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Journal of Veterinary Internal Medicine 1994Twenty-five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume... (Clinical Trial)
Clinical Trial
Twenty-five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy.
Topics: Administration, Oral; Animals; Dog Diseases; Dogs; Female; Male; Mast-Cell Sarcoma; Neoplasm Staging; Prednisone; Prospective Studies; Remission Induction; Skin Neoplasms
PubMed: 7884726
DOI: 10.1111/j.1939-1676.1994.tb03259.x -
Topics in Companion Animal Medicine Mar 2021Strong to moderate vascular endothelial growth factor (VEGF) expression may be a negative prognostic factor in canine mast cell tumors (MCTs). This study set out to...
Strong to moderate vascular endothelial growth factor (VEGF) expression may be a negative prognostic factor in canine mast cell tumors (MCTs). This study set out to determine the prognostic value of combined analysis of VEGF-A immunoreactivity, clinical presentation, patient staging, and tumor histologic grade in canine MCTs. In this study, intense VEGF staining was significantly associated with decreased survival (P = .025). Immunohistochemical expression of VEGF is not routinely employed as a prognostic factor in canine MCT workup. However, results of this study support the inclusion of this marker in the MCT prognostic panel. Investigation of VEGF expression may assist in the development of anti-VEGF drugs.
Topics: Animals; Biomarkers; Biomarkers, Tumor; Dog Diseases; Dogs; Immunohistochemistry; Mast Cells; Mast-Cell Sarcoma; Prognosis; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
PubMed: 33348010
DOI: 10.1016/j.tcam.2020.100506 -
The Veterinary Clinics of North... Mar 2004Although aural neoplasia is a relatively uncommon entity in companion animals, it remains a group of heterogeneous conditions that can have a significant negative impact... (Review)
Review
Although aural neoplasia is a relatively uncommon entity in companion animals, it remains a group of heterogeneous conditions that can have a significant negative impact on quality and duration of life of dogs and cats. Chronic ear disease that responds poorly or partially to empiric therapy should raise the suspicion that an underlying condition, such as neoplasia, may be the perpetrator of inflammation. Early diagnosis followed by appropriate therapy improves the likelihood of disease control and prolonged survival.
Topics: Animals; Carcinoma, Squamous Cell; Cat Diseases; Cats; Dog Diseases; Dogs; Ear Neoplasms; Histiocytoma, Benign Fibrous; Mast-Cell Sarcoma; Otoscopy; Polyps; Sebaceous Gland Neoplasms; Skin Neoplasms; Tomography, X-Ray Computed
PubMed: 15062621
DOI: 10.1016/j.cvsm.2003.10.008 -
The Veterinary Clinics of North... Nov 1980
Review
Topics: Animals; Carcinoma, Squamous Cell; Cat Diseases; Cats; Cryosurgery; Dog Diseases; Dogs; Granuloma; Mast-Cell Sarcoma; Nitrogen; Nitrous Oxide; Papilloma; Skin Diseases; Skin Neoplasms
PubMed: 6787778
DOI: 10.1016/s0195-5616(80)50080-x -
The Veterinary Clinics of North... Jul 1995This article contains practical information about the more common feline skin tumors and an update on recent treatments. The tumor type, gross appearance, clinical... (Review)
Review
This article contains practical information about the more common feline skin tumors and an update on recent treatments. The tumor type, gross appearance, clinical behavior, prognosis, and treatment are provided.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cat Diseases; Cats; Fibrosarcoma; Lymphoma; Mast-Cell Sarcoma; Neoplasms, Basal Cell; Skin Neoplasms
PubMed: 8525576
DOI: 10.1016/s0195-5616(95)50137-8 -
Journal of Veterinary Internal Medicine 2000Presence of matrix metalloproteinases has been associated with tumor invasion and metastasis in human neoplasia. The presence of matrix metalloproteinase 2 and matrix...
Presence of matrix metalloproteinases has been associated with tumor invasion and metastasis in human neoplasia. The presence of matrix metalloproteinase 2 and matrix metalloproteinase 9 was determined in canine mast cell tumor tissue and normal stromal tissue from 24 dogs with spontaneously occurring cutaneous mast cell tumors. Seventeen of the mast cell tumors were of histologic grade 2, and 7 were of histologic grade 3. Gelatin zymography and computer assisted densitometry image analysis were used to quantify matrix metalloproteinase concentration. Bands from canine tissues migrated in the same location as human proenzyme and active enzyme matrix metalloproteinase 2 and matrix metalloproteinase 9 standards. A semiquantitative value for each patient sample was obtained by comparing the optical assessment density of each unknown band to the optical density of the human standard. The presence of matrix metalloproteinase 2 and matrix metalloproteinase 9 in histologic grade 2 mast cell tumors and histologic grade 3 mast cell tumors was compared, as was presence of matrix metalloproteinases in tumor and stromal tissue. There was dramatically more proenzyme matrix metalloproteinase 9 activity in histologic grade 3 mast cell tumors when compared to grade 2 tumors (P = .03). There was also dramatically more active enzyme matrix metalloproteinase 2 and active enzyme matrix metalloproteinase 9 activity in tumor tissue compared to stromal tissue (P = .02, P < .0001). This study demonstrates that the proenzyme and active enzyme forms of matrix metalloproteinase 2 and matrix metalloproteinase 9 are present in canine mast cell tumors. This appears to be related to the degree of histologic malignancy, although histologic grade 1 tumors were not evaluated.
Topics: Animals; Dog Diseases; Dogs; Electrophoresis, Agar Gel; Image Processing, Computer-Assisted; Mast-Cell Sarcoma; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Skin Neoplasms; Statistics, Nonparametric
PubMed: 11110378
DOI: 10.1892/0891-6640(2000)014<0583:iommic>2.3.co;2 -
The Veterinary Clinics of North... Jul 2012Lymphomas, carcinomas, leiomyomas, and stromal tumors are the most common tumors found in the canine and feline gastrointestinal tract. Endoscopic and surgical biopsies... (Review)
Review
Lymphomas, carcinomas, leiomyomas, and stromal tumors are the most common tumors found in the canine and feline gastrointestinal tract. Endoscopic and surgical biopsies are often the mainstays of diagnosis, although ultrasound is playing an increasingly greater role. Small cell lymphocytic lymphoma of the feline intestines poses a special diagnostic dilemma and may require immunohistochemistry as well as polymerase chain reaction to distinguish it from lymphocytic-plasmacytic enteritis. This article will focus on the more common neoplastic problems of the esophagus and gastrointestinal tract (GIT) of geriatric dogs and cats.
Topics: Aging; Animals; Carcinoma; Cat Diseases; Cats; Dog Diseases; Dogs; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Leiomyoma; Lymphoma; Mast-Cell Sarcoma; Species Specificity
PubMed: 22720809
DOI: 10.1016/j.cvsm.2012.04.006 -
Veterinary Pathology Sep 1991A total of 340 cases of cutaneous neoplasia were diagnosed in 340 of 3,564 cats that were examined by biopsy or necropsy during a 41-month period from January 1, 1986...
A total of 340 cases of cutaneous neoplasia were diagnosed in 340 of 3,564 cats that were examined by biopsy or necropsy during a 41-month period from January 1, 1986 through May 31, 1989. Eighteen types of tumor occurred, but four types comprised 77% of the cases. These were basal cell tumor, 89 cases (26%, mean age 10.3); mast cell tumor, 72 cases (21%, mean age 8.6); squamous cell carcinoma, 52 cases (15%, mean age 11.6); and fibrosarcoma, 50 cases (15%, mean age 10.2). For each of these four types of tumors, peak number of cases occurred in cats older than 10 years. Mast cell tumor was the only tumor diagnosed in cats younger than 1 year. The head was the most common site for basal cell tumors, mast cell tumors, and squamous cell carcinomas. The legs were the most common location of fibrosarcomas. Siamese cats had approximately three times as many mast cell tumors as statistically expected, but only one-fourth as many squamous cell carcinomas. Breed predilection for other skin tumors was not apparent. Sex predilection was not detected for any skin tumor.
Topics: Animals; Breeding; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cat Diseases; Cats; Female; Fibrosarcoma; Incidence; Male; Mast-Cell Sarcoma; Retrospective Studies; Skin Neoplasms
PubMed: 1750164
DOI: 10.1177/030098589102800506 -
Journal of Veterinary Internal Medicine 1997Twenty-seven dogs with naturally occurring mast cell tumors were treated with weekly i.v. injections of vincristine (0.75 mg/m2) for 4 treatments. Two dogs (7%) had a...
Twenty-seven dogs with naturally occurring mast cell tumors were treated with weekly i.v. injections of vincristine (0.75 mg/m2) for 4 treatments. Two dogs (7%) had a partial response. Nine dogs (32%) had treatment stopped prematurely because of toxicity or a perceived deterioration in their quality of life. We conclude that vincristine is ineffective as a sole treatment for measurable mast cell tumors in dogs and produces an undesirable number of adverse reactions.
Topics: Animals; Antineoplastic Agents, Phytogenic; Dog Diseases; Dogs; Female; Injections, Intravenous; Male; Mast-Cell Sarcoma; Orchiectomy; Ovariectomy; Vincristine
PubMed: 9470165
DOI: 10.1111/j.1939-1676.1997.tb00484.x -
Veterinary and Comparative Oncology Dec 2017
Lymph node histology for the assessment of residual neoplastic disease in canine mast cell tumours: does the presence of metachromatic granules always identify mast cells?
Topics: Animals; Antineoplastic Agents; Dog Diseases; Dogs; Immunohistochemistry; Lymph Nodes; Macrophages; Mast Cells; Mast-Cell Sarcoma; Neoplasm Staging
PubMed: 27714908
DOI: 10.1111/vco.12278