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Neurology Nov 1986Carbamazepine (CBZ)-induced water intoxication occasionally limits its usefulness in refractory seizures and trigeminal neuralgia. Fluid restriction, CBZ dose reduction,...
Carbamazepine (CBZ)-induced water intoxication occasionally limits its usefulness in refractory seizures and trigeminal neuralgia. Fluid restriction, CBZ dose reduction, or concomitant phenytoin therapy may be impractical or ineffective. Demeclocycline (7-chloro-6 demethyl tetracycline) (DMC) corrected the CBZ-induced water intoxication in a 51-year-old man with refractory complex partial seizures and a normal antidiuretic hormone (ADH) level. DMC inhibits ADH-sensitive adenylate cyclase activity in the renal collecting duct and may be useful in correcting the ADH-like or renal antidiuretic effect of CBZ.
Topics: Carbamazepine; Demeclocycline; Humans; Male; Middle Aged; Vasopressins; Water Intoxication
PubMed: 3093919
DOI: 10.1212/wnl.36.11.1506 -
Journal of Pharmaceutical and... 1989A high-performance liquid chromatographic (HPLC) method suitable for the quality control of demeclocycline is described. The stationary phase is a...
A high-performance liquid chromatographic (HPLC) method suitable for the quality control of demeclocycline is described. The stationary phase is a poly(styrene-divinylbenzene) copolymer, kept at 60 degrees C. The mobile phase comprises 2-methyl-2-propanol-0.2 M potassium phosphate buffer (pH 9.0)-0.02 M tetrabutylammonium hydrogen sulphate (pH 9.0)-0.01 M sodium edetate (pH 9.0)-water (8:10:15:10:57, m/v/v/v/v). The flow rate is 1 ml min-1 and detection is performed at 254 nm. Official standards are compared and results for the analysis of a number of commercial bulk samples and preparations are presented. 4-Epidemeclocycline and demethyltetracycline are the main impurities. 4-Epidemethyltetracycline and 2-acetyl-2-decarboxamido-demeclocycline can also be present.
Topics: Capsules; Chromatography, High Pressure Liquid; Demeclocycline; Hydrogen-Ion Concentration; Indicators and Reagents; Ointments; Polystyrenes; Reference Standards; Spectrophotometry, Ultraviolet; Water
PubMed: 2518774
DOI: 10.1016/0731-7085(89)80183-9 -
Nephron 19848 cirrhotics with hyponatremia were given demeclocycline (DMC) 900 mg/day to investigate its effect on renal function, plasma renin activity, aldosterone and urinary...
8 cirrhotics with hyponatremia were given demeclocycline (DMC) 900 mg/day to investigate its effect on renal function, plasma renin activity, aldosterone and urinary excretion of prostaglandin E2 and kallikrein. In 7 patients DMC induced an increase of free water clearance (from -0.36 +/- 0.06 to 0.13 +/- 0.06 ml/min) and serum sodium concentration (from 125.4 +/- 0.09 to 131.1 +/- 1.0 mEq/l, mmol/l). In 5 of these patients DMC also induced a marked reduction of glomerular filtration rate (from 72.2 +/- 6.2 to 31,2 +/- 4.7 ml/min) and renal plasma flow (from 468 +/- 98 to 195 +/- 55 ml/min) which could not be explained on the basis of hypovolemia. In each case this renal impairment was not associated with changes in urinary concentration of beta 2-microglobulin, urinary casts excretion, fresh urine sediment or urine protein content and disappeared after discontinuation of the drug. DMC induced a marked increase in the urinary excretion of prostaglandin E2 (from 0.82 +/- 0.27 to 6.16 +/- 1.91 ng/min) in 6 out of the 7 patients who responded to DMC and a marked reduction in urinary kallikrein (from 16.1 +/- 4.4 to 4.2 +/- 1.6 pkat/min) in the 5 patients who developed renal insufficiency. The serum DMC concentration was greater than 5 micrograms/ml in all patients who responded to DMC, greater than 8 micrograms/ml in all cases who developed renal insufficiency and of 3 micrograms/ml in the case not responding to DMC. (ABSTRACT TRUNCATED AT 250 WORDS)
Topics: Acute Kidney Injury; Demeclocycline; Dinoprostone; Glomerular Filtration Rate; Humans; Hyponatremia; Kallikreins; Kidney; Liver Cirrhosis; Prostaglandins E; Renin-Angiotensin System
PubMed: 6419136
DOI: 10.1159/000183112 -
The Psychiatric Quarterly 1988Eight patients (7 men and 1 woman, mean age 43.1 +/- 8.9 years) with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome) underwent treatment with... (Clinical Trial)
Clinical Trial
Eight patients (7 men and 1 woman, mean age 43.1 +/- 8.9 years) with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome) underwent treatment with demeclocycline in an effort to normalize serum sodium levels and thereby protect the PIP patients against complications including hyponatremic seizures and coma. There tended to be an improvement (p = .080) in early morning serum sodium following treatment with demeclocycline (baseline 132.6 +/- SD 3.3 and treatment serum sodium 134.8 +/- SD 3.3 mEq/1). At the same time, there was an increase (p = .043) in urinary specific gravity following treatment with demeclocycline (baseline 1.0047 +/- SD .0029 and treatment urinary specific gravity 1.0063 +/- SD .0026). Clinical indications for and potential mechanisms of action of demeclocycline treatment in the PIP syndrome are discussed.
Topics: Adult; Clinical Trials as Topic; Demeclocycline; Drinking; Female; Humans; Hyponatremia; Male; Middle Aged; Psychotic Disorders; Sodium; Syndrome
PubMed: 3131788
DOI: 10.1007/BF01064293 -
The American Review of Respiratory... Mar 1968
Clinical Trial
Topics: Acute Disease; Clinical Trials as Topic; Demeclocycline; Disease Outbreaks; Humans; Placebos; Pneumonia; Radiography; Respiratory Tract Infections
PubMed: 4966268
DOI: 10.1164/arrd.1968.97.3.366 -
Antibiotics & Chemotherapy (Northfield,... Jul 1961
Topics: Cholecystectomy; Demeclocycline
PubMed: 14447668
DOI: No ID Found -
The New England Journal of Medicine Jan 1978
Topics: Demeclocycline; Humans; Hyponatremia; Lithium; Osmolar Concentration; Syndrome; Vasopressins
PubMed: 413038
DOI: 10.1056/NEJM197801262980410 -
Australian Endodontic Journal : the... Dec 2007The purpose of this research is to investigate the frequency of endodontic flare-ups using a visual analogue scale. Definitions of flare-ups vary widely as does their... (Randomized Controlled Trial)
Randomized Controlled Trial Review
The purpose of this research is to investigate the frequency of endodontic flare-ups using a visual analogue scale. Definitions of flare-ups vary widely as does their reported frequency. A flare-up was defined as an increase of 20 or more points on the visual analogue scale for a given tooth, within the periods of 4 h and 24 h after the initial treatment appointment. The data from a previous study were used to determine the incidence of flare-ups after using three modalities (Ledermix, calcium hydroxide and no medication) to manage patients presenting for relief of pain of endodontic origin. A statistical analysis showed that there were no significant differences in flare-up rates at both the 4-h and 24-h periods between the three modalities. Further research is required using the above definition of a flare-up and standardising treatment protocols.
Topics: Analysis of Variance; Calcium Hydroxide; Demeclocycline; Drug Combinations; Humans; Pain Measurement; Recurrence; Root Canal Irrigants; Toothache; Triamcinolone Acetonide
PubMed: 18076580
DOI: 10.1111/j.1747-4477.2007.00087.x -
Spectrochimica Acta. Part A, Molecular... Feb 2013This study was designed to examine the interaction of demeclocycline (DMCTC) with human serum albumin (HSA) by multi-spectroscopic and molecular docking methods. The...
This study was designed to examine the interaction of demeclocycline (DMCTC) with human serum albumin (HSA) by multi-spectroscopic and molecular docking methods. The inner filter effect was corrected before we calculated the binding parameters. Fluorescence and UV-vis spectroscopy revealed that DMCTC induced the fluorescence quenching of HSA though a static quenching procedure. Thermodynamic analysis by Van Hoff equation found enthalpy change (ΔH) and entropy change (ΔS) were -53.01 kJ mol(-1) and -65.13 J mol(-1)K(-1), respectively, which indicated hydrogen bond and van der Waals force were the predominant force in the binding process. According to fluorescence resonance energy transfer (FRET), the specific binding distances between Trp-214 (donor) and DMCTC (acceptor) were 3.18 nm. Through site marker competitive experiments, subdomain IIA of HSA has been assigned to possess the high-affinity binding site of DMCTC. The three dimensional fluorescence showed that the conformation of HSA was changed after its complexation with DMCTC, and the alternations of protein secondary structure were quantitatively calculated from FT-IR with reduction of α-helices content about 4.8%, β-sheet from 30.3% to 21.6% and with increases of β-turn from 15.6% to 22.2%. Furthermore, the binding details between DMCTC and HSA were further confirmed by molecular docking studies, which revealed that DMCTC was bound at subdomain IIA through multiple interactions, such as hydrophobic effect, polar forces and π-π interactions. Moreover, the coexist metal ions such as Al(3+), Fe(3+), Cu(2+), Cr(3+) and Cd(2+) can decrease the binding constants of DMCTC-HSA.
Topics: Anti-Bacterial Agents; Binding Sites; Demeclocycline; Humans; Molecular Docking Simulation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Serum Albumin; Spectroscopy, Fourier Transform Infrared; Thermodynamics
PubMed: 23261611
DOI: 10.1016/j.saa.2012.10.050 -
Archives of Dermatology Jan 1974
Topics: Demeclocycline; Humans; Light; Photosensitivity Disorders
PubMed: 4203340
DOI: No ID Found