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Journal of the American Veterinary... Nov 2023To assess the value of 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) for imaging the tarsus and proximal metatarsus and compare it with CT and...
OBJECTIVE
To assess the value of 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) for imaging the tarsus and proximal metatarsus and compare it with CT and lameness evaluation.
ANIMALS
25 horses with lameness localized to the tarsal and proximal metatarsal regions that underwent 18F-NaF PET/CT between 2016 and 2021.
METHODS
18F-NaF PET and CT images were retrospectively independently evaluated by 3 observers. Standardized uptake values (SUV) were used to characterize 18F-NaF uptake. Correlation between PET and CT findings with subjective and objective maximum (Max-D) and minimum pelvic height lameness data was estimated.
RESULTS
The inter-observer Kappa-weighted value (κ) was higher for PET (κ = 0.66) than CT (κ = 0.6). CT and PET scores were fairly correlated (R = 0.49; P < 0.05). PET SUVratio (SUV of the main lesion/SUV talus) had the highest correlation with Max-D (R = 0.71; P < .05). PET and CT scores for the plantar region were significantly higher in Quarter Horses (P < .05) and showed consistently higher correlation with objective lameness data (CT plantar grade - Max-D [R = 0.6; P < .05], PET plantar grade - Max-D [R = 0.47; P = .04]) than other regions of the distal tarsal joints. Three Warmbloods presented marked uptake at the medial cochlea of the distal tibia.
CLINICAL RELEVANCE
PET had a moderate correlation with CT for assessment of tarsal lesions. The degree of PET uptake can help differentiate active versus inactive lesions. Specific location of the uptake is important in determining clinical relevance.
Topics: Animals; Horses; Sodium Fluoride; Positron Emission Tomography Computed Tomography; Lameness, Animal; Retrospective Studies; Positron-Emission Tomography; Tomography, X-Ray Computed; Horse Diseases
PubMed: 37562781
DOI: 10.2460/javma.23.03.0164 -
La Revue de Medecine Interne Dec 2006Fluorodeoxyglucose positron emission tomography (FDG-PET) is a promising imaging technique that has already proven effective in modifying patient care in oncology.... (Review)
Review
PURPOSE
Fluorodeoxyglucose positron emission tomography (FDG-PET) is a promising imaging technique that has already proven effective in modifying patient care in oncology. Fluorodeoxyglucose still remains the main radiopharmaceutical agent routinely used for PET imaging. A growing interest has recently lead to broaden PET research on benign disorders. The field of inflammatory or immune diseases and globally the field of internal medicine could also be impacted by FDG-PET.
MAIN POINTS
Great vessels vasculitides and fever of unknown origin have both been studied by several teams and could become indications for PET. In addition, current indications now extend to paraneoplastic syndromes. It is thus possible to foresee that the clinical applications for PET will continue to expand in these patients.
PERSPECTIVES AND PROJECTS
In the future, inflammatory arthritis, chronic inflammatory bowel diseases, systemic erythematous lupus, histiocytosis, or pulmonary and retroperitoneal fibrosis might benefit from PET even if, available data remains scarce to this day. Although PET will probably alter the landscape of patient management in internal medicine in the near future, additional clinical research is still needed to ascertain the exact role of PET.
Topics: Fever of Unknown Origin; Fluorodeoxyglucose F18; Forecasting; Humans; Internal Medicine; Positron-Emission Tomography; Radiopharmaceuticals; Vasculitis
PubMed: 16870308
DOI: 10.1016/j.revmed.2006.06.012 -
European Heart Journal. Cardiovascular... Nov 2022
Topics: Humans; Fluorodeoxyglucose F18; Kounis Syndrome; Positron-Emission Tomography; Radiopharmaceuticals; Coronary Artery Disease; Inflammation; Computers; Positron Emission Tomography Computed Tomography
PubMed: 36047460
DOI: 10.1093/ehjci/jeac182 -
Anticancer Research May 2020To evaluate the utility of high spatial resolution digital positron emission tomography images with the source-to-background ratio (SBR) algorithm for gross tumour...
BACKGROUND/AIM
To evaluate the utility of high spatial resolution digital positron emission tomography images with the source-to-background ratio (SBR) algorithm for gross tumour volume (GTV) delineation.
MATERIALS AND METHODS
The bowl and spheres (10-37 mm) were filled with fluoro-2-deoxy-D-glucose to achieve 4-16 times background radioactivity. The images were reconstructed using three isotropic voxel sizes. The SBR and percentage threshold (TH) to SUV were calculated. The plots between SBR and TH were fitted using a regression equation. The contoured volumes (CVs) of the spheres were calculated by applying TH.
RESULTS
TH was 38.6+75.0/SBR for 4 mm voxel size; 39.6+37.0/SBR for 2 mm; and 38.8+35.2/SBR for 1 mm. The mean relative errors between CV and true volume for 4, 2, and 1 mm voxel sizes were 15%, 7%, and 7%, respectively.
CONCLUSION
The present technique is useful for GTV delineation with reduced contouring error.
Topics: Algorithms; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Neoplasms; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiotherapy Planning, Computer-Assisted
PubMed: 32366401
DOI: 10.21873/anticanres.14227 -
Equine Veterinary Journal May 2019
Topics: Animals; Horse Diseases; Horses; Positron-Emission Tomography
PubMed: 30950558
DOI: 10.1111/evj.13077 -
Journal of Labelled Compounds &... Jul 2023
Topics: Central Nervous System; Positron-Emission Tomography; Magnetic Resonance Imaging
PubMed: 37475588
DOI: 10.1002/jlcr.4047 -
Physics in Medicine and Biology May 2015The simultaneous acquisition of PET and MRI data shows promise to provide powerful capabilities to study disease processes in human subjects, guide the development of...
The simultaneous acquisition of PET and MRI data shows promise to provide powerful capabilities to study disease processes in human subjects, guide the development of novel treatments, and monitor therapy response and disease progression. A brain-size PET detector ring insert for an MRI system is being developed that, if successful, can be inserted into any existing MRI system to enable simultaneous PET and MRI images of the brain to be acquired without mutual interference. The PET insert uses electro-optical coupling to relay all the signals from the PET detectors out of the MRI system using analog modulated lasers coupled to fiber optics. Because the fibers use light instead of electrical signals, the PET detector can be electrically decoupled from the MRI making it partially transmissive to the RF field of the MRI. The SiPM devices and low power lasers were powered using non-magnetic MRI compatible batteries. Also, the number of laser-fiber channels in the system was reduced using techniques adapted from the field of compressed sensing. Using the fact that incoming PET data is sparse in time and space, electronic circuits implementing constant weight codes uniquely encode the detector signals in order to reduce the number of electro-optical readout channels by 8-fold. Two out of a total of sixteen electro-optical detector modules have been built and tested with the entire RF-shielded detector gantry for the PET ring insert. The two detectors have been tested outside and inside of a 3T MRI system to study mutual interference effects and simultaneous performance with MRI. Preliminary results show that the PET insert is feasible for high resolution simultaneous PET/MRI imaging for applications in the brain.
Topics: Magnetic Resonance Imaging; Multimodal Imaging; Positron-Emission Tomography
PubMed: 25856511
DOI: 10.1088/0031-9155/60/9/3459 -
Theranostics Dec 2013Positron Emission Tomography (PET) experienced accelerated development and has become an established method for medical research and clinical routine diagnostics on... (Review)
Review
Positron Emission Tomography (PET) experienced accelerated development and has become an established method for medical research and clinical routine diagnostics on patient individualized basis. Development and availability of new radiopharmaceuticals specific for particular diseases is one of the driving forces of the expansion of clinical PET. The future development of the ⁶⁸Ga-radiopharmaceuticals must be put in the context of several aspects such as role of PET in nuclear medicine, unmet medical needs, identification of new biomarkers, targets and corresponding ligands, production and availability of ⁶⁸Ga, automation of the radiopharmaceutical production, progress of positron emission tomography technologies and image analysis methodologies for improved quantitation accuracy, PET radiopharmaceutical regulations as well as advances in radiopharmaceutical chemistry. The review presents the prospects of the ⁶⁸Ga-based radiopharmaceutical development on the basis of the current status of these aspects as well as wide range and variety of imaging agents.
Topics: Animals; Drug Discovery; Gallium Radioisotopes; Humans; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 24396515
DOI: 10.7150/thno.7447 -
American Journal of Veterinary Research Sep 2023Measure 18F-FDG uptake in digital tissues of healthy horses subjected to different ambulatory conditions between the time of injection and positron emission tomography...
OBJECTIVE
Measure 18F-FDG uptake in digital tissues of healthy horses subjected to different ambulatory conditions between the time of injection and positron emission tomography (PET) scan acquisition.
ANIMALS
8 healthy adult horses.
METHODS
Horses were walked (AMB) or tied in stalls (NONAMB) immediately after injection with ∼1.5 MBq/kg 18F-FDG until scan acquisition using a randomized crossover design. Steps were quantified using accelerometers. Standardized uptake values (SUV; mean and maximum) in digital tissues including the dorsal lamellae (proximal, middle, and distal), quarter lamellae (medial and lateral), and coronary band were analyzed using a mixed-effects linear regression model.
RESULTS
Mean (95% CI) step count for AMB (569[484-653]) was higher than NONAMB (88[24-152]) P = <.001. The SUVmax (but not SUVmean) was increased in AMB compared with NONAMB in the proximal (2.74[2.52-2.98] vs 2.42[2.05-2.78]; P = .04) and middle (2.74[2.37-3.11] vs 2.36[2.05-2.68]; P = .03) dorsal lamellae but was not different in the distal lamellae or coronary band. In the medial quarter lamellae, both SUVmax (2.53[1.58-3.48] vs 2.07[0.81-3.33]; P = .01) and SUVmean (1.90[1.55-2.25] vs 1.49[0.91-2.06]; P = .007) were increased in AMB compared with NONAMB. The medial quarter lamellae also had lower SUVmax (P = .002) and SUVmean (P = .04) compared with the lateral quarter and lower SUVmax compared with the mid-dorsal lamellae (P = .01).
CLINICAL RELEVANCE
Lamellar 18F-FDG uptake was affected by ambulatory activity mostly in the medial quarter; however, this effect was relatively small and unlikely to interfere with clinical detection of laminitis.
Topics: Animals; Fluorodeoxyglucose F18; Horses; Positron-Emission Tomography; Radionuclide Imaging; Radiopharmaceuticals; Walking; Cross-Over Studies
PubMed: 37481253
DOI: 10.2460/ajvr.23.04.0077 -
Seminars in Ultrasound, CT, and MR Aug 2008The 1990s witnessed the development of the first dual-modality imaging devices for clinical applications. A combined PET-CT prototype underwent clinical evaluation from...
The 1990s witnessed the development of the first dual-modality imaging devices for clinical applications. A combined PET-CT prototype underwent clinical evaluation from mid-1998 onward. The results from the three-year evaluation program stimulated the demand for commercial designs and in 2001 the first commercial PET-CT scanner was installed in the clinic. The availability of designs from all the major vendors of medical imaging equipment was followed by a rapid adoption of the technology and today, over 2500 PET-CT scanners are in clinical operation world-wide. This article briefly summarizes the short history of PET-CT, and reviews the current status of the technology.
Topics: History, 20th Century; History, 21st Century; Positron-Emission Tomography; Tomography, X-Ray Computed
PubMed: 18795489
DOI: 10.1053/j.sult.2008.05.006