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The Breast Journal Nov 2018We aimed to evaluate the efficacy of vacuum assisted percutaneous excision in the treatment of benign phyllodes tumors of the breast. From 2007 to 2016, a total of 160...
We aimed to evaluate the efficacy of vacuum assisted percutaneous excision in the treatment of benign phyllodes tumors of the breast. From 2007 to 2016, a total of 160 benign fibroepithelial nodules were percutaneously removed in our department. Ultrasonographic follow-up was performed 12 months after the procedure to assess recurrence. Out of the 160 nodules excised, 11 lesions corresponded to benign phyllodes tumors. The median patient age was 39.7 years. The average size of the lesion was 16.9 mm. Ultrasound-guided biopsy was performed before the percutaneous removal in eight of them. Six were histopathologically diagnosed as fibroadenomas, one as phyllodes tumor and in one case histological findings were inconclusive. The mean surveillance period was 27.7 months. During the follow-up period, local recurrence was detected in one patient (9%). We conclude that percutaneous excision of benign phyllodes tumors is not associated with greater risk of recurrence than surgery.
Topics: Adult; Breast Neoplasms; Female; Humans; Middle Aged; Phyllodes Tumor; Ultrasonography, Interventional; Ultrasonography, Mammary
PubMed: 30251456
DOI: 10.1111/tbj.13122 -
The Breast Journal Dec 2020
Topics: Breast; Breast Neoplasms; Female; Humans; Phyllodes Tumor; Plastic Surgery Procedures
PubMed: 33108821
DOI: 10.1111/tbj.14095 -
Annals of Surgical Oncology Oct 2023Phyllodes tumors are rare breast neoplasms with limited prospective data to guide treatment, leading to heterogeneous management of this disease. We developed National... (Review)
Review
PURPOSE
Phyllodes tumors are rare breast neoplasms with limited prospective data to guide treatment, leading to heterogeneous management of this disease. We developed National consensus statements using modified Delphi methodology including patients and practitioners across Canada.
METHODS
Statements were developed based on a literature review. Two iterations of surveys were distributed with a planned virtual consensus meeting. Panelists were invited from surgery, radiation oncology, medical oncology, pathology, radiology, and plastic surgery.
RESULTS
Twenty-three participants attended the virtual conference. One hundred statements regarding diagnostics, pathology, surgical planning, adjuvant therapies, recurrence, surveillance, and patient support were approved with an a priori defined consensus of ≥ 80%. Two tables on locoregional management were developed and approved. The management of borderline phyllodes tumors was a source of uncertainty, and recommendations reflect the lack of evidence in this rare presentation.
CONCLUSION
A consensus document containing all approved statements for the care and management of phyllodes tumors was developed to help guide practice and future research.
Topics: Humans; Female; Phyllodes Tumor; Prospective Studies; Canada; Combined Modality Therapy; Breast Neoplasms
PubMed: 37556009
DOI: 10.1245/s10434-023-13912-7 -
The Australian and New Zealand Journal... Apr 1988Cystosarcoma phyllodes afflicting 106 female patients in a multiracial Asian society is reviewed and some interesting variations are noted when compared with Western... (Comparative Study)
Comparative Study
Cystosarcoma phyllodes afflicting 106 female patients in a multiracial Asian society is reviewed and some interesting variations are noted when compared with Western patients. The incidence of phyllodes tumour is 3.83% of surgically removed breast tumours compared with 0.5-2.5% in Western series. This lends weight to the belief that non-Caucasians are more prone to this enigmatic breast disease than the Caucasian population. The profile of the Asian phyllodes patient is that of a young female, aged 25-30 years, whereas her Western counterpart is in her 40s. As a result, she is liable to be mistaken clinically as having fibro-adenoma. The disease is notably rare among the females below 20 years of age but in the Asian context, as much as one-quarter-one-third may be in the adolescent group. There were only three malignant and six borderline phyllodes tumours out of 106 cases, and this incidence is far below that of many other studies in which the malignant cases are believed to constitute 23-27%. However, this may not be a racial variation but explicable by the fact that the present study is an unselected cohort from a general surgical unit. The presence of associated benign breast disease in 25.5% cases helps to reinforce the widely held belief that fibro-adenoma and phyllodes tumour are related to some degree.
Topics: Adult; Age Factors; Asia; Asian People; Breast Neoplasms; Female; Humans; Phyllodes Tumor; White People
PubMed: 2855393
DOI: No ID Found -
Medicine Aug 2018Phyllodes tumor or cystosarcoma phyllodes is a rare fibroepithelial neoplasm which arises from the periductal stroma of the breast. They are classified as benign,...
Phyllodes tumor or cystosarcoma phyllodes is a rare fibroepithelial neoplasm which arises from the periductal stroma of the breast. They are classified as benign, borderline, and malignant based on the histologic features. However, all phyllodes tumor (PT) subtypes are regarded as having malignant potential and correct diagnosis is important for surgical management and optimal care. This study is a retrospective review of 76 women diagnosed as PT with highlights on the imaging characteristics, pathology, and surgical treatment over a 7-year period in a tertiary medical center of urban population in Malaysia. There were 45 benign, 16 borderline, and 15 malignant PT. The median age for benign PT was 43, borderline 48.5, and malignant 42 years. The Malay ethnic group constitute 52.6% of cases, with 27.6% and 18.4% in Chinese and Indian ethnic groups, respectively. On mammograms, most benign (64.3%) and 33.3% of malignant PT showed high-density lesions. Calcifications were only seen in 2 benign PT. On ultrasound, 86% of benign PT was well-circumscribed whilst 50.0% of malignant PT had irregular outline. Cystic spaces were seen in 40.0% of malignant and 9.5% of benign PT. 80% of malignant PT lesions were heterogenous. Malignant PT demonstrates tumor heterogeneity, cystic spaces, and posterior acoustic enhancement on ultrasound. Half of malignant PT showed regular borders on ultrasound and appear well circumscribed on mammogram. A total of 46 patients had wide local excision or excision biopsy whilst 30 underwent mastectomy as primary treatment. The majority of the borderline and malignant PTs in our study (75.0% and 85.7% respectively) and only 5 out of the 43 (11.6%) benign PT underwent mastectomy. There were 2 tumor recurrence in the benign PT group and 1 case in the borderline and malignant group respectively.
Topics: Adult; Asian People; Breast Neoplasms; Female; Humans; Malaysia; Mammography; Middle Aged; Phyllodes Tumor; Retrospective Studies; Treatment Outcome
PubMed: 30075507
DOI: 10.1097/MD.0000000000011412 -
Zhonghua Zhong Liu Za Zhi [Chinese... May 2022
Topics: Breast; Breast Neoplasms; Female; Humans; Phyllodes Tumor
PubMed: 35615805
DOI: 10.3760/cma.j.cn112152-20220118-00044 -
Neoplasma 2014Expression patterns of proteins involved in serine and glycine metabolism, and correlations of these patterns with clinicopathologic factors in phyllodes tumor were...
UNLABELLED
Expression patterns of proteins involved in serine and glycine metabolism, and correlations of these patterns with clinicopathologic factors in phyllodes tumor were investigated. Tissue microarrays were prepared from 203 phyllodes tumors (PT) and stained with antibodies specific for glycine decarboxylase (GLDC), phosphoserine aminotransferase 1 (PSAT1), phosphoserine phosphatase (PSPH), phosphoglycerate dehydrogenase (PHGDH), and serine hydroxymethyltransferase 1 (SHMT1). These immunohistochemical results and clinicopathologic parameters were analyzed for correlation. Numbers of benign, borderline, and malignant tumors were 155, 32, and 16, respectively. Stromal expression of PHGDH, PSAT1, PSPH, SHMT1, and GLDC increased with increasing tumor grade, and epithelial expression of SHMT1 also increased with increasing tumor grade (p<0.001, and p=0.005, respectively). On univariate analysis, positive stainings for stromal PHGDH (p<0.001), stromal PSAT1 (p<0.001), stromal PSPH (p=0.003), epithelial SHMT1 (p=0.001), stromal SHMT1 (p=0.022), and stromal GLDC (p<0.001) were each associated with shorter disease-free survival. Stromal GLDC was associated with shorter overall survival (p<0.001). In conclusion, expression of proteins related to serine and glycine metabolism increased with increasing histologic grade in stromal components of phyllodes tumor.
KEYWORDS
glycine, tumor grade, metabolism, phyllodes tumor, serine.
Topics: Adult; Breast Neoplasms; Female; Glycine; Humans; Middle Aged; Phyllodes Tumor; Serine
PubMed: 25030440
DOI: 10.4149/neo_2014_069 -
Journal of Cancer Research and... 2023Phyllodes tumors are rare biphasic fibroepithelial lesions of the breast and account for 0.3%-0.5% of primary breast tumors. Malignant phyllodes tumor has a 10%-26% risk...
Phyllodes tumors are rare biphasic fibroepithelial lesions of the breast and account for 0.3%-0.5% of primary breast tumors. Malignant phyllodes tumor has a 10%-26% risk of distant metastasis. The most common site of metastasis is lungs followed by bone and soft tissue. This is a rare case of a 42-year-old female with a previous history of malignant phyllodes tumor breast. She presented after 10 years with metastases to multiple sites including lung, abdominal wall, retroperitoneum, bone, and brain. These tumors have a poor overall survival. Accurate diagnosis and aggressive management of malignant phyllodes tumors can help in effective treatment at diagnosis and for close follow-up of the patients.
Topics: Female; Humans; Adult; Phyllodes Tumor; Breast; Treatment Outcome; Lung Neoplasms; Breast Neoplasms
PubMed: 37787325
DOI: 10.4103/jcrt.jcrt_715_21 -
Annals of Surgical Oncology Oct 2023
Topics: Humans; Female; Consensus; Breast; Phyllodes Tumor; Breast Neoplasms
PubMed: 37580616
DOI: 10.1245/s10434-023-14147-2 -
Journal of Pediatric and Adolescent... Jun 2009Phyllodes tumor of the breast is a rare neoplasm, particularly in adolescent girls and young women. It is usually presented as a unilateral palpable mass. We are...
Phyllodes tumor of the breast is a rare neoplasm, particularly in adolescent girls and young women. It is usually presented as a unilateral palpable mass. We are reporting the case of an 11-year-old adolescent girl who came to our Diagnostical Imaging Department with non-hematic nipple discharge. Ultrasound, mammography, and magnetic resonance imaging were performed. The histological examination showed a phyllodes tumor. The management and the biological behavior of this uncommon tumor are discussed with particular regard to the very unusual clinical presentation in this patient.
Topics: Breast Neoplasms; Child; Female; Humans; Magnetic Resonance Imaging; Mammography; Phyllodes Tumor; Ultrasonography, Mammary
PubMed: 19539191
DOI: 10.1016/j.jpag.2007.11.006