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Journal of Separation Science Jun 2012A simple, robust, and rapid reversedphase high-performance liquid chromatographic method for the analysis of demeclocycline and its impurities is described....
A simple, robust, and rapid reversedphase high-performance liquid chromatographic method for the analysis of demeclocycline and its impurities is described. Chromatographic separations were achieved on a Symmetry Shield RP8 (75 mm × 4.6 mm, 3.5 μm) column kept at 40°C. The mobile phase was a gradient mixture of acetonitrile, 0.06 M sodium edetate (pH 7.5), 0.06 M tetrapropylammonium hydrogen sulphate (pH 7.5) and water, A (2:35:35:28 v/v/v/v) and B (30:35:35:0 v/v/v/v) pumped at a flow rate of 1 mL/min. UV detection was performed at 280 nm. The developed method was validated according to the ICH guidelines for specificity, limit of detection, limit of quantification, linearity, precision, and robustness. An experimental design was applied for robustness study. Results show that the peak shape, chromatographic resolution between the impurities, and the total analysis time are satisfactory and better than previous methods. The method has been applied for the analysis of commercial demeclocycline bulk samples available on the market.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Demeclocycline; Drug Contamination
PubMed: 22733511
DOI: 10.1002/jssc.201101071 -
The Journal of Clinical Psychiatry Jun 1994Hyponatremia has been reported to occur in approximately 5% of carbamazepine-treated patients who otherwise do well on that agent. Demeclocycline has been used in the...
BACKGROUND
Hyponatremia has been reported to occur in approximately 5% of carbamazepine-treated patients who otherwise do well on that agent. Demeclocycline has been used in the treatment of hyponatremia of various etiologies including one case of carbamazepine-induced hyponatremia.
METHOD
We extended these observations by studying the effects of demeclocycline on carbamazepine-induced hyponatremia in six psychiatric inpatients.
RESULTS
Once serum sodium concentrations had normalized after carbamazepine discontinuation, demeclocycline prevented further decreases in sodium levels upon rechallenge with carbamazepine in five of six patients. Gender, smoking, and neurologic compromise may have played a role in the development of carbamazepine-induced hyponatremia as well as response to this strategy, although our sample size is too small to make firm conclusions.
CONCLUSION
Demeclocycline was successfully used in the prophylaxis of carbamazepine-induced hyponatremia and may be useful in cases that respond best to carbamazepine treatment.
Topics: Adult; Aged; Carbamazepine; Demeclocycline; Drug Therapy, Combination; Female; Hospitalization; Humans; Hyponatremia; Male; Mental Disorders; Middle Aged; Sodium
PubMed: 8071279
DOI: No ID Found -
Nephron 1993We report a case of phosphate diabetes in a patient with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with sarcoidosis. Our patient...
We report a case of phosphate diabetes in a patient with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with sarcoidosis. Our patient was affected by systemic sarcoidosis and he fits the criteria of Schwartz for the diagnosis of SIADH. He presented with phosphate diabetes which appeared during demeclocycline (DMC) therapy and persisted for about 1 month from the end of DMC. It constitutes the fourth case of phosphate diabetes induced by tetracycline described in the literature and it is the third case of SIADH associated with sarcoidosis.
Topics: Demeclocycline; Humans; Hypophosphatemia, Familial; Inappropriate ADH Syndrome; Male; Middle Aged; Sarcoidosis
PubMed: 8450917
DOI: 10.1159/000187188 -
British Medical Journal Mar 1978
Topics: Body Weight; Demeclocycline; Diuresis; Edema, Cardiac; Heart Failure; Humans; Natriuresis
PubMed: 415789
DOI: 10.1136/bmj.1.6115.760 -
Panminerva Medica 1984
Topics: Biological Transport; Demeclocycline; Glomerular Filtration Rate; Humans; Kidney Tubules; Liver Cirrhosis; Osmolar Concentration; Permeability; Sodium; Water
PubMed: 6442767
DOI: No ID Found -
European Journal of Clinical... Nov 2015
Topics: Algorithms; Anti-Bacterial Agents; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Demeclocycline; Fluid Therapy; Humans; Hyponatremia; Inappropriate ADH Syndrome
PubMed: 26259932
DOI: 10.1111/eci.12516 -
Biological Psychiatry Aug 1991
Clinical Trial Randomized Controlled Trial
Topics: Adult; Demeclocycline; Double-Blind Method; Female; Humans; Hyponatremia; Male; Middle Aged; Schizophrenia; Thirst
PubMed: 1912134
DOI: 10.1016/0006-3223(91)90300-b -
Clinical Pharmacy Aug 1987The etiology, pathophysiology, clinical features, diagnosis, and medical treatment of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) are... (Review)
Review
The etiology, pathophysiology, clinical features, diagnosis, and medical treatment of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) are reviewed. SIADH is a common cause of hyponatremia in hospitalized patients. Increased concentrations of antidiuretic hormone (ADH) result in retention of free water, increased excretion of sodium, and hyponatremia. Symptoms generally occur only when hyponatremia is severe (less than or equal to 125 meq/L) and may include anorexia, vomiting, and confusion, followed by seizures, coma, and death. SIADH may result from a variety of diseases, as well as from the use of drugs such as chlorpropamide, carbamazepine, diuretics, and some antineoplastic agents. Diagnosis of SIADH is confirmed by demonstration of a high urine osmolality with a low plasma osmolality, in the absence of diuretic use. Immediate treatment of the symptomatic patient with SIADH includes intravenous furosemide and 3% sodium chloride injection to produce a negative free-water balance. If the underlying cause of SIADH cannot be corrected, the treatment of choice for chronic SIADH is fluid restriction. If this is not tolerated by the patient, demeclocycline can be used to induce a negative free-water balance. Urea, lithium, phenytoin, and loop diuretics have been reported to be effective, but there are few data to support their use. Future research into the treatment of SIADH must be directed at developing effective antagonists of ADH. Treatment of SIADH consists of elimination of underlying causes and restriction of fluid intake; if these measures are unsuccessful or poorly tolerated, long-term drug therapy may be indicated.
Topics: Demeclocycline; Drug-Related Side Effects and Adverse Reactions; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lithium; Urea
PubMed: 3121240
DOI: No ID Found -
Journal of Bacteriology Oct 1962Meyers, Edward (Squibb Institute for Medical Research, New Brunswick, N.J.) and Dorothy A. Smith. Microbiological degradation of tetracyclines. J. Bacteriol. 84:797-802....
Meyers, Edward (Squibb Institute for Medical Research, New Brunswick, N.J.) and Dorothy A. Smith. Microbiological degradation of tetracyclines. J. Bacteriol. 84:797-802. 1962-The degradation of tetracyclines by an ascomycete, Xylaria digitata, was demonstrated. Washedcell suspensions were capable of degrading tetracycline, 5-hydroxytetracycline, 7-chlortetracycline, 7-chlor-6-demethyltetracycline, 2-acetyl-2-decarboxamido-5-hydroxytetracycline, and 12-alpha-deoxytetracycline. The influence of environmental conditions upon the degradation of tetracycline was investigated. A nonantibacterial, nonfluorescent product was located from the degradation of (14)C 5-hydroxytetracycline. Evidence indicated that neither the A nor D ring of 5-hydroxytetracycline is attacked. Acetone powders, lyophilized powders, and cell-free extracts exhibited a relatively limited substrate specificity compared to the washed cells.
Topics: Anti-Bacterial Agents; Ascomycota; Chlortetracycline; Demeclocycline; Humans; Oxytetracycline; Tetracycline; Tetracyclines
PubMed: 13935339
DOI: 10.1128/jb.84.4.797-802.1962 -
The Journal of Investigative Dermatology Apr 1985
Topics: Animals; Demeclocycline; Guinea Pigs; Photosensitivity Disorders
PubMed: 3920332
DOI: 10.1111/1523-1747.ep12265378