-
American Journal of Ophthalmology Oct 1977Using the Cochet-Bonnet esthesiometer, we evaluated the corneal sensation of 11 patients with unilateral Adie's tonic pupil. We eliminated six other patients with... (Clinical Trial)
Clinical Trial
Using the Cochet-Bonnet esthesiometer, we evaluated the corneal sensation of 11 patients with unilateral Adie's tonic pupil. We eliminated six other patients with bilateral Adie's pupil or disease that lowered corneal sensation. An observed unfamiliar with each patient's condition tested 12 clock hour positions in the midperiphery in both eyes of all patients. We studied 30 normal subjects (60 eyes) in a similar fashion. Of those 11 patients with unilateral Adie's syndrome, ten had a regional decrease in corneal sensation. The 30 normal subjects examined did not exhibit any significant decrease in corneal sensation in any areas. Our study supports the concept that the lesion of Adie's tonic pupil is in the ciliary ganglion or short location where the innervation of the iris sphincter and corneal sensation are found together.
Topics: Adie Syndrome; Adult; Ciliary Body; Clinical Trials as Topic; Cornea; Female; Humans; Iris; Male; Middle Aged; Pupil; Sensory Receptor Cells
PubMed: 333920
DOI: 10.1016/0002-9394(77)90440-8 -
Neurology Sep 2012
Topics: Adie Syndrome; Adult; Female; Humans
PubMed: 22965679
DOI: 10.1212/WNL.0b013e3182698cc5 -
The Medical Clinics of North America May 1991Pain around the eye can be caused by local ophthalmic disorders or by disease of other structures sharing trigeminal nerve sensory innervation. In general, most ocular... (Review)
Review
Pain around the eye can be caused by local ophthalmic disorders or by disease of other structures sharing trigeminal nerve sensory innervation. In general, most ocular causes for pain also cause the eye to be red, thus alerting the examiner to the focality of the problem. However, conditions like eyestrain, intermittent angleclosure glaucoma or neovascular glaucoma, and low-grade intraocular inflammation can be painful and not be associated with obvious redness. Ocular signs and symptoms also occur with numerous other causes of headache. Double vision in association with periocular pain can result from orbital lesions, isolated cranial neuropathies, and cavernous sinus lesions. Pupillary abnormalities like Horner's syndrome may result from a variety of painful conditions, including cluster headache, parasellar neoplasms or aneurysms, internal carotid dissection or occlusion, and Tolosa-Hunt syndrome. Pain with a dilated and unreactive pupil may reflect a benign condition like Adie's syndrome or ophthalmoplegic migraine, or it may herald the presence of a life-threatening posterior communicating artery aneurysm. Headache and transient visual loss can be manifestations of classic migraine, or be symptoms of ocular hypoperfusion from ipsilateral internal carotid occlusion or increased intracranial pressure from pseudotumor cerebri. In a young patient, head pain with a fixed visual deficit may result from optic neuritis, in an older adult, temporal arteritis may be the culprit. Ophthalmologic aspects of headache thus encompass problems that range from simple and benign to complex and formidable.
Topics: Eye Diseases; Headache; Humans; Orbital Diseases; Vision Disorders
PubMed: 2020223
DOI: 10.1016/s0025-7125(16)30443-6 -
Journal of Neuro-ophthalmology : the... Sep 2001We report a 38-year-old woman with bilateral tonic (Adie's) pupils who was diagnosed as having Vogt-Koyanagi-Harada syndrome. The tonic pupils persisted after other...
We report a 38-year-old woman with bilateral tonic (Adie's) pupils who was diagnosed as having Vogt-Koyanagi-Harada syndrome. The tonic pupils persisted after other clinical features of this syndrome had disappeared.
Topics: Adult; Evoked Potentials, Visual; Female; Humans; Pilocarpine; Pupil; Tonic Pupil; Uveomeningoencephalitic Syndrome; Visual Acuity
PubMed: 11725186
DOI: 10.1097/00041327-200109000-00008 -
Archives of Ophthalmology (Chicago,... Apr 1978Ciliary muscle function in patients with Adie's syndrome was studied retrospectively in 122 patients and prospectively in 17 patients. When a careful history was taken,...
Ciliary muscle function in patients with Adie's syndrome was studied retrospectively in 122 patients and prospectively in 17 patients. When a careful history was taken, two thirds of the patients had ciliary muscle-related symptoms. Most of the patients with Adie's syndrome had a moderate accomodative paresis, but there was a strong tendency for the ciliary muscle to recover with time. Many patients showed a tonicity of accommodation, especially those who had had the condition for several years. Astigmatism could be induced with accommodation in one third of patients. This may be related to segmental paralysis of the ciliary muscle. Seventy-three percent of the patients showed supersensitivity of the ciliary muscle in the involved eye, when both eyes were treated with a mixture of 0.25% pilocarpine hydrochloride and hydroxypropyl methylcellulose (Isopto Carpine). This may be a clinical aid in diagnosing Adie's syndrome. Two patients were found to have bilateral ciliary muscle dysfunction but only unilateral pupillary abnormalities. These two patients may have had a "pupil-sparing" Adie's syndrome.
Topics: Accommodation, Ocular; Adie Syndrome; Adolescent; Adult; Astigmatism; Child; Ciliary Body; Female; Humans; Male; Methylcellulose; Myopia; Pilocarpine; Prospective Studies; Pupil; Retrospective Studies
PubMed: 646691
DOI: 10.1001/archopht.1978.03910050334008 -
The British Journal of Ophthalmology Apr 1944
PubMed: 18170002
DOI: 10.1136/bjo.28.4.190 -
Turkish Journal of Emergency Medicine Mar 2015Holmes-Adie syndrome (HAS) is a rare syndrome characterized by tonic pupil and the absence of deep tendon reflexes. HAS was first described in 1931 and is usually...
Holmes-Adie syndrome (HAS) is a rare syndrome characterized by tonic pupil and the absence of deep tendon reflexes. HAS was first described in 1931 and is usually idiopathic, with incidences reported to be 4-7 per 100,000. Although tonic pupil is usually unilateral, it can also be bilateral. Enlarged and irregular pupil is usually noticed by the patient. Light reflex is weak or unresponsive. Another characteristic of HAS is the absence of deep tendon reflexes, and unilateral involvement is more common. This case report emphasizes that HAS should be considered in the differential diagnosis of patients presenting to the emergency department with anisocoria, and the dilute pilocarpine test can be used in diagnosis.
PubMed: 27437522
DOI: 10.5505/1304.7361.2015.59144 -
Journal of Pediatric Ophthalmology and... 1987Adie's syndrome comprises a tonic pupil, which may be associated with impairment of accommodation, in the presence of diminished or absent deep tendon reflexes. We...
Adie's syndrome comprises a tonic pupil, which may be associated with impairment of accommodation, in the presence of diminished or absent deep tendon reflexes. We report a case of a 4-year-old boy with Adie's syndrome in which latent hypermetropia was made manifest by accommodative paresis and resulted in reversible amblyopia.
Topics: Accommodation, Ocular; Adie Syndrome; Amblyopia; Child, Preschool; Humans; Male; Pilocarpine; Pupil; Visual Acuity
PubMed: 3668764
DOI: 10.3928/0191-3913-19870701-06 -
Journal of Neuro-ophthalmology : the... Mar 2024
Topics: Humans; Tonic Pupil; BNT162 Vaccine; COVID-19 Vaccines; COVID-19; Adie Syndrome
PubMed: 36166780
DOI: 10.1097/WNO.0000000000001670 -
Ocular Immunology and Inflammation Aug 2014We report a 37-year-old woman with uveitic phase of Vogt Koyanagi Harada disease and tonic pupil, the tonic pupil persisted after other clinical features of this...
We report a 37-year-old woman with uveitic phase of Vogt Koyanagi Harada disease and tonic pupil, the tonic pupil persisted after other clinical features of this syndrome had disappeared; neurological evaluation shows absent knee and arm tendon reflexes and positive cholinergic supersensitivity test with Pilocarpine 0.125% confirming the diagnosis of Holmes Adie Syndrome.
Topics: Adie Syndrome; Adult; Diagnosis, Differential; Female; Humans; Uveomeningoencephalitic Syndrome; Visual Acuity
PubMed: 24215593
DOI: 10.3109/09273948.2013.848906