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Journal of Clinical and Experimental... Dec 2022Autoimmune pancytopenia is rarely seen with Hodgkin lymphoma, and only one pediatric case of pancytopenia after autologous hematopoietic stem cell transplantation (HSCT)...
Autoimmune pancytopenia is rarely seen with Hodgkin lymphoma, and only one pediatric case of pancytopenia after autologous hematopoietic stem cell transplantation (HSCT) has been reported. We herein report a case of autoimmune pancytopenia that developed after autologous HSCT for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). A 56-year-old Japanese woman underwent autologous HSCT for NLPHL. She developed autoimmune pancytopenia seven months after autologous HSCT. In this case, PSL was effective, and the blood cell counts normalized completely. However, the patient suffered from a fatal infection, probably because of immunosuppression caused by prolonged administration of PSL, as well as a history of several chemotherapies and autologous HSCT. To our knowledge, this is the first adult case of autoimmune pancytopenia after autologous HSCT for Hodgkin lymphoma. To further validate the optimal treatment strategy for autoimmune cytopenia after autologous HSCT, more cases are necessary.
Topics: Adult; Female; Humans; Child; Middle Aged; Hodgkin Disease; Pancytopenia; Neoplasm Recurrence, Local; Hematopoietic Stem Cell Transplantation; Transplantation, Autologous
PubMed: 36261334
DOI: 10.3960/jslrt.22006 -
Transfusion and Apheresis Science :... Aug 2021Autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), and autoimmune neutropenia (AIN) are reported in the literature after liver, intestinal, heart,...
INTRODUCTION
Autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), and autoimmune neutropenia (AIN) are reported in the literature after liver, intestinal, heart, pancreas, and kidney transplants. We report a case of autoimmune pancytopenia (AIHA, AIN and ITP) 9 years after liver transplantation with confirmed erythrocyte and neutrophil auto-antibodies.
CASE REPORT
A 49 years old man was admitted to our hospital presented with dysentery and fever, with history of liver transplantation in 2008. Laboratory evaluation demonstrated hemoglobin: 7.2 g/dL, granulocytes: 0.10 × 10/L and platelets: 15 × 10/mm³; indirect bilirubin: 3.62 mg/dL; lactate dehydrogenase: 603 U/L. Direct antiglobulin test revealed a monospecific anti-IgG plus C3 and the acid eluate was reactive to all panel red cells, consistent with an AIHA. Granulocyte immunofluorescence test (GIFT) and agglutination test (GAT) were reactive for granulocytes. Test with Luminex technology for human neutrophil antigen (HNA) antibody detection was strong reactive with beads expressing HNA-1a, -1b, -1c, -2, -4a and -5a antigens. HNA genotyping revealed the presence of the corresponding antigens, confirming the autoantibodies. Test with Luminex technology for human leucocyte antigen (HLA) antibody detection was negative. Monoclonal antibody immobilization of platelet antigens (MAIPA) assay was negative. Viral causes were excluded. The condition was compatible with clinical onset of autoimmune pancytopenia. Prednisone was administered at an initial dose of 1 mg/kg/day and immunosuppressive therapy was adjusted. This treatment resulted in rapid resolution of pancytopenia.
CONCLUSION
Combined autoimmune pancytopenia (AIHA, AIN and ITP) is a rare condition that may occur after liver transplantation. Early recognition of this phenomenon permits appropriate treatment.
Topics: Autoantibodies; Autoimmune Diseases; Humans; Immunosuppression Therapy; Liver Transplantation; Male; Middle Aged; Pancytopenia; Prednisolone
PubMed: 33895070
DOI: 10.1016/j.transci.2021.103136 -
The Veterinary Record Sep 2021
Topics: Animals; Cat Diseases; Cats; Pancytopenia; Phenols
PubMed: 34505701
DOI: 10.1002/vetr.914 -
Pediatrics in Review Dec 2022
Topics: Male; Humans; Infant; Pancytopenia; Fever; Transaminases
PubMed: 36450638
DOI: 10.1542/pir.2021-004969 -
Revista Medica Del Instituto Mexicano... Sep 2023Acute myeloid leukemia (AML) is characterized by the presence of ≥ 20% myeloblasts in peripheral blood or bone marrow, as well as specific cytogenetic alterations. It...
BACKGROUND
Acute myeloid leukemia (AML) is characterized by the presence of ≥ 20% myeloblasts in peripheral blood or bone marrow, as well as specific cytogenetic alterations. It can appear as a de novo disease or be associated with other hematologic diseases, which is why the clinical presentation is heterogeneous. Pancytopenia as a manifestation of aleukemic leukemia is a rare entity. Here, we described a case of AML that presented with pancytopenia as the only manifestation in a secondary care center.
CLINICAL CASE
72-year-old man, hospitalized due to pancytopenia, with no history of hematological diseases, asymptomatic, without hepatosplenomegaly or bleeding. Flow cytometry revealed pancytopenia without blasts in peripheral blood. Secondary causes of pancytopenia as infections, splenomegaly and nutritional deficiencies where ruled out. Bone marrow aspirate showed infiltration by 45% of myeloblasts and myelodysplasia. Immunophenotype was compatible with AML. Patient was sent to the Hematology Department at Centro Médico Nacional Siglo XXI (21st Century National Medical Center) to start chemotherapy.
CONCLUSIONS
AML that is presented as pancytopenia should be considered in the evaluation of marrow failure syndrome. In the context of our hospital, morphological findings remains an essential tool for early diagnosis, since more refined studies such as immunophenotyping and cytogenetic testing are unreachable in a timely manner.
Topics: Male; Humans; Aged; Pancytopenia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
PubMed: 37769139
DOI: 10.5281/zenodo.8316475 -
La Revue de Medecine Interne 1997Leuconeutropenia is a common manifestation of acute brucellosis, whereas other hematological abnormalities and pancytopenia are uncommon. We report a patient presenting... (Review)
Review
Leuconeutropenia is a common manifestation of acute brucellosis, whereas other hematological abnormalities and pancytopenia are uncommon. We report a patient presenting with acute brucellosis and pancytopenia.
Topics: Acute Disease; Adult; Brucellosis; Female; Humans; Pancytopenia
PubMed: 9500001
DOI: 10.1016/s0248-8663(97)80117-8 -
Blood Sep 2022
Topics: Diagnosis, Differential; Humans; Leishmaniasis, Visceral; Pancytopenia
PubMed: 36048473
DOI: 10.1182/blood.2022017141 -
Kansenshogaku Zasshi. the Journal of... Mar 2013
Review
Topics: Cambodia; Fever; HIV Infections; Humans; Male; Middle Aged; Pancytopenia; Practice Guidelines as Topic; Travel
PubMed: 23940880
DOI: No ID Found -
Zhonghua Xue Ye Xue Za Zhi = Zhonghua... Feb 2001A report of a group of patients with pancytopenia which might be related to abnormal immunity.
OBJECTIVE
A report of a group of patients with pancytopenia which might be related to abnormal immunity.
METHODS
The clinical and laboratory features of 29 patients with positive bone marrow mononuclear cell (BMMNC) Coombs tests were analyzed.
RESULTS
Most of these cases were pancytopenia with normal or decreased bone marrow cellularities and increased normoblasts. They were all found to have negative results of conventional hemolysis tests and hematopoietic nutrient determination and had no evidence of malignant clonal hematopoiesis. However, all of them showed positive BMMNC-Coombs test and good response to corticosteroids.
CONCLUSION
Immunorelated pancytopenia might be caused by abnormal immunity (especially autoantibody) mediated destruction or abnormal function of blood cells. It is beneficial to differentiate immunorelated pancytopenia from aplastic anemia or myelodysplastic syndromes.
Topics: Adolescent; Adult; Bone Marrow Cells; Cells, Cultured; Child; Coombs Test; Female; Hematopoiesis; Humans; Male; Middle Aged; Pancytopenia; Young Adult
PubMed: 11877054
DOI: No ID Found -
American Journal of Therapeutics May 2023
Topics: Humans; Ciprofloxacin; Pancytopenia; Drug-Related Side Effects and Adverse Reactions; Iatrogenic Disease
PubMed: 34224427
DOI: 10.1097/MJT.0000000000001406