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Clinical Oral Implants Research Jan 2010The aim of this paper is to review current investigations on functional assessments of osseointegration and assess correlations to the peri-implant structure. (Review)
Review
OBJECTIVES
The aim of this paper is to review current investigations on functional assessments of osseointegration and assess correlations to the peri-implant structure.
MATERIAL AND METHODS
The literature was electronically searched for studies of promoting dental implant osseointegration, functional assessments of implant stability, and finite element (FE) analyses in the field of implant dentistry, and any references regarding biological events during osseointegration were also cited as background information.
RESULTS
Osseointegration involves a cascade of protein and cell apposition, vascular invasion, de novo bone formation and maturation to achieve the primary and secondary dental implant stability. This process may be accelerated by alteration of the implant surface roughness, developing a biomimetric interface, or local delivery of growth-promoting factors. The current available pre-clinical and clinical biomechanical assessments demonstrated a variety of correlations to the peri-implant structural parameters, and functionally integrated peri-implant structure through FE optimization can offer strong correlation to the interfacial biomechanics.
CONCLUSIONS
The progression of osseointegration may be accelerated by alteration of the implant interface as well as growth factor applications, and functional integration of peri-implant structure may be feasible to predict the implant function during osseointegration. More research in this field is still needed.
Topics: Animals; Biomechanical Phenomena; Dental Implantation, Endosseous; Dental Implants; Finite Element Analysis; Humans; Intercellular Signaling Peptides and Proteins; Osseointegration; Surface Properties
PubMed: 20070743
DOI: 10.1111/j.1600-0501.2009.01826.x -
The International Journal of Oral &... 2014This paper presents the results of a structured review of the literature concerning in vitro molecular assessment of osseointegration at the level of cell-surface... (Review)
Review
This paper presents the results of a structured review of the literature concerning in vitro molecular assessment of osseointegration at the level of cell-surface topography interactions. A search of the electronic databases was performed up to and including November 2010, with 320 articles meeting the inclusion criteria. Characteristics of the included in vitro reports were model systems used, genes examined, techniques used for molecular assessment of the osseointegration process, and wide gene expression profiling studies. There exists a growing body of in vitro evidence to support a role for surface topography in the direct influence of cellular phenotypes as related to the process of osseointegration. Most recently, functional or mechanistic studies have provided evidence that particular topographic cues can be specifically integrated among the many extracellular signals received by the cell in its signal transduction network. Such investigations begin to define linkages between the character of the implant surface and adherent cellular responses, including cells from extravasated blood (eg, platelets) and of the immune system (eg, monocytes). In vitro studies involving cell culture on endosseous implant-related biomaterials offer important and beneficial insight into the clinical control of the implant-bone interface.
Topics: Bone and Bones; Cell Adhesion; Cell Differentiation; Cells, Cultured; Dental Implantation, Endosseous; Dental Implants; Extracellular Matrix; Gene Expression Profiling; Humans; Nanostructures; Osseointegration; Osteoclasts; Surface Properties
PubMed: 24683582
DOI: 10.11607/jomi.te55 -
The International Journal of Oral &... 2013This paper reports on the results of a structured review of the literature concerning in vivo molecular assessment of osseointegrated endosseous dental implants. A... (Review)
Review
This paper reports on the results of a structured review of the literature concerning in vivo molecular assessment of osseointegrated endosseous dental implants. A search of electronic databases was performed up to and including August 2011. Thirty articles met the inclusion criteria. A descriptive evaluation and analysis of the gene expression data concerning the process of osseointegration were performed. Broad consensus was observed among the study results, perhaps as a result of the similar targeted gene expression events. More recent investigations using gene arrays or gene profiling techniques offer new insights into the fundamental molecular events that support the osseointegration process. Evidence for the influence of surface topography on osteogenesis and osteoinduction has been reported. Additional investigations are required to further solidify the functional associations between individual or orchestrated gene expression events and the clinical result of osseointegration.
Topics: Animals; Dental Implantation, Endosseous; Dental Implants; Gene Expression; Gene Expression Profiling; Humans; Mice; Models, Animal; Osseointegration; Osteogenesis; Rabbits; Rats; Swine
PubMed: 24278948
DOI: 10.11607/jomi.te33 -
Revue de Stomatologie, de Chirurgie... Jun 2013Modeling is a group of cellular activities implicating osteoblasts in the development of various skeletal bones in the embryo and fetus. Remodeling is a complex adaptive... (Review)
Review
Modeling is a group of cellular activities implicating osteoblasts in the development of various skeletal bones in the embryo and fetus. Remodeling is a complex adaptive process involving the coordinated action of osteoblasts and osteoclasts. It occurs once the skeleton is mature. Intercellular signaling pathways involve a great number of cytokines and growth factors. However, bone modeling, occurring by direct action of osteoblasts without prior action of osteoclasts, can occur in some circumstances, especially when in contact with biomaterials such as implants and grafted materials. We reviewed the basic concepts of cell coupling and the microscopic aspects of transition from modeling to remodeling in direct contact with dental implants and biomaterials. Bone quality is greatly improved by remodeling which is associated with the deposit of lamellar bone, the biomechanical properties of which are superior to those of non-lamellar bone formed by modeling.
Topics: Animals; Biocompatible Materials; Bone Remodeling; Bone Substitutes; Humans; Osseointegration; Osteogenesis; Prostheses and Implants
PubMed: 23827269
DOI: 10.1016/j.revsto.2013.01.017 -
Zhonghua Kou Qiang Yi Xue Za Zhi =... Jan 2018Although many studies have focused on how material surface modifications can promote stem cell differentiation toward osteogenic osteoblasts, little is known about the... (Review)
Review
Although many studies have focused on how material surface modifications can promote stem cell differentiation toward osteogenic osteoblasts, little is known about the reaction between material surface and other cells, including osteoclasts and foreign body giant cells. Dental implant osseointegration results from the functional coupling and equilibrium not only between osteoblasts and osteoclasts but also between bone tissue and immune system. Osteoclasts and foreign body giant cells share the same origin, monocyte/macrophage lineage cells, which have initially got concerns in the field of implant osseointegration with regard to their peri-implant distribution and biological functions. Up-to-date data has shown that cells of monocyte/macrophage lineage origin manifest key roles in the establishment of peri-implant osseointegration and the long-term maintenance of marginal bone level and the prevalence of peri-implantitis. However, preliminary progress has been made in the subtypes, phenotypes vs. genotypes, and functions of monocyte/macrophage-lineage-originated cells on the osseointegration interface, quite a lot of facts still remain unclear, especially the potential and the rapeutic targets which could coordinate the cellular peri-implant microenvironment and the implant osseointegrated interface in the short and long term. This review will focus on the current progress in the function of monocyte/macrophage-lineage origin cells on the peri-implant osseointegration interface.
Topics: Bone and Bones; Dental Implantation, Endosseous; Dental Implants; Humans; Macrophages; Monocytes; Osseointegration; Osteoclasts; Osteogenesis; Peri-Implantitis; Research Report
PubMed: 29972968
DOI: 10.3760/cma.j.issn.1002-0098.2018.01.014 -
Journal of Dental Research Nov 2000Periodontology has broadened its scope by the research and clinical use of osseointegrated implants. Since tactile and reflex functions have been associated with...
Periodontology has broadened its scope by the research and clinical use of osseointegrated implants. Since tactile and reflex functions have been associated with periodontal ligament neural receptors, osseoperception could be associated with endosseous and/or periosteal innervation.
Topics: Alveolar Process; Animals; Biomechanical Phenomena; Dental Implantation, Endosseous; Dental Implants; Humans; Osseointegration; Touch; Trigeminal Nerve
PubMed: 11145351
DOI: 10.1177/00220345000790110301 -
Scientific Reports Jul 2021Dental implants are commonly used to repair missing teeth. The implant surface plays a critical role in promoting osseointegration and implant success. However, little... (Meta-Analysis)
Meta-Analysis
Dental implants are commonly used to repair missing teeth. The implant surface plays a critical role in promoting osseointegration and implant success. However, little information is available about which implant surface treatment technology best promotes osseointegration and implant stability. The aim of this network meta-analysis was to evaluate the osseointegration and stability of four commonly used dental implants (SLA, SLActive, TiUnite, and Osseotite). The protocol of the current meta-analysis is registered in PROSPERO (International Prospective Register of Systematic Reviews) under the code CRD42020190907 ( https://www.crd.york.ac.uk ). We conducted a systematic review following PRISMA and Cochrane Recommendations. Medline (PubMed), Cochrane Library, Embase, and the Web of Science databases were searched. Only randomized controlled trials were considered. Twelve studies were included in the current network meta-analysis, eleven studies were included concerning the osseointegration effect and five studies were included for stability analysis (four studies were used to assess both stability and osseointegration). Rank possibility shows that the SLActive surface best promoted bone formation at an early healing stage and TiUnite seemed to be the best surface for overall osseointegration. For stability, TiUnite seemed to be the best surface. The present network meta-analysis showed that the SLActive surface has the potential to promote osseointegration at an early stage. The TiUnite surface had the best effect on osseointegration regarding the overall healing period. The TiUnite surface also had the best effect in stability.
Topics: Animals; Bone Density; Bone Development; Bone and Bones; Dental Implants; Humans; Network Meta-Analysis; Osseointegration; Surface Properties; Titanium; Torque
PubMed: 34226607
DOI: 10.1038/s41598-021-93307-4 -
Periodontology 2000 2003
Review
Topics: Age Factors; Bone Density; Contraindications; Dental Care for Chronically Ill; Dental Implantation, Endosseous; Dental Implants; Humans; Osseointegration
PubMed: 12950849
DOI: 10.1046/j.0906-6713.2003.03313.x -
Orthopaedic Surgery May 2014The clinical outcome of lumbar spinal fusion is correlated with achievement of bony fusion. Improving interbody implant bone on-growth and in-growth may enhance fusion,... (Review)
Review
The clinical outcome of lumbar spinal fusion is correlated with achievement of bony fusion. Improving interbody implant bone on-growth and in-growth may enhance fusion, limiting pseudoarthrosis, stress shielding, subsidence and implant failure. Polyetheretherketone (PEEK) and titanium (Ti) are commonly selected for interbody spacer construction. Although these materials have desirable biocompatibility and mechanical properties, they require further modification to support osseointegration. Reports of extensive research on this topic are available in biomaterial-centric published reports; however, there are few clinical studies concerning surface modification of interbody spinal implants. The current article focuses on surface modifications aimed at fostering osseointegration from a clinician's point of view. Surface modification of Ti by creating rougher surfaces, modifying its surface topography (macro and nano), physical and chemical treatment and creating a porous material with high interconnectivity can improve its osseointegrative potential and bioactivity. Coating the surface with osteoconductive materials like hydroxyapatite (HA) can improve osseointegration. Because PEEK spacers are relatively inert, creating a composite by adding Ti or osteoconductive materials like HA can improve osseointegration. In addition, PEEK may be coated with Ti, effectively bio-activating the coating.
Topics: Benzophenones; Coated Materials, Biocompatible; Humans; Ketones; Osseointegration; Polyethylene Glycols; Polymers; Porosity; Prostheses and Implants; Prosthesis Design; Spinal Fusion; Surface Properties; Titanium
PubMed: 24890288
DOI: 10.1111/os.12098 -
Clinical Neurosurgery 1992
Review
Topics: Humans; Metals; Microscopy, Electron; Osseointegration; Spinal Fusion; Spine
PubMed: 1458753
DOI: No ID Found