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The Journal of Infectious Diseases Dec 1997JC virus (JCV), the causative agent of the fatal human demyelinating disease progressive multifocal leukoencephalopathy (PML), is an opportunistic papovavirus that... (Review)
Review
JC virus (JCV), the causative agent of the fatal human demyelinating disease progressive multifocal leukoencephalopathy (PML), is an opportunistic papovavirus that infects and destroys oligodendrocytes, the myelin-producing cells of the central nervous system. Since its isolation from the brain of a PML patient, JCV has long been classed as a neurotropic virus. Many studies, however, have demonstrated that JCV can infect various other cell types, including immune system cells. Moreover, several recent studies have focused specifically on lymphocytes as a target of JCV. This review chronicles the association of JCV with lymphocytes, including cell type localization, molecular regulation, and viral sequences, and discusses clinical implications of these findings.
Topics: Antigens, Viral; Blood Cells; Bone Marrow Cells; Brain; DNA, Viral; Humans; JC Virus; Lymphocytes; Papillomavirus Infections; Tumor Virus Infections
PubMed: 9395374
DOI: 10.1086/514161 -
Lancet (London, England) Jun 1971
Topics: Acute Kidney Injury; Adult; Antibodies; Azathioprine; Chronic Disease; Complement Fixation Tests; Hemagglutination Inhibition Tests; Humans; Inclusion Bodies, Viral; Kidney Transplantation; Male; Microscopy, Electron; Papillomaviridae; Polyomaviridae; Prednisone; Pyelonephritis; Time Factors; Transplantation, Homologous; Urine
PubMed: 4104714
DOI: 10.1016/s0140-6736(71)91776-4 -
The American Journal of Medicine May 1965
Review
Topics: Adenoviridae; Antiviral Agents; Arboviruses; Avian Leukosis Virus; Biochemical Phenomena; Biochemistry; DNA; DNA, Viral; Herpesviridae; Oncogenic Viruses; Orthomyxoviridae; Poxviridae; Proteins; RNA; RNA, Viral; Reoviridae; Reproduction; Virulence; Viruses
PubMed: 14286807
DOI: 10.1016/0002-9343(65)90190-7 -
Infection and Immunity Jun 1972A new member of the papovavirus group has been isolated and appears to infect swine. The new agent, tentatively named swine papovavirus, appears to be very defective and...
A new member of the papovavirus group has been isolated and appears to infect swine. The new agent, tentatively named swine papovavirus, appears to be very defective and replicates only within a very narrow host cell range. The original source of the isolate is under investigation. Preliminary evidence suggests that the origin of swine papovavirus is either a stable pig kidney cell line or pancreas-derived trypsin
Topics: Animals; Antibodies, Viral; Cell Line; Centrifugation, Density Gradient; DNA, Viral; Dogs; Ethers; Fluorescent Antibody Technique; Humans; Kidney; Mice; Microscopy, Electron; Neutralization Tests; Nucleic Acids; Papillomaviridae; Polyomaviridae; Polyomavirus; RNA, Viral; Swine; Swine Diseases; Temperature; Vibration
PubMed: 4344097
DOI: 10.1128/iai.5.6.961-967.1972 -
Journal of Clinical Microbiology Apr 1978Simian papovavirus SA12 agglutinated human, guinea pig, and chicken erythrocytes. SA12 hemagglutinin was most effectively released from debris of infected tissue culture...
Simian papovavirus SA12 agglutinated human, guinea pig, and chicken erythrocytes. SA12 hemagglutinin was most effectively released from debris of infected tissue culture cells at an alkaline pH.
Topics: Animals; Antibody Formation; BK Virus; Cross Reactions; Haplorhini; Hemagglutination, Viral; Hydrogen-Ion Concentration; Polyomavirus; Simian virus 40
PubMed: 29051
DOI: 10.1128/jcm.7.4.396-398.1978 -
Journal of Virology Sep 1973Some of the properties of a new human papovavirus, BK, have been examined. Host range studies of BK virus (BKV) showed human cells to be more sensitive to infection than...
Some of the properties of a new human papovavirus, BK, have been examined. Host range studies of BK virus (BKV) showed human cells to be more sensitive to infection than monkey cells; human fetal brain cells appear to be highly sensitive to BKV, with the production of extensive cytopathology characterized by cytoplasmic vacuolization. The hemagglutinin of BKV is associated with the virion and is resistant to ether or heating at 56 C for 30 min. Fluorescent antibody as well as neutralization tests indicated antigenic similarities between simian virus 40 (SV40) and BKV. Cells undergoing lytic infection with BKV synthesized intranuclear T antigen(s) which reacted with SV40 T antibody demonstrable by immunofluorescence. However, BKV did not appear to induce SV40 transplantation antigens in transplantation-resistance tests. Evidence was obtained that BKV was present in humans prior to the widespread use of polio vaccines, thus ruling out the possibility that BKV is an SV40-related monkey virus, introduced into the human population by accidental contamination of poliovirus vaccines.
Topics: Animals; Antibodies, Viral; Brain; Cell Line; Cells, Cultured; Centrifugation, Density Gradient; Cross Reactions; Culture Techniques; Cytopathogenic Effect, Viral; Fluorescent Antibody Technique; Haplorhini; Hemagglutination Inhibition Tests; Hemagglutination Tests; Hemagglutinins, Viral; Histocompatibility Antigens; Hot Temperature; Humans; Kidney; Lung; Neutralization Tests; Papillomaviridae; Poliovirus Vaccine, Inactivated; Polyomaviridae; Simian virus 40; Virus Replication
PubMed: 4355860
DOI: 10.1128/JVI.12.3.625-631.1973 -
Archives of Neurology Jul 1973
Topics: Animals; Antigens, Viral; Autopsy; Brain; Cells, Cultured; Fluorescent Antibody Technique; Guinea Pigs; Hemagglutination Tests; Humans; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Male; Microscopy, Electron; Middle Aged; Papillomaviridae; Polyomaviridae; Rabbits
PubMed: 4576212
DOI: 10.1001/archneur.1973.00490250019001 -
The Canadian Veterinary Journal = La... Aug 1984Feather abnormalities and skin lesions caused by a papovavirus infection in budgerigars are described. Diseased one to 15 day old birds displayed a lack of nestling down...
Feather abnormalities and skin lesions caused by a papovavirus infection in budgerigars are described. Diseased one to 15 day old birds displayed a lack of nestling down feathers and filoplumes on the head and neck. Survivors older than 15 days exhibited retarded growth and temporary absence of feathers variable from bird to bird. Several birds between 15 and 25 days of age had flight feathers with total absence or marked sparseness of the vanes. After 25 days, feathers began to grow, although the tail and/or some flight feathers of some of the birds remained underdeveloped or absent for several weeks. Several of these affected birds were unable to fly and are called "runners"Microscopic lesions in the feather follicles of the affected birds less than 15 days of age, were characterized by focal, multifocal or diffuse ballooning degeneration in the lateral and axial plate cells of the barb ridges with the presence of large basophilic or amphophilic intranuclear inclusions in the same cells. Focal areas of ballooning degeneration with intranuclear inclusions were also found in the epidermis. Clinical observations made on these birds are compared with those reported in the literature for French molt.
PubMed: 17422435
DOI: No ID Found -
Journal of Virology Mar 1978BK virus T antigen from BKV-transformed rat and hamster cells and from productively infected monkey cells has been examined by immunoprecipitation followed by sodium...
BK virus T antigen from BKV-transformed rat and hamster cells and from productively infected monkey cells has been examined by immunoprecipitation followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Forms of the antigen that migrate as proteins of 86,000 and 92,000 daltons have been identified. Both forms can be labeled by 32P.
Topics: Animals; Antigens, Neoplasm; Antigens, Viral; BK Virus; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chromatin; Cricetinae; Molecular Weight; Peptides; Polyomavirus; Rats; Viral Proteins
PubMed: 205676
DOI: 10.1128/JVI.25.3.871-877.1978 -
Journal of Medical Virology 1981Evidence has accumulated indicating that BK virus, following an inapparent primary infection, persists in the renal organs of normal healthy individuals and reactivates...
Evidence has accumulated indicating that BK virus, following an inapparent primary infection, persists in the renal organs of normal healthy individuals and reactivates upon immunosuppression. Data to support this hypothesis are presented and suggest that BK virus DNA sequences are present at very low levels in the kidneys of more than 50% of the population and that this persistence is localized in several foci within these organs.
Topics: Aged; BK Virus; Base Sequence; DNA Restriction Enzymes; DNA, Viral; Female; Humans; Infant, Newborn; Kidney; Kidney Cortex; Kidney Medulla; Male; Middle Aged; Nucleic Acid Hybridization; Polyomavirus
PubMed: 6271922
DOI: 10.1002/jmv.1890080208