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The Journal of Investigative Dermatology Jun 2013Munro's microabscesses contain polymorphonuclear leukocytes and form specifically in the epidermis of psoriasis patients. The mechanism whereby the neutrophils are...
Munro's microabscesses contain polymorphonuclear leukocytes and form specifically in the epidermis of psoriasis patients. The mechanism whereby the neutrophils are recruited into the epidermis is poorly understood. Using a combination of human and mouse primary keratinocyte cell cultures and the imiquimod-induced psoriasis-like mouse model of skin inflammation, we explored the role of IL-1 signaling in microabscess formation. In vitro imiquimod stimulated production of IL-1α and neutrophil recruiting chemokines. Imiquimod-activated chemokine expression was dependent upon adenosine signaling and independent of IL-1α and IL-1 receptor type 1 (IL-1R1); nevertheless, IL-1α could enhance chemokine expression initiated by imiquimod. Topical application of imiquimod in vivo led to epidermal microabscess formation, acanthosis, and increased IL-1α and chemokine expression in the skin of wild-type mice. However, in IL-1R1-deficient mice these responses were either absent or dramatically reduced. These results demonstrate that IL-1α and IL-1R1 signaling is essential for microabscess formation, neutrophil recruiting chemokine expression, and acanthosis in psoriasis-like skin inflammation induced by imiquimod.
Topics: Abscess; Adjuvants, Immunologic; Aminoquinolines; Animals; Animals, Newborn; Chemokine CXCL1; Chemokine CXCL2; Dermis; Drug Eruptions; Epidermal Cells; Humans; Imiquimod; Interleukin-1alpha; Interleukin-1beta; Keratinocytes; Mice; Mice, Knockout; Neutrophils; Primary Cell Culture; Psoriasis; Receptors, Interleukin-1 Type I; Signal Transduction
PubMed: 23407395
DOI: 10.1038/jid.2012.512 -
Revista Da Sociedade Brasileira de... 2015
Topics: Abscess; Adult; Brucellosis; Female; Humans; Pleural Effusion; Pneumonia, Bacterial
PubMed: 26108022
DOI: 10.1590/0037-8682-0003-2015 -
Indian Journal of Otolaryngology and... Sep 2023Kimura Disease, an eosinophilic hyperplastic granulomatous disease of idiopathic origin is most commonly seen in young males. It mostly presents with deep subcutaneous...
UNLABELLED
Kimura Disease, an eosinophilic hyperplastic granulomatous disease of idiopathic origin is most commonly seen in young males. It mostly presents with deep subcutaneous tissue swelling along with enlargement of salivary glands and regional lymphadenopathy. Diagnosis is mainly based on histopathological findings and raised serum IgE and hypereosinophilia. The radiological investigation of choice is Magnetic Resonance Imaging. Management strategy includes surgery and steroid therapy. Chemotherapeutic agents are also frequently used by some centres. Relapse and recurrence stands to be a common problem with management of this disease process.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s12070-023-03817-y.
PubMed: 37636657
DOI: 10.1007/s12070-023-03817-y -
Experimental Dermatology Nov 2015
Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Kallikreins; Mice, Knockout; Psoriasis
PubMed: 26121277
DOI: 10.1111/exd.12794 -
Frontiers in Pediatrics 2022More than 400 single gene defects have been identified as inborn errors of immunity, including many arising from genes encoding proteins that affect NF-κB activity. We... (Review)
Review
More than 400 single gene defects have been identified as inborn errors of immunity, including many arising from genes encoding proteins that affect NF-κB activity. We summarise the skin phenotypes in this subset of disorders and provide an overview of pathogenic mechanisms. NF-κB acts cell-intrinsically in basal epithelial cells during differentiation of skin appendages, influences keratinocyte proliferation and survival, and both responses to and amplification of inflammation, particularly TNF. Skin phenotypes include ectodermal dysplasia, reduction and hyperproliferation of keratinocytes, and aberrant recruitment of inflammatory cells, which often occur in combination. Phenotypes conferred by these rare monogenic syndromes often resemble those observed with more common defects. This includes oral and perineal ulceration and pustular skin disease as occurs with Behcet's disease, hyperkeratosis with microabscess formation similar to psoriasis, and atopic dermatitis. Thus, these genotype-phenotype relations provide diagnostic clues for this subset of IEIs, and also provide insights into mechanisms of more common forms of skin disease.
PubMed: 36733767
DOI: 10.3389/fped.2022.1098426 -
The Australian and New Zealand Journal... May 1976Granulomatous mastitis is a benign mammary lesion, which clinically can closely simulate breast cancer. The condition has only recently been recognized, less than a...
Granulomatous mastitis is a benign mammary lesion, which clinically can closely simulate breast cancer. The condition has only recently been recognized, less than a dozen cases being recorded in the English literature. Two further cases are presented, the histological features are illustrated, and the literature is reviewed.
Topics: Adult; Female; Granuloma; Humans; Mastitis; Pregnancy
PubMed: 1067078
DOI: 10.1111/j.1445-2197.1976.tb03227.x -
Acta Tropica Feb 2000Neurological abnormalities have long been recognised in animals with melioidosis, including laboratory rodents and sheep in the first Australian outbreak in 1949....
Neurological abnormalities have long been recognised in animals with melioidosis, including laboratory rodents and sheep in the first Australian outbreak in 1949. Autopsies in animals have shown microabscesses and lymphocytic infiltration to be present on occasion in the same animal, but Burkholderia pseudomallei is usually able to be grown from central nervous system (CNS) tissue. In humans CNS melioidosis is unusual, but both macroscopic brain abscesses and encephalitis occur. There has been a recently recognised syndrome of meningoencephalitis with varying involvement of brainstem, cerebellum and spinal cord. The prospective melioidosis study at Royal Darwin Hospital has documented 12 cases of CNS melioidosis over 9 years out of a total of 232 cases of melioidosis (5%). Prominent features on presentation were unilateral limb weakness (6), predominant cerebellar signs (2), mixed cerebellar and brainstem features with peripheral weakness (2) and flaccid paraparesis (2). Eight patients had unilateral VIIth nerve palsy and six bulbar palsy, with five requiring prolonged ventilation. Brain CT scans are usually normal initially, but MRI shows dramatic changes. Three patients died and only three made a full recovery. In two patients with predominant mononuclear CSF pleocytosis, B. pseudomallei was cultured from CSF and autopsy in one of these showed necrotising encephalitis with microabscesses. Although it has been postulated that a neurotropic exotoxin may account for melioidosis encephalomyelitis, the recent findings and comparison with the animal data suggest that direct organism spread within the CNS may be primarily responsible. Preliminary molecular typing of isolates shows no evidence of a specific strain of B. pseudomallei responsible for CNS melioidosis end further studies are required to determine if the apparent higher rate of CNS disease in Australia is due to true regional differences or is from increased ascertainment.
Topics: Adult; Aged; Animals; Burkholderia pseudomallei; Female; Humans; Male; Melioidosis; Middle Aged; Nervous System Diseases; Prospective Studies; Risk Factors
PubMed: 10674643
DOI: 10.1016/s0001-706x(99)00064-9 -
Future Oncology (London, England) Jun 2016Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory condition of the breast which although benign can mimic carcinoma. Establishing a diagnosis can be... (Review)
Review
Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory condition of the breast which although benign can mimic carcinoma. Establishing a diagnosis can be challenging and requires a high index of suspicion with exclusion of infective and autoimmune breast diseases. IGM is characterized histologically by noncaseating granulomas which are of a lobulo-centric pattern and often associated with microabscess formation. Management of confirmed cases remains controversial with proponents of initial surgical or medical therapies - each has its associated problems which can be worse than the original symptoms of IGM. However, many patients require more than one modality of treatment to completely resolve IGM lesions and careful judgment is necessary to ensure optimal type and sequencing of treatments.
Topics: Female; Granulomatous Mastitis; Humans
PubMed: 27067146
DOI: 10.2217/fon-2015-0038 -
Radiology Sep 1984Abdominal sonography in 7 patients with acute biliary disease revealed focal echo collections within the wall of the gallbladder in addition to cholelithiasis and... (Comparative Study)
Comparative Study
Abdominal sonography in 7 patients with acute biliary disease revealed focal echo collections within the wall of the gallbladder in addition to cholelithiasis and diffuse mural thickening. A prospective study was conducted, comparing in vivo and in vitro sonography of the gallbladder with histopathological findings. In 3 patients, microscopy of the hyperchoic tissue showed microabscesses. In 4, intramural diverticula containing inspissated bile, small stones, or cholesterol crystals were seen. The authors caution that hyperchoic foci within the wall of the gallbladder may indicate intrinsic disease separate from cholelithiasis or cholecystitis.
Topics: Abscess; Acute Disease; Diagnosis, Differential; Diverticulum; Gallbladder; Gallbladder Diseases; Humans; Prospective Studies; Ultrasonography
PubMed: 6431493
DOI: 10.1148/radiology.152.3.6431493 -
Current Drug Targets. Inflammation and... Jun 2004Psoriasis is characterized by sustained T cell activation by antigen-presenting cells (APCs) in the lesions, and by a deviation of T cell differentiation to type 1... (Review)
Review
Psoriasis is characterized by sustained T cell activation by antigen-presenting cells (APCs) in the lesions, and by a deviation of T cell differentiation to type 1 helper T and type 1 cytotoxic T cells, although no specific antigens have yet been determined. These characteristics are at least promoted by decreased IL-10 expression and the increased IL-12 expression observed in both the skin and stimulated peripheral blood mononuclear cells of psoriatic patients. Some of the cytokines produced by activated T cells are suspected to stimulate the proliferation of psoriatic keratinocytes. Among them, interferon-gamma is the most likely candidate, although interferon-gamma does not promote the growth of normal keratinocytes. In addition to the abnormal proliferation, psoriatic keratinocytes show abnormal differentiation and resistance to apoptosis. So far, however, it is still unknown whether these phenotypic and functional characteristics of psoriatic keratinocytes are only the consequences of the stimulation by activated T cells or are at least based on an inherent susceptibility. Recently, it has become clear that chemokines derived from activated keratinocytes or endothelial cells play a crucial role in recruiting T cells in the skin and inducing the neutrophilic infiltration that leads to the formation of subcorneal pustules (Munro's microabscess). Finally, recent developments in the detection and analysis of gene expression have revealed the molecules responsible for these steps. Some of them have become target molecules for the treatment of psoriasis. And indeed, it has become possible now to treat patients with new, innovative drugs.
Topics: Animals; Cell Differentiation; Cell Division; Cell Movement; Cytokines; Humans; Psoriasis; T-Lymphocytes
PubMed: 15180466
DOI: 10.2174/1568010043343868