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Journal of Fungi (Basel, Switzerland) Jan 2024Black spot needle blight is a minor disease in Mongolian Scots pine ( var. ) caused by , but it can cause economic losses in severe cases. Sodium pheophorbide a (SPA),...
Black spot needle blight is a minor disease in Mongolian Scots pine ( var. ) caused by , but it can cause economic losses in severe cases. Sodium pheophorbide a (SPA), an intermediate product of the chlorophyll metabolism pathway, is a compound with photoactivated antifungal activity, which has been previously shown to inhibit the growth of . In this study, SPA significantly reduced the incidence and disease index and enhanced the chlorophyll content and antioxidant enzyme activities of var. . To further study the molecular mechanism of the inhibition, we conducted a comparative proteomic analysis of mycelia with and without SPA treatment. The cellular proteins were obtained from mycelial samples and subjected to a tandem mass tag (TMT)-labelling LC-MS/MS analysis. Based on the results of de novo transcriptome assembly, 613 differentially expressed proteins (DEPs) ( < 0.05) were identified, of which 360 were upregulated and 253 downregulated. The 527 annotated DEPs were classified into 50 functional groups according to Gene Ontology and linked to 256 different pathways using the Kyoto Encyclopedia of Genes and Genomes database as a reference. A joint analysis of the transcriptome and proteomics results showed that the top three pathways were Amino acid metabolism, Carbohydrate metabolism, and Lipid metabolism. These results provide new viewpoints into the molecular mechanism of the inhibition of by SPA at the protein level and a theoretical basis for evaluating SPA as an antifungal agent to protect forests.
PubMed: 38392774
DOI: 10.3390/jof10020102 -
BMJ Case Reports Jul 2018
Topics: Brain; Humans; Infant; Lumbosacral Region; Magnetic Resonance Imaging; Male; Mongolian Spot; Sandhoff Disease
PubMed: 30061129
DOI: 10.1136/bcr-2018-225013 -
The British Journal of Dermatology May 2007
Topics: Arm; Back; Buttocks; Face; Female; Glaucoma; Humans; Infant, Newborn; Leg; Mongolian Spot; Port-Wine Stain; Skin Neoplasms; Taiwan; Telangiectasis; Thorax
PubMed: 17355231
DOI: 10.1111/j.1365-2133.2007.07798.x -
Anais Brasileiros de Dermatologia 2013Phacomatosis Pigmentovascularis is a rare syndrome characterized by capillary malformation and pigmentary nevus. A case of a 2-year-old patient is reported, who...
Phacomatosis Pigmentovascularis is a rare syndrome characterized by capillary malformation and pigmentary nevus. A case of a 2-year-old patient is reported, who presented extensive nevus flammeus and an aberrant Mongolian spot, without systemic disease, manifestations that allow us to classify this case as type IIa Phacomatosis Pigmentovascularis, according to Hasegawa's classification.
Topics: Child, Preschool; Hair Diseases; Humans; Male; Mongolian Spot; Neurocutaneous Syndromes; Nevus of Ota; Skin; Skin Neoplasms
PubMed: 24346888
DOI: 10.1590/abd1806-4841.20132248 -
Anais Brasileiros de Dermatologia 2015Phacomatosis pigmentovascularis is a rare, congenital condition characterized by a combination of cutaneous melanocytic lesions and vascular malformation. We discuss an...
The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis.
Phacomatosis pigmentovascularis is a rare, congenital condition characterized by a combination of cutaneous melanocytic lesions and vascular malformation. We discuss an entirely unique case of Phacomatosis pigmentovascularis with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita, which may represent a heretofore undescribed variant of phacomatosis pigmentovascularis.
Topics: Humans; Livedo Reticularis; Male; Mongolian Spot; Neurocutaneous Syndromes; Nevus of Ota; Port-Wine Stain; Skin Diseases, Vascular; Skin Neoplasms; Telangiectasis; Young Adult
PubMed: 26312661
DOI: 10.1590/abd1806-4841.20153466 -
Journal of Cellular Biochemistry Nov 2012As a microaerobe, Helicobacter pylori employs the global regulator SpoT for defending against oxidative stress in vitro. However, the mechanisms how SpoT affects...
As a microaerobe, Helicobacter pylori employs the global regulator SpoT for defending against oxidative stress in vitro. However, the mechanisms how SpoT affects bacterial gene expression is still unknown. Moreover, the function of SpoT in H. pylori colonization in the host is remaining undetermined. To explore the functions of the SpoT in H. pylori pathogenesis, we constructed H. pylori 26695 spoT-deficient mutant (ΔspoT). While grown in ambient atmosphere, protein expression profile of the ΔspoT was analyzed with 2D gel electrophoresis and real-time PCR. Compared to the wild type, the spoT-deficient strain downregulated its transcription of the oxidative-induced genes, as well as the genes responsible for protein degradation and that related to energy metabolism. Meanwhile, the colonization ability of ΔspoT strains in Mongolian gerbil was tested, the results demonstrated a decayed colonization in the mouse stomach with ΔspoT than the wild type. As a matter of facts, the AGS cells infected with the ΔspoT strains excreted increased level of the gastric inflammation cytokines IL-8, and the ΔspoT strains showed poor survival ability when treated with reactive oxygen stress (sodium nitroprusside). The elevated capacity of stimulating cytokines and fragility to reactive oxygen stress may be contribute to decreased colonization of the spoT-deficient mutant in the mouse stomach. Conclusively, we speculate that spoT is a key regulator of the genes for H. pylori spreading in the air and colonization in host stomach.
Topics: Aerobiosis; Animals; Bacterial Proteins; Colony Count, Microbial; Culture Media; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Interleukin-8; Microbial Viability; Mutation; Nitroprusside; Oxidants; Oxidative Stress; Proteomics; Pyrophosphatases; Real-Time Polymerase Chain Reaction; Stomach
PubMed: 22678710
DOI: 10.1002/jcb.24215 -
Journal of Cutaneous Pathology Aug 2007Dermal melanocytoses comprise a variety of congenital and acquired conditions characterized by a sparse population of intradermal dendritic, variably pigmented,... (Review)
Review
Dermal melanocytoses comprise a variety of congenital and acquired conditions characterized by a sparse population of intradermal dendritic, variably pigmented, spindle-shaped melanocytes. While Mongolian spot, Ota's and Ito's nevi are usually present at birth or appear around puberty; acquired dermal melanocytoses that appear in adult life are extremely rare. They include the facial lesions of acquired bilateral nevus of Ota-like macules, also named Hori's nevus, and the acquired unilateral nevus of Ota, also known as Sun's nevus. Uncommon extrafacial examples of acquired dermal melanocytoses include lesions involving upper extremities, wrist, back, lower extremities and dorsal aspects of the hands and feet. They are more prevalent among Asian women. In general, dermal melanocytoses are rare lesions in Caucasian patients and acquired variants are exceedingly uncommon. We report a rare example of acquired Ito's nevus that appeared in a Caucasian elderly woman and review the literature about acquired dermal melanocytoses.
Topics: Age of Onset; Aged; Biopsy; Female; Humans; Melanocytes; Nevus, Pigmented; Pigmentation Disorders; Skin Neoplasms; White People
PubMed: 17640235
DOI: 10.1111/j.1600-0560.2006.00683.x -
Environmental Science and Pollution... Sep 2023Pesticide exposure is a major health problem that cannot be ignored, and children are particularly vulnerable and sensitive. As a result, the study of health damage in... (Review)
Review
Pesticide exposure is a major health problem that cannot be ignored, and children are particularly vulnerable and sensitive. As a result, the study of health damage in children caused by pesticide exposure has gradually developed into an important cross-disciplinary research topic. In this study, we reviewed the current state, characteristics, and trends of existing research findings and summarized them comprehensively and systematically through bibliometrics. We collected and examined a large number of studies using Citespace and Vosviewer, employing a clustering method to analyze the effects of pesticide exposure on children and to highlight the hot keywords in the research field. Through an analysis of the active time of high-frequency keywords, we found that the research field is in a hot spot, and the occurrence value of keywords was used to judge the innovation of the research results, thereby highlighting the frontier and key directions of future research in this field. We conclude that in addition to core pesticides, children, exposure, and other malaria and polychlorinated biphenyls also appear as high-frequency keywords in the research field of pesticide exposure effects on children. The core issues of concern in this field include occupational pesticide exposure and childhood leukemia, history of pesticide exposure during pregnancy and childhood leukemia, environmental factors and dietary intake and organophosphorus pesticide exposure in children, and pyrethroid pesticide exposure and neurobehavioral development in children. Future research may focus on how to control the safe use of pesticides, quantitative research on pesticide hazards, and potential effects on children's health.
Topics: Female; Pregnancy; Humans; Child; Pesticides; Environmental Exposure; Organophosphorus Compounds; Leukemia; Bibliometrics
PubMed: 37648921
DOI: 10.1007/s11356-023-29457-x -
Journal of Cosmetic Dermatology Nov 2021Newborn period is a definition used for the first 4 weeks of life and it has some different characteristics compared with adult skin.
BACKGROUND
Newborn period is a definition used for the first 4 weeks of life and it has some different characteristics compared with adult skin.
AIMS
In this study, we tried to define the pathological and physiological skin manifestations and demographic data observed in newborns PATIENTS/METHODS: In this study, newborns born between 2018 and 2019 were evaluated prospectively. Along with demographic findings, temporary neonatal skin manifestations, congenital spots, benign neonatal pustulosis, congenital anomalies and other lesions were statistically evaluated.
RESULTS
A total of 2109 newborns, consisting of 1157 (54.9%) boys and 952 (45.1%) girls, were enrolled in the study. 94% of the newborns evaluated had at least one skin lesion. The most common skin manifestations in the study were Epstein pearls at a rate of 49.4%. This was followed by salmon patch (38.4%), Mongolian spot (20.1%), edema in the eyelids (15.5%), lanugo (15.4%), and erythema toxicum neonatarum (11.6%), respectively.
CONCLUSION
Several studies on dermatological findings observed in newborns have been conducted in many different countries around the world. In this study, we tried to identify many temporary and pathological skin manifestations and congenital anomalies observed in the first 48 h in newborns.
Topics: Adult; Erythema; Female; Humans; Infant, Newborn; Male; Skin
PubMed: 33609325
DOI: 10.1111/jocd.14013 -
Italian Journal of Dermatology and... Dec 2021
Topics: Female; Humans; Melanoma; Mongolian Spot; Nevus, Blue; Pregnancy; Skin Neoplasms
PubMed: 32041936
DOI: 10.23736/S2784-8671.19.06409-5