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Nihon Rinsho. Japanese Journal of... Oct 2007
Review
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Humans; Pancytopenia; Platelet Aggregation Inhibitors; Time Factors
PubMed: 18074581
DOI: No ID Found -
European Journal of Internal Medicine Oct 2022
Topics: Autoimmune Diseases; Chronic Disease; Epstein-Barr Virus Infections; Exanthema; Humans; Pancytopenia
PubMed: 35798590
DOI: 10.1016/j.ejim.2022.06.021 -
Scandinavian Journal of Immunology Aug 2020Some patients with pancytopenia do not conform to any diagnostic criteria of known haematological or non-haematological diseases; however, they respond well to... (Review)
Review
Some patients with pancytopenia do not conform to any diagnostic criteria of known haematological or non-haematological diseases; however, they respond well to corticosteroid, high-dose intravenous immunoglobulin and rituximab treatment. This abnormality is termed immunorelated pancytopenia (IRP). Later studies indicated that IRP might be a kind of autoimmune disease in which T helper (Th) type 2 cell function is enhanced, resulting in the hyperfunction of B lymphocytes, which then produce excess autoantibodies that attack the bone marrow (BM) and cause cytopenia. Hypofunction of regulatory T (Treg) cells and enhanced Th17 cell function, an elevated percentage of plasmacytoid dendritic cells (pDCs) and a decreased percentage of natural killer (NK) cells help to promote the process. Moreover, increased expression of a synergistic stimulator of B lymphocytes, CD70 and the reactive overexpression of the BCR inhibitory coreceptor CD22 also support this claim. Candidate autoantigens targeted by autoantibodies on haematopoietic cell membranes have also been reported in IRP. This review is focused on studies that demonstrate the role of immune responses in the pathogenesis of IRP. Current diagnostic criteria and treatments for IRP are also referenced to provide a thorough understanding. Distinguishing IRP from idiopathic cytopenias of undetermined significance (ICUS) and other haematological disorders, for example myelodysplastic syndrome (MDS), aplastic anaemia (AA), paroxysmal nocturnal hemoglobinuria (PNH) and Evans syndrome, may help patients with pancytopenia benefit from proper treatment. Further studies are required to achieve new insight into the pathophysiology of IRP with regard to the immune system, which will be instrumental for the development of novel therapies for inhibiting disease initiation and/or progression.
Topics: Humans; Pancytopenia
PubMed: 32474938
DOI: 10.1111/sji.12911 -
The Lancet. Infectious Diseases Oct 2022
Topics: Exanthema; Fever; Humans; Pancytopenia
PubMed: 36152667
DOI: 10.1016/S1473-3099(22)00453-4 -
The Veterinary Record Aug 2021
Topics: Animals; Cat Diseases; Cats; Pancytopenia
PubMed: 34415584
DOI: 10.1002/vetr.843 -
Journal of Clinical Rheumatology :... Dec 2021
Topics: Arthritis, Rheumatoid; Felty Syndrome; Humans; Pancytopenia; Splenomegaly
PubMed: 32378836
DOI: 10.1097/RHU.0000000000000906 -
The Journal of the Association of... Jan 2024We found the article on "The Digital Technology in Clinical Medicine: From Calculators to ChatGPT" interesting. According to Kulkarni et al., humanity has witnesses four...
We found the article on "The Digital Technology in Clinical Medicine: From Calculators to ChatGPT" interesting. According to Kulkarni et al., humanity has witnesses four important social system changes, starting with the primitive huntersgatherers and progressing to horticultural, agricultural, industrial, and the current fifth, which is based on digital information technology and has altered the way we present, recognize, and utilize different factors of production. In clinical medicine, digital technology has advanced significantly since the days of computations. According to Kulkarni et al., we have to benefit from these advancements as we all improve the lives of our patients while being cautious not to overturn the doctor-patient relationship. If technology, clinical expertise, and humanistic values are properly balanced, Kulkarni et al. concluded that the future is quite glorious. Regulatory organizations are pushing for improvements through clinical trials as a result of recognition of the expanding influence of digital technology in healthcare delivery. The "World Health Organizations Guidelines for Digital Interventions" and the "Food and Drug Administration's Digital Health Center of Excellence" are only two of the projects that are currently being highlighted in the study as efforts to analyze and implement digital health services.
Topics: Humans; Pancytopenia; Folic Acid Deficiency; Folic Acid
PubMed: 38736088
DOI: 10.59556/japi.71.0443 -
International Journal of Laboratory... Oct 2022
Topics: Humans; Mycoses; Pancytopenia; Talaromyces
PubMed: 35244336
DOI: 10.1111/ijlh.13822 -
Indian Journal of Pathology &... Jul 2002The present study was designed to ascertain the percentage of occurrence and causes of pancytopenia. All the cases of pancytopenia from July 2001 to June 2002 (one year)... (Review)
Review
The present study was designed to ascertain the percentage of occurrence and causes of pancytopenia. All the cases of pancytopenia from July 2001 to June 2002 (one year) were examined in the Department of haematology, Safdarjung Hospital, New Delhi. Bone marrow aspirations/biopsy were performed in most of the cases (200 out of 250 cases). The commonest cause of pancytopenia, in our hospital was Megaloblastic anaemia (72%), followed by Aplastic anaemia (14%) and others.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Anemia, Megaloblastic; Bone Marrow Examination; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Pancytopenia
PubMed: 12785191
DOI: No ID Found -
Primary Care Dec 2016Cytopenias are not disease entities in and of themselves; rather, they are the expression of various underlying disease processes. Careful attention to details in... (Review)
Review
Cytopenias are not disease entities in and of themselves; rather, they are the expression of various underlying disease processes. Careful attention to details in patients' presentation, careful history and examination, as well as attention to the ancillary parameters of the complete blood count with a peripheral blood smear can point the clinician toward the appropriate workup. Causes of cytopenias can be inherited or acquired; the latter include medication related, autoimmune, or neoplastic causes. Emergencies need to be recognized in a timely fashion and expert consultation obtained.
Topics: Hematologic Tests; Humans; Leukopenia; Pancytopenia; Primary Health Care
PubMed: 27866577
DOI: 10.1016/j.pop.2016.07.005