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Urologia Internationalis 1986For further cytomicrobiological analysis correct urine collection is required because, in women, there is the possibility of contaminating the urine sample at...
For further cytomicrobiological analysis correct urine collection is required because, in women, there is the possibility of contaminating the urine sample at micturition by the saprophyte flora of the vagina. In men, preputial hypertrophy and the germs growing on the prepuce, especially in the smegma, can cause false analytical results which may lead to misdiagnoses and inadequate treatment. To avoid this in women, the urine sample must be taken by urethral catheterization and in men by micturition but exposing the glans to avoid urine contamination by the balanopreputial flora.
Topics: Bacteriuria; Diagnosis, Differential; Female; Humans; Male; Penis; Specimen Handling; Urinary Catheterization; Urinary Tract Infections; Urine; Vagina
PubMed: 3727188
DOI: 10.1159/000281177 -
Virology Journal Oct 2020This study aims to screen the male human papillomavirus (HPV) infection status and genotyping in Qingcheng District, Qingyuan City, Guangdong Province, China to provide...
BACKGROUND
This study aims to screen the male human papillomavirus (HPV) infection status and genotyping in Qingcheng District, Qingyuan City, Guangdong Province, China to provide a reference basis for formulating prevention strategies for HPV infection.
METHODS
The present study collected urethral epithelium or scraped penile epidermis from high-risk male patients in Qingyuan People's Hospital during the last five years, extracted DNA fragments using the boiling method, and detected 23 types of HPV genotypes by PCR-reverse blot hybridization.
RESULTS
The positive detection rate was 54.31% of 1044 males with high risk of HPV (567/1044). Among these males, the positive detection rate of HPV was the highest in patients initially diagnosed with warts, and the rate was 66.47%. Five main HPV types are identified as follows: HPV6 18.87% (197/1044), HPV11 10.25% (107/1044), HPV52 8.81% (92/1044), HPV16 6.90% (72/1044), and HPV51 5.08% (53/1044). Among these HPV-infected patients, single infection mainly by low-risk HPV6 and HPV11 accounted for 56.61% (321/567); high- and low-risk combined HPV co-infections accounted for 29.10% (165/567). The HPV infected patients was mainly between 21 and 40 years old, and the HPV infection rate was higher with increased age.
CONCLUSIONS
The HPV infection rate in the Qingyuan area is higher than in other areas and the main infection is single infection. Furthermore, HPV52, HPV16, and HPV51 are the main high-risk infection types, while HPV6 and HPV11 are the main low-risk infection types.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; China; Coinfection; DNA, Viral; Epithelial Cells; Genotype; Humans; Male; Middle Aged; Papillomaviridae; Papillomavirus Infections; Penis; Retrospective Studies; Risk Factors; Young Adult
PubMed: 33076966
DOI: 10.1186/s12985-020-01423-w -
The Journal of Urology Nov 2020
Topics: Antibiotic Prophylaxis; Diabetes Mellitus; Humans; Infections; Male; Penile Prosthesis; Penis; United States
PubMed: 32909869
DOI: 10.1097/JU.0000000000001158.01 -
AJR. American Journal of Roentgenology Jun 2018The objective of our article is to review the role of imaging in the diagnosis of various complications of a penile prosthesis (PP). (Review)
Review
OBJECTIVE
The objective of our article is to review the role of imaging in the diagnosis of various complications of a penile prosthesis (PP).
CONCLUSION
Complications of a PP can be categorized into three groups: first, malpositioning, which includes buckling, floppy glans, erosion, migration, and crossover; second, mechanical failure, which includes fracture, aneurysm, and leakage; and, third, infection. Radiography, sonography, CT, and MRI are useful in the detection of these complications and complement each other, with MRI being the most useful imaging modality among them.
Topics: Erectile Dysfunction; Humans; Male; Multimodal Imaging; Penile Prosthesis; Penis; Postoperative Complications; Prosthesis Design; Prosthesis Implantation
PubMed: 29528712
DOI: 10.2214/AJR.17.18943 -
Pediatric Annals Mar 1989There are no absolutes regarding circumcision, and the decision to circumcise a child as a newborn or otherwise must be made after carefully weighing the alternatives... (Review)
Review
There are no absolutes regarding circumcision, and the decision to circumcise a child as a newborn or otherwise must be made after carefully weighing the alternatives to, and risks and benefits of, this common surgical procedure. These alternatives, risks, and benefits must be fully explained to parents considering circumcision, and informed consent must be obtained. In well-trained, experienced hands, circumcision is a safe procedure that effectively eliminates proven problems such as cancer of the penis, and may eliminate the problems of increased risk of urinary tract infection and sexually transmitted diseases.
Topics: Anesthesia, Local; Circumcision, Male; Humans; Infant, Newborn; Male; Nerve Block; Penis; Sexually Transmitted Diseases; Urinary Tract Infections
PubMed: 2664681
DOI: 10.3928/0090-4481-19890301-11 -
The American Journal of the Medical... Mar 2017
Topics: Adult; Anti-Bacterial Agents; Drug Resistance, Microbial; Gangrene; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Oxacillin; Penis; Pulmonary Embolism; Sepsis; Staphylococcal Infections
PubMed: 28262224
DOI: 10.1016/j.amjms.2016.05.006 -
Nature Reviews. Urology Dec 2019Penile wounds after traumatic and surgical amputation require reconstruction in the form of autologous tissue transfers. However, currently used techniques are... (Review)
Review
Penile wounds after traumatic and surgical amputation require reconstruction in the form of autologous tissue transfers. However, currently used techniques are associated with high infection rates, implant erosion and donor site morbidity. The use of tissue-engineered neocorpora provides an alternative treatment option. Contemporary tissue-engineering strategies enable the seeding of a biomaterial scaffold and subsequent implantation to construct a neocorpus. Tissue engineering of penile tissue should focus on two main strategies: first, correcting the volume deficit for structural integrity in order to enable urinary voiding in the standing position and second, achieving erectile function for sexual activity. The functional outcomes of the neocorpus can be addressed by optimizing the use of stem cells and scaffolds, or alternatively, the use of gene therapy. Current research in penile tissue engineering is largely restricted to rodent and rabbit models, but the use of larger animal models should be considered as a better representation of the anatomical and physiological function in humans. The development of a cell-seeded scaffold to achieve and maintain erection continues to be a considerable challenge in humans. However, advances in penile tissue engineering show great promise and, in combination with gene therapy and surgical techniques, have the potential to substantially improve patient outcomes.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Humans; Male; Penile Erection; Penis; Plastic Surgery Procedures; Recovery of Function; Regeneration; Tissue Engineering; Tissue Scaffolds; Urologic Surgical Procedures, Male
PubMed: 31649327
DOI: 10.1038/s41585-019-0246-7 -
The American Journal of Surgical... Dec 2023Compared with vulva, precursor lesions of human papillomavirus (HPV)-independent invasive squamous cell carcinoma (SCC) of the penis are insufficiently characterized. We...
Compared with vulva, precursor lesions of human papillomavirus (HPV)-independent invasive squamous cell carcinoma (SCC) of the penis are insufficiently characterized. We analyzed the histologic and immunohistochemical characteristics of 70 peritumoral precursor lesions and correlated them with the histology and mutational profile of the adjacent HPV-negative invasive penile SCC. Atypical basal keratinocyte proliferation with variously elongated epithelial rete with premature squamatiziation, but regular superficial cornification, termed differentiated penile intraepithelial neoplasia (d-PeIN), were identified adjacent to 42/70 (60%) SCC (36/42 keratinizing ( P <0.001); 3 papillary, and 1 each verrucous, clear cell, sarcomatoid SCC). d-PeIN were associated with chronic inflammatory dermatoses (32/42; P <0.001), p53 overexpression (26/42; P <0.001), and hotspot mutations in TP53 (32/42; P <0.001), CDKN2A (26/42; P <0.001) or both (21/42; P =0.003) in the adjacent SCC. Cytoplasmic p16 ink4a overexpression in 5/42 d-PeIN correlated with CDKN2A missense mutations in the adjacent SCC. In all, 21/70 (30%) cornified verrucous or glycogenated verruciform precursors with minimal atypia and wild-type p53 (18/21; P <0.001) occurred adjacent to verrucous or papillary SCC (17/21; P <0.001) and keratinizing (4/21) SCC, which harbored mutations in HRAS and/or PIK3CA (12/21; P <0.004). Undifferentiated p16 ink4a -negative full-thickness precursors were identified in 7/70 (10%) SCC. Four histologically different HPV-independent penile precursor lesions can be assigned to 2 major genetic/biological pathways with characteristic highly differentiated precursors requiring different clinical management decisions. These include d-PeIN in chronic inflammatory dermatoses, with p53 overexpression and TP53/CDKN2A mutations, and the p53 wild-type verrucous and verruciform precursors unassociated with dermatoses, but with mutations in oncogenes PIK3CA and HRAS .
Topics: Male; Female; Humans; Papillomavirus Infections; Tumor Suppressor Protein p53; Human Papillomavirus Viruses; Skin Neoplasms; Carcinoma in Situ; Carcinoma, Squamous Cell; Penile Neoplasms; Penis; Papillomaviridae; Class I Phosphatidylinositol 3-Kinases; Vulvar Neoplasms
PubMed: 37768009
DOI: 10.1097/PAS.0000000000002130 -
Veterinary Medicine and Science Mar 2022To describe a novel technique for partial anatomic penile amputation using a thoracoabdominal stapler in dogs and to report any associated short-term peri-operative...
OBJECTIVES
To describe a novel technique for partial anatomic penile amputation using a thoracoabdominal stapler in dogs and to report any associated short-term peri-operative complications and clinical outcomes associated with the procedure.
MATERIALS AND METHODS
Medical records from a tertiary referral hospital were reviewed for dogs undergoing penile amputation and scrotal urethrostomy between October 2007 and December 2019. Data collected included patient signalment, clinical signs on presentation, indication for penile amputation, surgical technique, duration of surgery, post-operative complications, and short-term outcome.
RESULTS
Nine dogs were included in the study. Indications for surgery were for treatment of chronic paraphimosis and priapism (n = 3), recurrent urethral prolapse (n = 2), balanoposthitis (n = 1), masses arising from the penis, prepuce, and/or urethra (n = 2), and penile trauma (n = 1). All dogs underwent a scrotal urethrostomy followed by a partial penile amputation with a thoracoabdominal stapler. All dogs suffered mild post-operative haemorrhage from the urethrostomy stoma. On recovery from general anaesthesia, 2/9 dogs were painful and another 2/9 dogs were dysphoric. Two dogs experienced incisional complications with mild swelling around the urethrostomy stoma. One dog experienced an infection of the penile amputation site 21 days after surgery. The short-term outcomes for this procedure were excellent in 8/9 dogs. These outcomes were based on owner assessment of comfort and monitoring throughout the recovery period, manual palpation of the surgical site at the time re-evaluation, and surgeon visualization of successful voluntary urination 14-35 days after surgery.
CLINICAL SIGNIFICANCE
Use of a thoracoabdominal stapler is effective in achieving partial anatomic penile amputation in dogs.
Topics: Amputation, Surgical; Animals; Dog Diseases; Dogs; Male; Penis; Postoperative Complications
PubMed: 35146966
DOI: 10.1002/vms3.723 -
Nature Communications Jun 2020Penile acquisition of HIV accounts for most infections among men globally. Nevertheless, candidate HIV interventions for men advance to clinical trials without...
Penile acquisition of HIV accounts for most infections among men globally. Nevertheless, candidate HIV interventions for men advance to clinical trials without preclinical efficacy data, due primarily to a paucity of relevant animal models of penile HIV infection. Using our recently developed macaque model, we show that a single subcutaneous administration of broadly neutralizing antibody (bNAb) 10-1074 conferred durable protection against repeated penile exposures to simian-human immunodeficiency virus (SHIV). Macaques co-administered bNAbs 10-1074 and 3BNC117, or 3BNC117 alone, also exhibited significant protection against repeated vaginal SHIV exposures. Regression modeling estimated that individual plasma bNAb concentrations of 5 μg ml correlated with ≥99.9% relative reduction in SHIV infection probability via penile (10-1074) or vaginal (10-1074 or 3BNC117) challenge routes. These results demonstrate that comparably large reductions in penile and vaginal SHIV infection risk among macaques were achieved at clinically relevant plasma bNAb concentrations and inform dose selection for the development of bNAbs as long-acting pre-exposure prophylaxis candidates for use by men and women.
Topics: AIDS Vaccines; Animals; Broadly Neutralizing Antibodies; Disease Models, Animal; Female; HIV Antibodies; HIV Infections; Half-Life; Immunization, Passive; Macaca mulatta; Male; Penis; Pre-Exposure Prophylaxis; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Vagina
PubMed: 32581216
DOI: 10.1038/s41467-020-16928-9