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Wiener Medizinische Wochenschrift (1946) Jun 2019Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and... (Review)
Review
Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Due to its possible negative effect on wound healing and its cytotoxic effect in higher concentrations, there are concerns about the safety of its use. The objective of this paper is to review the safety and beneficial effects of hydrogen peroxide.
Topics: Humans; Hydrogen Peroxide; Surgical Procedures, Operative; Wound Healing
PubMed: 29147868
DOI: 10.1007/s10354-017-0610-2 -
IARC Monographs on the Evaluation of... 1999
Review
Topics: Animals; Carcinogenicity Tests; Carcinogens; Chromosome Aberrations; Humans; Hydrogen Peroxide; Mutagenicity Tests; Mutagens; Neoplasms; Neoplasms, Experimental; Occupational Exposure; Salmonella typhimurium
PubMed: 10476467
DOI: No ID Found -
Journal of the American Academy of... Dec 2019Hydrogen peroxide (HO) is an endogenous reactive oxygen species that contributes to oxidative stress directly as a molecular oxidant and indirectly through free radical... (Review)
Review
Hydrogen peroxide (HO) is an endogenous reactive oxygen species that contributes to oxidative stress directly as a molecular oxidant and indirectly through free radical generation. Topically applied 1% to 45% HO can be used for a range of clinical purposes, which will be reviewed here in addition to its safety. In concentrations from 1% to 6%, HO has antimicrobial properties and can act as a debriding agent through its effervescence, making low-concentration HO useful for wound care. HO has also been shown to promote venous insufficiency ulcer healing, but studies in other wound types are needed. In 1% formulations, HO is used outside the United States to treat acne and has shown efficacy similar to or greater than benzoyl peroxide, with reduced side effects. In a concentration of 40%, HO is US Food and Drug Administration-approved to treat seborrheic keratoses and may cause fewer pigmentary changes than cryotherapy, although elimination often requires 2 to 4 treatments. However, HO should be used with caution, as exposure can cause adverse effects through its oxidant capabilities. Low HO concentrations cause only transient symptoms (blanching and blistering), but exposure to 9% to 45% HO can cause more severe skin damage, including epidermal necrosis leading to erythema and bullae. Overall, HO has numerous therapeutic uses, and novel indications, such as treating actinic keratoses and skin cancers, continue to be explored.
Topics: Humans; Hydrogen Peroxide; Risk Factors; Skin Diseases; Skin Physiological Phenomena; Translational Research, Biomedical
PubMed: 31103570
DOI: 10.1016/j.jaad.2019.05.030 -
ChemSusChem Dec 2016The global utilization of hydrogen peroxide, a green oxidant that decomposes in water and oxygen, has gone from 0.5 million tonnes per year three decades ago to... (Review)
Review
The global utilization of hydrogen peroxide, a green oxidant that decomposes in water and oxygen, has gone from 0.5 million tonnes per year three decades ago to 4.5 million tonnes per year in 2014, and is still climbing. With the aim of expanding the utilization of this eminent green chemical across different industrial and civil sectors, the production and use of hydrogen peroxide as a green industrial oxidant is reviewed herein to provide an overview of the explosive growth of its industrial use over the last three decades and of the state of the art in its industrial manufacture, with important details of what determines the viability of the direct production from oxygen and hydrogen compared with the traditional auto-oxidation process.
Topics: Green Chemistry Technology; Hydrogen Peroxide; Industry
PubMed: 27813285
DOI: 10.1002/cssc.201600895 -
Chemosphere Jun 2019The electrochemical production of hydrogen peroxide (HO) by 2-electron oxygen reduction reaction (ORR) is an attractive alternative to the present complex anthraquinone... (Review)
Review
The electrochemical production of hydrogen peroxide (HO) by 2-electron oxygen reduction reaction (ORR) is an attractive alternative to the present complex anthraquinone process. The objective of this paper is to provide a state-of-the-arts review of the most important aspects of this process. First, recent advances in HO production are reviewed and the advantages of HO electrogeneration via 2-electron ORR are highlighted. Second, the selectivity of the ORR pathway towards HO formation as well as the development process of HO production are presented. The cathode characteristics are the decisive factors of HO production. Thus the focus is shifted to the introduction of commonly used carbon cathodes and their modification methods, including the introduction of other active carbon materials, hetero-atoms doping (i.e., O, N, F, B, and P) and decoration with metal oxides. Cathode stability is evaluated due to its significance for long-term application. Effects of various operational parameters, such as electrode potential/current density, supporting electrolyte, electrolyte pH, temperature, dissolved oxygen, and current mode on HO production are then discussed. Additionally, the environmental application of electrogenerated HO on aqueous and gaseous contaminants removal, including dyes, pesticides, herbicides, phenolic compounds, drugs, VOCs, SO, NO, and Hg, are described. Finally, a brief conclusion about the recent progress achieved in HO electrogeneration via 2-electron ORR and an outlook on future research challenges are proposed.
Topics: Electrodes; Environmental Restoration and Remediation; Hydrogen Peroxide; Oxidation-Reduction; Oxygen
PubMed: 30903840
DOI: 10.1016/j.chemosphere.2019.03.042 -
The Medical Letter on Drugs and... Sep 2018
Review
Topics: Animals; Anti-Infective Agents, Local; Clinical Trials as Topic; Drug Compounding; Humans; Hydrogen Peroxide; Keratosis, Seborrheic
PubMed: 30383728
DOI: No ID Found -
Anaesthesia and Intensive Care Nov 2011Hydrogen peroxide solutions are found in almost every operating theatre and are used by many surgical specialties, often with little knowledge of their inherent risk. We... (Review)
Review
Hydrogen peroxide solutions are found in almost every operating theatre and are used by many surgical specialties, often with little knowledge of their inherent risk. We reviewed the literature and evidence related to the use of hydrogen peroxide in surgery. We found little evidence supporting the use of hydrogen peroxide solutions intraoperatively, a large number of reports of sometimes-fatal oxygen embolism and other evidence of tissue toxicity. We conclude that the use of hydrogen peroxide as an antiseptic has no direct benefit, but is associated with significant risk, and therefore should be reconsidered.
Topics: Embolism, Air; Evidence-Based Medicine; Humans; Hydrogen Peroxide; Intraoperative Period; Oxygen; Therapeutic Irrigation
PubMed: 22165350
DOI: 10.1177/0310057X1103900604 -
Cells Aug 2022The regulatory role of some reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as hydrogen peroxide or nitric oxide, has been demonstrated in some... (Review)
Review
The regulatory role of some reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as hydrogen peroxide or nitric oxide, has been demonstrated in some higher plants and algae. Their involvement in regulation of the organism, tissue and single cell development can also be seen in many animals. In green cells, the redox potential is an important photosynthesis regulatory factor that may lead to an increase or decrease in growth rate. ROS and RNS are important signals involved in the regulation of photoautotrophic growth that, in turn, allow the cell to attain the commitment competence. Both hydrogen peroxide and nitric oxide are directly involved in algal cell development as the signals that regulate expression of proteins required for completing the cell cycle, such as cyclins and cyclin-dependent kinases, or histone proteins and E2F complex proteins. Such regulation seems to relate to the direct interaction of these signaling molecules with the redox-sensitive transcription factors, but also with regulation of signaling pathways including MAPK, G-protein and calmodulin-dependent pathways. In this paper, we aim to elucidate the involvement of hydrogen peroxide and nitric oxide in algal cell cycle regulation, considering the role of these molecules in higher plants. We also evaluate the commercial applicability of this knowledge. The creation of a simple tool, such as a precisely established modification of hydrogen peroxide and/or nitric oxide at the cellular level, leading to changes in the ROS-RNS cross-talk network, can be used for the optimization of the efficiency of algal cell growth and may be especially important in the context of increasing the role of algal biomass in science and industry. It could be a part of an important scientific challenge that biotechnology is currently focused on.
Topics: Animals; Cell Cycle; Chlorophyta; Hydrogen Peroxide; Nitric Oxide; Plants; Reactive Oxygen Species
PubMed: 35954269
DOI: 10.3390/cells11152425 -
Methods in Enzymology 2013
Topics: Biochemistry; Cells; Humans; Hydrogen Peroxide; Oxidation-Reduction; Signal Transduction
PubMed: 23791105
DOI: 10.1016/B978-0-12-405883-5.09989-0 -
Injury Feb 2019
Topics: Debridement; Humans; Hydrogen Peroxide; Operating Rooms; Pharmaceutical Solutions; Therapeutic Irrigation; Wounds and Injuries
PubMed: 30563713
DOI: 10.1016/j.injury.2018.12.010