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Clinical Infectious Diseases : An... Sep 2001A severe, local, inflammatory, late-phase reaction accompanied by skin necrosis occurred after an infant was given an intramuscular injection of recombinant hepatitis B...
A severe, local, inflammatory, late-phase reaction accompanied by skin necrosis occurred after an infant was given an intramuscular injection of recombinant hepatitis B virus vaccine. The clinical course and appearance of the rash were typical of an Arthus reaction. Although not identical to this case, prior reported cases of complement-mediated reactions occurring after hepatitis B virus infection or vaccination provide theoretical support for this diagnosis.
Topics: Arthus Reaction; Complement Activation; Female; Hepatitis B Vaccines; Humans; Infant; Vaccines, Synthetic
PubMed: 11512098
DOI: 10.1086/322585 -
The Veterinary Clinics of North... Mar 2018Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune... (Review)
Review
Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune response to the disease agents in the vaccine. Side effects are sometimes associated with vaccination. These vary from development of acute hypersensitivity responses to vaccine components to local tissue reactions that are annoying but not significantly detrimental to the patient. The pathogenesis of these responses and the consequent clinical outcomes are discussed. Overstimulation of the immune response and the potential relationship to autoimmunity is evaluated in relation to genetic predisposition.
Topics: Anaphylaxis; Animals; Arthus Reaction; Autoimmunity; Cat Diseases; Cats; Dog Diseases; Dogs; Fibrosarcoma; Horse Diseases; Horses; Immunity, Herd; Immunoglobulin E; Vaccination; Vaccines
PubMed: 29195924
DOI: 10.1016/j.cvsm.2017.10.005 -
Journal of Anesthesia Apr 2013Neutrophil recruitment to the inflammatory sites is regulated by a variety of adhesion molecules including β2 integrins. The dependency of neutrophil recruitment on β2...
PURPOSE
Neutrophil recruitment to the inflammatory sites is regulated by a variety of adhesion molecules including β2 integrins. The dependency of neutrophil recruitment on β2 integrins is variable in different tissues, but has not yet been verified in the cutaneous passive reverse Arthus reaction. We examined this question and also evaluated the impact of isoflurane on neutrophil recruitment to the skin because we previously showed in vitro that isoflurane binds and inhibits β2 integrins.
METHODS
The dependency on β2 integrins in neutrophil recruitment to the skin in the Arthus reaction was examined using αL, αM and β2 knockout mice. Then, we evaluated the effect of isoflurane on neutrophil recruitment to the skin. In addition, the effects of isoflurane on neutrophil binding to intercellular adhesion molecule-1 (ICAM-1), one of the β2 integrin ligands, were studied in vitro using cell adhesion assays.
RESULTS
Neutrophil recruitment to the skin in the Arthus reaction model was totally dependent on β2 integrins, as β2 knockout mice completely abolished it. However, the defect of only one of the β2 integrins was not sufficient to abolish neutrophil recruitment. Isoflurane reduced neutrophil recruitment to the skin by approximately 90 %. Also, isoflurane inhibited neutrophil adhesion to β2 integrin ligand ICAM-1.
CONCLUSIONS
We demonstrated that (1) neutrophil recruitment to the skin was totally dependent on β2 integrins, and (2) isoflurane significantly impaired neutrophil recruitment. Based on the previous studies on the contribution of other adhesion molecules in neutrophil recruitment, it is likely that isoflurane at least partially affects on β2 integrins in this model.
Topics: Anesthetics, Inhalation; Animals; Arthus Reaction; CD11b Antigen; Cell Adhesion; Flow Cytometry; In Vitro Techniques; Integrin beta Chains; Intercellular Adhesion Molecule-1; Isoflurane; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Peroxidase; Skin
PubMed: 23096126
DOI: 10.1007/s00540-012-1508-1 -
Experimental and Molecular Pathology Oct 1987The concentrations of serotonin, tryptamine, dopamine, and tyramine were quantitatively determined in the Arthus reaction, since the activity of...
The concentrations of serotonin, tryptamine, dopamine, and tyramine were quantitatively determined in the Arthus reaction, since the activity of histamine-N-methyltransferase (HMT), a major histamine-metabolizing enzyme that had been demonstrated to be inhibited by such biogenic amines in vitro, decreased significantly in the reaction site. The concentrations of serotonin, tryptamine, and dopamine were unchanged in dinitrochlorobenzene allergic and croton oil dermatitis except for a slight increase of tryptamine in the latter. Tyramine was unable to be demonstrated quantitatively in all specimens tested. The concentration of serotonin decreased to about 30% that of the control level until 1 hr, followed by a prominent increase to about two-fold at 6 hr after the initiation of the Arthus reaction accompanying with a concomitant decrease in HMT activity. However, the concentrations of tryptamine and dopamine were rather decreased in the reaction site, and the net decrease of two amines was far greater than the increased amount of serotonin. The decrease in HMT activity is not stoichiometrically well elucidated from these results, and therefore, the presence of other hypothetic inhibitory factors that are increased in the Arthus reaction should be suspected.
Topics: Animals; Arthus Reaction; Biogenic Amines; Dermatitis; Dopamine; Female; Guinea Pigs; Histamine N-Methyltransferase; Male; Serotonin; Tryptamines; Tyramine
PubMed: 2958359
DOI: 10.1016/0014-4800(87)90073-6 -
Agents and Actions Jun 1979The Arthus reaction is an immunologically induced inflammatory response characterized by immune complex deposition, complement fixation, polymorphonuclear leukocyte...
The Arthus reaction is an immunologically induced inflammatory response characterized by immune complex deposition, complement fixation, polymorphonuclear leukocyte infiltration and tissue damage. Many of these same pathological tissue alterations are found in the lesions of rheumatoid arthritis (RA). The similarities between the reversed passive Arthus reaction (RPAR) and RA led us to investigate the usefulness of the RPAR in the search for new antirheumatic agents. The RPAR was elicited in the skin of rats using chicken ovalbumin and the IgG fraction of rabbit anti-ovalbumin. Paramethasone, hydrocortisone, indomethacin, pirprofen, sulfinpyrazone, thalidomide and theophylline all gave significant inhibition of the RPAR. Ibuprofen, naproxen, cyprohepatadine and cromolyn sodium were inactive, while phenylbutazone and ASA exhibited a dose-dependent effect. The data show that the Arthus reaction, which is the result of the complex interaction of many factors, can be affected either generally or selectively at different time intervals by various therapeutic agents. The RPAR in rats may prove useful in detecting new therapeutic agents for the treatment of RA.
Topics: Animals; Anti-Inflammatory Agents; Arthus Reaction; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Rats; Rheumatic Diseases
PubMed: 157676
DOI: 10.1007/BF02024732 -
Journal of Immunology (Baltimore, Md. :... Feb 1956
Topics: Animals; Antigens; Arthus Reaction; Hypersensitivity; Immune System Diseases; Injections; Mice; Rats
PubMed: 13295601
DOI: No ID Found -
Agents and Actions Mar 1992A novel and potent antagonist of platelet-activating factor (PAF), Y-24180 (4-(2-chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6,9-dimethyl-6H-...
A novel and potent antagonist of platelet-activating factor (PAF), Y-24180 (4-(2-chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6,9-dimethyl-6H- thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4] diazepine) was investigated for the effects on the skin reactions induced by chemical mediators and the Arthus reactions. In the rat dorsal skin, Y-24180 (0.1-10 mg/kg, p.o.) inhibited increase in vascular permeability by the intradermal PAF injection in a dose dependent manner and the inhibitory activity was 60 times more potent than that of WEB 2086. While even at doses as large as 10 mg/kg, p.o., it had no effect on vascular permeability in the rat skin induced by histamine, serotonin, bradykinin and leukotriene D4. On a reversed passive Arthus reaction in rat dorsal skin, Y-24180 (0.1-1 mg/kg, p.o.) markedly inhibited vascular permeability in a dose dependent manner and the inhibitory activity was 15 times more potent than that of WEB 2086. Y-24180 also inhibited the Arthus dermal reaction in rabbits (0.03-0.3 mg/kg, p.o.) and guinea pigs (0.1-1 mg/kg, p.o.). In addition, Y-24180 (0.1-10 mg/kg, p.o.) significantly reduced the exudate volume and the number of infiltrated inflammatory cells in the reversed passive Arthus pleural reaction in rats. Furthermore, in rat passive Arthus pancreatitis, Y-24180 (0.3-10 mg/kg, p.o.) significantly inhibited the dye extravasation from the pancreas. These results provide strong evidence that endogenous PAF plays an important role as a mediator in the type III allergic inflammation.
Topics: Animals; Arthus Reaction; Azepines; Capillary Permeability; Disease Models, Animal; Female; Guinea Pigs; Male; Molecular Structure; Ovalbumin; Pancreatitis; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Skin; Skin Diseases; Triazoles
PubMed: 1388318
DOI: 10.1007/BF01997493 -
Journal of Comparative Pathology Jan 1990A study was made of the Arthus reaction in an animal model of Hageman-factor deficiency, namely Hageman trait cats, and in control cats with normal Hageman-factor...
A study was made of the Arthus reaction in an animal model of Hageman-factor deficiency, namely Hageman trait cats, and in control cats with normal Hageman-factor activity. At three time points, there was a significant decrease (P less than 0.01) in the size of the cutaneous Arthus reaction to chicken red blood cells in biopsies from Hageman trait cats compared with the reaction in biopsies from control animals. Injection of a positive control, histamine, and a negative control, phosphate-buffered saline, produced no significant differences between the two groups. Hageman trait cats had a significant decrease (P less than 0.001) in the number of neutrophils in the skin lesions compared with controls. When Hageman trait cats were injected intravenously with purified cat Hageman factor, Arthus reactions were similar to those observed in control cats.
Topics: Animals; Arthus Reaction; Biopsy; Cats; Chickens; Erythrocyte Transfusion; Factor XII Deficiency; Female; Hemagglutination; Male; Skin; Skin Tests
PubMed: 2138171
DOI: 10.1016/s0021-9975(08)80005-9 -
International Journal of... 1989The effect of a 20% w/v RM101 (perfluorobutyltetrahydrofuran) emulsion containing 5% w/v of the detergent Pluronic F-68 or 5% w/v Pluronic F-68 given alone on the Arthus...
Enhancement of the Arthus reaction and suppression of delayed type hypersensitivity (DTH) by pluronic F-68, a detergent frequently used to prepare perfluorocarbon emulsions.
The effect of a 20% w/v RM101 (perfluorobutyltetrahydrofuran) emulsion containing 5% w/v of the detergent Pluronic F-68 or 5% w/v Pluronic F-68 given alone on the Arthus reaction and on delayed type hypersensitivity (DTH) were evaluated in female A/J mice. The test substances were administered i.v. at 1% body weight at 0,4,7,14 and 28 days prior to the i.p. immunization with 10(7) sheep red blood cells (SRBC). The increase in footpad swelling at 4 h (Arthus reaction) and at 24 h (DTH) after elicitation with the s.c. administration of 10(8) SRBC into the left footpad was used to assess immune competence. Pluronic F-68 given alone enhanced the Arthus reaction only when administered on day 0 of immunization. Pluronic F-68 given alone, as well as the perfluorocarbon emulsion containing Pluronic F-68, suppressed the 24 h DTH for as long as 4 days prior to immunization. Nonemulsified perfluorocarbon, on the other hand, had no effect on either the Arthus reaction or on DTH. The immunostimulatory agent, levamisole, administered (10 mg/kg i.p.) 1.5-2 h prior to immunization with SRBC counteracted both the Arthus reaction and the DTH response produced by Pluronic F-68. The present data clearly demonstrate that the changes in Arthus reaction and the DTH response are due to the Pluronic F-68 used to emulsify the RM101 perfluorocarbon; the changes induced by the detergent in these two immune parameters probably involve separate mechanisms.
Topics: Animals; Arthus Reaction; Dose-Response Relationship, Immunologic; Female; Hypersensitivity, Delayed; Levamisole; Mice; Poloxalene; Polyethylene Glycols
PubMed: 2525535
DOI: 10.1016/0192-0561(89)90161-6 -
Journal of Immunology (Baltimore, Md. :... Apr 2022
Topics: Arthus Reaction; Humans; Inflammation; Receptors, Fc
PubMed: 35361733
DOI: 10.4049/jimmunol.2200086