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The Medical Press Jun 1961
Topics: Chlortetracycline; Demeclocycline
PubMed: 13785682
DOI: No ID Found -
The Practitioner Dec 1969
Topics: Adolescent; Adult; Anemia, Hemolytic; Child; Demeclocycline; Humans; Middle Aged; Mycoplasma Infections; Pneumonia; Serologic Tests
PubMed: 4982353
DOI: No ID Found -
Lyon Medical Dec 1977
Topics: Demeclocycline; Humans; Hyponatremia; Male; Middle Aged; Osmolar Concentration; Syndrome; Vasopressins
PubMed: 414025
DOI: No ID Found -
Israel Journal of Medical Sciences Aug 1978Two patients with the syndrome of inappropriate secretion of antidiuretic hormone were studied in a metabolic ward during treatment with 1.2 g demeclocycline daily. In...
Two patients with the syndrome of inappropriate secretion of antidiuretic hormone were studied in a metabolic ward during treatment with 1.2 g demeclocycline daily. In both patients, demeclocycline treatment led to increased renal water excretion with consequent correction of hyponatremia and hypo-osmolality. Three episodes of reversible deterioration in glomerular filtration rate developed in these patients. Each episode was accompanied by clinical evidence of extracellular fluid volume contraction, and on each occasion there was an inappropriate natriuresis with daily urinary sodium excretion remaining above 50 mEq. Although demeclocycline effectively reverses the electrolyte abnormalities of this syndrome, the potentially dangerous side effects that may develop exclude the routine usage of the drug.
Topics: Demeclocycline; Glomerular Filtration Rate; Humans; Inappropriate ADH Syndrome; Kidney; Male; Middle Aged; Natriuresis
PubMed: 100473
DOI: No ID Found -
Archives of Dermatology Jan 1968
Clinical Trial
Topics: Demeclocycline; Humans; Photosensitivity Disorders; Placebos
PubMed: 4965106
DOI: No ID Found -
Nihon Shinkei Seishin Yakurigaku Zasshi... Feb 1999Excess intake of water by schizophrenic patients is referred to as psychiatric polydipsia. This symptom causes incontinence, vomiting and hyponatremia, and may sometimes...
Excess intake of water by schizophrenic patients is referred to as psychiatric polydipsia. This symptom causes incontinence, vomiting and hyponatremia, and may sometimes lead to death. We have no effective therapeutic methods other than administrating sodium chloride solution and diuretics, or restricting the intake itself. A case was reported stating that demeclocycline, used in case where there is the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), was effective for the treatment of psychiatric polydipsia. We administered demeclocycline to 8 schizophrenic patients with psychiatric polydipsia, and noticed improvement in incontinence, vomiting and hyponatremia. There was also a decrease of polydipsic behavior. Demeclocycline inhibits the antidiuretic effect of vasopressin on the distal renal tubule. Considering the function of demeclocycline and the relevance of vasopressin to the central nervous system, it has been suggested that demeclocycline has effects on the central nerve through vasopressin or cyclic AMP.
Topics: Anti-Bacterial Agents; Demeclocycline; Drinking; Humans; Male; Middle Aged; Schizophrenic Psychology
PubMed: 10374240
DOI: No ID Found -
Journal of Chromatography. A Jul 2012Aqueous two-phase systems have potential applications for separation and purification of bioproducts in bio-industry. However, a key problem is the recovery of the...
Aqueous two-phase systems have potential applications for separation and purification of bioproducts in bio-industry. However, a key problem is the recovery of the polymers forming aqueous two-phase systems. In this study, two novel random copolymers (P(ADB) and P(ADBA)) were synthesized using acrylic acid, dimethylamino-ethyl methacrylate, butyl methacrylate and allyl alcohol as monomers and used to form pH response aqueous two-phase systems. The recoveries of P(ADB) and P(ADBA) are 97.18% and 98.87% and the pI of P(ADB) and P(ADBA) are 2.79 and 4.01, respectively. Demeclocycline was partitioned in the P(ADB)/P(ADBA) aqueous two-phase systems and the partition coefficient reached 0.085, in the presence of MgSO₄ (60 mmol/L) at pH 5.28.
Topics: Adsorption; Anti-Bacterial Agents; Demeclocycline; Hydrogen-Ion Concentration; Liquid-Liquid Extraction; Polymers; Temperature; Water Pollutants, Chemical
PubMed: 22658298
DOI: 10.1016/j.chroma.2012.05.045 -
Semaine Therapeutique Nov 1966
Topics: Adult; Animals; Child; Demeclocycline; Humans; Mice; Oxytetracycline; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline; Urinary Tract Infections
PubMed: 4965480
DOI: No ID Found -
The New England Journal of Medicine Jun 1978
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Demeclocycline; Humans; Lung Neoplasms; Syndrome; Vasopressins
PubMed: 206831
DOI: 10.1056/NEJM197806222982515 -
Toxicology and Applied Pharmacology Jan 1969
Topics: Animals; Demeclocycline; Erythromycin; Female; Fluorescence; Lactation; Methacycline; Pregnancy; Rats; Tooth Discoloration
PubMed: 4975609
DOI: 10.1016/0041-008x(69)90161-6