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Archives of Surgery (Chicago, Ill. :... Oct 1976
Topics: Adult; Appendicitis; Barium Sulfate; Female; Humans; Radiography
PubMed: 971094
DOI: 10.1001/archsurg.1976.01360280126026 -
Radiology Feb 1971
Topics: Barium Sulfate
PubMed: 5541056
DOI: 10.1148/98.2.387 -
Particle and Fibre Toxicology Oct 2014Nanoparticulate barium sulfate has potential novel applications and wide use in the polymer and paint industries. A short-term inhalation study on barium sulfate... (Comparative Study)
Comparative Study
BACKGROUND
Nanoparticulate barium sulfate has potential novel applications and wide use in the polymer and paint industries. A short-term inhalation study on barium sulfate nanoparticles (BaSO₄ NPs) was previously published [Part Fibre Toxicol 11:16, 2014]. We performed comprehensive biokinetic studies of ¹³¹BaSO₄ NPs administered via different routes and of acute and subchronic pulmonary responses to instilled or inhaled BaSO₄ in rats.
METHODS
We compared the tissue distribution of ¹³¹Ba over 28 days after intratracheal (IT) instillation, and over 7 days after gavage and intravenous (IV) injection of ¹³¹BaSO₄. Rats were exposed to 50 mg/m³ BaSO₄ aerosol for 4 or 13 weeks (6 h/day, 5 consecutive days/week), and then gross and histopathologic, blood and bronchoalveolar lavage (BAL) fluid analyses were performed. BAL fluid from instilled rats was also analyzed.
RESULTS
Inhaled BaSO₄ NPs showed no toxicity after 4-week exposure, but a slight neutrophil increase in BAL after 13-week exposure was observed. Lung burden of inhaled BaSO₄ NPs after 4-week exposure (0.84 ± 0.18 mg/lung) decreased by 95% over 34 days. Instilled BaSO₄ NPs caused dose-dependent inflammatory responses in the lungs. Instilled BaSO₄ NPs (0.28 mg/lung) was cleared with a half-life of ≈ 9.6 days. Translocated ¹³¹Ba from the lungs was predominantly found in the bone (29%). Only 0.15% of gavaged dose was detected in all organs at 7 days. IV-injected ¹³¹BaSO₄ NPs were predominantly localized in the liver, spleen, lungs and bone at 2 hours, but redistributed from the liver to bone over time. Fecal excretion was the dominant elimination pathway for all three routes of exposure.
CONCLUSIONS
Pulmonary exposure to instilled BaSO₄ NPs caused dose-dependent lung injury and inflammation. Four-week and 13-week inhalation exposures to a high concentration (50 mg/m³) of BaSO₄ NPs elicited minimal pulmonary response and no systemic effects. Instilled and inhaled BaSO₄ NPs were cleared quickly yet resulted in higher tissue retention than when ingested. Particle dissolution is a likely mechanism. Injected BaSO₄ NPs localized in the reticuloendothelial organs and redistributed to the bone over time. BaSO₄ NP exhibited lower toxicity and biopersistence in the lungs compared to other poorly soluble NPs such as CeO₂ and TiO₂.
Topics: Administration, Oral; Air Pollutants; Animals; Barium Radioisotopes; Barium Sulfate; Dose-Response Relationship, Drug; Female; Half-Life; Inhalation Exposure; Injections, Intravenous; Intestinal Absorption; Intestinal Elimination; Lung; Male; Metal Nanoparticles; Pneumonia; Rats, Inbred WKY; Respiratory Mucosa; Respiratory Tract Absorption; Solubility; Tissue Distribution; Toxicity Tests, Acute; Toxicity Tests, Subchronic; Toxicokinetics
PubMed: 25331813
DOI: 10.1186/s12989-014-0055-3 -
The American Journal of Roentgenology,... Feb 1966
Topics: Barium Sulfate; Digestive System; Flavoring Agents; Humans; Radiography
PubMed: 5908404
DOI: 10.2214/ajr.96.2.484 -
The Western Journal of Medicine Apr 1988
Topics: Acute Disease; Aged; Appendicitis; Barium Sulfate; Humans; Male; Middle Aged
PubMed: 3388851
DOI: No ID Found -
Radiographics : a Review Publication of... 2019
Review
Topics: Barium Sulfate; Contrast Media; Esophageal Diseases; Humans
PubMed: 31498745
DOI: 10.1148/rg.2019190055 -
Journal of the Medical Association of... May 1953
Topics: Barium; Barium Sulfate; Humans; Peritonitis
PubMed: 13053106
DOI: No ID Found -
Radiology Jul 1989
Topics: Barium Sulfate; Digestive System; Extravasation of Diagnostic and Therapeutic Materials; Humans; Infant; Liver; Lung; Male; Pulmonary Edema; Radiography; Spleen
PubMed: 2740505
DOI: 10.1148/radiology.172.1.213-b -
Langmuir : the ACS Journal of Surfaces... May 2010BaSO(4) nanostructures with controlled morphologies were successfully produced via one-step process through precipitation of BaSO(4) in aqueous and organic media. The...
BaSO(4) nanostructures with controlled morphologies were successfully produced via one-step process through precipitation of BaSO(4) in aqueous and organic media. The synthesis is carried out by mixing solutions of BaCl(2) and Na(2)SO(4) in presence of EDTA (disodium ethylenediaminetetraacetic acid) at room temperature. The influence of the reaction conditions such as initial reactants concentration, pH, EDTA/[Ba(2+)] ratio and aging on the BaSO(4) nanoparticles organization is studied. Using EDTA in aqueous media, spherical secondary particles of 500 nm diameter are obtained, which are formed by 4 nm size primary particles. With dimethyl sulfoxide and small amounts of water (5%) and EDTA, the aging process allows the production of long homogeneous fibers, related to hierarchical organization of BaSO(4) nanoparticles. Direct observation of self-assembling of primary particles by HRTEM allows proposing a mechanism for fiber formation, which is based on multipolar attractions that lead to a brick-by-brick organization along a preferential orientation. Results evidence the role of EDTA as controlling agent of the morphology and primary and secondary mean particle size.
Topics: Barium Sulfate; Edetic Acid; Membranes, Artificial; Nanostructures; Particle Size; Surface Properties
PubMed: 20055367
DOI: 10.1021/la904197k -
Journal of Pharmaceutical Sciences Jul 1968
Topics: Barium Sulfate; Chemistry, Pharmaceutical; Methods
PubMed: 5662067
DOI: 10.1002/jps.2600570729