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Journal of Thoracic Imaging May 2018Simultaneous acquisition positron emission tomography-magnetic resonance imaging (PET-MRI) has the ability to combine anatomic information derived from cardiac MRI with... (Review)
Review
Simultaneous acquisition positron emission tomography-magnetic resonance imaging (PET-MRI) has the ability to combine anatomic information derived from cardiac MRI with quantitative capabilities of cardiac PET and MRI and the promise of molecular imaging by specific PET tracers. This combination of cardiac PET and MRI delivers a robust and comprehensive clinical examination. It has the potential to assess various cardiovascular conditions, including assessment of myocardial ischemia, infarction, and function, as well as specific characterization of inflammatory and infiltrative heart diseases such as cardiac sarcoid and amyloid. It also offers fascinating possibilities in imaging other cardiovascular-related disease states, such as tumor imaging and vascular imaging. In this review, we begin with a general overview of the potentials of PET-MRI in cardiovascular imaging, followed by a discussion of the technical challenges unique to cardiovascular PET-MRI. We then discuss PET-MRI in various cardiovascular disease imaging applications. Potential limitations of PET-MRI and future directions are also considered.
Topics: Cardiovascular Diseases; Heart; Humans; Magnetic Resonance Imaging; Multimodal Imaging; Positron-Emission Tomography
PubMed: 29489584
DOI: 10.1097/RTI.0000000000000327 -
International Journal of Cardiology Jan 2023
Topics: Humans; Tomography, X-Ray Computed; Positron-Emission Tomography; Heart; Risk Assessment; Positron Emission Tomography Computed Tomography
PubMed: 36179906
DOI: 10.1016/j.ijcard.2022.09.057 -
Molecular Pharmaceutics Nov 2014
Topics: Animals; Antibodies, Monoclonal; Drug Delivery Systems; Humans; Ligands; Nanoparticles; Neoplasms; Peptides; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 25364861
DOI: 10.1021/mp5005383 -
Zeitschrift Fur Medizinische Physik Feb 2023PET/CT imaging plays an increasing role in radiotherapy treatment planning. The aim of this article was to identify the major use cases and technical as well as medical... (Review)
Review
PET/CT imaging plays an increasing role in radiotherapy treatment planning. The aim of this article was to identify the major use cases and technical as well as medical physics challenges during integration of these data into treatment planning. Dedicated aspects, such as (i) PET/CT-based radiotherapy simulation, (ii) PET-based target volume delineation, (iii) functional avoidance to optimized organ-at-risk sparing and (iv) functionally adapted individualized radiotherapy are discussed in this article. Furthermore, medical physics aspects to be taken into account are summarized and presented in form of check-lists.
Topics: Positron Emission Tomography Computed Tomography; Radiotherapy Planning, Computer-Assisted; Tomography, X-Ray Computed; Positron-Emission Tomography; Physics
PubMed: 36272949
DOI: 10.1016/j.zemedi.2022.09.001 -
Internal Medicine Journal Jan 2010Abstract Positron emission tomography (PET) using fluorine-18-2-fluoro-2-deoxy-D-glucose (FDG) has made a major impact in clinical oncology in diagnosing, staging and... (Review)
Review
Abstract Positron emission tomography (PET) using fluorine-18-2-fluoro-2-deoxy-D-glucose (FDG) has made a major impact in clinical oncology in diagnosing, staging and restaging malignancy as well as in monitoring therapy response. Over the past decade, there has been an enormous growth in the scientific and clinical evidence supporting PET including recent important contribution from the Australian PET Data Collection Project. Since 2001, hybrid PET-computed tomography has also largely replaced PET alone systems with significant improvement in diagnostic accuracy. This review is a brief update on the current status of FDG-PET focusing on its oncologic applications.
Topics: Forecasting; Glucose-6-Phosphate; Humans; Neoplasm Staging; Neoplasms; Positron-Emission Tomography
PubMed: 20561362
DOI: 10.1111/j.1445-5994.2009.02072.x -
Stroke Dec 2022
Topics: Humans; Heuristics; Positron-Emission Tomography; Cognition; Perfusion; Alzheimer Disease
PubMed: 36337057
DOI: 10.1161/STROKEAHA.122.041406 -
Clinical Autonomic Research : Official... Dec 2022
Topics: Humans; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 36083420
DOI: 10.1007/s10286-022-00893-y -
Radiologic Clinics of North America Jan 2009Positron emission tomography (PET) and combined PET/CT provide powerful metabolic and anatomical information together in a single exam. This article reviews the... (Review)
Review
Positron emission tomography (PET) and combined PET/CT provide powerful metabolic and anatomical information together in a single exam. This article reviews the fundamentals of PET physics, the state of the art and future directions in PET technology, and the current clinical applications of PET. The latter is quite diverse and includes oncology, cardiology, neurology, and infection and inflammation imaging, all with FDG as the tracer. Additionally, novel radiopharmeuticals are under development, many of which are target cellular processes that are more specific than glucose metabolism.
Topics: Contrast Media; Equipment Design; Fluorodeoxyglucose F18; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, X-Ray Computed
PubMed: 19195540
DOI: 10.1016/j.rcl.2008.10.005 -
Science Translational Medicine Mar 2017The first total-body positron emission tomography (TB-PET) scanner represents a radical change for experimental medicine and diagnostic health care. (Review)
Review
The first total-body positron emission tomography (TB-PET) scanner represents a radical change for experimental medicine and diagnostic health care.
Topics: Biomedical Research; Delivery of Health Care; Humans; Positron-Emission Tomography; Whole Body Imaging
PubMed: 28298419
DOI: 10.1126/scitranslmed.aaf6169 -
Annual Review of Biomedical Engineering 2015Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The... (Review)
Review
Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges.
Topics: Algorithms; Animals; Biomedical Engineering; Biophysical Phenomena; Humans; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Multimodal Imaging; Positron-Emission Tomography; Scattering, Radiation; Tomography, X-Ray Computed
PubMed: 26643024
DOI: 10.1146/annurev-bioeng-071114-040723