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Journal of Wound, Ostomy, and...Acetic acid is bacteriostatic or bactericidal to many gram-negative and gram-positive microorganisms, especially Pseudomonas. Nevertheless, it has also been found to...
BACKGROUND
Acetic acid is bacteriostatic or bactericidal to many gram-negative and gram-positive microorganisms, especially Pseudomonas. Nevertheless, it has also been found to possess cytotoxic effects in concentrations as low as 0.25% inhibiting the epithelialization process during wound healing.
CASES
In this multiple case series, we present 2 cases of chronic traumatic leg wounds treated with gauze moistened with acetic acid (0.25%), which were covered with a securing dressing and compression stockinet. Both patients were told to apply gauze moistened with acetic acid (0.25%) twice daily. In both cases, the wound progressed to blue-green drainage and wet yellow slough tissue to near-complete beefy granulation tissue. At this point, acetic acid was replaced with collagen or petrolatum dressing until complete wound closure was achieved. The treatment of these wounds illustrated successful use of acetic acid for chronic wound care.
CONCLUSION
Our experience with these cases suggests that appearance of blue-green wound drainage and wet yellow slough tissue is a reasonable indication for the use of gauze moistened with acetic acid (0.25%). Further research is needed to test the efficacy of these principles in guiding acetic acid use in wound care.
Topics: Acetic Acid; Bandages; Collagen; Humans; Wound Healing
PubMed: 35255076
DOI: 10.1097/WON.0000000000000863 -
Food and Chemical Toxicology : An... Dec 2019
Review
Topics: Acetic Acid; Animals; Databases, Factual; Humans; Perfume; Registries; Risk Assessment
PubMed: 31589915
DOI: 10.1016/j.fct.2019.110828 -
Annual Review of Microbiology 1957
Topics: Acetates; Acetic Acid; Acetobacter; Bacteria
PubMed: 13470823
DOI: 10.1146/annurev.mi.11.100157.001533 -
Bioresource Technology Dec 2021At present, xylooligosaccharides (XOS) from corncob using acid-base conjugate system has not been reported. In this study, XOS production from corncob by two-step acetic...
At present, xylooligosaccharides (XOS) from corncob using acid-base conjugate system has not been reported. In this study, XOS production from corncob by two-step acetic acid/sodium acetate (AC/SA) conjugate system hydrolysis and xylanase hydrolysis was optimized, and monosaccharides were subsequently produced from corncob residues by cellulase hydrolysis. The XOS of 19.9 g/L was obtained from corncob (10%, w/v) using 0.15 M AC/SA hydrolysis at a molar ratio of 3.0 at 170 °C for 60 min, followed by xylanase hydrolysis. The second-step AC/SA hydrolysis of hydrolyzed corncob (10%, w/v) produced 3.1 g/L of XOS. Finally, the maximum XOS yield of 74.8% (based on xylan in corncob) was achieved, which is the highest yield among yields reported previously. The purity of XOS was high, whereas the contents of by-products were very low. This work presents a novel and promising strategy for co-production of XOS and monosaccharides from corncob without xylan isolation and purification.
Topics: Acetic Acid; Endo-1,4-beta Xylanases; Glucuronates; Hydrolysis; Oligosaccharides; Sodium Acetate; Zea mays
PubMed: 34571332
DOI: 10.1016/j.biortech.2021.125979 -
Biotechnology Progress Jul 2016Acetic acid is introduced into cellulose conversion processes as a consequence of composition of lignocellulose feedstocks, causing significant inhibition of adapted,...
Acetic acid is introduced into cellulose conversion processes as a consequence of composition of lignocellulose feedstocks, causing significant inhibition of adapted, genetically modified and wild-type S. cerevisiae in bioethanol fermentation. While adaptation or modification of yeast may reduce inhibition, the most effective approach is to remove the acetic acid prior to fermentation. This work addresses liquid-liquid extraction of acetic acid from biomass hydrolysate through a pathway that mitigates acetic acid inhibition while avoiding the negative effects of the extractant, which itself may exhibit inhibition. Candidate solvents were selected using simulation results from Aspen Plus™, based on their ability to extract acetic acid which was confirmed by experimentation. All solvents showed varying degrees of toxicity toward yeast, but the relative volatility of ethyl acetate enabled its use as simple vacuum evaporation could reduce small concentrations of aqueous ethyl acetate to minimally inhibitory levels. The toxicity threshold of ethyl acetate, in the presence of acetic acid, was found to be 10 g L(-1) . The fermentation was enhanced by extracting 90% of the acetic acid using ethyl acetate, followed by vacuum evaporation to remove 88% removal of residual ethyl acetate along with 10% of the broth. NRRL Y-1546 yeast was used to demonstrate a 13% increase in concentration, 14% in ethanol specific production rate, and 11% ethanol yield. This study demonstrated that extraction of acetic acid with ethyl acetate followed by evaporative removal of ethyl acetate from the raffinate phase has potential to significantly enhance ethanol fermentation in a corn stover bioethanol facility. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:929-937, 2016.
Topics: Acetates; Acetic Acid; Ethanol; Fermentation; Hydrolysis; Saccharomyces cerevisiae; Zea mays
PubMed: 27090191
DOI: 10.1002/btpr.2282 -
Fungal Genetics and Biology : FG & B Jan 2023The production of yeast oil from lignocellulosic biomasses is impaired by inhibitors formed during the pretreatment step, mainly acetic acid. Herein, we applied Adaptive...
The production of yeast oil from lignocellulosic biomasses is impaired by inhibitors formed during the pretreatment step, mainly acetic acid. Herein, we applied Adaptive Laboratory Evolution (ALE) to select three Acetic acid Tolerant Strains (ATS) of P. laurentii UFV-1. Different phenotypes emerged alongside evolution. The ATS II presented trade-offs in the absence of acetic acid, suggesting that it displays a specialized phenotype of tolerance to growth on organic acids. On the other hand, ATS I and ATS III presented phenotypes associated with the behavior of generalists. ATS I was considered the most promising evolved strain as it displayed the oleaginous phenotype in all conditions tested. Thus, we applied whole-genome sequencing to detect the mutations that emerged in this strain during the ALE. We found alterations in genes encoding proteins involved in different cellular functions, including multidrug resistance (MDR) transporters, energy metabolism, detoxification, coenzyme recycling, and cell envelope remodeling. To evaluate acetic acid stress responses, both parental and ATS I strains were cultivated in chemostat mode in the absence and presence of acetic acid. In contrast to ATS I, the parental strain presented alterations in the cell envelope and cell size under acetic acid stress conditions. Furthermore, the parental strain and the ATS I presented differences regarding acetic acid assimilation. Contrary to the parental strain, the ATS I displayed an increase in unsaturated fatty acid content irrespective of acetic acid stress, which might be related to improved tolerance to acetic acid. Altogether, these results provided insights into the mechanisms involved with the acetic acid tolerance displayed by ATS I and the responses of P. laurentii to this stressful condition.
Topics: Acetic Acid; Saccharomyces cerevisiae; Phenotype; Membrane Transport Proteins
PubMed: 36528339
DOI: 10.1016/j.fgb.2022.103765 -
International Journal of Molecular... Apr 2022Mitochondrial function in skeletal muscle, which plays an essential role in oxidative capacity and physical activity, declines with aging. Acetic acid activates...
Mitochondrial function in skeletal muscle, which plays an essential role in oxidative capacity and physical activity, declines with aging. Acetic acid activates AMP-activated protein kinase (AMPK), which plays a key role in the regulation of whole-body energy by phosphorylating key metabolic enzymes in both biosynthetic and oxidative pathways and stimulates gene expression associated with slow-twitch fibers and mitochondria in skeletal muscle cells. In this study, we investigate whether long-term supplementation with acetic acid improves age-related changes in the skeletal muscle of aging rats in association with the activation of AMPK. Male Sprague Dawley (SD) rats were administered acetic acid orally from 37 to 56 weeks of age. Long-term supplementation with acetic acid decreased the expression of atrophy-related genes, such as atrogin-1, muscle RING-finger protein-1 (MuRF1), and transforming growth factor beta (TGF-β), activated AMPK, and affected the proliferation of mitochondria and type I fiber-related molecules in muscles. The findings suggest that acetic acid exhibits an anti-aging function in the skeletal muscles of aging rats.
Topics: AMP-Activated Protein Kinases; Acetic Acid; Aging; Animals; Dietary Supplements; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley
PubMed: 35563082
DOI: 10.3390/ijms23094691 -
Classical World 2010Pliny the Elder's account of Cleopatra consuming a cocktail of vinegar and a pearl in order to win a bet with Antony was considered credible in the ancient world, but...
Pliny the Elder's account of Cleopatra consuming a cocktail of vinegar and a pearl in order to win a bet with Antony was considered credible in the ancient world, but many modern scholars have relegated the anecdote to the realm of fantasy. This paper identifies possible reasons for this skepticism, including the visual tradition of the story and the belief that increasing concentration always increases reaction rate. Experiments reveal that, in the case of acetic acid and pearls, the concentration found in vinegar made from wine is ideal.
Topics: Acetic Acid; Calcium Carbonate; Egypt, Ancient; History, Ancient; Mythology; Roman World
PubMed: 20213972
DOI: 10.1353/clw.0.0169 -
Bioresource Technology Jul 2023The production of xylo-oligosaccharides (XOS) from lignocelluloses with conjugated acid-base system is highly efficient. However, XOS production from wheat straw with...
The production of xylo-oligosaccharides (XOS) from lignocelluloses with conjugated acid-base system is highly efficient. However, XOS production from wheat straw with conjugated system of acetic acid/sodium acetate (HAc/NaAc) has not been reported. In addition, the impact of delignification of wheat straw for XOS production was not clear. In this study, the optimal conditions for HAc/NaAc hydrolysis were: 0.4 M, molar ratio 10:1, 170 °C, and 60 min. The yield of XOS could be rose to 50.2% after the HAc/NaAc hydrolysate was hydrolyzed using xylanase. After 70.3% of lignin in wheat straw was removed by hydrogen peroxide-acetic acid treatment, the XOS yield of delignified wheat straw using HAc/NaAc reached 54.7%. Finally, a glucose yield of 96.6% was gained by cellulase from wheat straw solid. This work suggested that HAc/NaAc hydrolysis could efficiently produce XOS from wheat straw and the delignification of wheat straw was conducive to XOS and monosaccharides production.
Topics: Monosaccharides; Sodium Acetate; Triticum; Oligosaccharides; Acetic Acid; Hydrolysis
PubMed: 37028530
DOI: 10.1016/j.biortech.2023.129025 -
Journal of Bacteriology Sep 1946
Topics: Acetates; Acetic Acid; Bacteria; Culture Media; Gram-Negative Bacteria
PubMed: 20998726
DOI: 10.1128/JB.52.3.353-356.1946