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Advances in Experimental Medicine and... 2024The family Poxviridae is a large family of viruses with a ubiquitous distribution, subdivided into two subfamilies: Chordopoxvirinae (poxviruses of vertebrates) and... (Review)
Review
The family Poxviridae is a large family of viruses with a ubiquitous distribution, subdivided into two subfamilies: Chordopoxvirinae (poxviruses of vertebrates) and Entomopoxvirinae (poxviruses of insects). Only three species from the first subfamily, Orthopoxvirus (OPV), Molluscipoxvirus and Parapoxvirus, can infect the human being. In the paediatric population, viruses belonging to the first two subfamilies have the greatest importance. Following the eradication of smallpox in 1980, vaccination of the general population was discontinued after careful consideration of the risks and benefits. However, nearly all children and most of the world's population had little to no protection against OPV. The aim of this chapter is to review the current evidence on the aetiology, clinical manifestations, diagnosis and management of Poxviridae infections in children.
Topics: Humans; Child; Poxviridae Infections; Poxviridae; Child, Preschool; Infant; Animals
PubMed: 38801580
DOI: 10.1007/978-3-031-57165-7_13 -
Indian Journal of Ophthalmology Jul 2019
Topics: Diagnosis, Differential; Eye Infections, Viral; Follow-Up Studies; Humans; Keratoconjunctivitis; Male; Molluscum Contagiosum; Molluscum contagiosum virus; Young Adult
PubMed: 31238446
DOI: 10.4103/ijo.IJO_1808_18 -
JAMA Dermatology Sep 2016
Topics: Age Distribution; Child; Child, Preschool; Female; Humans; Incidence; Male; Molluscum Contagiosum; Molluscum contagiosum virus; Physical Examination; Remission, Spontaneous; Severity of Illness Index
PubMed: 27627044
DOI: 10.1001/jamadermatol.2016.2367 -
Lakartidningen Nov 2016Molluscum contagiosum is a viral infection of the epidermis characterized by skin-colored papules or nodules frequently with a central depression. Atypical variants may...
Molluscum contagiosum is a viral infection of the epidermis characterized by skin-colored papules or nodules frequently with a central depression. Atypical variants may occur, primarily in immunosuppressed individuals. We here report a case of »giant Molluscum contagiosum« in an immunocompetent child. The patient was presented with a fairly smooth nodule of 2 cm in diameter on the ring finger. Molluscipoxvirus-like virus particles were detected by electron microscopy from the nodule, but since the clinical picture was not compatible with MC, next generation sequencing was performed in order to verify the diagnosis. Of the total number of obtained sequences, 25% belonged to molluscipoxvirus (MCV) and de novo assembly revealed three contigs corresponding to 95% of the MCV genome. The assembled genome was compared to previously published sequences of the »major envelope protein« used for genotyping of MCV genus. Several unique single nucleotide polymorphisms were identified, which led us to classify this virus as a new subtype of MCV.
Topics: Child, Preschool; Female; Fingers; High-Throughput Nucleotide Sequencing; Humans; Microscopy, Electron; Molluscum Contagiosum; Molluscum contagiosum virus; Sequence Analysis, DNA
PubMed: 27898140
DOI: No ID Found -
Medecine Et Sante Tropicales Feb 2017This article reviews the different types of poxvirus infections. Smallpox, although eradicated, must continue to be monitored because of the potential risk of accidental... (Review)
Review
This article reviews the different types of poxvirus infections. Smallpox, although eradicated, must continue to be monitored because of the potential risk of accidental or voluntary (by bioterrorism) reintroduction. Monkeypox and cowpox viruses are considered to be emergent today ; their high risk of dissemination is due to the increase in international transport as well as trends for new animals as pets and the loss of vaccinal protection against smallpox. Molluscum contagiosum (molluscipoxvirus) causes mild infections, is particularly frequent in children ; in adults it is a marker of the risk of sexually transmitted infections and can, in cases with profuse lesions, reveal AIDS.
Topics: Humans; Mpox (monkeypox); Poxviridae Infections
PubMed: 28406414
DOI: 10.1684/mst.2017.0653 -
Journal of the American Academy of... Feb 2024
Topics: Humans; Molluscum Contagiosum; Molluscum contagiosum virus
PubMed: 38007039
DOI: 10.1016/j.jaad.2023.11.022 -
Advances in Experimental Medicine and... 2024Molluscum contagiosum virus is a poxvirus belonging to the Poxviridae family, which includes Orthopoxvirus, Parapoxvirus, Yantapoxvirus, Molluscipoxvirus, Smallpox... (Review)
Review
Molluscum contagiosum virus is a poxvirus belonging to the Poxviridae family, which includes Orthopoxvirus, Parapoxvirus, Yantapoxvirus, Molluscipoxvirus, Smallpox virus, Cowpox virus and Monkeypox virus. MCV belongs to the genus Molluscipoxvirus and has a tropism for skin tissue. MCV infects keratinocytes and, after an incubation period of 2 weeks to 6 weeks, causes a breakdown of the skin barrier with the development of papules of variable size depending on the proper functioning of the immune response (both adaptive and acquired). MCV only infects humans and does not cause viraemia. MCV encodes for several inhibitory proteins responsible to circumvent the immune response through different signalling pathways. Individuals who can be infected with MCV are children, immunocompromised individuals such as organ transplant recipients and Human Immunodeficiency Virus (HIV)-infected individuals. Current treatments to manage MCV-induced lesions are different and include the use of immunomodulators, which, however, do not provide an effective response.
Topics: Humans; Molluscum contagiosum virus; Molluscum Contagiosum; Animals
PubMed: 38801577
DOI: 10.1007/978-3-031-57165-7_10 -
Cutis Nov 2019Molluscum contagiosum virus (MCV) is a poxvirus that causes infection in humans that is limited to the cutis and subcutaneous levels of the skin. The virus is... (Review)
Review
Molluscum contagiosum virus (MCV) is a poxvirus that causes infection in humans that is limited to the cutis and subcutaneous levels of the skin. The virus is transmitted from close associates in settings such as pools, day care, and bathtubs. Pediatric molluscum is common in school-aged children and resolves spontaneously in healthy children. Widespread lesions, complicated by comorbid dermatitis, are expected in children with atopic dermatitis (AD); however, even children without AD can develop dermatitis or signs of inflammation or pruritus. Molluscum is the great mimicker in pediatric dermatology; the morphology of the lesions and overlying rash can make molluscum look polymorphous and similar to other skin illnesses. This article addresses the issue of transmission, course of disease, comorbidities, and therapeutic options, including the gold standard-nonintervention. The decision to intervene is a joint decision among children, parents/guardians, and the practitioner. The first priority should be reduction of symptoms, followed by reduction of spread and then disease remission.
Topics: Child; Dermatitis, Atopic; Humans; Molluscum Contagiosum; Molluscum contagiosum virus
PubMed: 31886783
DOI: No ID Found -
Pediatric Dermatology 2015
Review
Topics: Administration, Oral; Administration, Topical; Adolescent; Aminoquinolines; Antiviral Agents; Child; Chronic Disease; Cryotherapy; Female; Humans; Imiquimod; Information Dissemination; Male; Molluscum Contagiosum; Molluscum contagiosum virus; Patient Education as Topic; Prognosis; Retinoids; Severity of Illness Index; Treatment Outcome
PubMed: 26584708
DOI: 10.1111/pde.12752 -
Journal of the American Academy of... Feb 2024
Topics: Humans; Molluscum Contagiosum; Molluscum contagiosum virus
PubMed: 38007037
DOI: 10.1016/j.jaad.2023.11.021