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Acta Pharmacologica Et Toxicologica Aug 1984Following intraperitoneal administration to male mice (strain AB Jena/Halle) of 14C-methyl-labelled trichlorphon, dimethoate, phosmet and bromophos, 10-20 Ci/mol, in... (Comparative Study)
Comparative Study
Following intraperitoneal administration to male mice (strain AB Jena/Halle) of 14C-methyl-labelled trichlorphon, dimethoate, phosmet and bromophos, 10-20 Ci/mol, in dosages of 0.06-0.55 mmol/kg, DNA from liver and kidneys was analyzed for 14C in N-7 methylguanine (7-MeG). The extents of methylation were in the range of 5-10 mumol 7-MeG/mol guanine for trichlorphon and dimethoate and of 0.2-0.4 for phosmet and bromophos, for high doses, respectively Excretion half-lives of 7-MeG were differing between trichlorphon (5 hrs, high dose, and 15-17 hrs, low dose) and dimethoate (23-160 hrs, high dose). The extents of methylation at 0-6 of guanine were estimated to be around 0.01 mumol 0-6 MeG/mol guanine for high doses of organophosphates of sufficient water solubility. Factors associated with the partition of organophosphates in mammalian systems are useful for estimating DNA attack by organophosphates in mammals in vivo.
Topics: Alkylation; Animals; Biotransformation; Carbon Radioisotopes; DNA; Dimethoate; Guanine; Half-Life; Injections, Intraperitoneal; Insecticides; Kidney; Liver; Male; Methylation; Mice; Organothiophosphates; Organothiophosphorus Compounds; Phosmet; Trichlorfon
PubMed: 6496111
DOI: 10.1111/j.1600-0773.1984.tb01970.x -
Journal of Economic Entomology Oct 1979
Comparative Study
Topics: Flour; Food Contamination; Humidity; Insect Control; Insecticides; Malathion; Organothiophosphates; Pesticide Residues; Triticum
PubMed: 544641
DOI: 10.1093/jee/72.5.728 -
Roczniki Panstwowego Zakladu Higieny 1968
Topics: Bromine; Chemistry, Agricultural; Chromatography, Thin Layer; Neutrons; Pesticides; Phosphates; Phosphorus Isotopes; Radiochemistry; Radioisotopes
PubMed: 5708685
DOI: No ID Found -
Polskie Archiwum Weterynaryjne 1975The studies were carried out on mice between the 14th and 19th days, i.e., in the period of maximum penetration of T. spiralis larvae in the host's muscles.... (Comparative Study)
Comparative Study
[Histochemical study of the effect of phosphoroorganic esters Z-50 (fenchlorfos) and Z-51 (bromophos) on cholinesteras activity in the course of the muscle phase in experimental trichinellosis in mice].
The studies were carried out on mice between the 14th and 19th days, i.e., in the period of maximum penetration of T. spiralis larvae in the host's muscles. Phosphoro-organic esters were given orally to experimental animals in oil solution, at the following doses: Z-50 -- 150 mg per kg of body weight and Z-51 -- 100 mg per kg of body weight. The influence of esters on the activity of cholinesterases was investigated with the Koelle-Friedenwald method, modified by Gomori. The aim of the study was to establish the joint activity of the migrating Trichinella larvae and phosphoro-organic esters on the organism of the host. Z-50 and Z-51 penetrate in therapeutic doses the striated muscles rather weakly. 24 hrs after these compounds were given, acetylcholinesterase (AChE) activity was inhibited in motor end-plates in about 30%, and in muscle fibres infected with T. spiralis larvae in about 60-70%. Pseudocholinesterase (PChE) activity was stronger inhibited than AChE. 24 hrs after applying Z-50 and Z-51 PChE was inhibited in about 90%. Of the two phosphoro-organic esters being examined Z-51 stronger inhibited the cholinesterases activity than Z-50. It was found that the efficiency of phosphoro-organic esters in the course of trichinellosis depends on its ability of infiltration into the host's muscles and on the degree of inhibition of the active cholinesterases in the motor end-plates. Attention was drawn to the fact that increased activity of cholinergic system is one of the main factors in the patholgenesis of the second phase of trichinellosis, i.e., the migration and penetration of the larvae in the muscular fibres of the host.
Topics: Animals; Cholinesterases; Depression, Chemical; Histocytochemistry; Insecticides; Mice; Motor Endplate; Muscles; Organothiophosphorus Compounds; Trichinellosis
PubMed: 52151
DOI: No ID Found -
Journal of Agricultural and Food... Sep 1969
PubMed: 21428340
DOI: 10.1021/jf60165a045 -
Food Chemistry Mar 2022A simple, environmentally-friendly and reliable method was developed to simultaneously monitor the residue of methyl 1-naphthalene acetate, parathion-methyl,...
A simple, environmental-friendly and reliable d-SPE method using amino-containing metal-organic framework MIL-125-NH to determine pesticide residues in pomelo samples from different localities.
A simple, environmentally-friendly and reliable method was developed to simultaneously monitor the residue of methyl 1-naphthalene acetate, parathion-methyl, fenitrothion, bromophos and phenthoate in pomelo by using dispersive solid-phase extraction technique (d-SPE). In this method, these target analytes were captured by MIL-125-NH and detected by GC-MS/MS. The key parameters of d-SPE were optimized by the single factor experiment. Under the optimized conditions, a good determination coefficient (R > 0.9922) and extraction recoveries (64.7-116.8%) are obtained. The limit of detections (0.03-1.07 ng/g) is lower than the MRLs in citrus fruits established by EU (10-15000 ng/g) and China (10-10000 ng/g). The precisions of intra-day and inter-day are 1.3-8.9% and 3.8-14.9%, respectively. In addition, the sorbent MIL-125-NH is stable and can be reused at least eight times. These results prove the established method is efficient and reliable to detect the pesticide residues in pomelo.
Topics: Fruit; Metal-Organic Frameworks; Pesticide Residues; Solid Phase Extraction; Tandem Mass Spectrometry
PubMed: 34601418
DOI: 10.1016/j.foodchem.2021.131208 -
Journal of Mass Spectrometry : JMS Nov 2022Lanolin, also known as wool wax, is derived from sheep and has diverse applications in food, cosmetic, textile and lubricant industries. Owing to its direct contact with...
Lanolin, also known as wool wax, is derived from sheep and has diverse applications in food, cosmetic, textile and lubricant industries. Owing to its direct contact with human, there is a need of studying pesticide residues as contaminants in lanolin. The present study describes a single novel hyphenated gas chromatography-tandem mass spectrometry (GC-MS/MS) technique for the quantification of 14 organophosphorus (OP) pesticides (tecnazene, propetamphos, diazinon, dichlofenthion, chlorpyrifos methyl, fenchlorphos, malathion, chlorpyrifos, pirimiphos ethyl, bromophos ethyl, tetrachlorvinphos, ethion, phosalone, and coumaphos) in lanolin using electrospray ionization (EI) with multiple reaction monitoring (MRM) acquisition mode. The method is simple in terms of sample preparation steps based on matrix solid-phase dispersion (MSPD). The method was found to be linear over the analytical range of 0.05-2.0 μg/g, with acceptable coefficient of determination (r ≥ 0.99) for all the 14 pesticides. The limit of detection (LOD) and limit of quantification (LOQ) of the method were found to be less than 0.05 and 0.1 μg/g, respectively, for all the 14 OP pesticide residues. The precision and accuracy of the method were found to be within the acceptable limits, that is, recoveries in the range of 83.5%-104.1% with less than 12.5% of relative standard deviation for all the pesticides. The multiresidue method for estimating pesticide residues employing GC-MS/MS technique will be useful for OP pesticide levels in large number of lanolin samples.
Topics: Sheep; Animals; Humans; Pesticides; Pesticide Residues; Tandem Mass Spectrometry; Lanolin; Organophosphorus Compounds; Gas Chromatography-Mass Spectrometry; Chlorpyrifos
PubMed: 36369744
DOI: 10.1002/jms.4894 -
Bulletin of Environmental Contamination... Mar 1984
Topics: Animals; Bone Marrow; Chromosome Aberrations; Female; Insecticides; Male; Mice; Mice, Inbred Strains; Mitomycin; Mitomycins; Mutagens; Organophosphates; Organothiophosphates; Organothiophosphorus Compounds; Spermatogonia
PubMed: 6424742
DOI: 10.1007/BF01607497 -
Zeitschrift Fur Naturforschung. Teil B,... Jun 1969
Topics: Animals; Cattle; Chromatography, Thin Layer; Female; Insecticides; Milk; Phosphoric Acids; Phosphorus Isotopes
PubMed: 4390026
DOI: No ID Found -
Archives of Environmental &... 2016This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides...
This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides were quantified in blood, serum, and urine (15 organochlorines, 10 organophosphorus, 5 carbamates, and ethylenethiourea), and the comet assay was performed. Twenty-four (77.42%) pesticides were present in the workers. The use of the maximum-likelihood factor analysis identified 8 different mixtures. Afterwards, robust regressions were used to explore associations between the factors identified and the comet assay. Two groups of mixtures--α-benzene hexachloride (α-BHC), hexachlorobenzene (HCB), and β-BHC (β: 1.21, 95% confidence interval [CI]: 0.33-2.10) and pirimiphos-methyl, malathion, bromophos-methyl, and bromophos-ethyl (β: 11.97, 95% CI: 2.34-21.60)--were associated with a higher percentage of DNA damage and comet tail length, respectively. The findings suggest that exposure to pesticides varies greatly among rice field workers.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Agriculture; Carbamates; Colombia; Comet Assay; Cross-Sectional Studies; DNA Damage; Ethylenethiourea; Female; Humans; Hydrocarbons, Chlorinated; Male; Middle Aged; Occupational Exposure; Organophosphorus Compounds; Oryza; Pesticides; Young Adult
PubMed: 24972111
DOI: 10.1080/19338244.2014.910489