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Anesthesia and Analgesia Jun 2017
Topics: Airway Management; Humans; Laryngoscopy; Patient Positioning
PubMed: 28430690
DOI: 10.1213/ANE.0000000000002119 -
Journal of Anaesthesiology, Clinical... 2018There are limited data on the effect of ampule size on drug dosing. The objective of this study is to determine the effect of ampule size on perioperative opioid dosing...
BACKGROUND AND AIMS
There are limited data on the effect of ampule size on drug dosing. The objective of this study is to determine the effect of ampule size on perioperative opioid dosing and post-anesthesia care unit (PACU) outcomes.
MATERIAL AND METHODS
This was a retrospective review of patients undergoing robotically assisted laparoscopic radical prostatectomy before and after a 5-ml fentanyl ampule was discontinued. The primary outcome was intraoperative opioid administration divided into fentanyl at induction of anesthesia, total fentanyl, and total opioid. Secondary outcomes observed in PACU included the opioid administered, visual analog scale (VAS) pain scores, postoperative nausea and vomiting, and length of stay in PACU.
RESULTS
A total of 100 patients (50 PRE and 50 POST) were included. In the intraoperative opioid administration, mean (SD) of fentanyl at induction was 117.0 (49.3) in PRE group and 85.0 (35.4) μg in POST group ( < 0.01). The total fentanyl requirement was 247.0 (31.0) in PRE group and 158.5 (85.1) μg in POST group ( < 0.01). The total opioid in intravenous morphine equivalents (IVME) was 34.1 (5.8) in PRE group and 23.2 (6.8) mg in POST group ( < 0.01). Among the secondary outcomes, mean (SD) of IVME of opioid was 7.7 (8.2) in PRE group and 9.9 (8.1) mg in POST group ( = 0.18). The VAS pain score on arrival was 0.7 (1.4) in PRE group and 3.8 (3.3) in POST group ( < 0.01). The cumulative VAS pain score was 2.3 (2.0) in PRE group and 3.3 (2.2) in POST group ( < 0.01). The length of stay was significantly more in POST group, 193.8 (75.8) minutes, as compared with PRE group, 138.6 (61.0) minutes ( < 0.01).
CONCLUSIONS
A change in the ampule size significantly affected intraoperative dosing, PACU pain scores, and PACU length of stay in patients undergoing robotically assisted laparoscopic radical prostatectomy under general anesthesia. This was explained by clinician's desire to conserve the drug and avoid the complex process of narcotic waste disposal.
PubMed: 30774233
DOI: 10.4103/joacp.JOACP_17_18 -
Asian Journal of Surgery Apr 2024
PubMed: 38212223
DOI: 10.1016/j.asjsur.2023.12.084 -
American Journal of Clinical and... 2022Considering that the use of aromatase inhibitors in the treatment of infertile men is a new approach and obesity in men is one of the factors affecting infertility, we...
Comparison of the effect of combined therapy of HCG ampule and letrozole tablet with each method separately on the spermogram parameters in the obese men with idiopathic infertility: a clinical trial.
INTRODUCTION
Considering that the use of aromatase inhibitors in the treatment of infertile men is a new approach and obesity in men is one of the factors affecting infertility, we decided to compare the effect of combined therapy of Human chorionic gonadotropin (HCG) and Letrozole and either of the two methods alone on the spermogram parameters in obese men with idiopathic infertility.
MATERIALS AND METHODS
This clinical trial study was performed with the participation of 15 infertile and obese men from 2018 to 2019 in Tabriz (infertility clinics); Patients were randomly divided into three groups; The first group received treatment with Letrozole 2.5 mg daily alone, the second group received treatment with HCG ampoules at a dose of 5000 units twice a week, and the third group received combination therapy with HCG ampoules at a dose of 5000 units twice a week and letrozole tablets at a dose of 2.5 mg daily; The results of testosterone and sperm tests before and after the intervention were evaluated by t-test and linear regression tests in SPSS21 software. A -value less than 0.05 was considered significant.
RESULTS
There was no statistically significant difference between semen indices and hormones studied before the intervention (P < 0.05), while after the intervention there were statistically significant differences between all variables compared to those before the intervention (P < 0.05); Also, the rate of change in the third group was much more favorable than the other two groups.
CONCLUSION
The combination of HCG ampules with letrozole tablets compared to the use of these drugs alone improved sperm count, sperm motility, and sperm morphology.
PubMed: 36051612
DOI: No ID Found -
Saudi Journal of Anaesthesia 2015
PubMed: 25829927
DOI: 10.4103/1658-354X.152903 -
Pielegniarka I Polozna Jun 1971
Topics: Antisepsis; Drug Packaging; Nursing
PubMed: 5209221
DOI: No ID Found -
Anesthesiology Aug 1990
Topics: Anesthesia, Intravenous; Drug Contamination; Glass; Propofol; Syringes
PubMed: 2382868
DOI: 10.1097/00000542-199008000-00044 -
Anesthesiology Mar 1950
Topics: Anesthesia; Anesthesia, Spinal; Anesthesiology; Drug Contamination; Drug Packaging; Humans
PubMed: 15411062
DOI: No ID Found -
AANA Journal Jun 1991Contamination of glass ampules by glass fragments can occur following ampule opening. The intravenous administration of these glass fragments in animal experiments has... (Comparative Study)
Comparative Study
Contamination of glass ampules by glass fragments can occur following ampule opening. The intravenous administration of these glass fragments in animal experiments has resulted in insult to the brain, pulmonary, hepatic, renal, and splenic systems of these animals. Thus, it is of clinical importance to determine quantitatively the extent of glass particulate contamination by examining the different methods of glass ampule opening. Twenty, 2-mL single-dose glass ampules were examined for glass fragments following opening. Ten of the ampules were snapped open by hand while 10 were snapped open with the use of a commercial ampule opener. The contents of the ampules were aspirated into a 5-mL glass syringe, attached to an 18-gauge nonfilter needle. The contents of the syringe were filtered, then examined for glass fragments under a microscope. The size and number of glass particles were recorded using a calibrated ocular micrometer. Analysis of variance for repeated measures and Duncan's test showed no significant difference between the two groups. Thus, no significant difference existed in the number and size of glass particles aspirated when comparing these two ampule opening methods.
Topics: Drug Contamination; Drug Packaging; Equipment and Supplies; Evaluation Studies as Topic; Glass; Humans
PubMed: 1950400
DOI: No ID Found