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Journal of Pharmacy & Bioallied Sciences Apr 2015Genodermatoses are an inherited disorder, present with multisystem involvement. Help us to identify regular mutations and appalling skin diseases with recessive... (Review)
Review
Genodermatoses are an inherited disorder, present with multisystem involvement. Help us to identify regular mutations and appalling skin diseases with recessive inheritance. Genetic heterogeneity is very common, and molecular diagnosis requires a broad effort. Recurrent mutations in unrelated families were seen in families with xeroderma, Griscelli. It seems likely that eventually oligonucleotide arrays will replace most other methods for routine mutation scanning of the more common diseases and planned sequencing will be increasingly used for rarer diseases.
PubMed: 26015711
DOI: 10.4103/0975-7406.155903 -
Diagnostics (Basel, Switzerland) May 2022To systematically review the clinicopathological features of oral warty keratoma based on published literature. (Review)
Review
OBJECTIVE
To systematically review the clinicopathological features of oral warty keratoma based on published literature.
MATERIALS AND METHODS
PubMed and Scopus databases were searched for reports of oral warty dyskeratoma. Of the 52 identified articles, only 25 articles (43 cases) satisfied the selection criteria (case report/series in the English language reporting clinicopathologically diagnosed oral warty dyskeratoma/oral focal acantholytic keratosis/oral isolated dyskeratosis follicularis in humans). Risk of bias was assessed using the Joanna Briggs institute critical appraisal checklist for case reports and case series.
RESULTS
Most cases had well-circumscribed, white, nodular verruco-papillary lesions with a central depressed/crater-like area. Alveolar ridges were the most frequent sites of occurrence and tobacco was the most commonly associated risk factor. Histopathologically, the most pathognomonic feature was the supra-basal clefting. The cleft had dyskeratotic acantholytic cells (corps ronds, and grains). Below the cleft were projections of the connective tissue villi lined by basal cells. The basal cells in a few cases exhibited hyperplasia in the form of budding into the stroma, but epithelial dysplasia was not reported. The surface epithelium had crypts filled with keratin debris.
CONCLUSION
Oral warty dyskeratoma is a rare solitary self-limiting benign entity, which due to its clinical and histopathological resemblance and associated habit history could be misdiagnosed as leukoplakia or carcinoma. None of the assessed articles provided molecular data, which in turn could be the reason for the lack of insight into the etiopathogenesis of this enigmatic lesion.
PubMed: 35626429
DOI: 10.3390/diagnostics12051273 -
Clinical Case Reports Jun 2023On dermoscopy, the central area was greenish-yellow with a coarse cobblestone-like structureless material-filled pattern, along with a bull's-horn-like tip and white...
KEY CLINICAL MESSAGE
On dermoscopy, the central area was greenish-yellow with a coarse cobblestone-like structureless material-filled pattern, along with a bull's-horn-like tip and white globules. The marginal area was skin-colored with a dark red background and a dome-shaped pattern. A collarette with white ring and radial streaks, and whitish globules was noted.
ABSTRACT
In recent years, the dermoscopic findings of Warty dyskeratoma have only been reported in a few cases. A 71-year-old man presented with a brownish papular lesion, with a central umbilical fossa, posterior to the right auricle. Histopathologically, a keratocystic tumor with a dome-like morphology and an epidermal invagination in its limbic part was noted. The central part surrounding the fissure was filled with horn-like cells with cornification tendency. Corps ronds were mostly distributed in the stratum corneum and granulosa, and grains were observed in the stratum corneum as acantholytic cells within the epidermal voids (lacunae). On dermoscopy, the central area was greenish-yellow with a coarse cobblestone-like structureless material-filled pattern, along with a bull's-horn-like tip and white globules. The marginal area was skin-colored with a dark red background and a dome-shaped pattern. A collarette with white ring and radial streaks, and whitish globules was noted. No prominent vascular pattern was observed.
PubMed: 37305894
DOI: 10.1002/ccr3.7495 -
Dermatology Reports Jun 2020Warty dyskeratoma is an uncommon benign skin lesion, which is mostly limited to the head or neck and is rarely seen in other areas of the skin or mucous membranes....
Warty dyskeratoma is an uncommon benign skin lesion, which is mostly limited to the head or neck and is rarely seen in other areas of the skin or mucous membranes. Although it is clinically similar to many skin lesions, its distinctive histopathologic features help distinguish it from other identical lesions. Herein, we report a case of warty dyskeratoma in a very unusual site (lateral border of the tongue) in a 56-year-old woman.
PubMed: 32670533
DOI: 10.4081/dr.2020.8236 -
International Journal of Women's... Sep 2017Warty (follicular) dyskeratoma (WD) is a discrete nodular lesion that demonstrates the characteristic histopathologic findings of acantholysis and dyskeratosis. WDs most...
Warty (follicular) dyskeratoma (WD) is a discrete nodular lesion that demonstrates the characteristic histopathologic findings of acantholysis and dyskeratosis. WDs most commonly occur on the head and neck of adults. We present a case of WD that occurred on the mons pubis of a 53-year-old woman. Only a few other cases of WDs occurring on the vulva have been reported. WD most likely represents a tumor of the follicular infundibulum. Despite its name, there is no evidence that WD is caused by a human papillomavirus (HPV) infection. Although occurrences on the vulva are rare, they must be distinguished from HPV-induced squamous tumors when found in this area.
PubMed: 28831426
DOI: 10.1016/j.ijwd.2017.07.003 -
Indian Journal of Pathology &... 2023
Topics: Humans; Keratoacanthoma; Scalp; Darier Disease; Papillomavirus Infections; Diagnosis, Differential
PubMed: 37530365
DOI: 10.4103/ijpm.ijpm_230_21 -
Iranian Journal of Public Health Aug 2014Warty dyskeratoma is a rare tumor that presents mainly as an isolated papule or nodule on the scalp, face or neck in the adults. Warty dyskeratoma frequently arises as a...
Warty dyskeratoma is a rare tumor that presents mainly as an isolated papule or nodule on the scalp, face or neck in the adults. Warty dyskeratoma frequently arises as a single lesion with a central keratotic plug on the skin of middle-aged or elderly people. Multiple warty dyskeratomas are very rare cutaneous lesions which are mostly seen on the scalp. We herein report a multiple warty dyskeratoma in a female patient.
PubMed: 25927045
DOI: No ID Found -
Case Reports in Dermatological Medicine 2017Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. The histopathology...
Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. The histopathology shows a pattern of acantholytic dyskeratosis. We report a 32-year-old man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first toe 2 years ago. A histopathologic diagnosis of subungual warty dyskeratoma was made. When dealing with focal acantholytic dyskeratosis several differential diagnoses should be considered including Darier's disease, transient focal acantholytic dyskeratosis or Grover disease, and Hailey-Hailey disease. We present an unusual location of warty dyskeratoma in the nail bed using a clinicohistopathological correlation for the diagnosis.
PubMed: 28326204
DOI: 10.1155/2017/3613109 -
Dermatology Reports Sep 2020Warty Dyskeratoma (WD) is a rare condition consisting in single or multiple papular or nodular lesions of the skin or of the oral mucosamucosa. Histologically, a...
Warty Dyskeratoma (WD) is a rare condition consisting in single or multiple papular or nodular lesions of the skin or of the oral mucosamucosa. Histologically, a cupshaped epidermal invagination centred by a plug of epidermal hyperparakeratosis with suprabasal acantholysis and dyskeratosis is typically observed. A case of post-inflammatory WD, which was also observed by dermoscopy, is described. Dermoscopy showed an eight-shape whitish collarette surrounded by light brown pigmentation. A central white structureless area with an adjacent rosette were observed. Some small rust-coloured blood crusts were also observed in the centre of the lesion; no prominent vascular pattern was detected. The etiopathogenesis of this benign neoplasm could be multifactorial. Dermoscopy of WD is not specific but may help to ruling out other skin tumors.
PubMed: 33408834
DOI: 10.4081/dr.2020.8791 -
Indian Dermatology Online Journal 2019
PubMed: 31149593
DOI: 10.4103/idoj.IDOJ_473_18