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La Revue Du Praticien Jan 1994
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Male; Pancytopenia; Reference Values
PubMed: 8178084
DOI: No ID Found -
Vascular and Endovascular Surgery Aug 2012It is well known that splenectomy is the standard of care in the management of clinically significant hypersplenism; however, some patients are found to be unacceptably... (Review)
Review
It is well known that splenectomy is the standard of care in the management of clinically significant hypersplenism; however, some patients are found to be unacceptably high risk to tolerate open or even laparoscopic surgery. We present a 62-year-old female with significant comorbidities who was declared a very high risk for any open surgical intervention. She underwent splenic artery embolization with remarkable improvement of her platelet count. Her postoperative course was uneventful and the patient was discharged from the hospital on the fifth hospital day.
Topics: Chronic Disease; Embolization, Therapeutic; Female; Humans; Hypersplenism; Middle Aged; Pancytopenia; Platelet Count; Radiography; Splenic Artery; Treatment Outcome
PubMed: 22786978
DOI: 10.1177/1538574412453347 -
Journal of Tropical Pediatrics Aug 2005Pancytopenia is a common occurrence in pediatric patients. Though acute leukemias and bone marrow failure syndromes are usual causes of pancytopenia, etiologies such as...
Pancytopenia is a common occurrence in pediatric patients. Though acute leukemias and bone marrow failure syndromes are usual causes of pancytopenia, etiologies such as infections and megaloblastic anemia also contribute. The aim of this study was to evaluate the clinico-hematological profile of varying degrees of childhood cytopenias with special reference to the non-malignant presentations. This is a retrospective study carried out in a tertiary care children's hospital. We retrospectively analyzed 109 pediatric patients who presented with pancytopenia for different etiologies. Acute leukemia (including ALL, AML and myelodysplastic syndrome) and aplastic anemia accounted for 21 per cent and 20 per cent cases respectively. Megaloblastic anemia was found in 31 (28.4 per cent) patients and was single most common etiological factor. Severe thrombocytopenia (platelet < or = 20 x 10(9)/l) occurred in 25.2 per cent of these patients. Various skin and mucosal bleeding occurred in 45.1 per cent of patients with megaloblastic anemia. Infections accounted for 23 (21 per cent) patients who presented with pancytopenia. Amongst infections, enteric fever occurred in 30 per cent patients. Malaria, kala-azar and bacterial infections were other causes of pancytopenia at presentation. The study focuses on identifying easily treatable causes such as megaloblastic anemia and infections presenting with pancytopenia. These conditions though look ominous but respond rapidly to effective therapy.
Topics: Acute Disease; Adolescent; Anemia; Child; Humans; India; Leukemia; Pancytopenia; Retrospective Studies
PubMed: 16014764
DOI: 10.1093/tropej/fmi010 -
Blood Apr 2015
Topics: Aged; Anti-Bacterial Agents; Fatal Outcome; Female; Humans; Macrophages; Mycobacterium avium; Pancytopenia; Tuberculosis
PubMed: 26016000
DOI: 10.1182/blood-2015-01-620195 -
Veterinary Clinical Pathology Jun 2009A 4-year-old, domestic shorthair, female spayed cat was presented for decreased appetite and depression. Severe pancytopenia with erythrocyte autoagglutination was...
A 4-year-old, domestic shorthair, female spayed cat was presented for decreased appetite and depression. Severe pancytopenia with erythrocyte autoagglutination was found. The cat was seronegative for feline immunodeficiency and leukemia viruses. Immune-mediated hemolytic anemia was suspected but no response to treatment with a blood transfusion, enrofloxacin, and prednisone was observed. Blood and bone marrow smears obtained 11 days later contained Leishmania amastigotes in the cytoplasm of neutrophils and macrophages, respectively. Serologic and PCR testing of peripheral blood confirmed infection with Leishmania infantum. Despite treatment, the cat worsened clinically and was euthanized. At necropsy, visceral dissemination of the parasite was confirmed. The findings in this case indicate that visceral leishmaniasis should be considered as a differential diagnoses in cats with pancytopenia in areas endemic for Leishmania. In addition, amastigotes may be observed in peripheral blood neutrophils.
Topics: Animals; Cat Diseases; Cats; Female; Leishmaniasis, Visceral; Pancytopenia
PubMed: 19490573
DOI: 10.1111/j.1939-165X.2009.00111.x -
BMC Psychiatry May 2018Patients with anorexia nervosa (AN) often present with pancytopenia. In most cases described in the literature, AN with pancytopenia demonstrates gelatinous marrow...
BACKGROUND
Patients with anorexia nervosa (AN) often present with pancytopenia. In most cases described in the literature, AN with pancytopenia demonstrates gelatinous marrow transformation (GMT), which is a typical bone marrow feature of malnutrition. Differentiation of AN-associated pancytopenia from other types of pancytopenia, especially idiopathic aplastic anemia (IAA), has not been studied. We encountered a case of pancytopenia in a patient with AN and relatively poor nutritional status, whose hematological findings mimicked those of IAA, specifically fatty bone marrow and absence of GMT.
CASE PRESENTATION
The patient was a 32-year-old woman with poorly controlled AN. At 31 years of age, her body mass index (BMI) had fallen from 17.0 kg/m to below 13.8 kg/m. The patient presented with ongoing fatigue and thus was examined by a hematologist. Hematological findings were consistent with IAA: peripheral blood tests revealed pancytopenia, whereas the bone marrow displayed fatty replacement without GMT. Despite the absence of bone marrow features typically seen in malnutrition, the patient's hematological abnormalities had manifested after a decrease in body weight. Thus, although the bone marrow findings indicated IAA, we considered that the nutritional etiology of pancytopenia could not be thoroughly ruled out. Using nutritional therapy alone, the hematological abnormalities improved as BMI increased to 16.5 kg/m. The final diagnosis was pancytopenia secondary to malnutrition because pancytopenia and fatty bone marrow improved after implementation of nutritional therapy alone.
CONCLUSIONS
The present case is the first documented case of AN with pancytopenia for which bone marrow examination confirmed fatty marrow without any evidence of GMT. IAA and pancytopenia secondary to malnutrition can present the same clinical findings. This case is significant because it suggests a need to differentiate between malnutrition and IAA.
Topics: Adult; Anemia, Aplastic; Anorexia Nervosa; Body Mass Index; Bone Marrow; Bone Marrow Examination; Diagnosis, Differential; Fatigue; Female; Humans; Pancytopenia
PubMed: 29801443
DOI: 10.1186/s12888-018-1743-6 -
Chest May 2022A 43-year-old woman without significant medical history was admitted with fatigue for 2 months. Before her current presentation, she had experienced several weeks of...
A 43-year-old woman without significant medical history was admitted with fatigue for 2 months. Before her current presentation, she had experienced several weeks of heavy menstrual bleeding and easy bruising. She denied night sweats, weight loss, chills, sore throat, neck swelling, rash, joint pain, cough, fever, or shortness of breath. The patient admitted a 20-year half-pack per day smoking habit that she had not been able to quit. She denied significant occupational or environmental exposures, a family history of malignancy, or current use of medications.
Topics: Adult; Cough; Diagnosis, Differential; Dyspnea; Fatigue; Female; Humans; Lymphadenopathy; Pancytopenia
PubMed: 35526899
DOI: 10.1016/j.chest.2021.12.653 -
British Journal of Haematology Apr 2022
Topics: Bone Marrow; Bone Marrow Diseases; Gelatin; Humans; Male; Pancytopenia
PubMed: 35128636
DOI: 10.1111/bjh.18007 -
Journal of the Indian Medical... Aug 2012Pancytopenia is defined by reduction of all the three formed elements of blood below the normal reference. It may be a manifestation of a wide variety of disorders,...
Pancytopenia is defined by reduction of all the three formed elements of blood below the normal reference. It may be a manifestation of a wide variety of disorders, which primarily or secondarily affect the bone marrow. Haematological investigation forms the bedrock in the management of patients with pancytopenia and therefore needs detailed study. The total number of cases studied were 100 over a period of two years in the department of pathology, JSS Hospital, Mysore. Megaloblastic anaemia (33%) was the commonest cause of pancytopenia. Other causes were nutritional anaemia (16%), aplastic anaemia (14%), hypersplenism (10%), sepsis (9%) and leukaemia (5%). Less common causes were alcoholic liver disease, haemolytic anaemia, HIV, dengue, systemic lupus erythematosus, viral hepatitis, disseminated TB and multiple myeloma. Most of the patients were in the age group of 11-30 years with a male:female ratio of 1.6:1.Generalised weakness and fatigue (88%) were the commonest presenting complaints. Haemoglobin level varied from 1-10 g/dl with majorIty (70%) of them in the range of 5.1-10 g/dI. TLC was in the range of 500-4000 cells/cmm. Most (34%) of them had 3100-4000 cells/cmm. Platelet count was in the range of 4000-1,40,000 cells/cmm. Reticulocyte count varied from 0.1%-15% with majority (82%) of them ranging from 0.1%-2%. The bone marrow cellularity was hypocellular in 14%, hypercellular in 75%, and normocellular in 11% of the patients. Pancytopenia is a relatively common entity with inadequate attention in Indian subcontinent. A comprehensive clinical and haematological study of patients with pancytopenia will usually help in the identification of the underlying cause. However in view of wide array of aetiologies, pancytopenia continues to be a diagnostic challenge for haematologists.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia, Aplastic; Anemia, Iron-Deficiency; Anemia, Megaloblastic; Bone Marrow; Bone Marrow Examination; Child; Female; Humans; Hypersplenism; India; Male; Middle Aged; Pancytopenia
PubMed: 23741821
DOI: No ID Found -
Comparative Immunology, Microbiology... 1980
Review
Topics: Animals; Antibody Formation; Blood Platelets; Cell Movement; Cytotoxicity, Immunologic; Dog Diseases; Dogs; Leukocyte Migration-Inhibitory Factors; Lymphocyte Activation; Lymphocytes; Pancytopenia
PubMed: 7009044
DOI: 10.1016/0147-9571(80)90005-3