-
Medical Oncology (Northwood, London,... Dec 2011We present a case of 49-year-old woman who presented with a three month history of progressive right-sided breast pain and swelling and was found with bulky tumor at her...
We present a case of 49-year-old woman who presented with a three month history of progressive right-sided breast pain and swelling and was found with bulky tumor at her initial presentation. She was diagnosed with phyllodes tumor of her breast and treated initially with neoadjuvant chemotherapy and mastectomy. We discuss recent advances in diagnosis and management of breast phyllodes tumors.
Topics: Breast Neoplasms; Doxorubicin; Female; Humans; Middle Aged; Phyllodes Tumor
PubMed: 20890734
DOI: 10.1007/s12032-010-9695-9 -
Surgical Oncology Jul 2003Cystosarcoma phyllodes constitutes only 0.3-0.9% of all breast tumors. The term "sarcoma" was initially used because of its fleshy appearance, a more modern term is... (Review)
Review
Cystosarcoma phyllodes constitutes only 0.3-0.9% of all breast tumors. The term "sarcoma" was initially used because of its fleshy appearance, a more modern term is Phyllodes tumor (PT). The behavior of PT constitutes a spectrum from benign and locally recurrent to malignant and metastatic. In a general surgical series, 6.2% of the tumors were malignant. The microscopic appearance of PT is that of epithelial elements and connective tissue stroma. Malignancy is determined by characteristics of the stroma. The metastatic spread of malignant PT is mainly hematogenous to lung, with infrequent lymphatic involvement. Wide local excision with 2 cm margins is the treatment of choice. In 20% of both benign and malignant cases, PT will locally recur. There is no proven benefit of radiation or chemotherapy, although radiotherapy may be useful in selected cases. We present a case of a sarcomatous overgrowth in a malignant phyllodes tumor involving multiple histologic types.
Topics: Aged; Aged, 80 and over; Breast Neoplasms; Female; Humans; Phyllodes Tumor; Treatment Outcome
PubMed: 12689668
DOI: 10.1016/s0960-7404(03)00005-7 -
International Journal of Surgical... Sep 2021Phyllodes tumors (PTs) represent a spectrum of rare, fibroepithelial neoplasms of the breast, which can be subcategorized as benign, borderline, or malignant based on...
Phyllodes tumors (PTs) represent a spectrum of rare, fibroepithelial neoplasms of the breast, which can be subcategorized as benign, borderline, or malignant based on their histological appearance. Accessory breast tissue may present anywhere along the embryological mammary ridge, and at distant locations as aberrant breast tissue. We present the case of a 56-year-old lady with an umbilical mass, thought to represent a strangulated hernia. Sections showed a fibroepithelial tumor with leaf-like ducts, conspicuous mitotic activity (up to 8 per 10 high-power fields), and focal infiltration into fat. Immunohistochemical studies showed diffuse positivity of epithelial cells for estrogen receptor, mammaglobin, GCDFP-15, and CK7. These findings were consistent with a borderline PT. This is the first case report of PT presenting as an umbilical mass, and the first extramammary borderline PT described.
Topics: Breast Neoplasms; Choristoma; Female; Humans; Middle Aged; Phyllodes Tumor; Umbilicus
PubMed: 33345669
DOI: 10.1177/1066896920981632 -
Phyllodes tumor with extensive intraductal spread radiologically mimicking ductal carcinoma in situ.The Breast Journal Feb 2020
Topics: Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Mastectomy, Segmental; Middle Aged; Phyllodes Tumor; Ultrasonography, Mammary
PubMed: 31538381
DOI: 10.1111/tbj.13545 -
Onkologie Feb 2007To distinguish between a benign and malignant phyllodes tumor before surgery is difficult. Wide excision or mastectomy with adequate free margins is necessary in the... (Review)
Review
BACKGROUND
To distinguish between a benign and malignant phyllodes tumor before surgery is difficult. Wide excision or mastectomy with adequate free margins is necessary in the case of a malignant phyllodes tumor. However, repairing the skin defect after removal of a giant malignant phyllodes tumor is a great challenge for the breast surgeon.
CASE REPORT
We report the case of a 45-year-old Taiwanese woman with a giant malignant phyllodes tumor measuring 30 x 25 x 22 cm. Prior to surgery, we carefully designed a flap to cover the skin defect, following standard mastectomy with at least 2 cm free margins. Postoperatively, the patient recovered well without any wound infection or flap necrosis. During follow-up at our outpatient department, there was no evidence of local relapse or distant metastasis.
CONCLUSION
Giant malignant phyllodes tumors can be treated by total mastectomy with adequate free margins, using a flap technique to cover the skin defect.
Topics: Breast Neoplasms; Diagnosis, Differential; Female; Humans; Mastectomy, Simple; Middle Aged; Phyllodes Tumor; Surgical Flaps; Treatment Outcome
PubMed: 17264525
DOI: 10.1159/000098219 -
Colombia Medica (Cali, Colombia) Sep 2015Breast Phyllodes tumors are rare breast tumors present in less than 1% of new cases of breast cancer, usually occurring among middle-aged women (40-50 yrs).
INTRODUCTION
Breast Phyllodes tumors are rare breast tumors present in less than 1% of new cases of breast cancer, usually occurring among middle-aged women (40-50 yrs).
OBJECTIVE
This study shows diagnostic experience, surgical management and follows up of patients with this disease during a period of ten years in a oncology referral center.
METHODS
Retrospectively, breast cancer registries at the institution were reviewed, identifying 77 patients with Phyllodes tumors between 2002 and 2012, who had been operated on at the Instituto de Cancerología - Clínica Las Américas, in Medellín (Colombia). Clinical and histopathological data belonging to these cases was captured and analyzed and descriptive statistics were used.
RESULTS
The follow up median was 22.5 months (IQR: 10.5-60.0), average age was 47.2 yrs (SD: 12.4), mean tumor size was 3.6 cm (SD: 4.6), 88.3% of the patients (68 cases) presented negative margins and none of them received adjuvant chemotherapy. Of the patients with Phyllodes tumors; 33.8% had benign, 31.2% had borderline and 35.0% had malignant tumor. Disease-free survival was 85.8% and overall survival was 94.5%.
DISCUSSION
Reported data in this article is in accordance with what has been reported in worldwide literature. In our cohort even the high mean size of the tumors, the risk of local relapse and metastatic disease is low than previously reported in literature. Trials with longer follow up and molecular trials in Phyllodes tumors are necessary to understand the behavior of these tumors in Hispanics population.
Topics: Adult; Breast Neoplasms; Colombia; Disease-Free Survival; Female; Follow-Up Studies; Humans; Middle Aged; Phyllodes Tumor; Retrospective Studies; Survival Rate
PubMed: 26600624
DOI: No ID Found -
The Gulf Journal of Oncology May 2018Phyllodes tumor is a rare fibroepithelial neoplasm of the breast and constitutes 0.3-0.5% of all breast tumors. They are usually benign and only few of them undergo...
Phyllodes tumor is a rare fibroepithelial neoplasm of the breast and constitutes 0.3-0.5% of all breast tumors. They are usually benign and only few of them undergo malignant transformation. Benign or borderline phyllodes tumor typically never recur however, malignant phyllodes tumors do have a recurrence and a metastatic potential. Differentiating these two groups is of prime importance for proper management of the patient. We report a rare case of Malignant Phyllodes tumor in an 18 year old female. She presented with a left breast lump which was gradually increasing in size. There was no significant past or family history. Physical examination revealed a 10x10 cm mass which involved the entire left breast. There was no axillary or supraclavicular lymphadenopathy. On fine needle aspiration cytology, a diagnosis suggestive of an atypical cytology (C3) was given and patient was advised to undergo urgent biopsy and on histopathological examination a possibility of malignant phyllodes tumor was rendered. Following this, lumpectomy was performed and a diagnosis of Malignant Phyllodes tumor was confirmed. Within two months of surgery patient had a recurrence of a huge breast lump with overlying skin ulcerations and underwent a left simple mastectomy. Patient is currently under follow up period and free of disease. A definitive preoperative diagnosis is of utmost importance in correct surgical management of the patient and in order to avoid local recurrences.
Topics: Adolescent; Breast Neoplasms; Female; Humans; Mastectomy; Phyllodes Tumor; Prognosis
PubMed: 30145554
DOI: No ID Found -
Nihon Hinyokika Gakkai Zasshi. the... Jan 2002Prostatic phyllodes tumor is an unusual lesion for which there are only occasional reports in the literature. We encountered a phyllodes tumor of the prostate in a... (Review)
Review
Prostatic phyllodes tumor is an unusual lesion for which there are only occasional reports in the literature. We encountered a phyllodes tumor of the prostate in a 36-year-old man who had complained of urinary frequency and dysuria for one month. In October 1998, he visited our hospital and had a transurethral resection of the prostate (TUR-P) for obstructive symptoms. He experienced recurrent same symptoms in September 1999 and underwent another TUR-P. The pathologic examination at this time revealed phyllodes tumor. In the tumor, despite its regular alternating growth of ducts and stroma, the stromal element appeared histologically malignant, showing marked atypia and rhabdomyosarcoma-like components. Consequently, in December 1999, the patient underwent radical prostatectomy with lymph node dissection. The resection margins and pelvic lymph nodes were free of tumor. The patient remains alive and well after 14 months.
Topics: Adult; Humans; Male; Phyllodes Tumor; Prostatectomy; Prostatic Neoplasms
PubMed: 11842541
DOI: 10.5980/jpnjurol1989.93.52 -
Seminars in Ultrasound, CT, and MR Feb 2018This report describes the clinical presentation, imaging findings, and treatment options of a case of metastatic malignant phyllodes.
This report describes the clinical presentation, imaging findings, and treatment options of a case of metastatic malignant phyllodes.
Topics: Breast; Breast Neoplasms; Female; Humans; Mammography; Middle Aged; Palliative Care; Phyllodes Tumor; Ultrasonography, Mammary
PubMed: 29317034
DOI: 10.1053/j.sult.2017.05.011 -
Cirugia Y Cirujanos 2008Phyllodes tumors occur with a frequency of 0.3- 0.9% and are rare in young women. Their clinical presentation is unilateral and behavior and management are unclear. We... (Review)
Review
BACKGROUND
Phyllodes tumors occur with a frequency of 0.3- 0.9% and are rare in young women. Their clinical presentation is unilateral and behavior and management are unclear. We present a phyllodes tumor in an 11-year-old female and we reviewed the literature regarding this pathology.
CASE REPORT
We present the case of an 11-year-old female with a diagnosis of phyllodes tumor. Her disease began 4 months previously. We made an incision biopsy followed by simple mastectomy. Histological report demonstrated benign phyllodes tumor. The patient is currently disease free after 1 year.
CONCLUSIONS
Small phyllodes tumors can be excised with a 1-cm surgical border, whereas larger phyllodes tumors are treated with simple mastectomy. Precise pathological evaluation is necessary to plan a better surgical approach and to determine recurrence possibility.
Topics: Breast Neoplasms; Child; Female; Humans; Mastectomy; Phyllodes Tumor
PubMed: 18492439
DOI: No ID Found