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International Journal of Infectious... Nov 2020Members of the bacterial genus Cedecea cause acute infections worldwide in compromised hosts with serious underlying medical conditions. While global reports of Cedecea... (Review)
Review
Members of the bacterial genus Cedecea cause acute infections worldwide in compromised hosts with serious underlying medical conditions. While global reports of Cedecea infections remain sporadic in the medical literature, cases of multidrug-resistant clinical isolates have been documented each year over the past decade, warranting a comprehensive update on this emerging opportunistic pathogen. Here, we review the clinical manifestations, pathogenesis, natural distribution, epidemiology, and antimicrobial resistance of Cedecea species. Acute infection commonly manifests as bacteremia and pneumonia; however, the spectrum of infectious pathologies associated with Cedecea has expanded to include oral and cutaneous ulcers, orbital cellulitis, and peritonitis. The frequency of resistance among reported clinical isolates was highest to ampicillin, cephalothin, cefoxitin, cefazolin, and ceftazidime. Cedecea isolates harboring metallo-β-lactamases exhibited resistance to carbapenems and fourth-generation cephalosporins. Further research is needed to understand the pathogenicity and multidrug resistance of Cedecea species. Appropriate therapeutic management of Cedecea infections depends on antibiotic susceptibility testing because of variable resistance patterns and the enhanced infection risk in vulnerable populations.
Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans
PubMed: 32950733
DOI: 10.1016/j.ijid.2020.09.036 -
Archives of Microbiology Dec 2022A Gram-stain-negative, motile, rod-shaped bacterium, designated strain LAM2020, was isolated from a sulfonylurea herbicides-degrading bacterial consortium. The optimal...
A Gram-stain-negative, motile, rod-shaped bacterium, designated strain LAM2020, was isolated from a sulfonylurea herbicides-degrading bacterial consortium. The optimal temperature and pH for the growth of strain LAM2020 were 30 °C and 7.0, respectively. Strain LAM2020 formed a distinct phylogenetic subclade within the genus Cedecea in the phylogenetic trees built with 16S rRNA gene sequences and shared the highest similarity with Cedecea davisae DSM 4568 (98.4%). The values of digital DNA-DNA hybridization and average nucleotide identity (ANI) based on the genome sequences between LAM2020 and C. davisae DSM 4568 were 22.7% and 80.0%, respectively. It contained 54.0 mol% of G + C in the genomic DNA. The major cellular fatty acids of strain LAM2020 were summed feature 3 (C ω6c and/or C ω7c), C and summed feature 8 (C ω7c/C ω6c). The major polar lipids present in strain LAM2020 were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and aminophospholipid. The respiratory quinone of strain LAM2020 was ubiquinone-8 and ubiquinone-7. Based on the phenotypic characteristics, chemotaxonomic data and genotypic analyses, strain LAM2020 should be classified as a novel species of genus Cedecea, for which the name Cedecea sulfonylureivorans sp. nov. is proposed. The type strain is LAM2020 (= GDMCC 1.2363 = JCM 34640).
Topics: RNA, Ribosomal, 16S; Ubiquinone; Phylogeny; Herbicides; DNA, Bacterial; Base Composition; Bacterial Typing Techniques; Phospholipids; Sequence Analysis, DNA; Fatty Acids; Bacteria
PubMed: 36484840
DOI: 10.1007/s00203-022-03362-2 -
The American Journal of Tropical... Aug 2023Cedecea lapagei is a gram-negative, non-encapsulated, facultative anaerobic bacterium that has been reported in only a few cases with varying clinical presentations,... (Review)
Review
Cedecea lapagei is a gram-negative, non-encapsulated, facultative anaerobic bacterium that has been reported in only a few cases with varying clinical presentations, drug susceptibility, and treatment since its first isolation in 1981. This study aimed to describe a case report of C. lapagei in Peru and systematically review the documented case reports of individuals infected with C. lapagei. A 59-year-old man who had become bedridden with Parkinson's disease and had epilepsy presented with a 1-week history of fever and sore throat and was admitted. Physical examination revealed an obtundation state and abolished vesicular murmur in the right hemithorax. During hospitalization, the patient was diagnosed with various infections, including tuberculosis, for which he received broad-spectrum antibiotics. In the absence of clinical improvement, a urine culture was performed showing C. lapagei (detected by BD Phoenix M50 system, Vernon Hills, IL). The patient received amoxicillin/clavulanate and was discharged. Case reports of C. lapagei were also searched in five databases on January 28, 2023. Twenty cases of C. lapagei were reported worldwide between 2006 and 2022, 16 of which involved adults. Fever was the most common manifestation (75%), and pneumonia was the primary form of presentation (45%). Moreover, 90% of the patients had at least one comorbidity, and 15% died. Also, most of the isolates were sensitive to ciprofloxacin (81%), meropenem (62%), and amikacin (60%). Overall, C. lapagei should be suspected in compromised hosts, particularly those with pneumonia. Although the bacterium can affect various organs and the antibiotic susceptibility pattern is variable, quinolones, tetracyclines, and carbapenems seem to be the first therapeutic option.
Topics: Male; Adult; Humans; Middle Aged; Enterobacteriaceae Infections; Peru; Base Composition; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Anti-Bacterial Agents
PubMed: 37339767
DOI: 10.4269/ajtmh.23-0168 -
Journal of Clinical Microbiology Oct 1986A case of bacteremia caused by Cedecea davisae is presented. This is the first reported case of bacteremia caused by this organism.
A case of bacteremia caused by Cedecea davisae is presented. This is the first reported case of bacteremia caused by this organism.
Topics: Aged; Catheters, Indwelling; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Humans; Sepsis
PubMed: 3771758
DOI: 10.1128/jcm.24.4.675-676.1986 -
Revista Chilena de Infectologia :... Feb 2013Cedecea lapagei is a gram-negative, facultative anaerobic, non-spore-forming bacteria, belonging to the family Enterobacteriaceae. It has been reported as a pathogen in... (Review)
Review
Cedecea lapagei is a gram-negative, facultative anaerobic, non-spore-forming bacteria, belonging to the family Enterobacteriaceae. It has been reported as a pathogen in few cases of bacterial peritonitis, wound infection, chemicals burns and pneumonia. We report a case of traumatic wound infection by this pathogen with a pertinent review.
Topics: Adult; Enterobacteriaceae Infections; Foot Injuries; Humans; Male; Wound Infection
PubMed: 23450417
DOI: 10.4067/S0716-10182013000100015 -
Microorganisms Feb 2020The genus is comprised of six rarely isolated species within the family. Representatives are Gram-negative motile bacilli, and are typically oxidase-negative,...
The genus is comprised of six rarely isolated species within the family. Representatives are Gram-negative motile bacilli, and are typically oxidase-negative, lipase-positive and resistant to colistin and cephalothin. In this study, a putative novel species (designated strain ZA_0188), isolated from the koala hindgut, was characterised using a polyphasic taxonomic approach. Maximum average nucleotide identity (ANI) and 16S ribosomal RNA (rRNA) similarity scores well below thresholds of species demarcation were reported, at 81.1% and 97.9%, respectively. Multilocus phylogenetic analysis indicated strain ZA_0188 was most similar to but divergent from recognised species. The isolate's genomic G+C content was determined as 53.0 mol%, >1% lower than previously reported in . Phenotypically, strain ZA_0188 was distinct from recognised species such as colistin- and cephalothin-sensitive, lipase-, sorbitol-, sucrose-, and Voges-Proskauer-negative, and melibiose-, arabinose-, arginine-, and rhamnose-positive. In preliminary experiments, strain ZA_0188 exhibited cellulase activity and high-level tolerance to eucalyptus oil compared to other enteric species surveyed. Collectively, these findings suggest that strain ZA_0188 represents a novel enteric species, for which the name is proposed.
PubMed: 32102268
DOI: 10.3390/microorganisms8020309 -
BMJ Case Reports Jul 2019A late preterm male infant of 36 weeks gestation and a birth weight of 2100 g was admitted on day 35 of life with complaints of respiratory distress and lethargy. He was... (Review)
Review
A late preterm male infant of 36 weeks gestation and a birth weight of 2100 g was admitted on day 35 of life with complaints of respiratory distress and lethargy. He was diagnosed as a case of sepsis screen positive culture negative sepsis and was managed with respiratory support and intravenous antibiotics for 10 days. The infant improved clinically and was on spoon feeds by day 14 of admission. On day 14 of admission, he developed new-onset respiratory distress and was diagnosed as a case of nosocomial pneumonia based on chest radiography findings. The blood culture grew a rare organism and a diagnosis of sepsis was also made. The antibiotics were tailored as per the blood culture sensitivity pattern and the infant had clinical improvement in the next 72 hours.
Topics: Anti-Bacterial Agents; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Infant; Lethargy; Male; Piperacillin, Tazobactam Drug Combination; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Sepsis; Spinal Puncture; Treatment Outcome
PubMed: 31300600
DOI: 10.1136/bcr-2019-229854 -
Transplant Infectious Disease : An... Oct 2010Cedecea davisae is a member of the Enterobacteriaceae family and is an uncommon pathogen. This organism has been isolated from the blood, sputum, and cutaneous ulcers of... (Review)
Review
Cedecea davisae is a member of the Enterobacteriaceae family and is an uncommon pathogen. This organism has been isolated from the blood, sputum, and cutaneous ulcers of only a handful of patients, most of these being elderly or otherwise medically compromised. This is a report of a patient, status post renal transplantation, who developed an oral ulcer associated with sirolimus use and superinfected with C. davisae. According to the literature, this is the first case of C. davisae detected in the oral cavity. Antibiotic therapy led to prompt resolution of this very large ulcer.
Topics: Adult; Aged; Enterobacteriaceae Infections; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Oral Ulcer; Sirolimus; Superinfection
PubMed: 20525018
DOI: 10.1111/j.1399-3062.2010.00514.x -
Scientific Reports Jun 2021With multidrug-resistant bacterial pathogens on the rise, there is a strong research focus on alternative antibacterial treatments that could replace or complement...
With multidrug-resistant bacterial pathogens on the rise, there is a strong research focus on alternative antibacterial treatments that could replace or complement classical antibiotics. Metallic nanoparticles, and in particular silver nanoparticles (AgNPs), have been shown to kill bacterial biofilms effectively, but their chemical synthesis often involves environmentally unfriendly by-products. Recent studies have shown that microbial and plant extracts can be used for the environmentally friendly synthesis of AgNPs. Herein we report a procedure for producing AgNPs using a putative Cedecea sp. strain isolated from soil. The isolated bacterial strain showed a remarkable potential for producing spherical, crystalline and stable AgNPs characterized by UV-visible spectroscopy, transmission electron microscopy, dynamic light scattering, and Fourier transform infrared spectroscopy. The concentration of produced nanoparticles was 1.31 µg/µl with a negative surface charge of - 15.3 mV and nanoparticles size ranging from 10-40 nm. The AgNPs was tested against four pathogenic microorganisms S. epidermidis, S. aureus, E. coli and P. aeruginosa. The nanoparticles exhibited strong minimum inhibitory concentration (MIC) values of 12.5 and 6.25 µg/µl and minimum bactericidal concentration (MBC) values of 12.5 and 12.5 µg/mL against E. coli and P. aeruginosa, respectively. One distinguishing feature of AgNPs produced by Cedecea sp. extracts is their extreme stability. Inductively coupled plasma mass spectrometry and thermogravimetric analysis demonstrated that the produced AgNPs are stable for periods exceeding one year. This means that their strong antibacterial effects, demonstrated against E. coli and P. aeruginosa biofilms, can be expected to persist during extended periods.
Topics: Anti-Bacterial Agents; Biofilms; Drug Stability; Enterobacteriaceae; Escherichia coli; Green Chemistry Technology; Metal Nanoparticles; Microbial Sensitivity Tests; Particle Size; Pseudomonas aeruginosa; Silver; Soil Microbiology; Spectrophotometry, Atomic; Staphylococcus aureus; Staphylococcus epidermidis; Thermogravimetry
PubMed: 34135368
DOI: 10.1038/s41598-021-92006-4 -
Orbit (Amsterdam, Netherlands) Jun 2016Cedecea is a gram-negative bacterium from the family Enterobacteriaceae, rarely associated with human infection. We report the first case of an orbital cellulitis and... (Review)
Review
Cedecea is a gram-negative bacterium from the family Enterobacteriaceae, rarely associated with human infection. We report the first case of an orbital cellulitis and corneal ulcer due to Cedecea in a patient who sustained a motor vehicle accident and was then found to have a retained wooden orbital foreign body.
Topics: Accidents, Traffic; Anti-Bacterial Agents; Combined Modality Therapy; Corneal Ulcer; Enterobacteriaceae Infections; Eye Foreign Bodies; Eye Infections, Bacterial; Humans; Magnetic Resonance Imaging; Male; Ophthalmologic Surgical Procedures; Orbit; Orbital Cellulitis; Tomography, X-Ray Computed; Young Adult
PubMed: 27070554
DOI: 10.3109/01676830.2016.1139597