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Acta Dermato-venereologica 1979Three uncommon idiopathic photodermatoses, refractory to other treatment, responded to oral psoralen photochemotherapy. Tow females with photosensitivity in association...
Three uncommon idiopathic photodermatoses, refractory to other treatment, responded to oral psoralen photochemotherapy. Tow females with photosensitivity in association with atopy, one female with persistent light reaction following a systemic drug-induced photosensitivity and an elderly male with actinic reticuloid were treated.
Topics: Administration, Oral; Adult; Aged; Child; Female; Humans; Male; Methoxsalen; Middle Aged; Photochemotherapy; Photosensitivity Disorders
PubMed: 92156
DOI: No ID Found -
Archives of Dermatology Jun 1976
Topics: Humans; Methoxsalen; Skin Diseases, Vesiculobullous; Ultraviolet Therapy
PubMed: 782369
DOI: 10.1001/archderm.112.6.883b -
Deutsche Medizinische Wochenschrift... Nov 1979
Topics: Humans; Methoxsalen; Neoplasms; Photochemotherapy; Psoriasis; Ultraviolet Therapy
PubMed: 498975
DOI: 10.1055/s-0028-1129139 -
Journal of the American Medical... Mar 1960
Topics: Dermatitis; Dermatitis, Phototoxic; Humans; Methoxsalen; Photosensitivity Disorders; Sunburn
PubMed: 14442610
DOI: 10.1001/jama.1960.03020110018005 -
Burns, Including Thermal Injury Aug 1984A patient is described in whom burn injury, caused by moderate exposure to sunlight in the U.K., was precipitated by undue sensitivity to a photosensitizing agent...
A patient is described in whom burn injury, caused by moderate exposure to sunlight in the U.K., was precipitated by undue sensitivity to a photosensitizing agent methoxsalen. This drug, although withdrawn in the UK, is freely available in the Republic of Ireland and many EEC countries for the treatment of psoriasis and acne vulgaris.
Topics: Adult; Humans; Male; Methoxsalen; Photochemotherapy; Sunburn; Sunlight
PubMed: 6478288
DOI: 10.1016/0305-4179(84)90082-2 -
Archives of Dermatology Apr 1994Twenty-eight subjects were phototested to determine their erythemal responses to oral methoxsalen with UV-A and UV-B irradiation. Skin pigmentation was measured by skin...
BACKGROUND AND DESIGN
Twenty-eight subjects were phototested to determine their erythemal responses to oral methoxsalen with UV-A and UV-B irradiation. Skin pigmentation was measured by skin reflectance at 550 and 660 nm before irradiation. The smallest UV radiation dose to produce erythema (minimal phototoxic dose and minimal erythema dose, respectively) was determined. The serum concentration of methoxsalen was measured at the time of UV-A irradiation.
RESULTS
There was a positive correlation between skin pigmentation and both 72-hour minimal phototoxic dose and 24-hour minimal erythema dose. No correlation was demonstrated between methoxsalen serum concentration and minimal phototoxic dose. The combination of skin pigmentation and methoxsalen level did not give a better prediction of minimal phototoxic dose than skin pigmentation alone.
CONCLUSIONS
Skin pigmentation measurements can be used to predict the minimal phototoxic and erythema doses. Skin pigmentation measurements are easy to perform and should be included in both phototherapy and photochemotherapy to improve the efficiency and reliability of the treatment.
Topics: Administration, Oral; Adult; Aged; Dermatitis, Phototoxic; Humans; Methoxsalen; Middle Aged; PUVA Therapy; Radiotherapy Dosage; Skin Pigmentation
PubMed: 8166483
DOI: No ID Found -
Acta Dermato-venereologica 1990Diurnal variations in drug pharmacokinetics are a well known phenomenon. Chronopharmacology studies now appear to be attracting increasing interest with a view to...
Diurnal variations in drug pharmacokinetics are a well known phenomenon. Chronopharmacology studies now appear to be attracting increasing interest with a view to establishing an optimum therapeutic prescription. In order to determine possible chronobiological variations of 5-methoxypsoralen (5-MOP) pharmacokinetic, 5-MOP blood concentrations were quantified in 8 healthy subjects after drug ingestion at different times during the day. Stolk's High Performance Liquid Chromatography technique was used to assess the 5-MOP serum concentrations. Each subject underwent three pharmacokinetic studies after oral ingestion of 5-MOP (1.2 mg/kg), in conjunction with a standardized low-lipid meal. The first pharmacokinetic study was started in the morning, the second in the afternoon and the third in the evening. Drug intake was at intervals of 2 days, to avoid drug accumulation. The results showed that the evening intake of the drug induced a higher 5-MOP maximum concentration and a higher 'area under curve' than morning or afternoon ingestion. This study suggests an optimized PUVA therapy, when performed in the evening.
Topics: 5-Methoxypsoralen; Adult; Chromatography, High Pressure Liquid; Circadian Rhythm; Female; Humans; Male; Methoxsalen
PubMed: 1981428
DOI: No ID Found -
British Journal of Clinical Pharmacology Sep 1996
Topics: Humans; Injections, Intravenous; Methoxsalen
PubMed: 8877036
DOI: No ID Found -
Journal of the American Academy of... Sep 1996Gastrointestinal side effects are associated with the oral ingestion of 8-methoxsalen (8-MOP), including the liquid and crystalline formulations.
BACKGROUND
Gastrointestinal side effects are associated with the oral ingestion of 8-methoxsalen (8-MOP), including the liquid and crystalline formulations.
OBJECTIVE
The objective of this study was to determine whether the gastrointestinal symptoms associated with 8-MOP could be decreased by altering the route of administration.
METHODS
In an open pilot study, 8-MOP rectal suppositories were given to six patients with psoriasis vulgaris who had significant nausea or abdominal pain with the oral liquid form of the drug.
RESULTS
On a scale of 0 to 5, this group of patients reported a mean score of 4.4 for nausea, 0.3 for vomiting, 2.1 for abdominal pain, and 1.3 for headaches with oral 8-MOP. With the suppository form, the mean scores were 0 for nausea, 0 for vomiting, 0 for abdominal pain, and 0 for headaches. These latter values represent scores for the entire treatment period. Clinical severity scores of psoriasis improved from a mean of 6.5 (maximum possible score = 9) at the start of the trial to a mean of 1 at its conclusion. Plasma 8-MOP levels of more than 100 ng/ml were observed in all patients who received the suppositories; in only one patient were the 8-MOP plasma levels significantly higher with the oral form than with the rectal form.
CONCLUSION
Rectal suppositories of 8-MOP were associated with significantly fewer gastrointestinal side effects than the oral form of the drug; this was accomplished without compromising clinical efficacy.
Topics: Abdominal Pain; Administration, Oral; Administration, Rectal; Crystallization; Headache; Humans; Intestines; Methoxsalen; Nausea; PUVA Therapy; Pilot Projects; Psoriasis; Solutions; Stomach; Suppositories; Vomiting
PubMed: 8784281
DOI: 10.1016/s0190-9622(96)90609-x -
Archives of Ophthalmology (Chicago,... Nov 1961
Topics: Eye; Humans; Methoxsalen; Photosensitivity Disorders
PubMed: 13879993
DOI: 10.1001/archopht.1961.00960010691014