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Biological Psychiatry Nov 1985Serum sodium concentration increased significantly in eight hyponatremic schizophrenic subjects treated with demeclocycline. The incidence of severe hyponatremic...
Serum sodium concentration increased significantly in eight hyponatremic schizophrenic subjects treated with demeclocycline. The incidence of severe hyponatremic episodes was significantly reduced. The authors argue that mild impairments in urinary dilution contribute to water intoxication in most chronic psychotics who develop this syndrome. Demeclocycline may help these patients.
Topics: Adult; Chronic Disease; Compulsive Behavior; Demeclocycline; Drinking Behavior; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Middle Aged; Schizophrenia
PubMed: 3931706
DOI: 10.1016/0006-3223(85)90172-6 -
The Medical Clinics of North America Sep 1970
Review
Topics: Absorption; Acne Vulgaris; Bacteria; Bacteriuria; Bronchial Diseases; Chemical Phenomena; Chemical and Drug Induced Liver Injury; Chemistry; Chlortetracycline; Demeclocycline; Drug Eruptions; Humans; Infections; Kidney Diseases; Methacycline; Oxytetracycline; Protein Binding; Tetracycline; Tooth Discoloration
PubMed: 4248510
DOI: No ID Found -
Talanta Feb 2021In this paper, for the first time, the study of voltammetric determination of tetracycline antibiotic demeclocycline was conducted. The oxidation of compound was...
In this paper, for the first time, the study of voltammetric determination of tetracycline antibiotic demeclocycline was conducted. The oxidation of compound was investigated using a commercially available boron-doped diamond electrode pretreated electrochemically (anodic and subsequent cathodic). Addition of anionic surfactant, sodium dodecylsulfate (SDS) and cationic surfactant, cetyltrimethylammonium bromide (CTAB) to the demeclocycline-containing electrolyte solution at pH 2.0 and 9.0, respectively, was found to improve the sensitivity of the stripping voltammetric measurements. Employing square-wave stripping mode (after 30 s accumulation at open-circuit condition) in Britton-Robinson buffer, the limits of detection were found to be 1.17 μg mL (2.3 × 10 M) for 4 × 10 SDS-containing buffer solution at pH 2, and 0.24 μg mL (4.8 × 10 M) for 1 × 10 CTAB-containing buffer solution at pH 9.0. The feasibility of the developed approach for the quantification of demeclocycline was tested in urine samples.
Topics: Anti-Bacterial Agents; Boron; Demeclocycline; Diamond; Electrodes; Surface-Active Agents
PubMed: 33303147
DOI: 10.1016/j.talanta.2020.121695 -
Lancet (London, England) Dec 1976
Topics: Demeclocycline; Hormones, Ectopic; Humans; Hyponatremia; Male; Middle Aged; Paraneoplastic Endocrine Syndromes; Tracheal Neoplasms; Vasopressins
PubMed: 63880
DOI: 10.1016/s0140-6736(76)91958-9 -
Annals of Internal Medicine Nov 1975We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented...
We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion.
Topics: Carcinoma, Small Cell; Demeclocycline; Diabetes Insipidus; Humans; Hyponatremia; Kidney Diseases; Lung Neoplasms; Male; Middle Aged; Osmolar Concentration; Syndrome; Urine; Vasopressins
PubMed: 173218
DOI: 10.7326/0003-4819-83-5-654 -
Postgraduate Medical Journal Feb 1980A patient with long-standing ischaemic heart disease and severe low output congestive cardiac failure received numerous diuretics, which gradually became ineffective....
A patient with long-standing ischaemic heart disease and severe low output congestive cardiac failure received numerous diuretics, which gradually became ineffective. Resistant oedema was treated by adding demeclocycline to the current diuretic regime of frusemide and metolazone. Diuresis resulted, oedema disappeared and body weight fell. This drug combination was continued without complication for a further 6 months until his death.
Topics: Demeclocycline; Diuretics; Drug Therapy, Combination; Edema; Heart Failure; Humans; Male; Middle Aged
PubMed: 6771750
DOI: 10.1136/pgmj.56.652.121 -
British Medical Journal Oct 1960
Topics: Chlortetracycline; Demeclocycline
PubMed: 13822921
DOI: 10.1136/bmj.2.5204.959 -
Annals of Internal Medicine Nov 1973
Clinical Trial Randomized Controlled Trial
Topics: Acne Vulgaris; Animals; Anura; Cyclic AMP; Demeclocycline; Diabetes Insipidus; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Osmosis; Urinary Bladder; Vasopressins
PubMed: 4356453
DOI: 10.7326/0003-4819-79-5-679 -
The New England Journal of Medicine Apr 1985
Review
Topics: Demeclocycline; Humans; Hyponatremia; Vasopressins
PubMed: 3920518
DOI: 10.1056/NEJM198504253121709 -
American Journal of Kidney Diseases :... May 1985We examined renal function and Na+ balance in a patient with congestive heart failure who was treated with demeclocycline (DMC) on three separate occasions under strict...
We examined renal function and Na+ balance in a patient with congestive heart failure who was treated with demeclocycline (DMC) on three separate occasions under strict metabolic balance conditions. Natriuresis and reversible renal insufficiency, which could not be explained solely on the basis of negative Na+ balance, developed on each occasion. In contrast to reports of an association between elevated serum DMC levels and renal insufficiency in patients with cirrhotic edema, the renal insufficiency in this patient with cardiac edema occurred in the absence of high DMC levels. Consequently, markedly elevated serum DMC levels do not appear to be a prerequisite for the development of natriuresis or renal insufficiency in edematous patients receiving this drug. In an attempt to clarify the mechanism of the natriuresis, we also examined the effects of DMC on Na+ transport in an in-vitro model system, the toad urinary bladder. DMC inhibited aldosterone-stimulated Na+ transport, but had no effect on Na+ transport when the latter was jointly stimulated by ADH and theophylline. Despite this selective inhibition of the natriferic effect of aldosterone in vitro, it is unlikely that such a mechanism completely accounts for the natriuresis observed in-vivo since the natriuresis is generally of large magnitude and is usually accompanied by some degree of kaliuresis, and DMC had no consistent effect on urinary aldosterone excretion. Consequently, other mechanisms must be sought to explain the natriuretic effect of DMC in edematous patients. Likewise, mechanisms other than negative Na+ balance (perhaps primary alterations in renal hemodynamics) must underly the development of renal insufficiency in such individuals.
Topics: Administration, Oral; Aldosterone; Animals; Anura; Biological Transport; Blood Urea Nitrogen; Body Weight; Demeclocycline; Glomerular Filtration Rate; Heart Failure; Humans; In Vitro Techniques; Kidney Failure, Chronic; Male; Middle Aged; Natriuresis; Nephrons; Potassium; Sodium; Theophylline; Vasopressins
PubMed: 3923829
DOI: 10.1016/s0272-6386(85)80121-9