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European Journal of Dermatology : EJD Dec 2023Mycosis fungoides (MF) is the most prevalent type of cutaneous T-cell lymphoma and is generally characterized by multiple patches or plaques with fine scales. One of its... (Review)
Review
Mycosis fungoides (MF) is the most prevalent type of cutaneous T-cell lymphoma and is generally characterized by multiple patches or plaques with fine scales. One of its variants manifests with multiple purpuric eruptions, mimicking benign pigmented purpuric dermatosis (PPD). To investigate clinicopathological features of PPD-like MF patients. We report four PPD-like MF cases and summarize the clinicopathological features described in reports of nine PPD-like MF cases published in the past 20 years. Compared with benign PPD, petechial lesions in PPD-like MF are more generalized, persistent, and resistant to conventional steroid treatment. Histologically, a superficial dermal band-like infiltrate of atypical lymphocytes with epidermotropism seems to be the most common feature of PPD-like MF. A lymphoid phenotype of CD4+ CD7- T cells and a monoclonal T-cell profile, demonstrated by T-cell receptor gene arrangement analysis, favour a diagnosis of PPD-like MF. Although the exact relationship between PPD and PPD-like MF remains unclear, our study has attached importance to the differential diagnosis of the two diseases in cases of overlooked MF variants. If persistent or generalized purpuric lesions are present, PPD-like MF should be taken into consideration. A thorough physical examination combined with pathological findings may lead to a correct diagnosis.
Topics: Humans; Mycosis Fungoides; Purpura; T-Lymphocytes; Diagnosis, Differential; Skin Neoplasms
PubMed: 38465544
DOI: 10.1684/ejd.2023.4574 -
The American Journal of the Medical... Apr 1973
Topics: Abscess; Adolescent; Catheterization; Chloramphenicol; Drug Resistance, Microbial; Gentamicins; Humans; Klebsiella; Klebsiella Infections; Male; Middle Aged; Sepsis; Thrombophlebitis; Veins
PubMed: 4706393
DOI: No ID Found -
Tumori Aug 1987Inflammatory pseudotumor of the liver is a rare benign lesion which clinically and grossly is often interpreted as a neoplastic condition. It usually arises in children... (Review)
Review
Inflammatory pseudotumor of the liver is a rare benign lesion which clinically and grossly is often interpreted as a neoplastic condition. It usually arises in children or young adults. Only 11 cases have been described in the literature, and its etiology is still uncertain. Two new cases of inflammatory pseudotumor in adult male patients are reported here. Morphologically, these cases summarize all the features seen in the other cases described previously. They showed fibrous bands delimiting microabscesses made up of granulocytes, mononuclear elements and foamy macrophages. These lesions have in common the symptomatology which is amenable to infectious disease. The purpose of this paper is to draw attention to the existence of a lesion that clinically simulates a neoplastic condition of the liver. This lesion should be histologically recognized to avoid excessive surgical treatment.
Topics: Aged; Fibroma; Humans; Liver Neoplasms; Male; Middle Aged
PubMed: 3310350
DOI: 10.1177/030089168707300415 -
The American Journal of Pathology Apr 1980An investigation of the pathologic events occurring during experimental Strongyloides ratti infection in rats was done. The chronologic sequence of the cellular... (Comparative Study)
Comparative Study
An investigation of the pathologic events occurring during experimental Strongyloides ratti infection in rats was done. The chronologic sequence of the cellular responses to the infecting larvae as they migrated through the skin and lungs was determined. Larvae penetrate the skin very quickly, eliciting considerable mast cell degranulation within the first few minutes, a modest neutrophil response within the first few hours, and an occasional mononuclear response within the first 2 days. The larval passage in the lungs appears to cause little damage except for microhemorrhages and an occasional microabscess. In the intestine S ratti adult worms lie in the cryptae without penetrating mucosa, and except for an increase in the number of mast cells at the time of expulsion (Days 20--25), there is no detectable cellular response. Differences from the human disease are discussed.
Topics: Animals; Disease Models, Animal; Humans; Intestinal Diseases, Parasitic; Intestine, Small; Jejunum; Lung; Male; Rats; Skin; Strongyloidiasis; Time Factors
PubMed: 7361857
DOI: No ID Found -
Journal of Education & Teaching in... Jan 2023Small bowel diverticulitis is an uncommon subset of acute diverticulitis and can mimic many other intra-abdominal processes. As a result, imaging modalities such as...
UNLABELLED
Small bowel diverticulitis is an uncommon subset of acute diverticulitis and can mimic many other intra-abdominal processes. As a result, imaging modalities such as ultrasound and computed tomography (CT) scan are especially important for timely recognition of diverticulitis and can expedite diagnosis and treatment and reduce complications. In the case described in this report, an 81-year-old male with history of esophageal cancer and recurrent diverticulitis with history of multiple bowel resections presented to the emergency department (ED) with right lower quadrant abdominal pain and constipation. Findings on ultrasound were suggestive of diverticulitis, and findings on CT of the abdomen and pelvis showed ileitis with phlegmon and micro-abscess suspicious for small bowel diverticulitis. ED providers should familiarize themselves with ultrasound findings of diverticulitis and be aware that diverticulitis can also present in the small bowel. Treatment of small bowel diverticulitis is similar to colonic diverticulitis.
TOPICS
Ileitis, small bowel diverticulitis, abdominal ultrasound.
PubMed: 37465035
DOI: 10.21980/J8F078 -
Dermatopathology (Basel, Switzerland) May 2022Pemphigus is a chronic blistering disorder caused by autoantibodies that target desmosomal proteins in the epidermis. Acantholysis may be absent, and pemphigus may...
Pemphigus is a chronic blistering disorder caused by autoantibodies that target desmosomal proteins in the epidermis. Acantholysis may be absent, and pemphigus may present only with spongiosis and vesiculation, thereby leading to a misdiagnosis of eczema. Herein, we conducted a retrospective, observational, single-center study to establish a pattern of spongiosis in cases of pemphigus confirmed by direct immunofluorescence. Immunopathologically diagnosed pemphigus specimens from 2001 to 2020 were retrieved, and specimens with spongiosis were analyzed for the following features: vesiculation, acantholysis, spongiosis, inflammatory cells in the epidermis, and inflammation in the dermis. Cases of spongiotic dermatitis were used as control. Out of 99 immunopathologically diagnosed pemphigus specimens, 41 samples with spongiosis were identified. About one quarter of the specimens did not have acantholysis. Spongiosis in the middle to lower thirds of the perilesional epidermis (p = 0.030), exocytosis with either neutrophils or eosinophils (p = 0.016), dermal infiltrates composed of lymphocytes, eosinophils, and neutrophils (p = 0.012), and absence of Langerhans cell microabscesses (p < 0.001) were more common in pemphigus than control. Spongiosis in pemphigus may mimic eczema in patients without acantholysis. The subtle histological findings in this study provide diagnostic clues and suggest that further immunofluorescence should be performed to confirm pemphigus diagnosis.
PubMed: 35645233
DOI: 10.3390/dermatopathology9020022 -
Yonago Acta Medica Aug 2023Psoriasis is a common chronical inflammatory skin disease with a prevalence of 2%-4% worldwide. In contrast, porocarcinoma is a relatively rare cutaneous neoplasm and an...
Psoriasis is a common chronical inflammatory skin disease with a prevalence of 2%-4% worldwide. In contrast, porocarcinoma is a relatively rare cutaneous neoplasm and an associated localization of both lesions is rare. Here, we describe the first case of porocarcinoma in a patient with psoriasis. A 71-year-old Japanese man was referred to our clinic for evaluation of nodule within a keratotic plaque of 20-years history on his leg. Histopathological examination showed that the plaque revealed acanthosis with regular elongation of rete ridges, agranulosis and the presence of Munro microabscesses. In contrast, massive proliferation of atypical poroid cells and a few cuticular cells in the dermis were seen in the nodule. We speculated that it is likely the porocarcinoma was caused by the elevated risk of skin cancer due to chronic inflammatory process of psoriasis itself in our patient.
PubMed: 37621981
DOI: 10.33160/yam.2023.08.005 -
Journal of Nephrology 2001The term peritoneal sclerosis simply means the presence of sclerotic tissue in the peritoneum. Qualitative and quantitative morphological aspects indicate that there are... (Review)
Review
The term peritoneal sclerosis simply means the presence of sclerotic tissue in the peritoneum. Qualitative and quantitative morphological aspects indicate that there are two nosological entities: simple sclerosis and sclerosing peritonitis. Simple sclerosis is a thin (<40-50 microm) layer of submesothelial sclerotic tissue often limited to certain peritoneal areas, with monotonous histology. It is a component of the slight anatomical alterations constantly detectable in peritoneal dialysis patients. Sclerosing peritonitis is characterized by very thick (1,0004,000 microm) sclerotic tissue involving the whole peritoneal wall, often with inflammatory infiltrates, microabscesses, giant cells of macrophagic origin, calcifications and severe vascular alterations. Intermediate stages between simple sclerosis and sclerosing peritonitis have rarely been detected. Simple sclerosis and sclerosing peritonitis also seem to be distinct with respect to frequency, etiology, reproducibility in animal models and clinical manifestations.
Topics: Animals; Fibrin; Humans; Peritoneal Diseases; Peritonitis; Sclerosis
PubMed: 11798143
DOI: No ID Found -
Seminars in Ultrasound, CT, and MR Apr 1997CT scans of the kidneys obtained approximately 3 hours after contrast administration often reveal useful information in patients with renal infections. In this article,... (Review)
Review
CT scans of the kidneys obtained approximately 3 hours after contrast administration often reveal useful information in patients with renal infections. In this article, we discuss three main features of these delayed scans. Feature 1 shows a nephrogram replacing a variable portion of the low density areas present in the early enhanced phase. The nephrogram can be streaky, band-like, cone or horseshoe-shaped; Feature 2 exhibits a focal staining or a hyperdense rim surrounding microabscesses and macroabscesses; Feature 3, very rare, is characterized by hyperdense areas located far from the lesions detected on early scans. These features make it possible to better define the actual extent of infection and the presence of the edema, improving diagnostic confidence.
Topics: Acute Disease; Contrast Media; Humans; Kidney Diseases; Time Factors; Tomography, X-Ray Computed
PubMed: 9163831
DOI: 10.1016/s0887-2171(97)90056-1 -
Clinical Medicine (London, England) Dec 2013Eosinophilic oesophagitis is a clinico-pathologic diagnosis that describes patients with dysphagia (intermittent or continuous), food bolus obstruction or regurgitation,...
Eosinophilic oesophagitis is a clinico-pathologic diagnosis that describes patients with dysphagia (intermittent or continuous), food bolus obstruction or regurgitation, where endoscopy and biopsy reveals high concentrations of eosinophils in the lining of the oesophagus. At endoscopy, the presence of rings (trachealisation), furrows, micro-abscesses and strictures may be noted, but sometimes the appearance is normal. Hence biopsy is essential in every patient with dysphagia. The condition, recognised 25 years ago as a separate disease entity, not related to gastro-oesophageal reflux, is now becoming common. It is important for all general physicians to recognise this and make an accurate diagnosis in order to give specific treatment. This may involve topical steroids, leukotreine D4 antagonists, dietary exclusions and dilatations.
Topics: Deglutition Disorders; Eosinophilic Esophagitis; Gastroesophageal Reflux; Humans; Leukocyte Count
PubMed: 24298180
DOI: 10.7861/clinmedicine.13-6-s32