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Acta Orthopaedica Scandinavica Feb 1982Collagen abnormalities in idiopathic scoliosis are on record. Since there is a correlation between the platelet aggregating power of the collagen and the bleeding time... (Comparative Study)
Comparative Study
Collagen abnormalities in idiopathic scoliosis are on record. Since there is a correlation between the platelet aggregating power of the collagen and the bleeding time in patients with scoliosis, the bleeding time was studied in 195 cases with scoliosis and in 318 controls. The bleeding time was longer in the females, especially in those with idiopathic scoliosis (n = 149). Patients with paralytic scoliosis (n = 5) also had a significantly longer bleeding time than non-scoliotic controls. The patients with congenital scoliosis (n = 13) did not differ significantly from the controls or from patients with idiopathic scoliosis. The bleeding time in idiopathic scoliosis did not vary with age or magnitude of the scoliosis. Our data support the view that collagen abnormalities play a role not only in the aetiology of idiopathic scoliosis, but also in other forms of scoliosis.
Topics: Adolescent; Adult; Age Factors; Bleeding Time; Female; Humans; Male; Platelet Function Tests; Scoliosis; Sex Factors
PubMed: 7064684
DOI: 10.3109/17453678208992182 -
Blut Jun 1986The occlusion time ("haemostasis time" - HT) of a thin, short cannula inserted into the cubital vein, was compared with the skin bleeding times of the Duke and... (Comparative Study)
Comparative Study
"Haemostasis time", a modified bleeding time test and its comparison with the Duke and Ivy/template bleeding times. I. Normal values, application in thrombocytopenic patients and evaluation of heparin and aspirin effects.
The occlusion time ("haemostasis time" - HT) of a thin, short cannula inserted into the cubital vein, was compared with the skin bleeding times of the Duke and Ivy/template techniques. 25 male and 25 female volunteers without a history of bleeding were divided into 5 equally large age groups ranging from 10 to over 50 years of age. They exhibited a range of 46 s-6 min 38 s (95% tolerance interval), while the Duke and Ivy/template bleeding times, which were simultaneously determined, corresponded to values given by other authors. HT is different from the skin bleeding times in that endothelium is replaced by a standard foreign surface which allows better standardization of the method. Similar results were obtained with HT compared to the skin bleeding times. These and a similar, non-significant heparin response with all three techniques suggest that HT is not more influenced by clotting factors than the Duke and Ivy/template bleeding times and, indeed, may be regarded as a bleeding time modification. HT, like both of the skin bleeding times, reflected lowered platelet counts and is even more sensitive in this respect. As tested in a group of 20 male and 20 female volunteers, HT showed a significant prolongation two hours after ingestion of 1 g aspirin. While male individuals exhibited longer bleeding times than females with the Ivy/template technique (sex-related difference p = 0.01), no male to female differences were found both with HT and the Duke bleeding time. HT is easy to perform, inexpensive, leaves no scars and is safe even for the patient with severe bleeding. Moreover, compared to the skin bleeding times, it permits a differential evaluation of vessel wall and tissue effects.
Topics: Adolescent; Adult; Aspirin; Bleeding Time; Catheterization; Child; Female; Hemostasis; Heparin; Humans; Male; Middle Aged; Platelet Function Tests; Reference Values; Thrombocytopenia
PubMed: 3719109
DOI: 10.1007/BF00320781 -
Thrombosis and Haemostasis May 1993
Comparative Study
Topics: Administration, Oral; Anticoagulants; Bleeding Time; Blood Coagulation; Humans; Methods; Sensitivity and Specificity
PubMed: 8357429
DOI: No ID Found -
American Journal of Clinical Pathology Sep 1990The authors measured the template bleeding time in 11 normal people before and 2, 4, 12, 24, and 48 hours after the subjects ingested a single dose of 74 mg of aspirin... (Clinical Trial)
Clinical Trial Randomized Controlled Trial
The authors measured the template bleeding time in 11 normal people before and 2, 4, 12, 24, and 48 hours after the subjects ingested a single dose of 74 mg of aspirin (ASA). The entire experiment was repeated twice at two-week intervals, with the dose of ASA increased to 325 mg and finally 3,900 mg. The mean increase was maximal at 4 and 12 hours, regardless of the dose administered, with a return to baseline by 48 hours. The authors then performed bleeding times in a prospective randomized double-blinded fashion on an additional 39 subjects at baseline and seven hours after they ingested either placebo or ASA 325 mg. The mean baseline bleeding time was 5.2 minutes (SD +/- 1.4), with a mean prolongation after ASA of 2.1 minutes (SD +/- 1.9). The authors identified 5 of 37 (14%) subjects as hyper-responders (HRs) using the criterion of a bleeding time prolongation of greater than 5.9 minutes (greater than 2 SD beyond the mean prolongation). Neither baseline bleeding time, threshold sensitivity of collagen-induced platelet aggregation, nor other tests of hemostatic function discriminated HRs from normals. The authors conclude that in subjects with normal baseline bleeding times, a prolongation of greater than 5.9 minutes when measured seven hours after the administration of a single dose of 325 mg of ASA can discriminate HRs from normals.
Topics: Adult; Aspirin; Bleeding Time; Blood Coagulation Tests; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests
PubMed: 2396603
DOI: 10.1093/ajcp/94.3.292 -
Hemodialysis International.... Oct 2022This study aimed to investigate the effect of the bevel orientation (facing upwards or downwards towards the skin) of the needle inserted into the arterial limb of the... (Randomized Controlled Trial)
Randomized Controlled Trial
AIM
This study aimed to investigate the effect of the bevel orientation (facing upwards or downwards towards the skin) of the needle inserted into the arterial limb of the arteriovenous fistula (AVF) on puncture pain and postremoval bleeding time.
METHODS
This study, using a single-blind crossover design, was conducted on 35 maintenance hemodialysis patients who had been dialyzed for at least 6 months and in whom blood access was via an AVF. AVF cannulation was performed with the needle bevel pointing upward in the first six sessions and the needle bevel pointing downwards (towards the skin) in the subsequent six sessions. Needles were always inserted in the direction of blood flow. At each dialysis session, cannulation pain was measured using a visual analog scale (VAS), and the bleeding time at the end of dialysis after needle removal was recorded.
FINDINGS
The VAS score and postremoval bleeding time were lower when the needle bevel pointed downwards towards the skin during insertion (P < 0.05).
DISCUSSION
Insertion of the needle with the bevel pointed downward decreased puncture pain during cannulation and bleeding time postdialysis on needle removal.
Topics: Arteriovenous Shunt, Surgical; Bleeding Time; Humans; Needles; Pain; Punctures; Renal Dialysis; Single-Blind Method
PubMed: 36068183
DOI: 10.1111/hdi.13044 -
Thrombosis and Haemostasis Oct 2019
Topics: Bleeding Time; Blood Platelets; Hemorrhage; Humans; Platelet Aggregation
PubMed: 31564056
DOI: 10.1055/s-0039-1696984 -
International Journal of Laboratory... Feb 2014Bleeding time is still widely performed in many developing countries including Thailand. To generate an accurate result, the procedure should be complied with standard...
INTRODUCTION
Bleeding time is still widely performed in many developing countries including Thailand. To generate an accurate result, the procedure should be complied with standard recommendations such as those from Clinical and Laboratory Standards Institute (CLSI) and World Federation of Hemophilia (WFH). The authors surveyed the current practices of bleeding time in Thailand in order to verify the practices that did not comply with the accepted standard.
METHODS
The questionnaires were sent to hospitals participating Thailand National External Quality Assessment Scheme (NEQAS) for blood coagulation. Items in the questionnaire comprised information about preanalytical, analytical, and postanalytical issues of bleeding time.
RESULTS
From a dispatch of 201 questionnaires, 155 (77.1%) were returned. The common noncompliance with standards observed in this survey included inappropriateness of indication, e.g. use for preoperative screening (95 of 126, 75.4%), use of devices other than standard template (130 of 132, 98.5%), and inappropriate reference range (125 of 127, 98.4%).
CONCLUSIONS
The noncompliance shown in this survey can affect the accuracy of bleeding time results. The authors would like to address these problems as an alert for other laboratories especially in the developing countries where the standard templates are not widely available.
Topics: Bleeding Time; Blood Coagulation; Hematology; Hemophilia A; Humans; Laboratories; Quality Assurance, Health Care; Reference Values; Surveys and Questionnaires; Thailand
PubMed: 23889816
DOI: 10.1111/ijlh.12129 -
British Journal of Haematology Oct 1989The bleeding time in healthy volunteers was determined according to both the Ivy and the Simplate II techniques. A significantly longer bleeding time in people with...
The bleeding time in healthy volunteers was determined according to both the Ivy and the Simplate II techniques. A significantly longer bleeding time in people with blood group O than in people with non-O blood groups was demonstrated with both techniques. This difference could not be attributed to a difference in sex ratio, platelet count or haematocrit. The mean level of von Willebrand factor in blood group O is lower than in non-O blood groups, but we found no association between the level of von Willebrand factor and the bleeding time, despite the very broad range of von Willebrand factor levels in the subjects examined.
Topics: ABO Blood-Group System; Bleeding Time; Blood Group Antigens; Female; Humans; Male; Platelet Function Tests; Reference Values; Sex Factors; von Willebrand Factor
PubMed: 2818940
DOI: 10.1111/j.1365-2141.1989.tb00255.x -
Transfusion Medicine Reviews Dec 1987Low hematocrit is an often neglected cause in the pathogenesis of a prolonged bleeding time in an anemic patient. There has been ample evidence in the literature,... (Review)
Review
Low hematocrit is an often neglected cause in the pathogenesis of a prolonged bleeding time in an anemic patient. There has been ample evidence in the literature, indicating a relationship between hematocrit and the bleeding time; and that the transfusion of RBCs may correct the prolonged bleeding time often observed in anemic patients. It is unclear how a low hematocrit causes a prolongation in the bleeding time; however, two hypotheses have been put forward. First, in small blood vessels, blood flow is such that the RBCs cause the physical dispersion of platelets towards the subendothelial surface, thus promoting interaction with the blood vessel wall. Secondly, following injury to a small blood vessel, RBCs activate platelets by releasing small amounts of adenosine diphosphate (ADP) into the microvasculature following the hemolysis that often occurs during hemostasis. The fact that the hematocrit influences the bleeding time may be of clinical importance in the treatment of anemic patients, particularly those presenting a bleeding tendency.
Topics: Adenosine Diphosphate; Bleeding Time; Erythrocytes; Hematocrit; Hemorrhage; Humans; Platelet Activation
PubMed: 2980277
DOI: 10.1016/s0887-7963(87)70020-0 -
Clinical and Laboratory Haematology 1984A questionnaire survey of current practice in the bleeding time test has been undertaken by the UK External Quality Assessment Scheme in blood coagulation. Completed...
A questionnaire survey of current practice in the bleeding time test has been undertaken by the UK External Quality Assessment Scheme in blood coagulation. Completed returns have been received from 358 centres. Most centres (88.5%) perform bleeding times and of these the Ivy test is the most commonly performed. Only 13.6% perform the Duke method. Templates are used to control the procedure by approximately half of the hospitals. There is considerable variability in the type and depth of incision and interpretation of the endpoint. The upper limit of normality not unexpectedly differs considerably between the centres with both Ivy and Duke methods. The use of a commercial template method, 'Simplate', provides a measure of agreement amongst the group of hospitals using this instrument but it remains to be established whether this is the most reliable procedure. In the interim, gross discrepancies in technique or interpretation should be corrected in the light of the findings of the survey.
Topics: Bleeding Time; Diagnostic Services; Hospitals; Humans; Platelet Function Tests; Quality Assurance, Health Care; Reference Standards; Surveys and Questionnaires; United Kingdom
PubMed: 6525804
DOI: 10.1111/j.1365-2257.1984.tb00564.x