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Journal of Virology May 1989Parvovirus H-1 has been shown to suppress spontaneous and chemically or virally induced tumorigenesis in hamsters. In human cell culture systems propagation of H-1 is...
Parvovirus H-1 has been shown to suppress spontaneous and chemically or virally induced tumorigenesis in hamsters. In human cell culture systems propagation of H-1 is restricted to transformed cells, which are killed by H-1 infection, in contrast to normal diploid cells, which are nonpermissive for H-1. By analyzing the permissiveness of a variety of human cells for H-1, it was determined that the majority of tested transformed or immortalized cells which were permissive for H-1 contained the DNA of oncogenic viruses (human papillomavirus, simian virus 40, adenovirus, hepatitis B virus, Epstein-Barr virus, and human T-cell lymphotropic virus type I). Of six transformed cell lines negative for persisting tumor virus DNA, only two were permissive for H-1, while two were semipermissive and two were nonpermissive. Thus, persistence and expression of tumor virus functions appears to promote full permissiveness for H-1 in human cells. However, neither expression of genes of specific viral genomes nor the transformed state of apparently virus-free cells alone was sufficient to render human cells permissive for H-1. Therefore, the effect of tumor virus functions on H-1 in transformed cells seems to be indirect, probably mediated by cellular factors which are induced or switched off during the transformation process. It appears that similar factors are induced or switched off by 5-azacytidine or calcium phosphate, both known inducers of cellular gene expression.
Topics: Animals; Calcium; Cell Line; Cell Transformation, Viral; DNA, Viral; Haplorhini; Humans; Neoplasms; Parvoviridae; RNA, Viral; Tumor Virus Infections; Virus Replication
PubMed: 2495371
DOI: 10.1128/JVI.63.5.2152-2158.1989 -
AIDS Education and Prevention :... Apr 2002Adolescents in psychiatric care are at increased risk of HIV, yet little is known about the family factors related to sexual risk taking among these youth. We explored...
Holding the line with a watchful eye: the impact of perceived parental permissiveness and parental monitoring on risky sexual behavior among adolescents in psychiatric care.
Adolescents in psychiatric care are at increased risk of HIV, yet little is known about the family factors related to sexual risk taking among these youth. We explored whether perceived parental monitoring and perceived parental permissiveness were linked to high-risk sexual behavior in 169 ethnically diverse urban youth seeking mental health services in Chicago, and we tested whether adolescent gender moderated these associations. We evaluated sexual risk taking at a global level and for specific risk behaviors (e.g., sex without a condom, sex while using drugs and alcohol). Girls reported more risky sex overall than boys, and girls were more likely than boys to report having sex without a condom. At low levels of parental permissiveness, rates of risky sex among boys and girls' did not differ, but at high levels of permissiveness girls reported more sexual risk taking than boys, and girls were more likely than boys to report having sex while using drugs and alcohol and having sex without a condom. Findings highlight the complexity of adolescent sexual behavior and the need for multilevel assessment of risk taking. Results suggest that parental monitoring and permissiveness are more strongly associated with sexual risk taking in troubled girls than troubled boys, and they underscore a need for gender-sensitive, family-focused HIV-prevention programs.
Topics: Adolescent; Adolescent Behavior; Adult; Chicago; Child; Female; HIV Infections; Humans; Longitudinal Studies; Male; Mentally Ill Persons; Parenting; Permissiveness; Psychiatric Department, Hospital; Risk Factors; Risk-Taking; Safe Sex; Sex Factors; Surveys and Questionnaires; Urban Population
PubMed: 12000232
DOI: 10.1521/aeap.14.2.138.23899 -
Journal of Sex & Marital Therapy 1995A new four-item version of the widely used Reiss Premarital Sexual Permissiveness (PSP) Scale is described and analyzed. The purpose of our research was to see if this...
A new four-item version of the widely used Reiss Premarital Sexual Permissiveness (PSP) Scale is described and analyzed. The purpose of our research was to see if this much quicker to answer format will equal the high scaling attributes of the earlier and longer versions. Samples of students from the United States (N = 217) and Sweden (N = 186) were administered the short form. The analysis and data are presented and compared with the results of the original, longer versions of the scale. Results indicated that the four-item version met all Guttman scale requirements. Comparisons among scales indicated that criteria measurement scores were higher for the four-item version than they were for Reiss's earlier versions. The ways in which the new scale may be used are discussed, including the possible use of only one or two items from this new format as a quick and accurate attitudinal assessment of premarital sexual permissiveness.
Topics: Adolescent; Adult; Attitude; Courtship; Culture; Female; Humans; Love; Permissiveness; Psychometrics; Sexual Behavior; Sweden; United States
PubMed: 7643425
DOI: 10.1080/00926239508404387 -
The Australian and New Zealand Journal... Mar 1978
Topics: Australia; Authoritarianism; History, 20th Century; New Zealand; Permissiveness; Psychiatry; Societies, Medical; Therapeutic Community
PubMed: 354630
DOI: 10.3109/00048677809159581 -
American Family Physician Sep 1975
Topics: Abortion, Spontaneous; Adolescent; Attitude; Contraception; Female; Humans; Illegitimacy; Male; Marriage; Permissiveness; Pregnancy; Psychology, Adolescent; Self Concept; Sex; Sex Education; Sexual Dysfunction, Physiological; Sexual Maturation; Sexually Transmitted Diseases
PubMed: 1174286
DOI: No ID Found -
Journal of the American College Health... Dec 1979
Comparative Study
Topics: Adolescent; Adult; Black or African American; Attitude; Black People; Cross-Cultural Comparison; Cultural Characteristics; Culture; Humans; Nigeria; Permissiveness; Sexual Behavior; United States
PubMed: 264042
DOI: 10.1080/01644300.1979.10392924 -
Frontiers in Psychology 2021Religiosity and sexuality present numerous interconnections. Little is known regarding the specific causal pathways between each religiosity dimension and sexual...
Religiosity and sexuality present numerous interconnections. Little is known regarding the specific causal pathways between each religiosity dimension and sexual behavior. The objectives of this study were (1) to explore the relationship between religiosity (measured through attendance at religious services, salience, and prayer) and sexual initiation in adolescents and (2) to establish the role of sexual permissiveness as mediator of the impact produced by religiosity in sexual initiation. This study analyzes data from an ongoing school-based international study examining what young people feel and think about relationships, love, and sexuality. An anonymous, self-administered online questionnaire was developed in Spanish. A total of 4,366 students, aged 14-18, completed the questionnaire. A final sample of 2,919 questionnaires was analyzed. Two unconditional logistic regression models were fit with religiosity variables and possible confounders as independent variables (with and without permissiveness, respectively). The dependent variable was sexual initiation. A final path analysis was performed to further understand the results. Our study highlights that, in predominantly Catholic and Spanish-speaking countries, the fact of attending church and praying may greatly contribute to postponing sexual relations during adolescence, even independently of their attitudes on sexual permissiveness. Conversely, the effect of salience on sexual initiation seems to be fostered only through the mediation of sexual permissiveness. Our findings point to an indirect effect of the three religiosity dimensions (and in particular, religious salience) through permissive attitudes. Religiosity could be a relevant factor to explain sexual initiation during adolescence.
PubMed: 34858256
DOI: 10.3389/fpsyg.2021.715032 -
Scientific Reports May 2022Monocyte-derived macrophages (MDM) are highly permissive to HIV-1 infection potentially due to the downregulation of innate factors during the differentiation process....
Monocyte-derived macrophages (MDM) are highly permissive to HIV-1 infection potentially due to the downregulation of innate factors during the differentiation process. The environmental milieu and innate anti-viral factors which are modulated during macrophage differentiation, have been associated with their increased permissiveness to HIV-1 infection. Here, we demonstrate that the Army Liposome Formulation containing MPLA, and QS-21 (ALFQ) activated MDM that are normally permissive to HIV-1 infection to generate a proinflammatory environment and upregulated anti-viral factors notably APOBEC3A. Induction of APOBEC3A by ALFQ decreased permissiveness to HIV-1 infection, while knockdown of APOBEC3A with APOBEC3AsiRNA resulted in a significant loss in the restriction of HIV-1 infectivity. The liposome formulation ALF55, with identical lipid composition but lacking QS-21 had no effect. Furthermore, the capacity of ALFQ to modulate MDM permissiveness to HIV-1 infection was predominantly mediated by large ALFQ liposomes. Our findings highlight a relationship between innate immune activation, proinflammatory milieu, and upregulation of anti-HIV proteins. Induction of these responses can switch the HIV-1 permissive MDM into a more refractory phenotype.
Topics: Cytidine Deaminase; HIV Infections; HIV-1; Humans; Liposomes; Macrophages; Proteins; Saponins; Virus Replication
PubMed: 35534646
DOI: 10.1038/s41598-022-11230-8 -
Annals of the New York Academy of... Nov 1994Protection against stress by glucocorticoids is discussed in relation to their permissive and suppressive actions. Evidence from the last decade is summarized regarding... (Review)
Review
Protection against stress by glucocorticoids is discussed in relation to their permissive and suppressive actions. Evidence from the last decade is summarized regarding the physiological nature of the suppressive actions, and the hypothesis that they prevent stress-activated defense mechanisms from overshooting and damaging the organism. Support for this hypothesis has come from observations on how endogenous or administered glucocorticoids control inflammatory and immune responses, protect in endotoxic and hemorrhagic shock, regulate central nervous system responses to stimuli, and moderate many defense reactions through suppression of cytokines and other mediators. Studies showing that glucocorticoids permissively induce receptors for several mediators that they suppress have led to a model in which stimulated activity of a mediator system is increased permissively through induction of mediator receptors and decreased through suppression of mediator production.
Topics: Animals; Anti-Inflammatory Agents; Brain; Cytokines; Glucocorticoids; Homeostasis; Humans; Immunosuppressive Agents; Models, Biological; Shock; Steroids; Stress, Physiological
PubMed: 7825870
DOI: 10.1111/j.1749-6632.1994.tb39221.x -
Journal of Abnormal Psychology Nov 1957
Topics: Galvanic Skin Response; Humans; Permissiveness; Psychotherapy; Reflex; Skin Physiological Phenomena
PubMed: 13474904
DOI: 10.1037/h0048306