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Journal of Cranio-maxillo-facial... Jan 2009Psoriasis is a common, chronic dermatologic disease. Cases affecting the oral mucous membranes are rarely reported in the international literature, in particular tongue...
INTRODUCTION
Psoriasis is a common, chronic dermatologic disease. Cases affecting the oral mucous membranes are rarely reported in the international literature, in particular tongue lesions are hardly ever documented.
MATERIAL AND METHODS
This article presents a 61 year old patient with persistent whitish lesion on his tongue. Biopsy specimens from mid surface and tip of the tongue were taken. Histopathologic sections were stained with haematoxylin-eosin (H-E) as well as with Periodic acid-Schiff (PAS) and examined by light microscopy.
RESULTS
Tongue lesions showing epithelial hyperplasia, parakeratosis, long papillae, neutrophils and microabscesses of Munro.
CONCLUSIONS
The reported case suggests that the clinical and histological appearances of the lesions are consistent with mucosal psoriasis.
Topics: Biopsy; Coloring Agents; Diagnosis, Differential; Epithelium; Humans; Hyperplasia; Leukoplakia, Oral; Male; Middle Aged; Neutrophils; Psoriasis; Tongue Diseases
PubMed: 18799317
DOI: 10.1016/j.jcms.2008.07.003 -
Cureus May 2020Tuberculosis (TB) is a major public health problem in developing countries. It can affect any organ of the body, and can have a multitude of clinical presentations. We...
Tuberculosis (TB) is a major public health problem in developing countries. It can affect any organ of the body, and can have a multitude of clinical presentations. We present the case of a 22-year-old male who presented with fever, abdominal pain, and weight loss, and was found to have enlarged liver and spleen, both studded with multiple microabscesses. He had deranged liver functions, mild anemia, and elevated acute phase reactants. Examination of the aspirate from the liver did not reveal any organism on microscopy or culture. Based on the demographics, history of contact with a TB patient, positive Mantoux test, and clinical and radiological features, the patient was successfully managed with empirical treatment for TB.
PubMed: 32596067
DOI: 10.7759/cureus.8247 -
Cardiovascular Pathology : the Official... 2014Granulomatosis with polyangiitis (GPA) (Wegener's) is a necrotizing systemic vasculitis of the small-sized blood vessels, affecting kidneys, lungs, upper respiratory... (Review)
Review
Granulomatosis with polyangiitis (GPA) (Wegener's) is a necrotizing systemic vasculitis of the small-sized blood vessels, affecting kidneys, lungs, upper respiratory tract and skin. Cardiac valvular involvement is an uncommon manifestation of GPA. We report the case of a 60-year-old woman with arthritis and lung nodules due to GPA without antineutrophil cytoplasmic antibodies (ANCA) at time of diagnosis. Remission was obtained with cyclophosphamide and corticosteroid. Azathioprine was then prescribed for 2years. Four years later, she developed severe inflammatory aortic and mitral valvular involvement characterized by GPA typical histopathological valvular lesions. Search for ANCA was positive at this time (anti-myeloperoxidase). Cardiac valvular involvement is a rare and potentially fatal complication of GPA and may misleadingly suggest infectious endocarditis. A review of literature revealed few cases of histologically well-documented cardiac valvular involvement in GPA. Pathologists should be aware of valvular heart diseases in GPA, which usually comprise valvular necrotic lesions without any microbial agents.
Topics: Antibodies, Antineutrophil Cytoplasmic; Aortic Valve; Female; Granulomatosis with Polyangiitis; Heart Valve Diseases; Humans; Middle Aged; Mitral Valve
PubMed: 25194969
DOI: 10.1016/j.carpath.2014.07.007 -
Biotechnic & Histochemistry : Official... May 2022Mast cells in the brain are associated with increased inflammation during the acute period following exposure to infection; these cells are important for destroying the...
Mast cells in the brain are associated with increased inflammation during the acute period following exposure to infection; these cells are important for destroying the infectious agents. We investigated the relation between histopathological lesions and mast cells in sheep brains infected with . Pons and medulla regions from 17 infected and eight normal sheep brains were examined. Microabscesses and perivascular infiltration were assessed for histopathology. Mast cells were identified using toluidine blue and were investigated immunohistochemically. We found a significant increase in mast cells in infected sheep brains that was related directly to the extent of brain lesions. A strong correlation was found between mast cells and microabscess formation. A correlation between bacteria level and brain lesions also was observed, but not between bacteria level and mast cells. Our findings indicate that mast cells are increased following infection in sheep in proportion to the severity of brain lesions; the increase may contribute to acute inflammatory reactions and also may destroy bacteria directly.
Topics: Animals; Brain; Listeria monocytogenes; Listeriosis; Mast Cells; Sheep; Sheep Diseases
PubMed: 34157924
DOI: 10.1080/10520295.2021.1941256 -
The Annals of Otology, Rhinology, and... 1980Blastomycosis is an uncommon fungal disease which may mimic carcinoma of the larynx. Physical examination may show a granular appearance early in the disease with...
Blastomycosis is an uncommon fungal disease which may mimic carcinoma of the larynx. Physical examination may show a granular appearance early in the disease with progression to laryngeal fibrosis. Histologic examination usually shows pseudoepitheliomatous hyperplasia, microabscesses, and giant cells. The broad-based budding yeast organisms may be easily overlooked unless special stains are used. Two cases of laryngeal blastomycosis which were originally treated as carcinoma are reported.
Topics: Aged; Blastomycosis; Diagnostic Errors; Humans; Laryngeal Diseases; Laryngeal Neoplasms; Larynx; Male; Middle Aged
PubMed: 7458148
DOI: 10.1177/000348948008900616 -
BJR Case Reports Mar 2020is the third most frequent cause of bacterial meningitis and has a predilection for elderly patients and the immunosuppressed. A small number of patients with...
is the third most frequent cause of bacterial meningitis and has a predilection for elderly patients and the immunosuppressed. A small number of patients with meningoencephalitis have previously been reported to experience stroke-like symptoms that were attributed to microabscess formation and the mass effect of collections of infection in the brain. These infections led to temporary neurological deficits that resolved with antimicrobial treatment, rather than to true strokes with permanent neurological deficits. This report discusses the case of an 80- year-old male, who was immunosuppressed with mesalazine for the treatment of Crohn's disease, and who went on to develop meningoencephalitis. 1 week into his admission, for antibiotic therapy, the patient began to experience new onset right upper limb weakness, nystagmus and past pointing. These symptoms were initially thought to be a complication of the infection. However, subsequent diffusion-weighted MRI revealed that the patient had more likely suffered an acute ischaemic event and a contrast-enhanced MRI performed later could not detect any abscess or large infective focus in a region that could explain the symptoms. This case report highlights the fact that ischaemic and infective pathologists may coexist in immunosuppressed Listeria patients and that clinical signs and symptoms should guide the use of appropriate imaging modalities such as MRI to clarify differentials so that ischaemia is not mistaken for the more common stroke mimic caused by infection in these patients.
PubMed: 32201611
DOI: 10.1259/bjrcr.20190068 -
Blood May 2018
Topics: Abscess; Aged; Biomarkers; Biopsy; Humans; Immunohistochemistry; Male; Tonsillitis
PubMed: 29748171
DOI: 10.1182/blood-2018-01-825943 -
Anales de Medicina Interna (Madrid,... Nov 1994
Topics: Humans; Liver Abscess; Male; Middle Aged; Yersinia Infections; Yersinia enterocolitica
PubMed: 7654909
DOI: No ID Found -
Veterinary Clinical Pathology Jun 2019
Topics: Animals; Goat Diseases; Goats; Leukocytosis; Listeriosis; Male; Neutrophils
PubMed: 30720882
DOI: 10.1111/vcp.12686 -
European Journal of Dermatology : EJD Dec 2023Mycosis fungoides (MF) is the most prevalent type of cutaneous T-cell lymphoma and is generally characterized by multiple patches or plaques with fine scales. One of its... (Review)
Review
Mycosis fungoides (MF) is the most prevalent type of cutaneous T-cell lymphoma and is generally characterized by multiple patches or plaques with fine scales. One of its variants manifests with multiple purpuric eruptions, mimicking benign pigmented purpuric dermatosis (PPD). To investigate clinicopathological features of PPD-like MF patients. We report four PPD-like MF cases and summarize the clinicopathological features described in reports of nine PPD-like MF cases published in the past 20 years. Compared with benign PPD, petechial lesions in PPD-like MF are more generalized, persistent, and resistant to conventional steroid treatment. Histologically, a superficial dermal band-like infiltrate of atypical lymphocytes with epidermotropism seems to be the most common feature of PPD-like MF. A lymphoid phenotype of CD4+ CD7- T cells and a monoclonal T-cell profile, demonstrated by T-cell receptor gene arrangement analysis, favour a diagnosis of PPD-like MF. Although the exact relationship between PPD and PPD-like MF remains unclear, our study has attached importance to the differential diagnosis of the two diseases in cases of overlooked MF variants. If persistent or generalized purpuric lesions are present, PPD-like MF should be taken into consideration. A thorough physical examination combined with pathological findings may lead to a correct diagnosis.
Topics: Humans; Mycosis Fungoides; Purpura; T-Lymphocytes; Diagnosis, Differential; Skin Neoplasms
PubMed: 38465544
DOI: 10.1684/ejd.2023.4574