology &... 2023
Topics: Humans; Keratoacanthoma; Scalp; Darier Disease; Papillomavirus Infections; Diagnosis, Differential
PubMed: 37530365
DOI: 10.4103/ijpm.ijpm_230_21 -
Dermatology Practical & Conceptual Apr 2024
Review
PubMed: 38810041
DOI: 10.5826/dpc.1402a124 -
Dermatology Reports Sep 2020Warty Dyskeratoma (WD) is a rare condition consisting in single or multiple papular or nodular lesions of the skin or of the oral mucosamucosa. Histologically, a...
Warty Dyskeratoma (WD) is a rare condition consisting in single or multiple papular or nodular lesions of the skin or of the oral mucosamucosa. Histologically, a cupshaped epidermal invagination centred by a plug of epidermal hyperparakeratosis with suprabasal acantholysis and dyskeratosis is typically observed. A case of post-inflammatory WD, which was also observed by dermoscopy, is described. Dermoscopy showed an eight-shape whitish collarette surrounded by light brown pigmentation. A central white structureless area with an adjacent rosette were observed. Some small rust-coloured blood crusts were also observed in the centre of the lesion; no prominent vascular pattern was detected. The etiopathogenesis of this benign neoplasm could be multifactorial. Dermoscopy of WD is not specific but may help to ruling out other skin tumors.
PubMed: 33408834
DOI: 10.4081/dr.2020.8791 -
Anais Brasileiros de Dermatologia 2019
Topics: Biopsy; Hair Follicle; Humans; Keratosis; Male; Middle Aged; Scalp Dermatoses; Warts
PubMed: 31777373
DOI: 10.1016/j.abd.2019.09.015 -
Dermatology Practical & Conceptual Jan 2024
PubMed: 38364415
DOI: 10.5826/dpc.1401a62 -
Dermatopathology (Basel, Switzerland) Dec 2023Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the...
Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the granular layer that serves as a gatekeeper of the paracellular pathway. The aim of this study is to illustrate claudin-4 immunohistochemical staining patterns of different blistering disorders. We collected 35 cases, including two Hailey-Hailey disease, one Darier disease, three Grover disease, one acantholytic acanthoma, two warty dyskeratoma, 11 pemphigus vulgaris (PV) including six mucosal PV, and two pemphigus foliaceus. For comparison, we included five cases of normal skin, five eczema, and three bullous pemphigoid cases. Claudin-4 demonstrated weak-to-moderate expression in keratinocytes located in the stratum granulosum, keratinocytes surrounding hair follicles, and adnexal glands. Further, claudin-4 exhibited moderate-to-strong membranous staining in disrupted keratinocytes surrounding and within the acantholytic and bullous areas in 16/22 of the acantholytic cases (not seen in the six cases of mucosal PV) and all three bullous pemphigoids. This finding suggests that claudin-4 is upregulated in these conditions, which may be a compensatory response to the disrupted barrier function. This finding could shed light on the molecular mechanisms underlying disrupted barrier function in blistering disorders, independent of the specific underlying disease mechanism.
PubMed: 38534263
DOI: 10.3390/dermatopathology11010001 -
Annals of Dermatology Nov 2023
PubMed: 38061738
DOI: 10.5021/ad.21.175