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The Canadian Veterinary Journal = La... Dec 2021A 4-year-old neutered male St. Bernard-mastiff crossbred dog showed clinical signs of lethargy and anorexia after being administered phenobarbital for the treatment of...
A 4-year-old neutered male St. Bernard-mastiff crossbred dog showed clinical signs of lethargy and anorexia after being administered phenobarbital for the treatment of idiosyncratic seizures. A complete blood (cell) count revealed pancytopenia. Auto-agglutination and Coombs tests were negative suggesting that an immunemediated cause was unlikely; therefore, an idiosyncratic reaction to phenobarbital was suspected. Supportive care and control of seizures with zonisamide was initiated and clinical signs improved. Blood values were monitored closely and returned to normal after 3 wk.
Topics: Animals; Dog Diseases; Dogs; Male; Pancytopenia; Phenobarbital; Seizures
PubMed: 34857972
DOI: No ID Found -
Pediatrics in Review Mar 2016
Review
Topics: Adolescent; Child, Preschool; Chronic Disease; Disease Management; Female; Humans; Infant; Male; Pancytopenia
PubMed: 26933225
DOI: 10.1542/pir.2014-0087 -
American Journal of Medical Genetics Jan 2000We report on a Mexican girl who developed cerebellar ataxia at age 3 years and pancytopenia at age 13 years. Cerebral computed tomography scan and magnetic resonance...
We report on a Mexican girl who developed cerebellar ataxia at age 3 years and pancytopenia at age 13 years. Cerebral computed tomography scan and magnetic resonance imaging showed evidence of severe cerebellar atrophy. Telangiectasias were not present; immunoglobulins and alpha-fetoprotein levels were normal. Cytogenetic studies showed no evidence of spontaneous chromosome aberrations, a normal rate of diepoxybutane (DEB) and mitomycin C (MMC)-induced chromosome aberrations, but an increased response to bleomycin. The phenotype support the diagnosis of ataxia-pancytopenia syndrome, although monosomy of chromosome 7 was not found in bone marrow. The cytogenetic studies suggest that this may be a chromosomal instability disorder.
Topics: Adult; Ataxia Telangiectasia; Cerebellar Ataxia; Diagnosis, Differential; Fanconi Anemia; Female; Humans; Karyotyping; Pancytopenia; Syndrome
PubMed: 10678666
DOI: 10.1002/(sici)1096-8628(20000131)90:3<252::aid-ajmg14>3.3.co;2-m -
Journal of Wildlife Diseases Oct 1970Tropical canine pancytopenia (TCP) is a newly recognized infectious disease of dogs in diverse tropical and subtropical areas. The disease is characterized by... (Review)
Review
Tropical canine pancytopenia (TCP) is a newly recognized infectious disease of dogs in diverse tropical and subtropical areas. The disease is characterized by hemorrhage, pancytopenia, severe emaciation and persistent infection. Dogs with TCP are often presented with epistaxis, which is the most dramatic sign of the disease; however, a large number of affected dogs develop severe pancytopenia and die without manifesting clinical signs of hemorrhage. The disease has been reported most frequently in the German Shepherd. Pathological findings consist of petechial and ecchymotic hemorrhages on serosal and mucosal surfaces of numerous organs. The most prominent histological finding is a perivascular plasma cell infiltrate in most organs. Disease, indistinguishable from the natural disease, has been produced in laboratory dogs inoculated with whole blood from affected dogs. Ehrlichia canis has been consistently recovered from all experimentally infected dogs. Attempts to transmit the disease to other laboratory animals and to propagate the agent in cell cultures and embryonating eggs have been unsuccessful. The tick is the probable vector of the disease.
Topics: Animals; Dog Diseases; Dogs; Ehrlichia; Ehrlichiosis; Hemorrhage; Pancytopenia; Tropical Climate
PubMed: 16512116
DOI: 10.7589/0090-3558-6.4.220 -
Medicina Clinica May 2021
Topics: Antirheumatic Agents; Humans; Methotrexate; Pancytopenia; Renal Dialysis
PubMed: 32434657
DOI: 10.1016/j.medcli.2020.01.039 -
Tropical Doctor Oct 2020Filariasis is a major public health hazard in tropical and subtropical countries and is endemic among the Indian population. Asymptomatic microfilariaemia,...
Filariasis is a major public health hazard in tropical and subtropical countries and is endemic among the Indian population. Asymptomatic microfilariaemia, elephantiasis, acute adenolymphangitis, hydrocoele and chronic lymphatic disease are its common manifestations. We hereby report a case of microfilaria found in the bone marrow presenting as pancytopenia. There was no classical feature of elephantiasis or lymphoedema present.
Topics: Adult; Animals; Bone Marrow; Female; Filariasis; Humans; Microfilariae; Pancytopenia; Wuchereria bancrofti
PubMed: 32539585
DOI: 10.1177/0049475520932011 -
BMJ Case Reports Jul 2020A 21-year-old man presented to the emergency department with generalised weakness, weight loss and decreased appetite for few weeks. He had evidence of severe...
A 21-year-old man presented to the emergency department with generalised weakness, weight loss and decreased appetite for few weeks. He had evidence of severe pancytopenia and haemolysis. His peripheral smear with many schistocytes was suspicious for thrombotic thrombocytopenic purpura (TTP). He was supported with blood transfusions and daily plasmapheresis. His platelet counts worsened despite 4 days of therapy. Bone marrow biopsy was significant for hypercellular bone marrow with megaloblastic changes. Further workup revealed normal ADAMTS13 level, low vitamin B, positive intrinsic factor antibodies and high methylmalonic acid. Diagnosis of pernicious anaemia was established and he was started on daily treatment with intramuscular vitamin B which subsequently improved his symptoms and haematological parameters. This report highlights the importance of checking vitamin B level in patients presenting with pancytopenia and TTP-like picture before making a diagnosis of TTP.
Topics: Anemia, Pernicious; Humans; Male; Pancytopenia; Purpura, Thrombotic Thrombocytopenic; Young Adult
PubMed: 32624489
DOI: 10.1136/bcr-2020-235288 -
Internal Medicine (Tokyo, Japan) 2008Only a dozen cases of pancytopenia caused by copper deficiency have been reported. We report the case of an 81-year-old man who underwent total gastrectomy for gastric... (Review)
Review
Only a dozen cases of pancytopenia caused by copper deficiency have been reported. We report the case of an 81-year-old man who underwent total gastrectomy for gastric cancer. He received total parenteral nutrition without trace element supplementation for 6 months. Serum levels of copper and ceruloplasmin were low, but serum zinc was normal. The administration of copper into TPN led to rapid improvement in anemia and neutropenia. We review 11 previous cases of copper-deficient cytopenia, categorized into two groups according to etiology, and define the characteristic symptom of copper malabsorption caused by excess Zn as peripheral neuropathy.
Topics: Aged, 80 and over; Copper; Humans; Male; Pancytopenia; Peripheral Nervous System Diseases
PubMed: 19043262
DOI: 10.2169/internalmedicine.47.1323 -
Ryoikibetsu Shokogun Shirizu 2001
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Journal of Veterinary Emergency and... Mar 2022(1) To report an unusual etiology for nontraumatic hemoabdomen in cats, and (2) to describe onset and recovery from severe, unexpected pancytopenia seen after surgical...
OBJECTIVE
(1) To report an unusual etiology for nontraumatic hemoabdomen in cats, and (2) to describe onset and recovery from severe, unexpected pancytopenia seen after surgical removal of a large intra-abdominal myelolipoma.
CASE SUMMARY
A 14-year-old neutered male domestic shorthair cat was presented for emergent treatment of suspected nontraumatic hemoabdomen. A hyperechoic mass, with ultrasonographic echogenicity similar to fat, was found in the right cranial abdomen and believed to be associated with the mesentery. Cytological examination of abdominal fluid identified marked extramedullary hematopoiesis within the hemorrhagic effusion. Exploratory laparotomy identified a hepatic mass, which was resected, and revealed to be a hepatic myelolipoma on histopathological examination. The patient's initial recovery was uneventful. However, continued hyporexia resulted in readmission 4 days postoperatively, at which time the patient was found to have a profound, tri-lineage pancytopenia, and cytological evidence indicative of bone marrow recovery. The pancytopenia resolved with continued medical management and supportive care.
NEW OR UNIQUE INFORMATION PROVIDED
Ruptured myelolipoma is not a commonly considered differential for nontraumatic hemoabdomen in cats. Furthermore, severe pancytopenia is unexpected following surgical resection of a myelolipoma. This case provides a unique clinical presentation of both nontraumatic hemoabdomen and bone marrow recovery.
Topics: Abdomen; Adrenal Gland Neoplasms; Animals; Cat Diseases; Cats; Hemoperitoneum; Male; Myelolipoma; Pancytopenia
PubMed: 34766713
DOI: 10.1111/vec.13157