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IDCases 2022was first identified in 1993 as normal flora of the oral cavities of dogs and cats. The species has been reported to cause localized infections in immunocompromised...
was first identified in 1993 as normal flora of the oral cavities of dogs and cats. The species has been reported to cause localized infections in immunocompromised humans only three times. We report the first description of severe disseminated infection attributed to .
PubMed: 35079573
DOI: 10.1016/j.idcr.2022.e01396 -
Frontiers in Veterinary Science 2022A 5-year-old castrated male bulldog was diagnosed with a corneal ulcer accompanied by edema and conjunctival hyperemia. Ophthalmic examination and microbiological...
A 5-year-old castrated male bulldog was diagnosed with a corneal ulcer accompanied by edema and conjunctival hyperemia. Ophthalmic examination and microbiological analysis were performed, and the bacteria were found to be gram-negative and globular. The isolated clone was identified as (MZ579539) MALDI-TOF MS and 16S rDNA sequencing. Antimicrobial susceptibility testing showed that the bacteria were sensitive to tetracycline and chloramphenicol, but resistant to levofloxacin and ciprofloxacin. After a conjunctival flap was placed, tobramycin ophthalmic solution and 5% sodium hyaluronate were administered. Following surgery, the ulcer was effectively controlled, and after 3 weeks, the cornea healed. This is the first case report of a canine corneal ulcer associated with , which should be considered when corneal ulceration or keratitis were suspected.
PubMed: 35812875
DOI: 10.3389/fvets.2022.934081 -
Joint Bone Spine May 2009
Topics: Animals; Anti-Bacterial Agents; Arthritis, Infectious; Cefotaxime; Diagnosis, Differential; Disease Vectors; Dog Diseases; Dogs; Humans; Immunocompromised Host; Male; Middle Aged; Moraxella; Moraxellaceae Infections; Multiple Myeloma; Ofloxacin
PubMed: 19286409
DOI: 10.1016/j.jbspin.2008.09.015 -
International Journal of Systematic... Jul 1993The taxonomic position of a group of 16 Moraxella catarrhalis-like strains, isolated mainly from dogs, was examined by using morphological tests, biochemical tests,... (Comparative Study)
Comparative Study
The taxonomic position of a group of 16 Moraxella catarrhalis-like strains, isolated mainly from dogs, was examined by using morphological tests, biochemical tests, serology, ribotyping with oligonucleotide probes, polymerase chain reaction typing of the 16S rRNA gene and the 16S-23S rRNA gene spacer region, polyacrylamide gel electrophoresis of total proteins, fatty acid profiles, moles percent G+C, dot spot and in-solution DNA-DNA hybridizations, and DNA-rRNA hybridizations. It was found that these organisms constitute a distinct cluster within the genus Moraxella. Since they differ genotypically as well as phenotypically from previously described Moraxella species, a new species, Moraxella canis, is proposed to accommodate these isolates. The type strain is LMG 11194 (= N7 = CCUG 8415A).
Topics: Animals; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Cats; Cluster Analysis; Cross Reactions; DNA, Ribosomal; Dogs; Fatty Acids; Lipopolysaccharides; Molecular Sequence Data; Moraxella; Moraxella catarrhalis; Neisseria meningitidis; Nucleic Acid Hybridization; Respiratory Tract Infections; Serotyping
PubMed: 8347504
DOI: 10.1099/00207713-43-3-438 -
Scandinavian Journal of Infectious... 2001Moraxella canis was isolated from an infected foot ulcer in a patient suffering from diabetes mellitus with neuropathy. Bacteriological findings and 16S rDNA data are...
Moraxella canis was isolated from an infected foot ulcer in a patient suffering from diabetes mellitus with neuropathy. Bacteriological findings and 16S rDNA data are presented.
Topics: DNA, Bacterial; Diabetic Foot; Humans; Male; Middle Aged; Molecular Sequence Data; Moraxella; Neisseriaceae Infections; RNA, Bacterial; RNA, Ribosomal, 16S; Wound Infection
PubMed: 11233854
DOI: 10.1080/003655401750065580 -
Journal of Clinical Microbiology Feb 2010Two tributyrin hydrolysis-negative Moraxella isolates obtained in cases of keratoconjunctivitis in Camelus dromedarius in the Canary Islands showed highest degrees of...
Two tributyrin hydrolysis-negative Moraxella isolates obtained in cases of keratoconjunctivitis in Camelus dromedarius in the Canary Islands showed highest degrees of 16S rRNA gene sequence similarity to Moraxella canis. A level of DNA relatedness to the M. canis type strain of 79% confirmed the identity of the isolates as a tributyrin hydrolysis-negative biovar of M. canis.
Topics: Animals; Bacterial Typing Techniques; Camelus; Cluster Analysis; DNA, Bacterial; DNA, Ribosomal; Disease Outbreaks; Keratoconjunctivitis; Male; Molecular Sequence Data; Moraxella; Moraxellaceae Infections; Phylogeny; Polymorphism, Genetic; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Spain; Triglycerides
PubMed: 20032257
DOI: 10.1128/JCM.02329-09 -
Viruses Mar 2023Canine diarrhea is a common intestinal illness that is usually caused by viruses, bacteria, and parasites, and canine diarrhea may induce morbidity and mortality of...
Canine diarrhea is a common intestinal illness that is usually caused by viruses, bacteria, and parasites, and canine diarrhea may induce morbidity and mortality of domestic dogs if treated improperly. Recently, viral metagenomics was applied to investigate the signatures of the enteric virome in mammals. In this research, the characteristics of the gut virome in healthy dogs and dogs with diarrhea were analyzed and compared using viral metagenomics. The alpha diversity analysis indicated that the richness and diversity of the gut virome in the dogs with diarrhea were much higher than the healthy dogs, while the beta diversity analysis revealed that the gut virome of the two groups was quite different. At the family level, the predominant viruses in the canine gut virome were certified to be Microviridae, Parvoviridae, Siphoviridae, Inoviridae, Podoviridae, Myoviridae, and others. At the genus level, the predominant viruses in the canine gut virome were certified to be , , , , , , , , , , , and others. However, the viral communities between the two groups differed significantly. The unique viral taxa identified in the healthy dogs group were and , while the unique viral taxa identified in the dogs with diarrhea group were , , , , , , and other viruses. Phylogenetic analysis based on the near-complete genome sequences showed that the CPV strains collected in this study together with other CPV Chinese isolates clustered into a separate branch, while the identified CAV-2 strain D5-8081 and AAV-5 strain AAV-D5 were both the first near-complete genome sequences in China. Moreover, the predicted bacterial hosts of phages were certified to be , , , , , , , and other commensal microbiota. In conclusion, the enteric virome of the healthy dogs group and the dogs with diarrhea group was investigated and compared using viral metagenomics, and the viral communities might influence canine health and disease by interacting with the commensal gut microbiome.
Topics: Animals; Dogs; Wolves; Metagenomics; Phylogeny; Viruses; Microviridae; Diarrhea; Myoviridae; Siphoviridae; Podoviridae; Bacteria
PubMed: 36992396
DOI: 10.3390/v15030685 -
Journal of Clinical Microbiology Oct 2000Moraxella canis was isolated in large numbers from an ulcerated supraclavicular lymph node of a terminal patient, who died a few days later. Although the patient...
Moraxella canis was isolated in large numbers from an ulcerated supraclavicular lymph node of a terminal patient, who died a few days later. Although the patient presented with septic symptoms and with a heavy growth of gram-negative diplococci in the lymph node, blood cultures remained negative. M. canis is an upper-airway commensal from dogs and cats and is considered nonpathogenic for humans, although this is the third reported human isolate of this species.
Topics: DNA, Ribosomal; Fatal Outcome; Humans; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Microbial Sensitivity Tests; Middle Aged; Moraxella; Phylogeny; Polymerase Chain Reaction; RNA, Ribosomal, 16S; Sepsis
PubMed: 11015424
DOI: 10.1128/JCM.38.10.3870-3871.2000 -
Biotech (Basel (Switzerland)) Oct 2023(1) Background: The COVID-19 pandemic left many intriguing mysteries. Retrospective vulnerability trends tie as strongly to odd demographics as to exposure profiles,...
(1) Background: The COVID-19 pandemic left many intriguing mysteries. Retrospective vulnerability trends tie as strongly to odd demographics as to exposure profiles, genetics, health, or prior medical history. This article documents the importance of nasal microbiome profiles in distinguishing infection rate trends among differentially affected subgroups. (2) Hypothesis: From a detailed literature survey, microbiome profiling experiments, bioinformatics, and molecular simulations, we propose that specific commensal bacterial species in the genus confer protection against SARS-CoV-2 infections by expressing proteases that may interfere with the proteolytic priming of the Spike protein. (3) Evidence: Various reports have found elevated fractions in the nasal microbiomes of subpopulations with higher resistance to COVID-19 (e.g., adolescents, COVID-19-resistant children, people with strong dietary diversity, and omnivorous canines) and less abundant ones in vulnerable subsets (the elderly, people with narrower diets, carnivorous cats and foxes), along with bioinformatic evidence that bacteria express proteases with notable homology to human TMPRSS2. Simulations suggest that these proteases may proteolyze the SARS-CoV-2 spike protein in a manner that interferes with TMPRSS2 priming.
PubMed: 37987478
DOI: 10.3390/biotech12040061 -
Antimicrobial Agents and Chemotherapy Jun 2017Animal bite wounds affect more than 5 million Americans annually, resulting in 300,000 emergency department visits, 10,000 hospitalizations, and an untold number of...
Activity of Pexiganan and 10 Comparator Antimicrobials against 234 Isolates, Including 93 Pasteurella Species and 50 Anaerobic Bacterial Isolates Recovered from Animal Bite Wounds.
Animal bite wounds affect more than 5 million Americans annually, resulting in 300,000 emergency department visits, 10,000 hospitalizations, and an untold number of physician office visits. Various forms of topical therapy are empirically self-employed by many patients prior to seeking medical attention. Pexiganan, a 22-amino-acid synthetic cationic analogue of the peptide magainin II, acts by selectively damaging bacterial cell membranes. We determined the MICs for pexiganan and other antimicrobial agents often used for treatment of bite wounds. Most isolates were from U.S. patients, and ∼10% were from European and Canadian patients. The comparator antimicrobials studied were penicillin, amoxicillin-clavulanate, piperacillin-tazobactam, meropenem, clindamycin, doxycycline, moxifloxacin, ceftriaxone, linezolid, and metronidazole. The MICs of pexiganan were 32 μg/ml (against subsp. ), 16 μg/ml ( subsp. , , and ), 8 μg/ml (), 8 μg/ml (), 2 μg/ml (, , and group), 16 μg/ml (), 64 μg/ml (), 4 μg/ml (), 32 μg/ml (), and 64 μg/ml (). The concentration of pexiganan in the cream used was 8,000 μg/ml, more than 60 to 100 times the highest MIC obtained. Pexiganan exhibited a broad range of antimicrobial activity, showing potential for treating animal bite infections. A clinical trial seems warranted.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Cationic Peptides; Bacteria, Anaerobic; Bites and Stings; Clindamycin; Doxycycline; Fluoroquinolones; Linezolid; Meropenem; Metronidazole; Microbial Sensitivity Tests; Moxifloxacin; Pasteurella; Penicillanic Acid; Penicillins; Piperacillin; Piperacillin, Tazobactam Drug Combination; Thienamycins
PubMed: 28373186
DOI: 10.1128/AAC.00246-17