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The Journal of Biological Chemistry Apr 1953
Topics: Acids; Enzymes; Glyoxylates; Oxidation-Reduction; Oxidoreductases
PubMed: 13061410
DOI: No ID Found -
Journal of Periodontology Nov 1969
Topics: Dental Plaque; Electrodes; Humans; In Vitro Techniques; Oxidation-Reduction; Periodontitis
PubMed: 5260618
DOI: 10.1902/jop.1969.40.11.630 -
Annual Review of Biochemistry 1964
Review
Topics: Mitochondria; Oxidation-Reduction; Research
PubMed: 14268850
DOI: 10.1146/annurev.bi.33.070164.003501 -
Biodynamica 1945
Topics: Oxidation-Reduction; Plant Pathology; Plants
PubMed: 21016935
DOI: No ID Found -
Methods in Molecular Biology (Clifton,... 1999
Topics: Electron Transport; Flavoproteins; Oxidation-Reduction; Potentiometry; Spectrophotometry
PubMed: 10494541
DOI: 10.1385/1-59259-266-X:49 -
PDM: Physicians' Drug Manual 1976pH, the symbol for "hydrogen-ion concentration", is a series of dimensionless "units" that have only general significance. The author shows that, when considered on the...
pH, the symbol for "hydrogen-ion concentration", is a series of dimensionless "units" that have only general significance. The author shows that, when considered on the basis of the relationship to oxidation-reduction, the relative significance of any pair of coordinates becomes more significant. However, the theoretical relationship as currently accepted by the Nernst equation, i.e. a shift of 59.1 milivolts for each shift of 1.0 pH, does not apply to macromolecular systems, such as in vivo. The author solved this difficulty by plotting the corrdinates graphically by bisecting pH relationships at 7.0 and oxidation-reduction relationships at Eh 0.0 milivolts, forming four quadrants. With this scheme the significance of any pair of coordinates can be readily recognized. The application of this method to biology and medicine is shown in the companion paper "pH and Eh relationships in the body".
Topics: Hydrogen-Ion Concentration; Models, Biological; Oxidation-Reduction
PubMed: 30933
DOI: No ID Found -
Pharmaceutica Acta Helvetiae Mar 1951
Topics: Oxidation-Reduction; Pharmaceutical Services; Pharmacies; Pharmacy
PubMed: 14875471
DOI: No ID Found -
Water Research Apr 2013Many pharmaceutical compounds and metabolites are found in surface and ground waters suggesting their ineffective removal by conventional wastewater treatment...
Many pharmaceutical compounds and metabolites are found in surface and ground waters suggesting their ineffective removal by conventional wastewater treatment technologies. Advanced oxidation/reduction processes (AO/RPs), which utilize free radical reactions to directly degrade chemical contaminants, are alternatives to traditional water treatment. This study reports the absolute rate constants for reaction of diclofenac sodium and model compound (2, 6-dichloraniline) with the two major AO/RP radicals: the hydroxyl radical (•OH) and hydrated electron (e(aq)(-)). The bimolecular reaction rate constants (M(-1) s(-1)) for diclofenac for •OH was (9.29 ± 0.11) × 10(9), and for e(-)(aq) was (1.53 ± 0.03) ×10(9). To provide a better understanding of the decomposition of the intermediate radicals produced by hydroxyl radical reactions, transient absorption spectra are observed from 1 - 250 μs. In addition, preliminary degradation mechanisms and major products were elucidated using (60)Co γ-irradiation and LC-MS. The toxicity of products was evaluated using luminescent bacteria. These data are required for both evaluating the potential use of AO/RPs for the destruction of these compounds and for studies of their fate and transport in surface waters where radical chemistry may be important in assessing their lifetime.
Topics: Absorption; Animals; Cattle; Diclofenac; Electrons; Gamma Rays; Halogenation; Hydroxyl Radical; Kinetics; Oxidation-Reduction; Spectrum Analysis; Toxicity Tests; Vibrio
PubMed: 23384514
DOI: 10.1016/j.watres.2013.01.016 -
Seminars in Radiation Oncology Jan 2019Since the recognition during the 20 century that cancer cells demonstrated fundamental alterations in the regulation of oxidative and glycolytic metabolism, many basic...
Since the recognition during the 20 century that cancer cells demonstrated fundamental alterations in the regulation of oxidative and glycolytic metabolism, many basic as well as translational scientists have proposed that targeting metabolic differences in cancer versus normal cells could be exploited to improve cancer therapy outcomes. With the recognition that dysregulation of mitochondrial redox metabolism leads to the increased steady-state levels of superoxide and hydrogen peroxide which could contribute to both aging and cancer; radiation biologists have pursued many avenues of targeting oxidative metabolic pathways to both selectively radiosensitive cancer cells as well as protect normal tissues during cancer therapy. Recent advances in exploiting redox metabolism for improving radiochemotherapy both from a basic and translational science point of view are the focus of the papers in this current issue of . The historical perspective underlying these areas of research as well as a unifying hypothesis for further advancing this research into clinical trials will be presented in this overview.
Topics: Antioxidants; Chemoradiotherapy; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Oxidation-Reduction; Oxidative Stress; Signal Transduction
PubMed: 30573179
DOI: 10.1016/j.semradonc.2018.10.010 -
Antioxidants & Redox Signaling 2006Over the last three decades, it is has become increasing clear that intracellular signaling pathways are activated via changes in intracellular metabolic... (Review)
Review
Over the last three decades, it is has become increasing clear that intracellular signaling pathways are activated via changes in intracellular metabolic oxidation/reduction (redox) reactions involving reactive oxygen species (ROS; i.e., superoxide and hydrogen peroxide). The initial proposals hypothesized that signaling through metabolic oxidation/reduction (redox) reactions involving ROS could contribute to carcinogenesis and progression to malignancy. Strong evidence for this hypothesis was obtained from studies showing that environmental insults (i.e., ionizing radiation) as well as xenobiotics (i.e., polycyclic aromatic hydrocarbons and phorbol esters) capable of inducing steady-state increases in free radical production and ROS could act as both initiators and promoters of carcinogenesis. This Forum is directed at understanding possible redox signaling mechanisms governing cellular radiation response, tumor growth, and response to therapy, as well as the role of nitric oxide in cancer biology.
Topics: Animals; Free Radicals; Humans; Neoplasms; Nitric Oxide; Oxidation-Reduction; Radiation, Ionizing; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Xenobiotics
PubMed: 16910772
DOI: 10.1089/ars.2006.8.1249