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The American Journal of Medicine Jul 2023
Topics: Humans; Aged; Pancytopenia; Stomatitis; Methotrexate
PubMed: 36828213
DOI: 10.1016/j.amjmed.2023.01.047 -
Hematology (Amsterdam, Netherlands) Dec 2019Pancytopenia is a frequent entity in clinical practice as a feature of a myriad of conditions, ranging from benign to malignant diseases. Since the cause of pancytopenia... (Review)
Review
BACKGROUND
Pancytopenia is a frequent entity in clinical practice as a feature of a myriad of conditions, ranging from benign to malignant diseases. Since the cause of pancytopenia depends on environmental factors, it is important to know the common etiologies of pancytopenia, however, few studies address this.
OBJECTIVES
To identify the etiology of pancytopenia in our population and compare them with what is reported elsewhere.
METHODS
We conducted an observational study of patients with pancytopenia in a Mexican Tertiary Care Center. Clinical, hematological and bone marrow studies were performed in all patients.
RESULTS
Of 109 cases included, the mean age at diagnosis was 49.4 years, with a slightly higher female incidence (53.2%). The most common causes of pancytopenia were: MDS (20.2%), megaloblastic anemia (18.3%) and AML (12.8%).
DISCUSSION
We found a complex picture of pancytopenia in Mexico and compared it with what is reported elsewhere in the literature.
CONCLUSION
The sociocultural context in which the patients develop helps narrowing the possible etiology of pancytopenia, and therefore hasten the diagnostic process. Of all the studies available, bone marrow aspiration seems the most useful.
Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Female; Humans; Male; Mexico; Middle Aged; Pancytopenia; Sex Factors; Tertiary Care Centers
PubMed: 30890036
DOI: 10.1080/16078454.2019.1590961 -
Expert Review of Hematology Nov 2022Copper is increasingly being recognized as a vital mineral required by both animals and humans. It plays a vital role in many metabolic processes such as cellular... (Review)
Review
INTRODUCTION
Copper is increasingly being recognized as a vital mineral required by both animals and humans. It plays a vital role in many metabolic processes such as cellular respiration, iron oxidation, and hemoglobin synthesis. Copper deficiency, which can be hereditary or acquired, can lead to a wide spectrum of disease processes such as ringed sideroblastic anemia, myelodysplasia, and pancytopenia. Timely identification and management of copper deficiency is necessary to prevent irreversible complications.
AREAS COVERED
Our study focuses on prevalence, etiology, pathophysiology, complications, and treatment of copper deficiency.
EXPERT OPINION
Copper deficiency is frequently underrecognized as the cause of anemia, neutropenia, and bone marrow dysplasia. As it is potentially treatable, it should always be kept in the differentials when patients present with neurological and hematological abnormalities.
Topics: Animals; Humans; Pancytopenia; Copper; Anemia; Hematologic Diseases; Neutropenia; Myelodysplastic Syndromes
PubMed: 36314081
DOI: 10.1080/17474086.2022.2142113 -
Indian Journal of Medical Microbiology Jan 2021A 31 years old male presented with fever, dry cough, weight loss. Patient was found to be HIV positive and was started on empirical Anti-tubercular drugs (ATT). However,...
A 31 years old male presented with fever, dry cough, weight loss. Patient was found to be HIV positive and was started on empirical Anti-tubercular drugs (ATT). However, his symptoms persisted and he developed pancytopenia along with jaundice, and was shifted to our health care facility for further investigations. The patient has a history of travel to Bali and Thailand a few months ago. Patient was examined and relevant investigations were performed.
Topics: Adult; Diagnosis, Differential; Fever; HIV Infections; Humans; Male; Pancytopenia; Travel
PubMed: 33610248
DOI: 10.1016/j.ijmmb.2020.12.005 -
The Veterinary Record Jan 2023
Topics: Cats; Animals; Pancytopenia; Cat Diseases
PubMed: 36661151
DOI: 10.1002/vetr.2647 -
Indian Journal of Gastroenterology :... Apr 2023Pancytopenia in children with celiac disease (CeD) is postulated to be due to nutritional deficiency such as vitamin B, folate and copper or an autoimmune process...
Pancytopenia in children with celiac disease (CeD) is postulated to be due to nutritional deficiency such as vitamin B, folate and copper or an autoimmune process resulting in aplastic anemia with hypoplastic marrow. In the present case series, we report the profile and explore the etiology of pancytopenia among children with CeD. There are only a few case reports of pancytopenia in children with CeD. We enrolled newly diagnosed cases of CeD and pancytopenia presenting in the celiac disease clinic over three years. Detailed evaluation was carried out for the cause of pancytopenia. We followed up on the cases for compliance and response to gluten-free diet at three months, six months and 12 months. Twenty patients were eligible for inclusion. They were divided into two groups: one with aplastic anemia with hypoplastic marrow labeled as Gp CeD-AA and the other with megaloblastic/nutritional anemia labeled as Gp CeD-MA. Patients in Gp CeD-MA presented with classical symptoms of CeD as recurrent diarrhea, abdomen distension, pallor and poor weight gain. They had none or just one transfusion requirement and had an early and complete recovery from pancytopenia. Patients in Gp CeD-AA presented with atypical symptoms such as epistaxis, short stature, fever, pallor and weakness. They had a multiple blood transfusion requirement and had delayed and partial recovery from pancytopenia. Pancytopenia is not a disease in itself but is the presentation of an underlying disease. It can occur due to various coexisting disorders in children with CeD, which can be as simple as nutritional deficiencies to as complex as an autoimmune process or malignancy. CeD should be included in the differential diagnosis of aplastic anemia as CeD and aplastic anemia both have a similar pathological process involving T cell destruction of tissues.
Topics: Humans; Child; Pancytopenia; Anemia, Aplastic; Celiac Disease; Pallor; Anemia, Megaloblastic
PubMed: 37162701
DOI: 10.1007/s12664-022-01327-3 -
Veterinary Journal (London, England :... Apr 2019Canine monocytic ehrlichiosis (CME), caused by Ehrlichia canis, a gram-negative, obligate intracellular bacterium, is a tick-borne disease of worldwide distribution.... (Review)
Review
Canine monocytic ehrlichiosis (CME), caused by Ehrlichia canis, a gram-negative, obligate intracellular bacterium, is a tick-borne disease of worldwide distribution. Experimentally, the course of E. canis infection can be sequentially divided into acute, subclinical and chronic phases, although distinction of these phases is challenging in the clinical setting. Spontaneous clinical recovery of acutely infected dogs is common; however, dogs at this stage require medical treatment in order to hasten their clinical recovery, and to prevent clinical exacerbation or death. An unpredictable proportion of subclinically infected dogs will eventually develop the chronic, severe form of ehrlichiosis, characterized by aplastic pancytopenia and high mortality. The aims of antimicrobial treatment in CME include the achievement of clinical remission, resolution of the clinicopathologic abnormalities, and eradication of the infection, although the latter is not always feasible or diagnostically confirmable. Treatment of dogs with aplastic pancytopenia should be undertaken with the clear understanding that medical management will require long-term care, will be expensive, and may eventually prove ineffective. This manuscript reviews the current state of knowledge regarding treatment of ehrlichiosis, caused by E. canis infection in dogs, provides expert opinion guidelines for the management of the CME-associated aplastic pancytopenia, and outlines methods for evaluation of treatment outcomes.
Topics: Animals; Anti-Bacterial Agents; Dog Diseases; Dogs; Ehrlichia canis; Ehrlichiosis; Pancytopenia; Treatment Outcome
PubMed: 30902188
DOI: 10.1016/j.tvjl.2019.01.015 -
Deutsche Medizinische Wochenschrift... Jan 2022The 79-year-old patient was admitted with recurring fever, weight loss, night sweat, a decrease in physical capacity and hematomas of the extremities.
HISTORY
The 79-year-old patient was admitted with recurring fever, weight loss, night sweat, a decrease in physical capacity and hematomas of the extremities.
FINDINGS
The patient presented with pancytopenia, elevated CRP and impaired renal function. A splenomegaly was evident in abdominal sonography. A bone marrow aspiration was performed.
DIAGNOSIS
Histopathologic examination revealed a visceral Leishmaniasis. The diagnosis was confirmed by PCR from peripheral blood.
THERAPY AND COURSE
After initiation of liposomal amphotericin B haematopoiesis recovered and CRP decreased. Initially the renal function deteriorated with prolongated improvement in the course of therapy.
CONCLUSIONS
Pancytopenia and corresponding symptoms are suspect for visceral Leishmaniasis also in patients supposed to be immunocompetent with travel history of endemic regions.
Topics: Aged; Antiprotozoal Agents; Diagnosis, Differential; Fever; Humans; Leishmaniasis, Visceral; Pancytopenia; Splenomegaly
PubMed: 35100643
DOI: 10.1055/a-1685-5173 -
The Journal of the Association of... Apr 2022Pancytopenia is a common cause of hematological consultation. Common underlying causes include vitamin deficiency (vitamin B12, folic acid), drugs (hydroxyurea,... (Observational Study)
Observational Study
Pancytopenia is a common cause of hematological consultation. Common underlying causes include vitamin deficiency (vitamin B12, folic acid), drugs (hydroxyurea, phenytoin, methotrexate), and bone marrow failure syndrome. Aplastic anemia is one of the rarest hematological diseases and presents as pancytopenia. However, it is the most sinister one and is a hematological emergency that needs urgent medical attention. Absolute neutrophil count (ANC) is a measure of disease severity and is expected to be low in patients with pancytopenia of any cause. Aim & Objective: We aimed to analyze the absolute neutrophil count (ANC) level in patients presenting with pancytopenia. Material & Method: This prospective, observational study was conducted at a tertiary care hospital in northern India. We included patients with pancytopenia diagnosed at our center or reported to our center for therapy. ANC was measured before starting therapy. Observation: One hundred twenty-seven patients were included in this study. After evaluation, megaloblastic anemia was the commonest underlying cause in 42 (33%) patients followed by myelodysplastic syndrome in 31 (24.4%) patients. Twenty-three (18.1%) patients having pancytopenia were diagnosed with aplastic anemia. Other causes included leukemia, paroxysmal nocturnal hemoglobinuria and drugs. The median age was 37 years (range 18-75 years), and 67 (52.75%) were male. The mean hemoglobin was 5.5 g/dL (95% CI ±1.9). The median WBC was 2570/cmm (300-3130) and the median platelet was 36000/cmm (2000-92000). The median ANC in patients with aplastic anemia was 594/cmm (range 25- 3850). When compared, the ANC level was significantly lower in aplastic anemia than other causes of pancytopenia (p<0.001). Conclusion: On univariate and multivariate analysis ANC was significantly lower at baseline in patients of aplastic anemia. A longer follow-up of the patients will be required to assess the value of ANC in predicting response to therapy.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Anemia, Megaloblastic; Female; Humans; Male; Middle Aged; Neutrophils; Pancytopenia; Prospective Studies; Young Adult
PubMed: 35443536
DOI: No ID Found -
Blood Oct 2012
Topics: Amphotericin B; Anti-Bacterial Agents; Histoplasma; Histoplasmosis; Humans; Male; Middle Aged; Pancytopenia; Prognosis
PubMed: 23230591
DOI: 10.1182/blood-2012-03-417782