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BMC Anesthesiology Mar 2019
Topics: Anesthesiology; Animals; Humans; Organ Transplantation; Specialization
PubMed: 30832567
DOI: 10.1186/s12871-019-0704-z -
Seminars in Cardiothoracic and Vascular... Jun 2020In the year 2019, we identified and screened over 400 peer-reviewed publications on pancreatic transplantation, over 200 on intestinal transplantation, and over 1900 on... (Review)
Review
In the year 2019, we identified and screened over 400 peer-reviewed publications on pancreatic transplantation, over 200 on intestinal transplantation, and over 1900 on kidney transplantation. The liver transplantation section focuses on and features selected articles among 70 clinical trials published in 2019. This review highlights noteworthy literature pertinent to anesthesiologists and critical care physicians caring for patients undergoing abdominal organ transplantation. We explore a broad range of topics, including risks for and prediction of perioperative complications, updated indications for transplantation, recommendations on perioperative management, including Enhanced Recovery After Surgery programs, and topics relevant to optimization of patient and graft outcomes and survival.
Topics: Enhanced Recovery After Surgery; Fluid Therapy; Graft Survival; Humans; Intestines; Kidney Transplantation; Liver Transplantation; Organ Transplantation; Pain Management; Pancreas Transplantation; Tissue Donors
PubMed: 32342763
DOI: 10.1177/1089253220920497 -
Transplantation Jul 2019
Topics: Diffusion of Innovation; Government Regulation; History, 20th Century; History, 21st Century; Humans; Lithuania; Organ Transplantation; Policy Making; Tissue and Organ Procurement
PubMed: 31241549
DOI: 10.1097/TP.0000000000002575 -
Science Progress 2010Organ transplantation started in the mid-1950s with a kidney transplant between identical twins, demonstrating the surgical technique could provide successful therapy.... (Review)
Review
Organ transplantation started in the mid-1950s with a kidney transplant between identical twins, demonstrating the surgical technique could provide successful therapy. The immunological barrier to be overcome, however proved to be far more difficult to deal with. The introduction of immunosuppressive agents produced some success but it was not until Cyclosporin became available in the 1980s that results became sufficiently good for widespread acceptance and rapid development of organ grafting. Now with more powerful and selective agents, although there is still much room for improvement in immunosuppression, one of the main problems in organ transplantation is a result of its success, namely a shortage of organ donors. In this review, I summarise these matters.
Topics: Graft vs Host Disease; Humans; Immunosuppression Therapy; Organ Transplantation
PubMed: 20681319
DOI: 10.3184/003685010X12708274571283 -
Transplantation Mar 2020
Topics: Ecuador; Female; Geography; History, 20th Century; History, 21st Century; Humans; Intersectoral Collaboration; Male; Organ Transplantation; Quality of Life; Tissue and Organ Procurement
PubMed: 32106198
DOI: 10.1097/TP.0000000000002974 -
EBioMedicine Nov 2020
Topics: Humans; Organ Transplantation; Quality Improvement; Tissue and Organ Procurement
PubMed: 33213763
DOI: 10.1016/j.ebiom.2020.103135 -
Transplantation May 2019
Topics: Humans; Organ Transplantation; Registries; Switzerland; Tissue and Organ Procurement
PubMed: 31033850
DOI: 10.1097/TP.0000000000002565 -
Saudi Journal of Kidney Diseases and... Nov 2007The first renal transplantation in Iran was carried out in 1967. Between 1967 to 1988 almost all renal transplants were from living-related donors and the number of... (Review)
Review
The first renal transplantation in Iran was carried out in 1967. Between 1967 to 1988 almost all renal transplants were from living-related donors and the number of renal transplants performed was much lower than the national demand. In 1988, a compensated and regulated living-unrelated donor renal transplantation program was adopted. As a result, the number of renal transplants performed substantially increased such that in 1999, the renal transplant waiting list was completely eliminated. By the end of 2006, a total of 21251 renal transplants were performed (3641 from living-related, 16544 from living-unrelated and 1066 from deceased-donors). In this program, many ethical problems that were associated with paid kidney donation were prevented. Currently, Iran is the only country with no renal transplant waiting lists, and> 50% of patients with end-stage renal disease have functioning grafts. In April 2000, the legislation was passed by parliament accepting brain death and allowing deceased-donor organ transplantation. By the end of 2006, 18 brain death identification units, 13 organ procurement units were organized, and a total of 1546 deceased-donor organ transplantations were performed (1066 kidney, 327 liver, 122 heart, 20 lungs, 7 pancreas-kidney, 2 heart-lungs and 2 small bowel transplants). The number of deceased-donor organ transplants have slowly but steadily increased in the country. The majority of deceased-donor kidney, liver, and pancreas transplants have been performed by transplant team of Shiraz University of Medical Sciences.
Topics: Humans; Iran; Living Donors; Organ Transplantation; Waiting Lists
PubMed: 17951961
DOI: No ID Found -
La Revue Du Praticien Mar 2014
Review
Topics: Humans; Immunosuppressive Agents; Organ Transplantation; Tissue Donors; Tissue and Organ Procurement; Transplantation Conditioning; Transplantation Immunology
PubMed: 24851380
DOI: No ID Found -
Current Opinion in Nephrology and... Nov 2017Ischemia reperfusion injury (IRI) is an inevitable complication in solid organ transplantation. Limiting this injury can increase patient and graft survival and can... (Review)
Review
PURPOSE OF REVIEW
Ischemia reperfusion injury (IRI) is an inevitable complication in solid organ transplantation. Limiting this injury can increase patient and graft survival and can decrease complications associated with transplantation. We provide an extensive literature review analyzing the available evidence for ischemic conditioning in solid organ transplantation, including kidney, liver, heart, and lung.
RECENT FINDINGS
Ischemic conditioning strategies are a group of interventions, characterized by episodes of ischemia and reperfusion to an organ which confirm tissue protection. Arguably, transplantation is the ideal setting to use this novel strategy due to the predictable timing and duration of the ischemic insult. Liver transplantation has provided us with the most number of clinical trials, followed by kidney transplantation. Most of these trials have been negative but the methodology has been variable, making comparison difficult.
SUMMARY
Despite the promising results seen in animal models, translating these results in clinical trials has proved to be difficult. The promising effects of ischemic conditioning are present in some trials with weaker positive signals existing in other trials. We believe that tailoring trials to allow better comparison will provide positive results in the future.
Topics: Animals; Heart Transplantation; Humans; Ischemic Preconditioning; Kidney Transplantation; Liver Transplantation; Lung Transplantation; Models, Animal; Organ Transplantation; Reperfusion Injury
PubMed: 28877040
DOI: 10.1097/MNH.0000000000000367