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Journal of the American Pharmaceutical... Mar 1976
Topics: Biological Availability; Humans; Prednisolone
PubMed: 1254891
DOI: 10.1016/s0003-0465(16)33514-5 -
Postgraduate Medical Journal Jan 1960
Topics: Humans; Methylprednisolone; Prednisolone
PubMed: 14416486
DOI: 10.1136/pgmj.36.411.29 -
The British Journal of Ophthalmology Jun 1970
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Eye Diseases; Female; Humans; Male; Middle Aged; Prednisolone; Psychoses, Substance-Induced; Sclera
PubMed: 5448130
DOI: 10.1136/bjo.54.6.394 -
Current Pharmaceutical Design 2011Glucocorticoid drugs are commonly used in the treatment of many acute and chronic inflammatory diseases. However, application of these steroids is limited because of... (Review)
Review
Glucocorticoid drugs are commonly used in the treatment of many acute and chronic inflammatory diseases. However, application of these steroids is limited because of their physico-chemical properties, such as very low water solubility. Glucocorticoids also exhibit serious adverse side effects. Therefore, new drug delivery systems are being developed, with the aim of improving the physicochemical properties of glucocorticoids while avoiding undesirable side effects associated with systemic administration. Here we discuss the design and synthesis of conjugates of prednisolone (PD), methylprednisolone (MPD) and similar glucocorticoids. In this review, possibilities for targeting inflammatory sites, and reducing dosages and administration frequency through increasing drug circulation time are discussed. This review summarises synthetic approaches for the preparation of covalent conjugates, which are divided into two groups: low molecular weight conjugates and polymeric conjugates. These two groups are further divided into subgroups based on the chemical structure of the conjugates. Published results from in vitro and in vivo testing of prepared conjugates are also discussed.
Topics: Animals; Anti-Inflammatory Agents; Drug Delivery Systems; Drug Design; Humans; Methylprednisolone; Molecular Structure; Molecular Weight; Prednisolone; Prodrugs
PubMed: 22074428
DOI: 10.2174/138161211798194530 -
The CLAO Journal : Official Publication... Oct 1991The superior bioavailability and therapeutic effect of prednisolone acetate over prednisolone sodium phosphate was described about 15 years ago. Review of the original... (Review)
Review
The superior bioavailability and therapeutic effect of prednisolone acetate over prednisolone sodium phosphate was described about 15 years ago. Review of the original articles and subsequent studies show that in clinical situations the two medications are probably equally effective. Further, patient compliance studies show that prednisolone sodium phosphate may actually be superior.
Topics: Animals; Biological Availability; Cornea; Humans; Keratitis; Patient Compliance; Prednisolone
PubMed: 1764775
DOI: No ID Found -
Tidsskrift For Den Norske Laegeforening... Mar 2016
Topics: Anti-Inflammatory Agents; Fatigue Syndrome, Chronic; Humans; Hydrocortisone; Prednisolone
PubMed: 26983139
DOI: 10.4045/tidsskr.16.0088 -
Deutsche Medizinische Wochenschrift... Jul 1998
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Hormonal; Glucocorticoids; Humans; Prednisolone
PubMed: 9721570
DOI: 10.1055/s-0029-1237264 -
Archives of Ophthalmology (Chicago,... May 1998
Topics: Chemical Precipitation; Crystallization; Drugs, Generic; Humans; Ophthalmic Solutions; Prednisolone; Suspensions
PubMed: 9596522
DOI: No ID Found -
Orvosi Hetilap Dec 1971
Topics: Adult; Asthma; Diabetes Mellitus; Female; Humans; Kidney; Pancreas; Pancreatitis; Prednisolone
PubMed: 5132732
DOI: No ID Found -
Yokohama Medical Bulletin Dec 1956
Topics: Hodgkin Disease; Prednisolone; Sarcoidosis
PubMed: 13456587
DOI: No ID Found