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Journal of Biomedical Materials... Mar 2018In order to improve surface hydrophilicity, blood compatibility and cell-antiadhesion of polypropylene (PP) film, polypropylene oxide (PPO)-polyethylene oxide-PPO used...
In order to improve surface hydrophilicity, blood compatibility and cell-antiadhesion of polypropylene (PP) film, polypropylene oxide (PPO)-polyethylene oxide-PPO used as macromolecular surface modifier through physical blending. Surface properties of blended PP/Pluronic F127 (PF127) samples were investigated by attenuated total reflection infrared spectroscopy and water contact angle measurements. Results demonstrated that PF127 migrated to the surface. Thus, mechanical properties of blended PP/PF127 samples with the aim of the revealing the effects of the presence of modifier in the bulk were investigated through differential scanning calorimetry, X-ray diffraction, and tensile tests. The biocompatibility and hemocompatibility of modified PP films were evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, platelet-rich plasma, and hemolysis tests. These results showed excellent anticell and antiplatelet adhesion which deems the prepared blended films proper biomaterials. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 652-662, 2018.
Topics: Calorimetry, Differential Scanning; Cell Adhesion; Cell Survival; Elastic Modulus; Hemolysis; Humans; Hydrophobic and Hydrophilic Interactions; Materials Testing; Mesenchymal Stem Cells; Platelet Adhesiveness; Poloxamer; Polypropylenes; Spectroscopy, Fourier Transform Infrared; Surface Properties; Temperature; Tensile Strength; Water; X-Ray Diffraction
PubMed: 29027360
DOI: 10.1002/jbm.a.36269 -
Langmuir : the ACS Journal of Surfaces... Jan 2017To overcome the thrombogenic reactions of hydrocarbon-based biomaterials in clinical blood treatment, we introduce a model study of surface zwitterionization of a...
To overcome the thrombogenic reactions of hydrocarbon-based biomaterials in clinical blood treatment, we introduce a model study of surface zwitterionization of a polypropylene (PP) substrate using a set of well-defined copolymers for controlling the adhesion of blood cells in vitro. Random and block copolymers containing zwitterionic units of 2-methacryloyloxyethyl phosphorylcholine (MPC), [3-(methacryloylamino)propyl]dimethyl(3-sulfopropyl)ammonium hydroxide inner salt (SBAA), or nonionic units of 2-hydroxyethyl methacrylate (HEMA) with a controlled hydrophobic segment of 70% n-butyl methacrylate (BMA) units in these polymers were synthesized through reversible addition-fragmentation chain transfer polymerization. A systematic study of how zwitterionic and nonionic copolymer architectures associated with controlled chain orientation via hydration processes affect blood compatibility is reported. The surface wettability of PP substrates coated with the block copolymer with poly(MPC) (PMPC) segments was higher than that of the random copolymer poly(MPC-random-BMA). However, only the random copolymers with SBAA units demonstrate a higher surface wettability. The PP substrate coated with nonionic copolymers containing HEMA units showed relatively lower hydration capability associated with higher protein adsorption, platelet adhesion, and leukocyte attachment than those with zwitterionic copolymers. The random copolymer poly(SBAA-random-BMA) coated on the PP substrates exhibited resistance to cell adhesion in human whole blood at a level comparable to that of MPC copolymers. An ideal zwitterionic PP substrate could be obtained by coating it with a block copolymer composed of PMPC and poly(BMA) (PBMA) segments, PMPC-block-PBMA. The water contact angle decreased dramatically from approximately 100° on the original PP substrate to 11° within 30 s. The number of blood cells attached on PMPC-block-PBMA decreased significantly to less than 2.5% of that on original PP. These results prove that the rational design of zwitterionic polymers incorporated with a hydrophobic anchoring portion provides a promising approach to reduce blood cell adhesion and protein adsorption of hydrocarbon-based biomaterials applied in direct contact with human whole blood.
Topics: Biocompatible Materials; Cell Adhesion; Humans; Materials Testing; Methacrylates; Phosphorylcholine; Polymers; Polypropylenes
PubMed: 27802598
DOI: 10.1021/acs.langmuir.6b03295 -
Waste Management (New York, N.Y.) May 2018The prior properties of recycled polypropylene depend on the origin of waste deposits and its chemical constituents. To obtain specific properties with a predefine melt...
The prior properties of recycled polypropylene depend on the origin of waste deposits and its chemical constituents. To obtain specific properties with a predefine melt flow index of polypropylene, the suppliers of polymer introduce additives and fillers. However, the addition of additives and/or fillers can modify strongly the mechanical behaviour of recycled polypropylene. To understand the impact of the additives and fillers on the quasi-static mechanical behaviour, we consider, in this study, three different recycled polypropylenes with three different melt flow index obtained from different waste deposits. The chemical constituents of the additives and filler contents of the recycled polypropylenes are determined through thermo-physico-chemical analysis. Tensile and bending tests performed at different strain rates allow identifying the mechanical properties such as the elastic modulus, the yield stress, the maximum stress, and the failure mechanisms. The results obtained are compared with non-recycled polypropylene and with few researches to explain the combined effect of additives. Finally, a post-mortem analysis of the samples was carried out to make the link between the obtained mechanical properties and microstructure.
Topics: Polymers; Polypropylenes; Recycling
PubMed: 29463419
DOI: 10.1016/j.wasman.2018.02.006 -
Artificial Cells, Nanomedicine, and... Feb 2017Surface modification of medical polymers is carried out to improve biocompatibility. In this study, conventional polymers (chitosan and polypropylene) were modified to...
Surface modification of medical polymers is carried out to improve biocompatibility. In this study, conventional polymers (chitosan and polypropylene) were modified to laser at different features (oriented and non-oriented) to create a vast range of physicochemical characteristics on the surface of polymers and investigate their effects on biocompatibility of treated surfaces. Atomic force microscope (AFM) was applied to study the morphology of treated samples in comparison with those of the untreated PS. Contact angle analyses were used to evaluate the wettability and surface energy of the treated films. AFM studies showed that after laser treatment, some distinctive nanostructures are created on the surface of polymers. The data from contact angle measurements demonstrated that laser irradiation created surfaces with a vast range of properties in the wettability point of view. The cellular results revealed that after surface modification by laser irradiation, biocompatibility of polymeric films, especially oriented films was enhanced.
Topics: Cell Line; Chitosan; Humans; Lasers; Materials Testing; Polypropylenes; Surface Properties
PubMed: 26836973
DOI: 10.3109/21691401.2016.1138485 -
ACS Applied Materials & Interfaces Jun 2014Polypropylene is one of the most widely used commercial commodity polymers; among many other applications, it is used for electronic and structural applications. Despite...
Polypropylene is one of the most widely used commercial commodity polymers; among many other applications, it is used for electronic and structural applications. Despite its commercial importance, the hydrophobic nature of polypropylene limits its successful application in some fields, in particular for the preparation of polymer nanocomposites. Here, a facile, plasma-assisted, biomimetic, environmentally friendly method was developed to enhance the interfacial interactions in polymer nanocomposites by modifying the surface of polypropylene. Plasma treated polypropylene was surface-modified with polydopamine (PDA) in an aqueous medium without employing other chemicals. The surface modification strategy used here was based on the easy self-polymerization and strong adhesion characteristics of dopamine (DA) under ambient laboratory conditions. The changes in surface characteristics of polypropylene were investigated using FTIR, TGA, and Raman spectroscopy. Subsequently, the surface modified polypropylene was used as the matrix to prepare SiO2-reinforced polymer nanocomposites. These nanocomposites demonstrated superior properties compared to nanocomposites prepared using pristine polypropylene. This simple, environmentally friendly, green method of modifying polypropylene indicated that polydopamine-functionalized polypropylene is a promising material for various high-performance applications.
Topics: Biomimetics; Hydrophobic and Hydrophilic Interactions; Indoles; Nanocomposites; Polymers; Polypropylenes; Silicon Dioxide; Spectrum Analysis, Raman; Surface Properties; Water
PubMed: 24841134
DOI: 10.1021/am501726d -
Journal of the American Chemical Society Jun 2020Phage display biopanning with Illumina next-generation sequencing (NGS) is applied to reveal insights into peptide-based adhesion domains for polypropylene (PP). One...
Phage display biopanning with Illumina next-generation sequencing (NGS) is applied to reveal insights into peptide-based adhesion domains for polypropylene (PP). One biopanning round followed by NGS selects robust PP-binding peptides that are not evident by Sanger sequencing. NGS provides a significant statistical base that enables motif analysis, statistics on positional residue depletion/enrichment, and data analysis to suppress false-positive sequences from amplification bias. The selected sequences are employed as water-based primers for PP-metal adhesion to condition PP surfaces and increase adhesive strength by 100% relative to nonprimed PP.
Topics: High-Throughput Screening Assays; Materials Science; Polypropylenes; Surface Properties
PubMed: 32460497
DOI: 10.1021/jacs.0c03482 -
American Journal of Hospital Pharmacy Nov 1993The stability of octreotide acetate in polypropylene syringes was studied. Polypropylene syringes were aseptically filled with 1 mL of octreotide acetate 0.2 mg/mL and... (Comparative Study)
Comparative Study
The stability of octreotide acetate in polypropylene syringes was studied. Polypropylene syringes were aseptically filled with 1 mL of octreotide acetate 0.2 mg/mL and stored at 3 or 23 degrees C under light protection or light exposure. Three syringes were prepared for each condition and each sampling time. Unopened 5-mL glass vials of the drug served as controls. Samples were removed immediately and at 8, 15, 22, and 29 days and analyzed by high-performance liquid chromatography. At 3 degrees C, octreotide stored in light-protected syringes maintained more than 90% of its initial concentration for up to 29 days. However, at 22 days the concentration in the syringes stored at that temperature and exposed to light was less than 90% when the standard deviation is considered. At 23 degrees C, the drug was stable for only up to 15 days (light protection) and 22 days (light exposure) when the standard deviation is considered. Octreotide acetate in polypropylene syringes was stable for up to 29 days when stored at 3 degrees C and protected from light and for up to 22 days when stored at 23 degrees C and exposed to light.
Topics: Chemistry, Pharmaceutical; Drug Stability; Drug Storage; Humans; Octreotide; Polypropylenes; Syringes
PubMed: 8266962
DOI: No ID Found -
ACS Applied Materials & Interfaces Aug 2014Hemocompatibility and oxidative stress are significant for blood-contacting devices. In this study, N-isopropylacrylamide (NIPAAm) and N-(3-aminopropyl)methacrylamide...
Hemocompatibility and oxidative stress are significant for blood-contacting devices. In this study, N-isopropylacrylamide (NIPAAm) and N-(3-aminopropyl)methacrylamide hydrochloride (APMA) were cografted on polypropylene (PP) membrane using ultraviolet grafting to load antioxidative d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and control the release of TPGS. The immobilization of NIPAAm and APMA onto PP membrane was confirmed by attenuated total reflectance Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy. Combined with data from platelet adhesion, red blood cell (RBC) attachment, and hemolysis rate, the hemocompatibility of PP was significantly improved. An in-depth characterization using hemolysis rate test, scanning electron microscopy, atomic force microscopy, and confocal laser scanning microscopy was conducted to confirm that the mechanism of the release of TPGS interacted with RBCs was different at different stages. The release of TPGS from the loading PP membranes affected hemolysis at different stages. At the early stage of release, TPGS maintained the tiny (nanometer-sized) tubers on the membrane surface and enhanced the membrane permeabilization by generating nanosized pores on the cell membranes. Afterward, the incorporated TPGS slowed the lipid peroxidation of erythrocytes and filled in the lipid bilayer of erythrocyte to prevent hemolysis. Thus, the approach implemented to graft NIPAAm and APMA and load TPGS was suitable to develop medical device with excellent hemocompatibility and antioxidative property.
Topics: Erythrocytes; Hemolysis; Humans; Lipid Peroxidation; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Polyethylene Glycols; Polypropylenes; Vitamin E
PubMed: 25051204
DOI: 10.1021/am503332z -
American Journal of Hospital Pharmacy Nov 1993The stability of bupivacaine hydrochloride injection 1.25 mg/mL in 0.9% sodium chloride injection in polypropylene syringes was studied. Plastic syringes containing...
The stability of bupivacaine hydrochloride injection 1.25 mg/mL in 0.9% sodium chloride injection in polypropylene syringes was studied. Plastic syringes containing bupivacaine hydrochloride 1.25 mg/mL in 0.9% sodium chloride injection or 0.9% sodium chloride injection alone were stored at 3 or 25 degrees C. A glass vial containing the admixture was stored at 25 degrees C as a control. For each condition, triplicate samples were observed immediately and 5, 11, 15, and 32 days after preparation for precipitation and color change and analyzed for pH and for drug concentration by high-performance liquid chromatography. No change in bupivacaine concentration was observed during the 32-day study period, nor was there any change in color or pH nor any development of precipitation. Bupivacaine hydrochloride 1.25 mg/mL in 0.9% sodium chloride injection in polypropylene syringes was stable for up to 32 days when stored at 3 or 23 degrees C.
Topics: Bupivacaine; Drug Stability; Drug Storage; Humans; Polypropylenes; Syringes; Temperature
PubMed: 8266964
DOI: No ID Found -
The British Journal of Surgery Oct 2000
Topics: Cutaneous Fistula; Herniorrhaphy; Humans; Intestinal Fistula; Polypropylenes; Surgical Mesh; Time Factors
PubMed: 11044175
DOI: 10.1046/j.1365-2168.2000.0870101436.x