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Hepatobiliary & Pancreatic Diseases... Apr 2014
Topics: China; Consensus; Humans; Organ Transplantation; Practice Patterns, Physicians'; Tissue and Organ Procurement
PubMed: 24686539
DOI: 10.1016/s1499-3872(14)60022-9 -
Transplantation Feb 2019
Topics: Costa Rica; Humans; Organ Trafficking; Organ Transplantation; Registries
PubMed: 30681645
DOI: 10.1097/TP.0000000000002525 -
Transplantation Jul 2016Organ transplantation started in the Kingdom of Saudi Arabia (KSA) in 1979 with a kidney transplanted from a live donor. The Saudi Center for Organ Transplantation has...
Organ transplantation started in the Kingdom of Saudi Arabia (KSA) in 1979 with a kidney transplanted from a live donor. The Saudi Center for Organ Transplantation has been established in 1985 as a governmental agency that supervises all national transplant activities in the KSA. Organ transplantation in the KSA has made great strides since 1985. Saudi Center for Organ Transplantation is playing a central role in all aspects of transplantation including education on all levels, allocation, coordination and procurement. A new initiative has started an ambitious program in 2014 to improve the identification and reporting of organ donors aiming at an annual rate of 15 donors per million populations within 3 years in the KSA.
Topics: History, 20th Century; History, 21st Century; Humans; Kidney Transplantation; Living Donors; Organ Transplantation; Saudi Arabia; Tissue Donors
PubMed: 27326805
DOI: 10.1097/TP.0000000000001295 -
Orvosi Hetilap Nov 2018Machine perfusion of marginal grafts might be a possible solution to organ shortage and a promising tool for reducing waiting list morbidity and mortality. In recent... (Review)
Review
Machine perfusion of marginal grafts might be a possible solution to organ shortage and a promising tool for reducing waiting list morbidity and mortality. In recent years, optimizing the circumstances of organ preservation prior to implantation via machine perfusion has become a hot topic of research. Machine perfusion offers a platform for organ reconditioning, assessment of cell viability and function, pharmacological preconditioning, prolongation of preservation time (ischemia time) and finally reducing graft injury. The objective of the new technology is to increase the pool of transplantable organs safely. Multicentric prospective studies have been evaluating the short and long term outcomes of different methods, however, several questions still remain unanswered. This review summarizes the recent advances in the field of machine perfusion, focusing on preclinical and clinical results. Machine perfusion seems to be a new milestone in the modern era of solid organ transplantation. Orv Hetil. 2018; 159(46): 1882-1890.
Topics: Heart Transplantation; Humans; Kidney Transplantation; Liver Transplantation; Lung Transplantation; Organ Preservation; Organ Transplantation; Pancreas Transplantation; Perfusion
PubMed: 30450928
DOI: 10.1556/650.2018.31282 -
Cellular Immunology Sep 2020
Topics: Humans; Organ Transplantation; Transplantation Immunology
PubMed: 32619810
DOI: 10.1016/j.cellimm.2020.104156 -
Psychotherapie, Psychosomatik,... May 2018
Topics: Adult; Child; Germany; Humans; Organ Transplantation
PubMed: 29723904
DOI: 10.1055/a-0594-7070 -
Blood Reviews Nov 2014Thrombotic microangiopathy (TMA) is a rare but serious complication of organ transplantation. This article presents the first literature review on TMA following... (Review)
Review
Thrombotic microangiopathy (TMA) is a rare but serious complication of organ transplantation. This article presents the first literature review on TMA following non-renal solid organ transplantation (SOT). Ischemia-reperfusion, immunosuppressive drugs, acute interfering disease and a relative deficiency of the von Willebrand factor (vWF) cleaving protease (ADAMTS13) appear to play a major role in its pathogenesis. De novo TMA occurs in 4.0% of liver and 2.3% of lung transplant recipients, whereas the incidence remains unknown after intestinal transplantation. The median time of onset is 2, 37 and 8 weeks after liver, lung and intestinal transplantations respectively, with a three month survival of about 70%. In heart transplantation TMA is rare, occurrence is late and prognosis is poor. In TMA early after liver transplantation an elevated vWF/ADAMTS13 ratio may show diagnostic value. Early withdrawal of calcineurin inhibitors (CNI) proves to be lifesaving. Conversion to another CNI and rechallenge after resolution are generally safe, except after heart transplantation. The value of plasma exchange therapy remains controversial.
Topics: Humans; Organ Transplantation; Thrombotic Microangiopathies
PubMed: 25266355
DOI: 10.1016/j.blre.2014.09.001 -
American Journal of Transplantation :... Mar 2012To overcome severe donor shortage, Japanese doctors over the years have developed innovative strategies to maximize organs transplanted per brain death donor and... (Review)
Review
To overcome severe donor shortage, Japanese doctors over the years have developed innovative strategies to maximize organs transplanted per brain death donor and expanded the donor pool using living donors. They also used living and marginal organs and drastically improved living donor lung, liver, pancreas and kidney transplantations. Moreover, they initiated ABO blood type incompatible liver transplantation advancements and succeeded in overcoming the blood type barrier in kidney and liver transplantations. Similar efforts are underway for pancreas transplantation. Furthermore, Japanese doctors have developed a nonaggressive step to achieve immunosuppression following organ transplantation by carefully monitoring donor-specific hyporesponsiveness and infectious immunostatus. However, the institution of amendments to allocation systems and the intensification of efforts to decrease living donor morbidity and to increase the number of brain death donors have remained important issues needing attention. Overall, the strategies Japan has adopted to overcome donor shortage can provide useful insights on how to increase organ transplantations.
Topics: Humans; Japan; Organ Transplantation; Tissue Donors
PubMed: 22054061
DOI: 10.1111/j.1600-6143.2011.03822.x -
Pharmacotherapy 1987Advances in organ transplantation have come rapidly and consistently in recent years as the result of improved surgical techniques and immunosuppressive drug therapies.... (Review)
Review
Advances in organ transplantation have come rapidly and consistently in recent years as the result of improved surgical techniques and immunosuppressive drug therapies. Experience gained in renal transplantation over the past 30 years has made this a standard therapeutic approach for treating chronic renal failure. This knowledge has been successfully applied to the transplantation of other organs to produce steadily increasing survival rates and improved quality of life. This article reviews the advances that have been made in solid organ transplantation and immunosuppressive drug therapy.
Topics: Heart Transplantation; Humans; Intestines; Kidney Transplantation; Liver Transplantation; Lung Transplantation; Pancreas Transplantation; Transplantation, Homologous
PubMed: 3299295
DOI: 10.1002/j.1875-9114.1987.tb03508.x -
Transplantation Nov 2018
Topics: Colombia; Delivery of Health Care; Government Regulation; Health Policy; History, 20th Century; History, 21st Century; Humans; Medical Tourism; Organ Transplantation; Tissue Donors
PubMed: 30346371
DOI: 10.1097/TP.0000000000002409